9G3Y: Gamma-tubulin complex component
Structure of the Native CMG-decorated gamma-Tubulin Ring Complex from Pig Brain. Determined by electron microscopy at 6.8 Å resolution. Released 2 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 6.8 Å
- Organisms
- Sus scrofa, Homo sapiens
- Chains
- 45
- Atoms
- 82,406
- Mol. weight
- 4195.3 kDa
- Released
- 2 Oct 2024
Explore 9G3Y in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9G3Y contains 874 α-helices and 324 β-strands across 45 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 28 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-9 | 5 | 89 |
| α-helix | 11-28 | 18 | |
| β-strand | 31 | 1 | 90 |
| β-strand | 37 | 1 | 90 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-51 | 4 | |
| β-strand | 53-54 | 2 | 91 |
| β-strand | 60-61 | 2 | 91 |
| β-strand | 64-66 | 3 | 89 |
| β-strand | 67-68 | 2 | 92 |
| α-helix | 71-78 | 8 | |
| α-helix | 81-84 | 4 | |
| α-helix | 88-90 | 3 | |
| β-strand | 92-93 | 2 | 92 |
| α-helix | 104-113 | 10 | |
| α-helix | 115-128 | 14 | |
| β-strand | 134-140 | 7 | 89 |
| α-helix | 144 | 1 | |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 165-171 | 7 | 89 |
| α-helix | 184-197 | 14 | |
| β-strand | 201-204 | 4 | 89 |
| α-helix | 207-216 | 10 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 268-274 | 7 | 89 |
| α-helix | 290-298 | 9 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 89 |
| β-strand | 317-326 | 10 | 89 |
| α-helix | 330-343 | 14 | |
| α-helix | 347 | 1 | |
| β-strand | 348 | 1 | 89 |
| α-helix | 349 | 1 | |
| β-strand | 356 | 1 | 89 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 89 |
| α-helix | 383-401 | 19 | |
| α-helix | 405-409 | 5 | |
| α-helix | 412-414 | 3 | |
| α-helix | 419-439 | 21 | |
| α-helix | 441-443 | 3 | |
Chain A: 33 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 151-167 | 17 | |
| α-helix | 210-225 | 16 | |
| β-strand | 234-237 | 4 | 1 |
| α-helix | 238 | 1 | |
| β-strand | 244-247 | 4 | 1 |
| α-helix | 254-263 | 10 | |
| α-helix | 265-281 | 17 | |
| α-helix | 283-285 | 3 | |
| α-helix | 287-315 | 29 | |
| α-helix | 321-346 | 26 | |
| α-helix | 353-365 | 13 | |
| α-helix | 370-391 | 22 | |
| α-helix | 392-396 | 5 | |
| α-helix | 416-419 | 4 | |
| α-helix | 441-462 | 22 | |
| α-helix | 481-502 | 22 | |
| α-helix | 503-507 | 5 | |
| α-helix | 509-515 | 7 | |
| α-helix | 525-529 | 5 | |
| α-helix | 548-560 | 13 | |
| α-helix | 563-566 | 4 | |
| β-strand | 574-577 | 4 | 2 |
| α-helix | 584-589 | 6 | |
| α-helix | 612-615 | 4 | |
| β-strand | 616-619 | 4 | 2 |
| α-helix | 632-659 | 28 | |
| α-helix | 670-672 | 3 | |
| α-helix | 674-697 | 24 | |
| α-helix | 698-702 | 5 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-736 | 18 | |
| α-helix | 744-766 | 23 | |
| α-helix | 767-769 | 3 | |
