9E12: Cytoplasmic dynein 1 heavy chain 1

Full-length human dynein-1 in phi comformation under Lis1 condition. Determined by electron microscopy at 4.5 Å resolution. Released 6 Aug 2025.

Method: Electron microscopy
Resolution: 4.5 Å
Organism: Homo sapiens
Chains: 12
Atoms: 89,391
Mol. weight: 1388.84 kDa
Ligands: MG, ATP, ADP
Released: 6 Aug 2025

Explore 9E12 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9E12 contains 509 α-helices and 281 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 228 helices, 79 β-strands

Element	Residues	Length	Sheet
α-helix	23-26	4
α-helix	27-43	17
α-helix	50-56	7
α-helix	59-70	12
β-strand	78-82	5	1
β-strand	85-87	3	2
β-strand	95-97	3	2
β-strand	100-104	5	1
β-strand	115-120	6	1
α-helix	131-134	4
β-strand	135-139	5	1
α-helix	145-167	23
α-helix	178-192	15
α-helix	211-222	12
α-helix	230-237	8
α-helix	239-261	23
α-helix	271-288	18
α-helix	295-306	12
α-helix	310-317	8
α-helix	324-328	5
α-helix	334-346	13
α-helix	350-367	18
α-helix	374-399	26
α-helix	401-403	3
α-helix	406-443	38
α-helix	456-483	28
α-helix	513-533	21
α-helix	540-571	32
α-helix	582-586	5
α-helix	591-593	3
α-helix	597-600	4
α-helix	606-624	19
α-helix	631-638	8
α-helix	643-669	27
α-helix	673-675	3
α-helix	677-692	16
α-helix	696-709	14
β-strand	721-723	3	3
β-strand	732-734	3	3
α-helix	741-755	15
α-helix	764-772	9
α-helix	775-797	23
α-helix	799-801	3
α-helix	806-820	15
α-helix	829-865	37
α-helix	871-890	20
α-helix	896-927	32
α-helix	956-957	2
β-strand	958-961	4	4
α-helix	965-967	3
α-helix	975-994	20
α-helix	996-999	4
α-helix	1011-1013	3
α-helix	1014-1017	4
α-helix	1022-1025	4
α-helix	1031-1055	25
α-helix	1056-1061	6
α-helix	1065-1071	7
α-helix	1082-1089	8
β-strand	1099-1102	4	4
β-strand	1105-1108	4	4
α-helix	1115-1153	39
α-helix	1163-1199	37
α-helix	1208-1210	3
α-helix	1211-1235	25
α-helix	1238-1264	27
α-helix	1273-1304	32
α-helix	1313-1347	35
α-helix	1356-1371	16
α-helix	1375-1379	5
α-helix	1381-1393	13
α-helix	1396-1400	5
α-helix	1410-1420	11
α-helix	1431-1434	4
α-helix	1443-1455	13
α-helix	1458-1472	15
β-strand	1474	1	5
β-strand	1476-1480	5	6
β-strand	1484-1488	5	6
α-helix	1490-1509	20
α-helix	1513-1516	4
α-helix	1517-1551	35
α-helix	1556-1560	5
α-helix	1562-1584	23
β-strand	1587	1	5
α-helix	1588-1592	5
α-helix	1598-1612	15
α-helix	1616-1625	10
α-helix	1627-1631	5
α-helix	1634-1642	9
