9B1E: Native SWR1

Cryo-EM structure of native SWR1 bound to nucleosome (composite structure). Determined by electron microscopy at 4.4 Å resolution. Released 9 Oct 2024.

Method: Electron microscopy
Resolution: 4.4 Å
Organisms: Saccharomyces cerevisiae W303, Saccharomyces cerevisiae, Drosophila melanogaster
Chains: 21
Atoms: 49,842
Mol. weight: 1099.12 kDa
Ligands: ADP, BEF, ZN, MG
Released: 9 Oct 2024

Explore 9B1E in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9B1E contains 281 α-helices and 248 β-strands across 19 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	686-689	4
α-helix	698-712	15
β-strand	717-721	5	1
α-helix	727-740	14
β-strand	748-752	5	1
α-helix	754-767	14
β-strand	773-776	4	1
α-helix	780-787	8
β-strand	798-802	5	1
α-helix	803-815	13
β-strand	820-823	4	1
α-helix	826-830	5
α-helix	835-842	8
β-strand	847-851	5	1
α-helix	855-857	3
α-helix	860-870	11
β-strand	874-876	3	2
β-strand	879-881	3	2
α-helix	887-890	4
α-helix	891-895	5
α-helix	913-928	16
β-strand	929-932	4	1
α-helix	934-937	4
β-strand	944-951	8	3
α-helix	952-954	3
α-helix	955-966	12
α-helix	968-976	9
α-helix	979-994	16
α-helix	996-999	4
β-strand	1006	1	4
β-strand	1008-1009	2	5
α-helix	1015-1018	4
α-helix	1019-1035	17
α-helix	1050-1053	4
α-helix	1056-1064	9
β-strand	1066	1	6
α-helix	1068-1089	22
α-helix	1096-1097	2
α-helix	1100-1130	31
α-helix	1138-1145	8
α-helix	1159-1162	4
α-helix	1166-1172	7
α-helix	1174-1180	7
β-strand	1187-1188	2	5
α-helix	1191-1195	5
α-helix	1207-1219	13
α-helix	1225-1232	8
β-strand	1233	1	4
α-helix	1240-1243	4
α-helix	1246-1261	16
β-strand	1265-1269	5	3
α-helix	1272-1285	14
β-strand	1289-1292	4	3
α-helix	1298-1310	13
β-strand	1316-1320	5	3
α-helix	1321-1324	4
β-strand	1335-1338	4	3
α-helix	1345-1355	11
β-strand	1364-1371	8	3
α-helix	1375-1393	19
α-helix	1402-1406	5
α-helix	1409-1413	5

Chain B: 19 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	183-187	5
α-helix	197-232	36
α-helix	238-262	25
α-helix	270-278	9
α-helix	282	1
β-strand	286-296	11	7
α-helix	299-315	17
β-strand	588-598	11	7
β-strand	602	1	7
α-helix	606-614	9
β-strand	635-640	6	8
α-helix	658-665	8
α-helix	676-685	10
α-helix	695-697	3
β-strand	701	1	9
α-helix	706	1
β-strand	707	1	9
α-helix	708	1
β-strand	709	1	10
α-helix	710	1
α-helix	715	1
β-strand	716	1	10
α-helix	717	1
β-strand	719-720	2	11
β-strand	727-728	2	11
α-helix	731-740	10
α-helix	763-765	3
β-strand	769-774	6	12
β-strand	777-782	6	12
α-helix	787-788	2
α-helix	791-792	2

Chain C: 27 helices, 23 β-strands

Element	Residues	Length	Sheet
α-helix	4-5	2
β-strand	6-9	4	13
β-strand	16-19	4	13
β-strand	32-34	3	14
β-strand	40-42	3	14
α-helix	43-48	6
α-helix	52-54	3
β-strand	56-58	3	14
β-strand	61	1	15
β-strand	66	1	15
α-helix	69-81	13
β-strand	98-102	5	13
α-helix	109-117	9
α-helix	118-122	5
β-strand	127-131	5	13
α-helix	133-136	4
α-helix	137-142	6
β-strand	147-151	5	16
β-strand	187-193	7	16
β-strand	198-204	7	16
β-strand	207-208	2	16
α-helix	210-212	3
β-strand	214-216	3	16
α-helix	220-234	15
α-helix	242-251	10
α-helix	260-265	6
β-strand	272-275	4	17
α-helix	276-277	2
β-strand	278	1	18
β-strand	282	1	18
β-strand	286-288	3	17
α-helix	295-298	4
β-strand	303-306	4	17
α-helix	309-312	4
α-helix	314-317	4
α-helix	330-340	11
α-helix	346-351	6
β-strand	353-356	4	16
α-helix	359-361	3
α-helix	365-376	12
β-strand	378	1	19
β-strand	384-388	5	16
α-helix	392-394	3
α-helix	395-404	10
α-helix	407-412	6
β-strand	414-415	2	13
α-helix	416-421	6
α-helix	424-426	3
α-helix	427-432	6
α-helix	434-436	3