| α-helix | 816-820 | 5 | |
| α-helix | 824-850 | 27 | |
| α-helix | 854-862 | 9 | |
| α-helix | 867-876 | 10 | |
Chain b: 26 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-10 | 5 | 93 |
| α-helix | 11-28 | 18 | |
| β-strand | 31 | 1 | 94 |
| β-strand | 36 | 1 | 95 |
| β-strand | 37 | 1 | 94 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-51 | 4 | |
| β-strand | 52-54 | 3 | 96 |
| β-strand | 59 | 1 | 95 |
| β-strand | 60-62 | 3 | 96 |
| β-strand | 64-67 | 4 | 93 |
| α-helix | 71-79 | 9 | |
| α-helix | 81-83 | 3 | |
| α-helix | 88-90 | 3 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 134-139 | 6 | 93 |
| α-helix | 144 | 1 | |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 165-172 | 8 | 93 |
| α-helix | 184-198 | 15 | |
| β-strand | 201-206 | 6 | 93 |
| α-helix | 207-217 | 11 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 268-274 | 7 | 93 |
| α-helix | 290-298 | 9 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 93 |
| β-strand | 317-325 | 9 | 93 |
| α-helix | 330-343 | 14 | |
| β-strand | 348 | 1 | 93 |
| β-strand | 356-361 | 6 | 93 |
| α-helix | 362-364 | 3 | |
| β-strand | 375-381 | 7 | 93 |
| α-helix | 383-400 | 18 | |
| α-helix | 405-410 | 6 | |
| α-helix | 412-415 | 4 | |
| α-helix | 419-439 | 21 | |
| α-helix | 443-446 | 4 | |
Chain B: 35 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 252-261 | 10 | |
| β-strand | 269-272 | 4 | 8 |
| β-strand | 277-280 | 4 | 8 |
| α-helix | 288-295 | 8 | |
| α-helix | 298-300 | 3 | |
| α-helix | 301-316 | 16 | |
| α-helix | 322-348 | 27 | |
| α-helix | 367-389 | 23 | |
| α-helix | 397-403 | 7 | |
| α-helix | 404-406 | 3 | |
| α-helix | 412-434 | 23 | |
| α-helix | 435-439 | 5 | |
| β-strand | 451-453 | 3 | 9 |
| α-helix | 459-465 | 7 | |
| β-strand | 467-469 | 3 | 9 |
| α-helix | 480-494 | 15 | |
| α-helix | 495-499 | 5 | |
| α-helix | 533-551 | 19 | |
| α-helix | 552-556 | 5 | |
| α-helix | 558-567 | 10 | |
| α-helix | 574-589 | 16 | |
| α-helix | 597-610 | 14 | |
| α-helix | 612-615 | 4 | |
| α-helix | 618-623 | 6 | |
| β-strand | 624-625 | 2 | 10 |
| α-helix | 637-640 | 4 | |
| β-strand | 644-645 | 2 | 10 |
| α-helix | 650-654 | 5 | |
| α-helix | 657-689 | 33 | |
| α-helix | 690-693 | 4 | |
| α-helix | 699-725 | 27 | |
| α-helix | 726-730 | 5 | |
| α-helix | 731-741 | 11 | |
| α-helix | 747-763 | 17 | |
| α-helix | 772-808 | 37 | |
| α-helix | 810-819 | 10 | |
| α-helix | 826-841 | 16 | |
| α-helix | 843-859 | 17 | |
| α-helix | 862-869 | 8 | |
| α-helix | 874-881 | 8 | |
| α-helix | 894-896 | 3 | |
Chain c: 28 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-9 | 5 | 97 |
| α-helix | 12-28 | 17 | |
| β-strand | 31 | 1 | 98 |
| β-strand | 36 | 1 | 99 |
| β-strand | 37 | 1 | 98 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-51 | 4 | |
