9B4P: Tetramer Formation of the BCL11A ZF0 Domain
Tetramer Formation of the BCL11A ZF0 Domain. Determined by X-ray diffraction at 2.56 Å resolution. Released 18 Dec 2024.
- Method
- X-ray diffraction
- Resolution
- 2.56 Å
- Organism
- Homo sapiens
- Chains
- 10
- Atoms
- 2,252
- Mol. weight
- 33.06 kDa
- Ligands
- ZN
- Released
- 18 Dec 2024
Explore 9B4P in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9B4P contains 19 α-helices and 20 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A and G: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-47 | 3 | 2 |
| β-strand | 54-56 | 3 | 2 |
| α-helix | 57-59 | 3 | |
| α-helix | 60-67 | 8 | |
Chain B: 1 helix, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-47 | 3 | 1 |
| β-strand | 54-56 | 3 | 1 |
| α-helix | 60-68 | 9 | |
Chain C: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-47 | 3 | 1 |
| β-strand | 54-55 | 2 | 1 |
| α-helix | 57-59 | 3 | |
| α-helix | 60-66 | 7 | |
Chains D and I: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-47 | 3 | 2 |
| β-strand | 54-56 | 3 | 2 |
| α-helix | 57-59 | 3 | |
| α-helix | 60-68 | 9 | |
Chains E, F and H: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-47 | 3 | 3 |
| β-strand | 54-56 | 3 | 3 |
| α-helix | 57-59 | 3 | |
| α-helix | 60-69 | 10 | |
Chain J: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-47 | 3 | 5 |
| β-strand | 54-56 | 3 | 5 |
| α-helix | 57-59 | 3 | |
| α-helix | 60-66 | 7 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| B-cell lymphoma/leukemia 11A | A, B, C, D, E, F, G, H, I, J | protein | 28 | Homo sapiens | Q9H165 (AlphaFold model) |
Sequence of entity 1 (A, B, C, D, E, F, G, H, I, J), FASTA
>9B4P_1 B-cell lymphoma/leukemia 11A (chains A, B, C, D, E, F, G, H, I, J)
SLLTCGQCQMNFPLGDILIFIEHKRKQC
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 10 |
Primary citation
A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing. Zheng, G., Yin, M., Mehta, S. et al. Science (2024) 386:1010-1018. DOI 10.1126/science.adp3025 · PubMed
Other PDB entries of the same protein (UniProt Q9H165 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6U9Q 1.83 Å, Crystal Structure Analysis of DNA-BCL11A Znf domain complex
- 9YLM 1.91 Å, BCL11A ZF4-6 in Complex with a DNA Sequence Observed in the Human Globin Locus…
- 9YLO 1.97 Å, BCL11A ZF2-3 in Complex with a DNA Sequence Observed in the Human Globin Locus…
- 9YLP 2.04 Å, BCL11A ZF2-3 in Complex with a DNA Sequence Observed in the Human Globin Locus…
- 9E6R 2.09 Å, BCL11A ZF4-6 in Complex with a DNA Sequence Observed in the Human Globin Locus…
- 9YLN 2.15 Å, BCL11A ZF4-6 in Complex with a DNA Sequence Observed in the Human Globin Locus…
- 8DTN 2.2 Å, The complex of nanobody 6101 with BCL11A ZF6
- 9E6S 2.2 Å, BCL11A ZF4-6 with K784T Mutation in Complex with a DNA Sequence Observed in the Human…
- 9YLL 2.38 Å, BCL11A ZF4-6 in Complex with a DNA Sequence Observed in the Human Globin Locus…
- 5VTB 2.4 Å, Crystal structure of RBBP4 bound to BCL11a peptide
- 8DTU 2.45 Å, The complex of nanobody 5344N74D with BCL11A ZF6.
- 6KI6 2.5 Å, Crystal structure of BCL11A in complex with gamma-globin -115 HPFH region
Browse structure collections
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