Chain D: 12 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	5-7	3	20
β-strand	18-20	3	21
α-helix	53-61	9
α-helix	92-106	15
α-helix	110-115	6
α-helix	116-124	9
α-helix	128-133	6
α-helix	169-178	10
α-helix	193-201	9
α-helix	208-213	6
α-helix	219-222	4
α-helix	223-228	6
β-strand	254-256	3	21
β-strand	262-263	2	21
α-helix	266-271	6
α-helix	272-276	5

Chain E: 20 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	24	1	22
β-strand	35	1	23
β-strand	41	1	23
β-strand	44-45	2	24
β-strand	48-49	2	24
α-helix	52-67	16
β-strand	70	1	25
β-strand	74-79	6	26
α-helix	85-96	12
β-strand	102-106	5	26
α-helix	107-110	4
α-helix	117-127	11
β-strand	129-149	21	20
β-strand	166-172	7	20
β-strand	175-181	7	20
α-helix	183-191	9
β-strand	198-203	6	20
β-strand	208-215	8	20
α-helix	216-218	3
β-strand	224	1	7
β-strand	229-230	2	20
α-helix	231-234	4
β-strand	238-248	11	20
α-helix	249-257	9
α-helix	265-272	8
α-helix	282-298	17
β-strand	301-305	5	20
β-strand	307-311	5	26
α-helix	313-315	3
α-helix	318-328	11
β-strand	335-340	6	26
β-strand	342	1	27
α-helix	345	1
β-strand	346	1	28
α-helix	347	1
β-strand	354	1	28
α-helix	361-364	4
β-strand	367-372	6	26
α-helix	377-390	14
β-strand	395	1	29
α-helix	397-409	13
α-helix	412-428	17
β-strand	434	1	29
α-helix	436-445	10
β-strand	447	1	30
α-helix	449-456	8

Chain F: 21 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	20	1	31
β-strand	31	1	32
α-helix	36	1
β-strand	37	1	32
α-helix	38	1
β-strand	40-41	2	33
β-strand	44-45	2	33
α-helix	48-63	16
β-strand	66	1	22
β-strand	70-74	5	30
α-helix	81-92	12
β-strand	98-102	5	30
α-helix	103-105	3
α-helix	113-122	10
β-strand	125-148	24	7
β-strand	154-161	8	7
β-strand	166-171	6	7
α-helix	173-182	10
β-strand	188-193	6	7
β-strand	199-204	6	7
β-strand	207	1	7
β-strand	221	1	7
α-helix	223-225	3
β-strand	230-240	11	7
α-helix	241-249	9
α-helix	253-259	7
α-helix	267-283	17
β-strand	287-290	4	7
β-strand	292-296	5	30
α-helix	298-300	3
α-helix	303-314	12
β-strand	320-325	6	30
β-strand	330-331	2	34
α-helix	332	1
β-strand	338-339	2	34
α-helix	345-349	5
β-strand	352-355	4	30
α-helix	361-374	14
β-strand	379	1	35
α-helix	381-393	13
α-helix	396-412	17
β-strand	418	1	35
α-helix	420-429	10
β-strand	431	1	36
α-helix	433-442	10
α-helix	444-446	3
β-strand	448	1	37