α-helix	1647-1653	7
α-helix	1654-1657	4
β-strand	1663-1666	4	7
β-strand	1672-1677	6	7
β-strand	1683-1691	9	7
α-helix	1698-1727	30
α-helix	1735-1744	10
α-helix	1747-1769	23
α-helix	1778-1796	19
α-helix	1802-1828	27
α-helix	1836-1839	4
β-strand	1843-1846	4	8
α-helix	1853-1855	3
β-strand	1857-1860	4	8
β-strand	1866-1867	2	8
α-helix	1878-1880	3
α-helix	1883-1897	15
β-strand	1901-1905	5	9
α-helix	1913-1922	10
β-strand	1927-1931	5	9
α-helix	1938-1951	14
β-strand	1954-1958	5	9
α-helix	1960-1962	3
α-helix	1965-1985	21
α-helix	1995-1997	3
β-strand	1998-2001	4	10
β-strand	2004-2007	4	10
β-strand	2013-2018	6	9
α-helix	2025-2029	5
α-helix	2030-2033	4
β-strand	2036-2040	5	9
α-helix	2046-2056	11
α-helix	2062-2077	16
α-helix	2090-2117	28
α-helix	2124-2129	6
α-helix	2133-2144	12
α-helix	2146-2148	3
α-helix	2153-2164	12
α-helix	2176-2188	13
α-helix	2201-2216	16
β-strand	2219-2223	5	11
α-helix	2230-2245	16
β-strand	2249-2254	6	11
α-helix	2256-2258	3
α-helix	2261-2265	5
β-strand	2266-2268	3	12
β-strand	2275-2277	3	12
α-helix	2279-2289	11
α-helix	2294-2296	3
β-strand	2298-2304	7	11
α-helix	2312-2315	4
α-helix	2316-2319	4
β-strand	2324-2326	3	13
β-strand	2332-2334	3	13
α-helix	2335-2336	2
β-strand	2339-2345	7	11
α-helix	2353-2356	4
β-strand	2360-2363	4	11
α-helix	2366-2368	3
α-helix	2371-2384	14
α-helix	2411-2423	13
α-helix	2424-2426	3
α-helix	2432-2440	9
α-helix	2451-2475	25
α-helix	2483-2502	20
α-helix	2508-2521	14
α-helix	2534-2536	3
β-strand	2537-2539	3	14
β-strand	2545-2547	3	14
α-helix	2548-2551	4
α-helix	2559-2561	3
α-helix	2572-2586	15
β-strand	2591-2594	4	15
α-helix	2601-2610	10
β-strand	2615-2620	6	15
α-helix	2628-2638	11
β-strand	2639-2644	6	16
β-strand	2647-2652	6	16
β-strand	2658-2663	6	15
α-helix	2670-2672	3
α-helix	2678-2689	12
β-strand	2691-2694	4	16
β-strand	2699-2703	5	16
β-strand	2706-2712	7	15
α-helix	2722-2724	3
α-helix	2725-2728	4
β-strand	2733-2735	3	15
α-helix	2737-2740	4
α-helix	2741-2756	16
α-helix	2760-2765	6
α-helix	2766-2783	18
α-helix	2796-2810	15
α-helix	2818-2833	16
α-helix	2840-2857	18
α-helix	2863-2867	5
β-strand	2873-2874	2	17
β-strand	2882-2883	2	17
α-helix	2886-2903	18
α-helix	2913-2925	13
β-strand	2932-2937	6	18
α-helix	2943-2954	12
α-helix	2956	1
β-strand	2957-2959	3	18
α-helix	2969-2984	16
β-strand	2990-2995	6	18
α-helix	2996-2998	3
α-helix	3002-3014	13
