9E28: Phi dynein tail
Cryo-EM structure of Phi dynein tail. Determined by electron microscopy at 4.4 Å resolution. Released 9 Jul 2025.
- Method
- Electron microscopy
- Resolution
- 4.4 Å
- Organism
- Homo sapiens
- Chains
- 16
- Atoms
- 21,249
- Mol. weight
- 2666.18 kDa
- Released
- 9 Jul 2025
Explore 9E28 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9E28 contains 177 α-helices and 143 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-32 | 5 | |
| α-helix | 33-37 | 5 | |
| α-helix | 38-40 | 3 | |
| α-helix | 50-56 | 7 | |
| α-helix | 59-70 | 12 | |
| β-strand | 84 | 1 | 1 |
| β-strand | 98 | 1 | 1 |
| β-strand | 109 | 1 | 2 |
| β-strand | 114 | 1 | 2 |
| α-helix | 145-155 | 11 | |
| α-helix | 158-167 | 10 | |
| α-helix | 179-197 | 19 | |
Chain B: 15 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-47 | 20 | |
| β-strand | 55 | 1 | 3 |
| α-helix | 67-74 | 8 | |
| β-strand | 88-95 | 8 | 3 |
| β-strand | 100-107 | 8 | 3 |
| α-helix | 113-115 | 3 | |
| α-helix | 116-119 | 4 | |
| α-helix | 120-122 | 3 | |
| α-helix | 128-130 | 3 | |
| β-strand | 133 | 1 | 4 |
| β-strand | 138 | 1 | 5 |
| α-helix | 142-163 | 22 | |
| α-helix | 167-182 | 16 | |
| β-strand | 227 | 1 | 4 |
| β-strand | 232 | 1 | 5 |
| α-helix | 234-236 | 3 | |
| α-helix | 237-242 | 6 | |
| α-helix | 248-265 | 18 | |
| α-helix | 280-292 | 13 | |
| α-helix | 305-307 | 3 | |
| α-helix | 317-325 | 9 | |
| α-helix | 359-372 | 14 | |
Chain C: 17 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-43 | 16 | |
| α-helix | 44-46 | 3 | |
| β-strand | 56-60 | 5 | 6 |
| α-helix | 67-75 | 9 | |
| β-strand | 87-95 | 9 | 6 |
| β-strand | 100-108 | 9 | 6 |
| α-helix | 113-115 | 3 | |
| α-helix | 119-122 | 4 | |
| β-strand | 131-135 | 5 | 6 |
| α-helix | 142-163 | 22 | |
| α-helix | 167-182 | 16 | |
| α-helix | 213-215 | 3 | |
| β-strand | 227-231 | 5 | 6 |
| α-helix | 234-236 | 3 | |
| α-helix | 237-242 | 6 | |
| α-helix | 248-265 | 18 | |
| β-strand | 268-271 | 4 | 6 |
| α-helix | 280-287 | 8 | |
| α-helix | 288-292 | 5 | |
| α-helix | 298-300 | 3 | |
| β-strand | 309-310 | 2 | 6 |
| α-helix | 317-324 | 8 | |
| α-helix | 336-339 | 4 | |
| α-helix | 359-372 | 14 | |
Chain d: 2 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-13 | 3 | 38 |
| α-helix | 15-31 | 17 | |
| α-helix | 35-49 | 15 | |
| β-strand | 57 | 1 | 39 |
| β-strand | 59 | 1 | 40 |
| β-strand | 72-74 | 3 | 38 |
| β-strand | 76-78 | 3 | 41 |
| β-strand | 81-83 | 3 | 41 |
| β-strand | 84 | 1 | 39 |
Chain D: 5 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 185-191 | 7 | |
| α-helix | 194-211 | 18 | |
| α-helix | 233-237 | 5 | |
| β-strand | 240-245 | 6 | 7 |
| β-strand | 256-260 | 5 | 8 |
| β-strand | 270-273 | 4 | 8 |
| β-strand | 285 | 1 | 9 |
| β-strand | 287-288 | 2 | 8 |
| β-strand | 305 | 1 | 9 |
| β-strand | 309-314 | 6 | 10 |
| β-strand | 321-326 | 6 | 10 |
| β-strand | 331-335 | 5 | 10 |
| β-strand | 345-346 | 2 | 10 |
| β-strand | 360-364 | 5 | 11 |
| β-strand | 371-375 | 5 | 11 |
| β-strand | 380-381 | 2 | 12 |
| β-strand | 382-385 | 4 | 11 |
| β-strand | 396-397 | 2 | 12 |
| β-strand | 411-412 | 2 | 13 |
| β-strand | 420-423 | 4 | 13 |
| β-strand | 430-434 | 5 | 13 |
| β-strand | 442-446 | 5 | 13 |
| β-strand | 453 | 1 | 14 |
| β-strand | 457 | 1 | 15 |
| β-strand | 470-472 | 3 | 15 |
| β-strand | 475 | 1 | 14 |
| β-strand | 480-484 | 5 | 15 |
| β-strand | 492-494 | 3 | 15 |
| α-helix | 500-501 | 2 | |
| β-strand | 504 | 1 | 16 |
| β-strand | 513-518 | 6 | 16 |
| β-strand | 522-527 | 6 | 16 |
| β-strand | 537 | 1 | 16 |
| β-strand | 540 | 1 | 16 |
| β-strand | 550-552 | 3 | 7 |
| β-strand | 558-561 | 4 | 7 |
| β-strand | 568-572 | 5 | 7 |
| α-helix | 582-608 | 27 | |
Chain e: 49 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 211-222 | 12 | |
| α-helix | 225-227 | 3 | |
| α-helix | 234-237 | 4 | |
| α-helix | 239-260 | 22 | |
| α-helix | 271-293 | 23 | |
| α-helix | 295-306 | 12 | |