Chain G: 20 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	24	1	38
β-strand	35	1	39
β-strand	41	1	39
β-strand	44-45	2	40
β-strand	48-49	2	40
α-helix	52-67	16
β-strand	70	1	31
β-strand	74-79	6	36
α-helix	85-96	12
β-strand	102-106	5	36
α-helix	107-110	4
α-helix	117-128	12
β-strand	130-152	23	7
β-strand	161-172	12	7
β-strand	175-181	7	7
α-helix	185-192	8
β-strand	198-203	6	7
β-strand	209-215	7	7
α-helix	216-218	3
β-strand	224	1	8
α-helix	228	1
β-strand	229-230	2	7
α-helix	231-234	4
β-strand	238-248	11	7
α-helix	249-257	9
α-helix	265-272	8
α-helix	282-297	16
β-strand	301-304	4	7
β-strand	307-311	5	36
α-helix	313-315	3
α-helix	318-327	10
β-strand	335-340	6	36
β-strand	342	1	37
β-strand	345-346	2	41
α-helix	347	1
β-strand	354-355	2	41
α-helix	361-364	4
β-strand	367-372	6	36
α-helix	377-390	14
β-strand	395	1	42
α-helix	397-409	13
α-helix	412-428	17
β-strand	434	1	42
α-helix	436-445	10
β-strand	447	1	43
α-helix	449-454	6

Chain H: 22 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	20	1	44
β-strand	31	1	45
α-helix	36	1
β-strand	37	1	45
α-helix	38	1
β-strand	40-41	2	46
β-strand	44-45	2	46
α-helix	48-63	16
β-strand	66	1	38
β-strand	70-74	5	43
α-helix	81-92	12
β-strand	98-102	5	43
α-helix	104-106	3
α-helix	113-123	11
β-strand	125-146	22	8
β-strand	155-162	8	8
β-strand	165-171	7	8
α-helix	173-182	10
β-strand	188-192	5	8
β-strand	199-204	6	8
α-helix	206-211	6
β-strand	214	1	19
β-strand	221	1	8
β-strand	222	1	6
α-helix	223-225	3
β-strand	230-240	11	8
α-helix	241-249	9
α-helix	253-259	7
α-helix	267-283	17
β-strand	286-290	5	8
β-strand	292-296	5	43
α-helix	298-300	3
α-helix	303-312	10
β-strand	320-325	6	43
β-strand	330-331	2	47
α-helix	332	1
β-strand	338-339	2	47
α-helix	345-349	5
β-strand	351-355	5	43
α-helix	361-374	14
α-helix	381-393	13
α-helix	396-412	17
α-helix	420-429	10
β-strand	431	1	48
α-helix	433-442	10
α-helix	444-446	3
β-strand	448	1	49

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Helicase SWR1	A	protein	1544	Saccharomyces cerevisiae W303	Q05471 (AlphaFold model)
Vacuolar protein sorting-associated protein 72	B	protein	795	Saccharomyces cerevisiae W303	Q03388 (AlphaFold model)
Actin-like protein ARP6	C	protein	438	Saccharomyces cerevisiae W303	Q12509 (AlphaFold model)
Vacuolar protein sorting-associated protein 71	D	protein	280	Saccharomyces cerevisiae W303	Q03433 (AlphaFold model)
RuvB-like protein 1	E, G, I	protein	837	Saccharomyces cerevisiae W303	Q03940
RuvB-like protein 2	F, H, J	protein	471	Saccharomyces cerevisiae W303	Q12464
SWR1-complex protein 3	K	protein	625	Saccharomyces cerevisiae W303	P31376
Histone H2A	Q, S	protein	132	Saccharomyces cerevisiae	P04911
Histone H2B	R, T	protein	131	Saccharomyces cerevisiae	P02293
Histone H3	U, W	protein	136	Drosophila melanogaster	P02299
Histone H4	V, X	protein	103	Drosophila melanogaster	A0A0B4KFZ9
DNA (214-mer)	Y	DNA	214	synthetic construct