α-helix	3024-3039	16
α-helix	3047-3061	15
β-strand	3062-3068	7	18
α-helix	3072-3081	10
α-helix	3084-3087	4
β-strand	3089-3095	7	18
α-helix	3097-3098	2
α-helix	3099-3109	11
α-helix	3139-3163	25
α-helix	3173-3297	125
α-helix	3300-3307	8
α-helix	3314-3326	13
α-helix	3334-3342	9
α-helix	3344-3346	3
α-helix	3349-3352	4
α-helix	3355-3357	3
α-helix	3360-3372	13
α-helix	3378-3383	6
α-helix	3389-3397	9
α-helix	3406-3481	76
α-helix	3483-3501	19
α-helix	3503-3516	14
α-helix	3522-3538	17
α-helix	3549-3553	5
α-helix	3556-3564	9
α-helix	3571-3582	12
α-helix	3586	1
β-strand	3587-3590	4	19
α-helix	3595-3603	9
β-strand	3610-3613	4	19
α-helix	3619-3629	11
β-strand	3632-3636	5	19
α-helix	3638-3640	3
α-helix	3643-3645	3
α-helix	3646-3650	5
β-strand	3653-3656	4	20
β-strand	3659-3664	6	20
β-strand	3667-3670	4	20
β-strand	3676-3681	6	19
α-helix	3690-3695	6
β-strand	3697-3700	4	19
α-helix	3702-3704	3
α-helix	3705-3720	16
α-helix	3722-3755	34
α-helix	3760-3762	3
α-helix	3764-3798	35
α-helix	3799-3801	3
α-helix	3802-3817	16
α-helix	3818-3820	3
α-helix	3829-3840	12
α-helix	3852-3872	21
α-helix	3877-3879	3
α-helix	3880-3893	14
α-helix	3902-3910	9
α-helix	3929-3938	10
α-helix	3942-3944	3
α-helix	3947-3953	7
α-helix	3957-3961	5
α-helix	3966-3969	4
α-helix	3982-3996	15
α-helix	3998-4000	3
α-helix	4001-4013	13
α-helix	4020-4022	3
α-helix	4024-4025	2
α-helix	4027-4029	3
α-helix	4030-4034	5
β-strand	4041-4045	5	21
α-helix	4052-4061	10
β-strand	4066-4070	5	21
α-helix	4074-4090	17
β-strand	4093-4097	5	21
α-helix	4099-4101	3
α-helix	4103-4114	12
β-strand	4123-4129	7	21
α-helix	4136-4141	6
β-strand	4143-4147	5	21
α-helix	4153-4163	11
α-helix	4166-4169	4
α-helix	4175-4193	19
α-helix	4197-4200	4
α-helix	4209-4226	18
α-helix	4235-4237	3
α-helix	4240-4246	7
α-helix	4247-4251	5
α-helix	4259-4272	14
α-helix	4275-4278	4
β-strand	4283-4285	3	22
β-strand	4294-4295	2	22
α-helix	4296-4297	2
α-helix	4302-4310	9
α-helix	4325-4327	3
α-helix	4329-4345	17
α-helix	4375-4390	16
α-helix	4396-4398	3
α-helix	4408-4438	31
α-helix	4446-4456	11
α-helix	4475-4497	23
α-helix	4502-4505	4
β-strand	4509	1	23
α-helix	4517-4532	16
β-strand	4539-4545	7	23
β-strand	4557-4560	4	23
β-strand	4564-4571	8	24
β-strand	4574-4584	11	24
β-strand	4588-4594	7	23
α-helix	4598-4600	3
β-strand	4604-4610	7	24
β-strand	4618-4626	9	24
α-helix	4632-4637	6
β-strand	4641-4643	3	24