| β-strand | 52-54 | 3 | 100 |
| β-strand | 59 | 1 | 99 |
| β-strand | 60-62 | 3 | 100 |
| β-strand | 64-66 | 3 | 97 |
| β-strand | 67-68 | 2 | 101 |
| α-helix | 71-79 | 9 | |
| α-helix | 81-83 | 3 | |
| α-helix | 88-90 | 3 | |
| β-strand | 92-93 | 2 | 101 |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 134-139 | 6 | 97 |
| α-helix | 144 | 1 | |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 165-172 | 8 | 97 |
| α-helix | 184-198 | 15 | |
| β-strand | 201-206 | 6 | 97 |
| α-helix | 207-212 | 6 | |
| α-helix | 213-217 | 5 | |
| α-helix | 225-238 | 14 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 268-274 | 7 | 97 |
| α-helix | 290-298 | 9 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 97 |
| β-strand | 317-325 | 9 | 97 |
| α-helix | 330-343 | 14 | |
| α-helix | 347-349 | 3 | |
| β-strand | 355-361 | 7 | 97 |
| α-helix | 362-364 | 3 | |
| β-strand | 374-381 | 8 | 97 |
| α-helix | 383-400 | 18 | |
| α-helix | 406-410 | 5 | |
| α-helix | 412-415 | 4 | |
| α-helix | 419-438 | 20 | |
| α-helix | 441-443 | 3 | |
Chain C: 43 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-6 | 2 | |
| α-helix | 7-11 | 5 | |
| α-helix | 12-16 | 5 | |
| α-helix | 26-33 | 8 | |
| α-helix | 46-56 | 11 | |
| α-helix | 60-73 | 14 | |
| α-helix | 78-90 | 13 | |
| α-helix | 92-115 | 24 | |
| α-helix | 150-169 | 20 | |
| α-helix | 176-178 | 3 | |
| α-helix | 179-182 | 4 | |
| α-helix | 210-225 | 16 | |
| β-strand | 234-236 | 3 | 15 |
| β-strand | 245-247 | 3 | 15 |
| α-helix | 254-280 | 27 | |
| α-helix | 287-316 | 30 | |
| α-helix | 321-347 | 27 | |
| α-helix | 353-365 | 13 | |
| α-helix | 370-395 | 26 | |
| β-strand | 409-410 | 2 | 16 |
| α-helix | 416-419 | 4 | |
| α-helix | 427-430 | 4 | |
| β-strand | 433-434 | 2 | 16 |
| α-helix | 443-462 | 20 | |
| α-helix | 481-502 | 22 | |
| α-helix | 503-507 | 5 | |
| α-helix | 509-514 | 6 | |
| α-helix | 525-540 | 16 | |
| α-helix | 548-560 | 13 | |
| α-helix | 569-572 | 4 | |
| β-strand | 573-577 | 5 | 17 |
| α-helix | 582-590 | 9 | |
| α-helix | 597-601 | 5 | |
| α-helix | 605-607 | 3 | |
| α-helix | 612-615 | 4 | |
| β-strand | 616-620 | 5 | 17 |
| α-helix | 632-661 | 30 | |
| α-helix | 664-667 | 4 | |
| α-helix | 670-672 | 3 | |
| α-helix | 674-687 | 14 | |
| α-helix | 691-696 | 6 | |
| α-helix | 697-701 | 5 | |
| α-helix | 702-715 | 14 | |
| α-helix | 719-737 | 19 | |
| α-helix | 742-770 | 29 | |
| α-helix | 816-820 | 5 | |
| α-helix | 825-849 | 25 | |
| α-helix | 854-862 | 9 | |
| α-helix | 866-877 | 12 | |
Chain d: 25 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-9 | 4 | 102 |
| α-helix | 11-28 | 18 | |
| β-strand | 31 | 1 | 103 |
| β-strand | 36 | 1 | 104 |
| β-strand | 37 | 1 | 103 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-51 | 4 | |