1 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9B1E_1 Helicase SWR1 (chains A)
MTTSRKSHAKDKKAGGEQDLADLKFRYDLLTNELFHLREFVSLVDYDPTHFNDSESFQKF
LRETHLSLEERGEKFTDDVAKKGTNGDLTRRRRNLRTSTVVSSETTNEKKGDIELKLESI
APLVRNKCEELKYKLSDHSNRKSIVPQKRPIQHLKKREAAKSLKFKSERKENPLPLHEHI
AEERYDHIAKVEEPSEAFTIKCPSDDSSFENTSEHYSDNFYFTTSSEEEDIKKKRGRKKK
KPRIKLVVHPPKQTITNPLHVVKPGYESLHEYIASFKSLEDDLTLEEYNKYIDEQRRLLS
RLKKGIENGALKYDKETDSLQPITSKEIKTIITYKPDPISYFYKQQDLQIHTDHLINQGI
HMSKLFRSSTKARIARAKKVSQMIEQHFKHVAGAEERKAKEEERHKKSLARFAVQAVKKR
WNMAEKAYRILRKDEEEQLKRIEGKQHLSKMLEKSTQLLEAQLNQVNDDGRSSTPSSDSN
DVLSESDDDMDDELSTSSDEDEEVDADVGLENSPASTEATPTDESLNLIQLKEKYGHFNG
SSTVYDSRNKDEKFPTLDKHESSSSESSVMTGEESSIYSSSENESQNENDRESDDKTPSV
GLSALFGKGEESDGDLDLDDSEDFTVNSSSVEGEELEKDQVDNSAATFERAGDFVHTQNE
NRDDIKDVEEDAETKVQEEQLSVVDVPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILA
DEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSP
QQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQAL
LNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTVIDGKKVSGFADLDAFQQWFGRPVDK
IIETGQNFGQDKETKKTVAKLHQVLRPYLLRRLKADVEKQMPAKYEHIVYCKLSKRQRFL
YDDFMSRAQTKATLASGNFMSIVNCLMQLRKVCNHPNLFEVRPILTSFVLEHCVASDYKD
VERTLLKLFKKNNQVNRVDLDFLNLVFTLNDKDLTSYHAEEISKLTCVKNFVEEVNKLRE
TNKQLQEEFGEASFLNFQDANQYFKYSNKQKLEGTVDMLNFLKMVNKLRCDRRPIFGKNL
IDLLTKDRRVKYDKSSIIDNELIKPLQTRVLDNRKIIDTFAVLTPSAVSLDMRKLALGLN
DDSSVGENTRLKVMQNCFEVSNPLHQLQTKLTIAFPDKSLLQYDCGKLQKLAILLQQLKD
NGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRITVFILS
SRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEHTIESNIL
KKANQKRQLDNVVIQEGDFTTDYFSKLSVRDLLGSELPENASGGDKPLIADADVAAKDPR
QLERLLAQAEDEDDVKAANLAMREVEIDNDDFDESTEKKAANEEEENHAELDEYEGTAHV
DEYMIRFIANGYYYGSGGSGDYKDHDGDYKDHDIDYKDDDDKGS

Sequence of entity 2 (B), FASTA

>9B1E_2 Vacuolar protein sorting-associated protein 72 (chains B)
MSDEGADKSLDTNTEFIIQTRSRRSNAGNKLQKLLEQELRDIESTKRQISSYKNGNDDEE
DEIGLLFQEDEDDEDFEMMAKDDDDEGEEKEDETQSIRKEPSQASSEQAADDLMFSSSES
EDSSNENDEDAEEKEIRRQELLSRKKRNKRLQKGPVVIKKQKPKPKSGEAIPRSHHTHEQ
LNAETLLLNTRRTSKRSSVMENTMKVYEKLSKAEKKRKIIQERIRKHKEQESQHMLTQEE
RLRIAKETEKLNILSLDKFKEQEVWKKENRLALQKRQKQKFQPNETILQFLSTAWLMTPA
MELEDRKYWQEQLNKRDKKKKKYPRKPKKNLNLGKQDASDDKKRESEESIKNDGDVNSLG
ENSSSVHNQKRIEETSTNDTVEGESSPDAAVSRVNSDELKPTALPDVTLDAIANKQSTVD
EAPNSQPQKNIITNEQKITNVGEPIQNLHNEEIKDEMVSALESRENTFENSSPAAQVVSQ
RDNSATPTPSNSTGTEDTILISPDTDIKGEPEPCLKTEGIENLSHNVPQETKSNTDVSFL
KQVTFTDHPQVAIIDTEESPSKKDTANVDESSAENSLSTQTYEGPEQLTSRNFVTLYDFP
NAPPNLKDFNTNLFGDRWSYTNGLSATQRPQDMKTVFHSILPSPPQSSVPSPTVDISLDL
SALANFPSFGEYDKKIVHQINTEINKDLEIKIKTQPPTGVFLANGIRKKCLITNKECQYF
DPRTGVPYSDVEAYKIIQRIQDPISKEEGRSDIKRDETTNEDSDDQVRFKWFGFKNGGIY
LDLSQRPAKGVPEGF