| α-helix | 310-318 | 9 | |
| α-helix | 322-330 | 9 | |
| α-helix | 341-346 | 6 | |
| α-helix | 350-369 | 20 | |
| α-helix | 374-399 | 26 | |
| α-helix | 406-440 | 35 | |
| α-helix | 457-479 | 23 | |
| α-helix | 480-484 | 5 | |
| α-helix | 514-532 | 19 | |
| α-helix | 540-574 | 35 | |
| α-helix | 578-588 | 11 | |
| α-helix | 589-591 | 3 | |
| α-helix | 597-624 | 28 | |
| α-helix | 631-638 | 8 | |
| α-helix | 643-669 | 27 | |
| α-helix | 673-675 | 3 | |
| α-helix | 677-692 | 16 | |
| α-helix | 696-709 | 14 | |
| β-strand | 722-725 | 4 | 42 |
| β-strand | 728-733 | 6 | 42 |
| α-helix | 741-756 | 16 | |
| α-helix | 762-797 | 36 | |
| α-helix | 806-821 | 16 | |
| α-helix | 829-866 | 38 | |
| α-helix | 871-890 | 20 | |
| α-helix | 896-926 | 31 | |
| α-helix | 975-994 | 20 | |
| β-strand | 997 | 1 | 43 |
| α-helix | 998-999 | 2 | |
| α-helix | 1000-1003 | 4 | |
| α-helix | 1014-1017 | 4 | |
| β-strand | 1018 | 1 | 43 |
| α-helix | 1021-1023 | 3 | |
| α-helix | 1031-1054 | 24 | |
| α-helix | 1055-1057 | 3 | |
| α-helix | 1058-1062 | 5 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1076-1091 | 16 | |
| α-helix | 1110-1155 | 46 | |
| α-helix | 1163-1199 | 37 | |
| α-helix | 1203-1205 | 3 | |
| α-helix | 1211-1263 | 53 | |
| α-helix | 1272-1304 | 33 | |
| α-helix | 1314-1348 | 35 | |
| α-helix | 1356-1370 | 15 | |
| α-helix | 1375-1379 | 5 | |
| α-helix | 1381-1403 | 23 | |
Chain E: 2 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-12 | 10 | |
| β-strand | 19 | 1 | 17 |
| β-strand | 22-24 | 3 | 18 |
| α-helix | 36-60 | 25 | |
| β-strand | 69-70 | 2 | 19 |
| β-strand | 78 | 1 | 17 |
| β-strand | 79-80 | 2 | 19 |
| β-strand | 81-82 | 2 | 18 |
| β-strand | 86-88 | 3 | 18 |
| β-strand | 91 | 1 | 17 |
Chain f: 53 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 211-222 | 12 | |
| α-helix | 229-232 | 4 | |
| α-helix | 234-237 | 4 | |
| α-helix | 239-261 | 23 | |
| α-helix | 271-293 | 23 | |
| α-helix | 295-306 | 12 | |
| α-helix | 310-320 | 11 | |
| α-helix | 322-332 | 11 | |
| α-helix | 340-346 | 7 | |
| α-helix | 350-369 | 20 | |
| α-helix | 374-399 | 26 | |
| α-helix | 406-440 | 35 | |
| α-helix | 457-484 | 28 | |
| α-helix | 514-532 | 19 | |
| α-helix | 540-573 | 34 | |
| α-helix | 578-588 | 11 | |
| α-helix | 589-591 | 3 | |
| α-helix | 598-624 | 27 | |
| α-helix | 631-638 | 8 | |
| α-helix | 643-669 | 27 | |
| α-helix | 677-692 | 16 | |
| α-helix | 695-709 | 15 | |
| β-strand | 719-723 | 5 | 44 |
| β-strand | 732-736 | 5 | 44 |
| α-helix | 741-756 | 16 | |
| α-helix | 762-797 | 36 | |
| α-helix | 801-805 | 5 | |
| α-helix | 806-821 | 16 | |
| α-helix | 829-866 | 38 | |
| α-helix | 871-890 | 20 | |
| α-helix | 896-926 | 31 | |
| α-helix | 975-994 | 20 | |
| α-helix | 997-998 | 2 | |
| α-helix | 1001-1003 | 3 | |
| α-helix | 1010-1012 | 3 | |
| α-helix | 1014-1017 | 4 | |
| α-helix | 1020-1022 | 3 | |
| α-helix | 1031-1055 | 25 | |
| α-helix | 1056-1058 | 3 | |
| α-helix | 1059-1062 | 4 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1076-1092 | 17 | |
| α-helix | 1110-1155 | 46 | |
| α-helix | 1163-1199 | 37 | |
| α-helix | 1203-1205 | 3 | |
| α-helix | 1209-1210 | 2 | |
| α-helix | 1211-1230 | 20 | |
| α-helix | 1232-1234 | 3 | |
| α-helix | 1236-1264 | 29 | |
| α-helix | 1266-1268 | 3 | |
| α-helix | 1273-1304 | 32 | |
| α-helix | 1314-1347 | 34 | |
| α-helix | 1356-1371 | 16 | |
| α-helix | 1375-1379 | 5 | |
| α-helix | 1381-1403 | 23 | |
8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Cytoplasmic dynein 1 heavy chain 1 | A, G, e, f | protein | 4843 | Homo sapiens | Q14204 |
| Cytoplasmic dynein 1 light intermediate chain 2 | B, C | protein | 492 | Homo sapiens | O43237 (AlphaFold model) |
| Isoform 2C of Cytoplasmic dynein 1 intermediate chain 2 | D, H, g, h | protein | 612 | Homo sapiens | Q13409 (AlphaFold model) |
| Dynein light chain roadblock-type 1 | E, F | protein | 96 | Homo sapiens | Q9NP97 (AlphaFold model) |