| β-strand | 52-54 | 3 | 105 |
| β-strand | 59 | 1 | 104 |
| β-strand | 60-62 | 3 | 105 |
| β-strand | 64-66 | 3 | 102 |
| α-helix | 71-79 | 9 | |
| α-helix | 81-83 | 3 | |
| α-helix | 88-90 | 3 | |
| β-strand | 91 | 1 | 102 |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 135-140 | 6 | 102 |
| α-helix | 144 | 1 | |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 167-171 | 5 | 102 |
| α-helix | 184-197 | 14 | |
| β-strand | 201-204 | 4 | 102 |
| α-helix | 207-217 | 11 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 268-269 | 2 | 102 |
| β-strand | 270-274 | 5 | 106 |
| α-helix | 290-298 | 9 | |
| α-helix | 300-302 | 3 | |
| β-strand | 317-326 | 10 | 106 |
| α-helix | 330-343 | 14 | |
| β-strand | 348 | 1 | 106 |
| β-strand | 355-361 | 7 | 106 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 106 |
| α-helix | 384-401 | 18 | |
| α-helix | 405-410 | 6 | |
| α-helix | 412-414 | 3 | |
| α-helix | 419-438 | 20 | |
Chain D: 35 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 250-261 | 12 | |
| β-strand | 266 | 1 | 23 |
| β-strand | 269-272 | 4 | 23 |
| β-strand | 277-280 | 4 | 23 |
| α-helix | 288-297 | 10 | |
| α-helix | 299-313 | 15 | |
| α-helix | 318-320 | 3 | |
| α-helix | 322-349 | 28 | |
| α-helix | 367-372 | 6 | |
| α-helix | 375-390 | 16 | |
| α-helix | 397-404 | 8 | |
| α-helix | 412-438 | 27 | |
| α-helix | 462-465 | 4 | |
| α-helix | 471-473 | 3 | |
| α-helix | 480-494 | 15 | |
| α-helix | 495-499 | 5 | |
| α-helix | 530-555 | 26 | |
| α-helix | 558-564 | 7 | |
| α-helix | 565-569 | 5 | |
| α-helix | 575-583 | 9 | |
| α-helix | 585-589 | 5 | |
| β-strand | 591 | 1 | 24 |
| α-helix | 592-594 | 3 | |
| α-helix | 598-608 | 11 | |
| α-helix | 612-615 | 4 | |
| α-helix | 618-623 | 6 | |
| β-strand | 624-625 | 2 | 25 |
| β-strand | 636 | 1 | 24 |
| α-helix | 637-640 | 4 | |
| β-strand | 644-645 | 2 | 25 |
| α-helix | 649-654 | 6 | |
| α-helix | 657-693 | 37 | |
| α-helix | 698-700 | 3 | |
| α-helix | 701-725 | 25 | |
| α-helix | 726-731 | 6 | |
| α-helix | 732-743 | 12 | |
| α-helix | 747-763 | 17 | |
| α-helix | 769-771 | 3 | |
| α-helix | 772-818 | 47 | |
| α-helix | 826-869 | 44 | |
| α-helix | 874-882 | 9 | |
| α-helix | 894-896 | 3 | |
35 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Gamma-tubulin complex component | A, C, E, G, M | protein | 905 | Sus scrofa | A0A480VJI0 (AlphaFold model) |
| Gamma-tubulin complex component 3 | B, D, F, H, N | protein | 910 | Sus scrofa | F1RN46 (AlphaFold model) |
| Gamma-tubulin complex component | I, K | protein | 667 | Sus scrofa | A0A8D1V2H0 (AlphaFold model) |
| Gamma-tubulin complex component | J | protein | 1061 | Sus scrofa | I3L738 (AlphaFold model) |
| Tubulin gamma complex associated protein 6 | L | protein | 1715 | Sus scrofa | A0A8W4FDV6 |