Sequence of entity 3 (C), FASTA

>9B1E_3 Actin-like protein ARP6 (chains C)
METPPIVIDNGSYEIKFGPSTNKKPFRALNALAKDKFGTSYLSNHIKNIKDISSITFRRP
HELGQLTLWELESCIWDYCLFNPSEFDGFDLKEGKGHHLVASESCMTLPELSKHADQVIF
EEYEFDSLFKSPVAVFVPFTKSYKGEMRTISGKDEDIDIVRGNSDSTNSTSSESKNAQDS
GSDYHDFQLVIDSGFNCTWIIPVLKGIPYYKAVKKLDIGGRFLTGLLKETLSFRHYNMMD
ETILVNNIKEQCLFVSPVSYFDSFKTKDKHALEYVLPDFQTSFLGYVRNPRKENVPLPED
AQIITLTDELFTIPETFFHPEISQITKPGIVEAILESLSMLPEIVRPLMVGNIVCTGGNF
NLPNFAQRLAAELQRQLPTDWTCHVSVPEGDCALFGWEVMSQFAKTDSYRKARVTREEYY
EHGPDWCTKHRFGYQNWI

Sequence of entity 4 (D), FASTA

>9B1E_4 Vacuolar protein sorting-associated protein 71 (chains D)
MKALVEEIDKKTYNPDIYFTSLDPQARRYTSKKINKQGTISTSRPVKRINYSLADLEARL
YTSRSEGDGNSISRQDDRNSKNSHSFEERYTQQEILQSDRRFMELNTENFSDLPNVPTLL
SDLTGVPRDRIESTTKPISQTSDGLSALMGGSSFVKEHSKYGHGWVLKPETLREIQLSYK
STKLPKPKRKNTNRIVALKKVLSSKRNLHSFLDSALLNLMDKNVIYHNVYNKRYFKVLPL
ITTCSICGGYDSISSCVNCGNKICSVSCFKLHNETRCRNR

Sequence of entity 5 (E, G, I), FASTA

>9B1E_5 RuvB-like protein 1 (chains E, G, I)
MVAISEVKENPGVNSSNSGAVTRTAAHTHIKGLGLDESGVAKRVEGGFVGQIEAREACGV
IVDLIKAKKMSGRAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTET
LMENFRRAIGLRIKETKEVYEGEVTELTPEDAENPLGGYGKTISHVIVGLKSAKGTKTLR
LDPTIYESIQREKVSIGDVIYIEANTGAVKRVGRSDAYATEFDLETEEYVPLPKGEVHKK
KEIVQDVTLHDLDVANARPQGGQDVISMMGQLLKPKKTEITEKLRQEVNKVVAKYIDQGV
AELIPGVLFIDEVNMLDIEIFTYLNKALESNIAPVVVLASNRGMTTVRGTEDVISPHGVP
PDLIDRLLIVRTLPYDKDEIRTIIERRATVERLQVESSALDLLATMGTETSLRYALQLLA
PCGILAQTSNRKEIVVNDVNEAKLLFLDAKRSTKILETSANYLSGGGASMKIEEGKLVIW
INGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGY
AQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWE
EIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKA
GLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEE
LAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTN

Sequence of entity 6 (F, H, J), FASTA

>9B1E_6 RuvB-like protein 2 (chains F, H, J)
MSIQTSDPNETSDLKSLSLIAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKM
VQNGTIAGRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIAGSEIFSLELSKTEALTQA
FRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIDGLT
KEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGADTRFVQCPEGELQKRKTVVHTVS
LHEIDVINSRTQGFLALFTGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHM
LDIECFSFINRALEDEFAPIVMMATNRGVSKTRGTNYKSPHGLPLDLLDRSIIITTKSYN
EQEIKTILSIRAQEEEVELSSDALDLLTKTGVETSLRYSSNLISVAQQIAMKRKNNTVEV
EDVKRAYLLFLDSARSVKYVQENESQYIDDQGNVQISIAKSADPDAMDTTE