Chain B: 223 helices, 91 β-strands

Element	Residues	Length	Sheet
β-strand	21	1	25
α-helix	27-42	16
α-helix	50-57	8
α-helix	59-70	12
β-strand	76-82	7	26
β-strand	83-85	3	27
β-strand	97-99	3	27
β-strand	102-104	3	26
β-strand	113-119	7	26
β-strand	125	1	25
α-helix	131-134	4
β-strand	136-140	5	26
α-helix	145-167	23
α-helix	170-172	3
α-helix	178-195	18
α-helix	211-221	11
α-helix	229-232	4
α-helix	233-236	4
α-helix	239-259	21
α-helix	271-292	22
α-helix	295-306	12
α-helix	310-318	9
α-helix	323-336	14
α-helix	341-345	5
α-helix	350-365	16
α-helix	366-369	4
α-helix	374-399	26
α-helix	406-444	39
α-helix	456-483	28
α-helix	514-531	18
α-helix	540-574	35
α-helix	578-587	10
α-helix	598-603	6
α-helix	605-624	20
α-helix	631-638	8
α-helix	643-669	27
α-helix	673-675	3
α-helix	677-692	16
α-helix	696-709	14
β-strand	716	1	28
β-strand	720	1	29
β-strand	723	1	30
β-strand	732	1	30
β-strand	735	1	29
α-helix	743-753	11
α-helix	758-761	4
α-helix	762-797	36
α-helix	802-820	19
β-strand	823	1	28
α-helix	829-866	38
α-helix	871-890	20
α-helix	896-926	31
β-strand	958-960	3	31
β-strand	961-965	5	32
β-strand	968-972	5	32
α-helix	975-994	20
β-strand	997	1	33
α-helix	1014-1017	4
β-strand	1018	1	33
α-helix	1030-1056	27
α-helix	1057-1060	4
α-helix	1065-1072	8
α-helix	1076-1093	18
β-strand	1099	1	34
β-strand	1102	1	31
β-strand	1105-1107	3	31
β-strand	1108	1	34
α-helix	1110-1129	20
α-helix	1131-1155	25
α-helix	1163-1199	37
α-helix	1211-1234	24
α-helix	1237-1264	28
α-helix	1273-1304	32
α-helix	1313-1348	36
α-helix	1357-1372	16
α-helix	1375-1378	4
α-helix	1381-1404	24
α-helix	1410-1420	11
α-helix	1431-1436	6
α-helix	1443-1472	30
β-strand	1474	1	35
β-strand	1476-1480	5	36
β-strand	1484-1488	5	36
α-helix	1490-1509	20
α-helix	1511-1516	6
α-helix	1517-1553	37
α-helix	1556-1560	5
α-helix	1562-1584	23
β-strand	1587	1	35
α-helix	1588-1592	5
α-helix	1598-1612	15
α-helix	1616-1625	10
α-helix	1627-1631	5
α-helix	1634-1642	9
α-helix	1647-1652	6
α-helix	1654-1656	3
β-strand	1663-1666	4	37
β-strand	1672-1677	6	37
β-strand	1683-1691	9	37
α-helix	1698-1727	30
α-helix	1735-1744	10
α-helix	1747-1769	23
α-helix	1778-1797	20
α-helix	1802-1827	26
α-helix	1836-1839	4
β-strand	1843-1846	4	38
α-helix	1853-1855	3
β-strand	1857-1860	4	38
β-strand	1866-1867	2	38
α-helix	1883-1897	15
β-strand	1901-1905	5	39
α-helix	1912-1922	11
β-strand	1927-1931	5	39
α-helix	1938-1951	14
β-strand	1954-1958	5	39
α-helix	1960-1962	3
α-helix	1965-1985	21
α-helix	1995-1997	3
β-strand	1998-2001	4	40
β-strand	2004-2007	4	40
β-strand	2013-2018	6	39
α-helix	2025-2029	5
α-helix	2030-2033	4
β-strand	2036-2040	5	39
α-helix	2046-2056	11
α-helix	2062-2079	18
α-helix	2090-2117	28
α-helix	2124-2129	6
α-helix	2133-2144	12
α-helix	2146-2148	3
α-helix	2151-2153	3
α-helix	2154-2164	11
α-helix	2176-2188	13
α-helix	2201-2216	16
β-strand	2219-2223	5	41
α-helix	2230-2245	16
β-strand	2249-2254	6	41
α-helix	2256-2258	3
α-helix	2261-2265	5
β-strand	2266-2268	3	42
β-strand	2275-2277	3	42
α-helix	2279-2289	11
α-helix	2294-2296	3
β-strand	2298-2304	7	41
α-helix	2313-2315	3
α-helix	2316-2319	4
β-strand	2324-2326	3	43
β-strand	2332-2334	3	43
α-helix	2335-2336	2
β-strand	2339-2345	7	41
α-helix	2353-2356	4
β-strand	2360-2363	4	41
α-helix	2366-2368	3
α-helix	2371-2384	14
α-helix	2411-2423	13
α-helix	2432-2440	9
α-helix	2451-2475	25
α-helix	2483-2502	20
α-helix	2508-2521	14