| Mitotic spindle organizing protein 1 | O, P, Q | protein | 79 | Sus scrofa | A0A287AS02 |
| Mitotic-spindle organizing protein 2A isoform X4 | V, W, X, Y | protein | 155 | Sus scrofa | F1RK97 |
| Tubulin gamma chain | a, b, c, d, e, f, g, h, i, j, k, l, m, n | protein | 451 | Sus scrofa | A0A287BRH5 |
| CDK5 regulatory subunit-associated protein 2 | o, p, q, r, s, t, u, v, w, x | protein | 1663 | Homo sapiens | A0A0A0MRG9 |
Sequence of entity 1 (A, C, E, G, M), FASTA
>9G3Y_1 Gamma-tubulin complex component (chains A, C, E, G, M)
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTP
EDFLKKYDELKSKNTRNLDPLVYLLSKLMEDRETLQYLQQNAKERAELAASAAASSTASF
GASATASKISMQELEELRKQLGSVATGPTWQQSLELTRKMLRDKQSKKNSGQRLPVLPAW
VYERPALLGDFLPGTGGSADTAVPIGSLPLASQEAAVVEDLLYVLVGVDGRYISAQPLTG
RQGRTFLVDPNLDLSIRELVSRILPVAASYSTVTRFIEEKSSFEYGQVNHALAAAMRTLV
KEYLVLVTQLEQLQRQGLLSLQKLWFYIQPAMRSLDILASLATSVDKGECIGGATLSLLH
DRSFSYTGDSQAQELCLHLTKAASTPYFEILEKWIYRGIIDDPYSEFMVEEHELRKEKIQ
EDYNDKYWDQRYTVVQRQIPSFLQKMAGKVLSTGKYLNVVRECGHDVTCPVAKEVVYTLK
ERAYVEQIEKAFSYASKVLLDFLMGEKELLAHLRSIKRYFLMDQGDFFVHFMDLTEEELK
KPVDDITPTRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETQQEKAM
VHADPTELTLSGLEAFSFDYVVTWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWI
SNKAAKRFSLHSAKWFAGAFTLRQRMLNFVQNIQSYMMFEVMEPTWHVLEQNLRSASNID
DVLGHHASFLDNCLKDCMLTNPELLRVFSKLMSVCVMFTNCLQRFTQSMKLDSELGHPAL
EPGAMLGPPTEAERAEERARKELARKCLAEHVDAPQLASSFEATITKFDKNFSAHLLDLL
ARLSIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKAAPPVPGPRGPPALVPRV
AVTAQ
Sequence of entity 2 (B, D, F, H, N), FASTA
>9G3Y_2 Gamma-tubulin complex component 3 (chains B, D, F, H, N)
MATPDQKSPNVLLQNLCCRILGKSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELTRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRKQPSKVSGYAALFAQ
ALPRDAHSTPYYYARPQSLPLNYQERGAPSAQSAGSAGSSGVSSLGTYALNGPTPPPPPP
ALLPGQPLPAPGVGDGLRQQLGSRLAWTLTASQPSLPSTTSKAVPSSGSRGAARPRREGD
AAAGAVEVTEAALVRDILYVFQGIDGKHVKMSNADNCYTVEGKANLSKSLRDTAVRLAEL
GWLHNKIRKYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLG
LESSLTLRRLLVWTYDPKMRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYARSLVQH
ILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPAVKADRLWHDKYALRKPMIPSFMTM
DQCRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAA
YFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNL
TGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECM
SHYLRAFNFLWRAKRVEYILTDIRKGHMCNARLLRSMPEFSGVLHHCHILASEMVHFIHQ
MQYYVTFEVLECSWDELWNRVQRAQDLDHIIAAHEAFLGTVISRCLLDSDSRALLNQLRA
VFDQIIELQNTQDAIYRAALEELQRRLQFEEKKKQREAEGQWGVSAAEEEQEKRRVQEFQ
ESIPKMCSQLRILTHFYQGVVQQFLVSLTTSSDESLRFLSFRLDFNEHYRAREPRLRVSL
GTRGRRSSHT
Sequence of entity 3 (I, K), FASTA
>9G3Y_3 Gamma-tubulin complex component (chains I, K)
MIHELLLALSGYPGSIFTWNKRGGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLADPHLSIS
HINYSLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KDQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFK
YLLSVRRVQAELQHCWALQMQRKHLKSNQTDAVKWRLRNHMAFLVDNLQYYLQVDVLESQ
FSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQN
LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGG
TLGSFGM
Sequence of entity 4 (J), FASTA
>9G3Y_4 Gamma-tubulin complex component (chains J)
MASPAPSWTRLDPQQERDVRELIRLVSGVQDEADPNFQLALHFAWSNFRFHRFLDVNSHK
VEKTIEGIYEKFIIHSDLSKAASWKRLTDEFLNASLPSIKEIKTDAHYSILSLLLCLSDS
PSNSNYVETPRNKEVEKKDDFDWGKYLMEGEEIDLGPNVDTPNWSEESEDEDDPQPLSRE
DSGIQVDRTPLEEQDQSRKPASRVSWKVDEPDARSWLEQHVVRQYWTTRSSKFPHSLHLH
SNLAAVWDQHLYSSDPLYVPDDRVSVTETQVIRETLWLLSGVKKLFIFQLIDGKVAVRNN
IMVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESTLPGNGSVPKKSTDAPFR
TYQAFMWALYKYFISFKEELSEIEKCIINNDTTVTLAIVVDKLSPRLAQLKVLHKVFSTG
VAEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQIVDEW
IVHGHLCDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQ
GPSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAMARDAERKSLYTLFLES
VQSRLRHGEDATAQALTEQQATRETLIKMQSIAERHLELDDVHDPLLAINFARLYLEQSD
FHEKFAGGDICVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMRTLKKDYRLVEY
LQAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSI
SFENTDTAKKKLPVHTLDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLD
VLLFGELASSAEKPQSKEGLLSGQDTAAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHN
YIMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLN
LALMFADGWQAGLGAWQMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMA
GMEQKREDDLFNHTWGQGDLPNYTCAVRLLGVRKGGGTRPK
Sequence of entity 5 (L), FASTA
>9G3Y_5 Tubulin gamma complex associated protein 6 (chains L)
MASVPQLLDDLCEALLPAAKAHLGQRRGSRKRAKQSLKKVAYNALFTNLFQDEARKLQPD
LPRLPVKNRILMLSFDLRVGGLAAEADRLEELVEGLETAPRGPLAELGSVLDLLVQLAGS
GPPRVLQRRRDYFLPKEHVGRNVRYGGYDCCHLSGIEADVRSIISGEEELCRDLIRKTLQ
VMEAAPGTGLPAFGLSSYGDPYGDRFERDTRVSLFGALVHSRTADLDVRLDLPPVPDSAD
VSGLAIKVPLSVDQSEDEGFQSAPNLTPDSQSEPGVTPDIDLWEAVLTYEASRRRCWEQI
GCPPGHREEPYLTEAGRDAFDRFCRLRQGELQVLGGALLQAPQPVLVKESELVKDTLNVL
LGVVSATFSLCQPAQAFTVKRGVHVSGASPESVSSLLSEVAECGTHYARLSDFSLQPVLD
SSCSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
TALPGTGGGEPRAAFPTGVRLLSYLYQEALDNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
YSGVFRDVYGEFMIQVNHEYLGCRDKSYWTHGYVLVSKEVEACVPVFLKHVAHDVYVCGK
TINLLKLCCPRHYLCCSDVPVPRISVIFSLEELKDIEKDCAIYVGRMERVARHSSLSKEE
KELRMEIAKQELIVHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFMRDQERR
RAARQEELDDDFSYARELRDRERRLKALEEQLERKARQALVDHYSKLSAEAARRERKALW
RVQRHRLADARRRFLLEEEKRVQVMPSCSWERNQGALVFQASLPCPEHPDGGGGCGSGPS
EQPKAARDGPRGPSRLMPQLPESPAEAACGLLSVGLSIRDFLPTAQGAEQPLHTGSALVL
EEALQTIGSDLPPPAPSAAVGTGPSGPQEYDFRTILRPAVATSAFPGPLQSTGGGLGSEG
QPQWEDTHVQLDMCVLDGQVALPHACSPQKTSPQEGSQAMGQLLRQVSEGDVPTGGYASG
TAPSRPRWNVHGHVSDASIKVGENVCDVVPSRPRWNVHGHVSDASIKVGENVCDVVPSRP