Sequence of entity 7 (K), FASTA

>9B1E_7 SWR1-complex protein 3 (chains K)
MPAVLRTRSKESSIEQKPASRTRTRSRRGKRGRDDDDDDDDEESDDAYDEVGNDYDEYAS
RAKLATNRPFEIVAGLPASVELPNYNSSLTHPQSIKNSGVLYDSLVSSRRTWVQGEMFEL
YWRRPKKIVSESTPAATESPTSGTIPLIRDKMQKMCDCVMSGGPHTFKVRLFILKNDKIE
QKWQDEQELKKKEKELKRKNDAEAKRLRMEERKRQQMQKKIAKEQKLQLQKENKAKQKLE
QEALKLKRKEEMKKLKEQNKNKQGSPSSSMHDPRMIMNLNLMAQEDPKLNTLMETVAKGL
ANNSQLEEFKKFIEIAKKRSLEENPVNKRPSVTTTRPAPPSKAKDVAEDHRLNSITLVKS
SKTAATEPEPKKADDENAEKQQSKEAKTTAESTQVDVKKEEEDVKEKGVKSEDTQKKEDN
QVVPKRKRRKNAIKEDKDMQLTAFQQKYVQGAEIILEYLEFTHSRYYLPKKSVVEFLEDT
DEIIISWIVIHNSKEIEKFKTKKIKAKLKADQKLNKEDAKPGSDVEKEVSFNPLFEADCP
TPLYTPMTMKLSGIHKRFNQIIRNSVSPMEEVVKEMEKILQIGTRLSGYNLWYQLDGYDD
EALSESLRFELNEWEHAMRSRRHKR

Sequence of entity 8 (Q, S), FASTA

>9B1E_8 Histone H2A (chains Q, S)
MSGGKGGKAGSAAKASQSRSAKAGLTFPVGRVHRLLRRGNYAQRIGSGAPVYLTAVLEYL
AAEILELAGNAARDNKKTRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHQNLLPK
KSAKATKASQEL

Sequence of entity 9 (R, T), FASTA

>9B1E_9 Histone H2B (chains R, T)
MSAKAEKKPASKAPAEKKPAAKKTSTSTDGKKRSKARKETYSSYIYKVLKQTHPDTGISQ
KSMSILNSFVNDIFERIATEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTR
AVTKYSSSTQA

Sequence of entity 10 (U, W), FASTA

>9B1E_10 Histone H3 (chains U, W)
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA

Sequence of entity 11 (V, X), FASTA

>9B1E_11 Histone H4 (chains V, X)
MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Sequence of entity 12 (Y), FASTA

>9B1E_12 DNA (214-MER) (chains Y)
ATCGCATCGATCTTCACACCGAGTTCATCCCTTATGTGATGGACCCTATACGCGGCCGCC
CTGGAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGCAAGCTCTAGCACCGCTTAA
ACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCA
GGCACGTGTCAGATATATACATCCTGTGCATGAT

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	8
BEF	Beryllium trifluoride ion	Be F3	2
ZN	Zinc ion	Zn	2
MG	Magnesium ion	Mg	8

Primary citation

Molecular basis of global promoter sensing and nucleosome capture by the SWR1 chromatin remodeler. Louder, R.K., Park, G., Ye, Z. et al. Cell (2024) 187:6849-6864.e18. DOI 10.1016/j.cell.2024.09.007 · PubMed

Other PDB entries of the same protein (UniProt Q05471 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4M6B 1.78 Å, Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer
5I9E 2.8 Å, Crystal structure of a nuclear actin ternary complex
9B1D 3.3 Å, Cryo-EM structure of native SWR1 bound to DNA (composite structure)
8QYV 3.5 Å, SWR1-hexasome complex
6GEJ 3.6 Å, Chromatin remodeller-nucleosome complex at 3.6 A resolution.
6GEN 3.6 Å, Chromatin remodeller-nucleosome complex at 4.5 A resolution.
8QKU 3.8 Å, SWR1-nucleosome complex in configuration 1
8QZ0 3.8 Å, SWR1-hexasome-dimer complex
9FBW 4.4 Å, SWR1 lacking Swc5 subunit in complex with hexasome
8QKV 4.7 Å, SWR1-nucleosome complex in configuration 2

Browse structure collections

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