| Dynein light chain 1, cytoplasmic | d, i | protein | 89 | Homo sapiens | P63167 |
| Dynein light chain Tctex-type 1 | k, v | protein | 113 | Homo sapiens | P63172 |
Sequence of entity 1 (A, G, e, f), FASTA
>9E28_1 Cytoplasmic dynein 1 heavy chain 1 (chains A, G, e, f)
GDYDIPTTENLYFQGDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGKGTSAADAVEV
PAPAAVLGGPEPLMQATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVV
KFGEVISYSHLAALAGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVGGYEGGLAVKE
WLLAHEGHRLGKPGLGGSSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLE
DGGEAPAALEAALEEKSALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNI
NIDIHYGVKSNSLAFIKRTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKS
YIRESGKADRDGDKMAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYER
GEKPKVTDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLER
ALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLND
LLSATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMH
VAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARL
DQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEV
NLAYENVKEVDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFR
IFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPP
VSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWA
RKVQQRNLGVSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLA
IVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALV
WESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQK
AVDDLNLHSYSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAP
QVSHKPGGEPKIKNVVHELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQR
YQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDM
QAENIYNRLGEDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSW
HKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQF
EKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKI
VQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEA
LELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNL
DALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVN
WVVSELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNK
CRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRR
WVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLER
LADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSS
IILNEDNSVVLGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTE
VEIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLS
NVEVTLNVLADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMR
FYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGS
PFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRL
EERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYA
GRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQ
SHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCE
TMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMW
VEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDH
LYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNK
LLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLR
SIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQL
EHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLS
GDSRLKMRAELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVA
APDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFS
SATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFI
RQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPAS
LTQIYGTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWV
RGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDR
EKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRID
RIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRS
GCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLM
LDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALY
QVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAK
RGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLR
IKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLD
KVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIM
RENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYA
DMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKA
DLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQ
MRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRF
NRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDP
VLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTV
TRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDD
DTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHF
LYQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITF
AMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPA
FKDLIAKVQADEQFGIWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLA
MAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQN
TQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFR
LFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLL
AWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSAL
KTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRRE
EFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKK
TRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKL
LQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFS
ERIKQLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEV
NVTTSQGATLDACSFGVTGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKAS
VVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCTE
Sequence of entity 2 (B, C), FASTA
>9E28_2 Cytoplasmic dynein 1 light intermediate chain 2 (chains B, C)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA
Sequence of entity 3 (D, H, g, h), FASTA
>9E28_3 Isoform 2C of Cytoplasmic dynein 1 intermediate chain 2 (chains D, H, g, h)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQV
DFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPH
ELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLS
LNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPE
YVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYC
VNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNN
FVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTV
KLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS
VEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRA
DAEEEAATRIPA
Sequence of entity 4 (E, F), FASTA
>9E28_4 Dynein light chain roadblock-type 1 (chains E, F)
MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE
Sequence of entity 5 (d, i), FASTA
>9E28_5 Dynein light chain 1, cytoplasmic (chains d, i)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
Sequence of entity 6 (k, v), FASTA
>9E28_6 Dynein light chain Tctex-type 1 (chains k, v)
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKP
FKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
Primary citation
Cryo-EM captures early intermediate steps in dynein activation by LIS1. Nguyen, K.H.V., Karasmanis, E.P., Kendrick, A.A. et al. Nat Commun (2025) 16:7054-7054. DOI 10.1038/s41467-025-62185-z · PubMed
Other PDB entries of the same protein (UniProt Q14204), best resolution first:
- 5OWO 1.79 Å, Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution
- 9BLZ 2.2 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATP
- 9BMR 2.6 Å, State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP
- 9DH5 2.6 Å, State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+
- 9E0X 2.7 Å, Cryo-EM structure of Phi dynein
- 9E10 2.71 Å, Dimeric motor domains from phi dynein-1 under Lis1 condition
- 9BM0 2.8 Å, State-2 of motor domain from full-length human dynein-1 in 5mM ATP
- 9BMF 2.8 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi
- 9BMH 2.8 Å, State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi
- 9BN3 2.8 Å, The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1
- 9BM2 2.82 Å, State-4 of motor domain from full-length human dynein-1 in 5 mM ATP
- 9BMG 2.86 Å, State-2 of full-length human dynein-1 in 5mM ATPVi
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