α-helix	2534-2536	3
β-strand	2537-2539	3	44
β-strand	2545-2547	3	44
α-helix	2548-2551	4
α-helix	2559-2561	3
α-helix	2572-2586	15
β-strand	2591-2594	4	45
α-helix	2601-2609	9
β-strand	2615-2620	6	45
α-helix	2629-2638	10
β-strand	2639-2644	6	46
β-strand	2647-2652	6	46
β-strand	2658-2663	6	45
α-helix	2670-2672	3
α-helix	2678-2688	11
β-strand	2691-2694	4	46
β-strand	2699-2703	5	46
β-strand	2706-2712	7	45
α-helix	2722-2724	3
α-helix	2725-2728	4
β-strand	2733-2735	3	45
α-helix	2737-2739	3
α-helix	2741-2756	16
α-helix	2760-2765	6
α-helix	2766-2783	18
α-helix	2796-2810	15
α-helix	2818-2833	16
α-helix	2840-2857	18
α-helix	2863-2867	5
β-strand	2873-2874	2	47
β-strand	2882-2883	2	47
α-helix	2886-2903	18
α-helix	2913-2925	13
β-strand	2932-2936	5	48
α-helix	2943-2953	11
α-helix	2956	1
β-strand	2957-2959	3	48
α-helix	2969-2980	12
α-helix	2981-2985	5
β-strand	2990-2995	6	48
α-helix	2996-2998	3
α-helix	3002-3014	13
α-helix	3024-3040	17
α-helix	3047-3061	15
β-strand	3062-3068	7	48
α-helix	3072-3081	10
α-helix	3084-3087	4
β-strand	3089-3093	5	48
α-helix	3097-3098	2
α-helix	3099-3109	11
α-helix	3139-3163	25
α-helix	3173-3297	125
α-helix	3300-3307	8
α-helix	3314-3326	13
α-helix	3334-3342	9
α-helix	3344-3346	3
α-helix	3349-3352	4
α-helix	3355-3357	3
α-helix	3360-3372	13
α-helix	3378-3383	6
α-helix	3389-3397	9
α-helix	3409-3481	73
α-helix	3483-3501	19
α-helix	3503-3516	14
α-helix	3522-3538	17
α-helix	3549-3553	5
α-helix	3556-3564	9
α-helix	3571-3582	12
α-helix	3586	1
β-strand	3587-3590	4	49
α-helix	3595-3603	9
β-strand	3610-3613	4	49
α-helix	3619-3629	11
β-strand	3632-3636	5	49
α-helix	3638-3640	3
α-helix	3643-3645	3
α-helix	3646-3650	5
β-strand	3653-3656	4	50
β-strand	3659-3664	6	50
β-strand	3667-3670	4	50
β-strand	3676-3681	6	49
α-helix	3686-3689	4
α-helix	3690-3695	6
β-strand	3697-3700	4	49
α-helix	3702-3704	3
α-helix	3705-3720	16
α-helix	3722-3755	34
α-helix	3760-3762	3
α-helix	3764-3798	35
α-helix	3799-3801	3
α-helix	3802-3816	15
α-helix	3817-3820	4
α-helix	3829-3840	12
α-helix	3844-3846	3
α-helix	3852-3872	21
α-helix	3877-3879	3
α-helix	3880-3893	14
α-helix	3902-3910	9
α-helix	3929-3938	10
α-helix	3942-3944	3
α-helix	3947-3953	7
α-helix	3957-3961	5
α-helix	3966-3968	3
α-helix	3979-3981	3
α-helix	3982-3996	15
α-helix	3998-4000	3
α-helix	4001-4013	13
α-helix	4019-4022	4
α-helix	4024-4025	2
α-helix	4027-4029	3
α-helix	4030-4034	5
β-strand	4041-4045	5	51
α-helix	4052-4061	10
β-strand	4066-4070	5	51
α-helix	4074-4090	17
β-strand	4093-4097	5	51
α-helix	4099-4101	3
α-helix	4103-4114	12
β-strand	4123-4129	7	51
α-helix	4136-4141	6
β-strand	4143-4147	5	51
α-helix	4153-4163	11
α-helix	4166-4169	4
α-helix	4175-4194	20
α-helix	4197-4200	4
α-helix	4209-4226	18
α-helix	4240-4246	7
α-helix	4247-4251	5
α-helix	4259-4272	14
α-helix	4275-4278	4
β-strand	4283-4286	4	52
β-strand	4293-4295	3	52
α-helix	4296-4297	2
α-helix	4302-4310	9
α-helix	4318-4321	4
α-helix	4325-4327	3
α-helix	4329-4345	17
α-helix	4375-4390	16
α-helix	4396-4398	3
α-helix	4408-4438	31
α-helix	4446-4456	11
α-helix	4475-4497	23
α-helix	4502-4505	4
β-strand	4509-4510	2	53
α-helix	4517-4532	16
β-strand	4539-4546	8	53
β-strand	4557-4561	5	53
β-strand	4564-4571	8	54
β-strand	4574-4584	11	54
β-strand	4587-4594	8	53
α-helix	4598-4600	3
β-strand	4604-4610	7	54
β-strand	4618-4626	9	54
α-helix	4632-4637	6
β-strand	4641-4643	3	54

Chain C: 5 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	186-192	7
α-helix	197-210	14
β-strand	265-271	7	55
β-strand	282	1	56
β-strand	286-287	2	56
β-strand	294-296	3	56
β-strand	299	1	56
β-strand	311-317	7	56
β-strand	327-331	5	56
β-strand	335-340	6	57
β-strand	347-352	6	57
β-strand	357-361	5	57
β-strand	372	1	57
β-strand	384-392	9	58
β-strand	395-402	8	58
β-strand	406-410	5	58
β-strand	420-423	4	58
β-strand	425	1	59
β-strand	431	1	59
β-strand	434-438	5	60
α-helix	439-440	2
β-strand	446-451	6	60
β-strand	457-460	4	60
β-strand	467-468	2	60
β-strand	481-484	4	61
β-strand	496-500	5	61
β-strand	505-510	6	61
β-strand	520-521	2	61
β-strand	532	1	62
β-strand	539-540	2	62
β-strand	548-551	4	63
β-strand	552-553	2	62
β-strand	563-566	4	63
β-strand	576-578	3	55
β-strand	584-587	4	55
β-strand	594-599	6	55
α-helix	601-604	4
α-helix	608-620	13

Chain D: 6 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	186-192	7
α-helix	197-210	14
β-strand	265-271	7	64
β-strand	282-287	6	65
β-strand	294-299	6	65
β-strand	311-317	7	65
β-strand	327-331	5	65
β-strand	335-340	6	66
β-strand	347-352	6	66
β-strand	357-361	5	66
β-strand	371-372	2	66
α-helix	383	1
β-strand	384-390	7	67
β-strand	397-402	6	67
β-strand	406-410	5	67
β-strand	420-423	4	67
β-strand	425-427	3	68
β-strand	430-431	2	68
β-strand	434-438	5	69
β-strand	447-451	5	69
β-strand	455-460	6	69
β-strand	467-472	6	69
β-strand	479-484	6	70
β-strand	496-501	6	70
β-strand	506-510	5	70
β-strand	518	1	70
β-strand	527-532	6	71
β-strand	539-544	6	71
β-strand	549-553	5	71
β-strand	563-565	3	71
β-strand	573-578	6	64
α-helix	579	1
β-strand	584-589	6	64
β-strand	594-599	6	64
α-helix	601-604	4
α-helix	608-618	11

Chain E: 15 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	39-45	7
β-strand	56-61	6	72
α-helix	67-75	9
β-strand	87-95	9	72
β-strand	100-108	9	72
α-helix	113-121	9
α-helix	128-130	3
β-strand	131-136	6	72
α-helix	142-144	3
α-helix	146-162	17
α-helix	167-182	16
β-strand	227-231	5	72
α-helix	236-243	8
α-helix	248-264	17
β-strand	268-271	4	72
β-strand	273	1	73
β-strand	278	1	73
α-helix	280-291	12
β-strand	309-310	2	72
α-helix	318-325	8
α-helix	336-339	4
α-helix	341-342	2
α-helix	348-353	6
α-helix	359-372	14

Chain F: 16 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	40-44	5
β-strand	56-60	5	74
α-helix	67-75	9
β-strand	89	1	74
β-strand	92-95	4	75
β-strand	100-103	4	75
β-strand	105-109	5	74
α-helix	113-115	3
α-helix	117-122	6
α-helix	128-130	3
β-strand	131-136	6	74
α-helix	142-162	21
α-helix	167-182	16
β-strand	227-231	5	74
α-helix	235-243	9
α-helix	248-264	17
β-strand	268-271	4	74
β-strand	273	1	76
β-strand	278	1	76
α-helix	280-292	13
α-helix	298-300	3
β-strand	301	1	74
β-strand	309	1	74
α-helix	317-325	9
α-helix	337-340	4
α-helix	341-345	5
α-helix	353-355	3
α-helix	359-372	14

Chain G: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	4-12	9
β-strand	22-23	2	77
β-strand	29	1	77
α-helix	36-60	25
β-strand	70-72	3	77
β-strand	77-82	6	77
β-strand	87-92	6	77

Chain H: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	5-13	9
β-strand	19	1	78
α-helix	36-60	25
β-strand	68	1	77
β-strand	69-72	4	78
β-strand	77-80	4	78
β-strand	91-92	2	78

3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cytoplasmic dynein 1 heavy chain 1	A, B	protein	4646	Homo sapiens	Q14204
Cytoplasmic dynein 1 intermediate chain 2	C, D	protein	638	Homo sapiens	Q13409 (AlphaFold model)
Cytoplasmic dynein 1 light intermediate chain 2	E, F	protein	492	Homo sapiens	O43237 (AlphaFold model)
Dynein light chain roadblock-type 1	G, H	protein	96	Homo sapiens	Q9NP97 (AlphaFold model)
Dynein light chain 1, cytoplasmic	I, J	protein	89	Homo sapiens	P63167
Dynein light chain Tctex-type 1	K, L	protein	113	Homo sapiens	P63172

Sequence of entity 1 (A, B), FASTA

>9E12_1 Cytoplasmic dynein 1 heavy chain 1 (chains A, B)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE

Sequence of entity 2 (C, D), FASTA

>9E12_2 Cytoplasmic dynein 1 intermediate chain 2 (chains C, D)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA

Sequence of entity 3 (E, F), FASTA

>9E12_3 Cytoplasmic dynein 1 light intermediate chain 2 (chains E, F)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA

Sequence of entity 4 (G, H), FASTA

>9E12_4 Dynein light chain roadblock-type 1 (chains G, H)
MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Sequence of entity 5 (I, J), FASTA

>9E12_5 Dynein light chain 1, cytoplasmic (chains I, J)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG

Sequence of entity 6 (K, L), FASTA

>9E12_6 Dynein light chain Tctex-type 1 (chains K, L)
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKP
FKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	4
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	2
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6

Primary citation

Nde1 promotes Lis1 binding to full-length autoinhibited human dynein 1. Yang, J., Zhao, Y., Chai, P. et al. Nat Chem Biol (2026) 22:274-283. DOI 10.1038/s41589-025-01981-6 · PubMed

Other PDB entries of the same protein (UniProt Q14204), best resolution first:

5OWO 1.79 Å, Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution
9BLZ 2.2 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATP
9BMR 2.6 Å, State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP
9DH5 2.6 Å, State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+
9E0X 2.7 Å, Cryo-EM structure of Phi dynein
9E10 2.71 Å, Dimeric motor domains from phi dynein-1 under Lis1 condition
9BM0 2.8 Å, State-2 of motor domain from full-length human dynein-1 in 5mM ATP
9BMF 2.8 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi
9BMH 2.8 Å, State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi
9BN3 2.8 Å, The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1
9BM2 2.82 Å, State-4 of motor domain from full-length human dynein-1 in 5 mM ATP
9BMG 2.86 Å, State-2 of full-length human dynein-1 in 5mM ATPVi

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