RWNVHGHVSDASIKVGENVCDVVPSRPRWNIHGHVSDASIKVGENVCDVVPSRPRWNVHG
HVSQSQVTLGVLSGEAEPIVPWPHQTPPDHGSQSGLSLGAQSPAQEGEPQPAAETAVEGA
ESGPQASPTAGAGSSLLSGSRLGPEARPPPPPPHLFCPGRSEDTVDLPASCRPSSQVRGQ
GLGVGGESSAGCPSHPACPFMGNEGSVPGPGVDTQSSPGLGEEAAQRWGMEQAYLAGLAG
QYRLEQYPDSYEAMSEPPVARLLHHGLPRAFALPEDSGVQPDTDETAVQLSELLPLPVLM
KHSVTAPLAAHVSLVNKAAVDYFFVELHLGAHFEALRHFLLMEDGEFAQSLSDLLFEKLG
AGQTPGELLSPLVLNSVLSKALQYSLHGDTPHAANLSFALKFLPEAFAPNAPDVLSCLEL
RYKVDWPLNIVVTEGCLSRYSGIFSFLLQLKLMMWTLKDVCFHLKRTARMSHVASSVQFR
QLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLASVGDLEEIQRAHAEYLHKAVFRG
LLTEKAAPAMNIIHSLFSLVLKFRSQLISQPWGLAGGPHGAEHPNFALMQQSYSTFKYYS
HFLFKVVSKLVNRGYQPHLEDFLLRINFNNYYQDA
Sequence of entity 6 (O, P, Q), FASTA
>9G3Y_6 Mitotic spindle organizing protein 1 (chains O, P, Q)
MAGNSGSGAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEALSSV
IKELRKATEALKAAENMTS
Sequence of entity 7 (V, W, X, Y), FASTA
>9G3Y_7 Mitotic-spindle organizing protein 2A isoform X4 (chains V, W, X, Y)
MAAPGAGPGPGAPPGLEAALQKLALRRKKVLSAEETELFELAQAAGGAMDPEVFKILVDL
LKLNVAPLAVFQMLKSMCAGQRLASEPQDPVAVPLPTTSVPETRGRNRGSSALGGGPALA
ERSGREGSSQRMPRQPSATRLPKGGGPGKSPTRST
Sequence of entity 8 (a, b, c, d, e, f, g, h, i, j, k, l, m, n), FASTA
>9G3Y_8 Tubulin gamma chain (chains a, b, c, d, e, f, g, h, i, j, k, l, m, n)
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQYDKLRKREAFLEQFRKEDIFKENFDE
LDRSREVVQELIDEYHAATRPDYISWGTQEQ
Sequence of entity 9 (o, p, q, r, s, t, u, v, w, x), FASTA
>9G3Y_9 CDK5 regulatory subunit-associated protein 2 (chains o, p, q, r, s, t, u, v, w, x)
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
YQNLRKTLEEQISEIRRREESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLI
QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTEEAKKSRLPILIKPSRSLGN
MYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQ
PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPE
DVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFI
FQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLA
PEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQA
RELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE
KLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFF
SRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF
VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVS
LEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN
DKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIE
TSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLF
DSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGL
IEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTL
EEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSK
RQEKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Primary citation
Partial closure of the gamma-tubulin ring complex by CDK5RAP2 activates microtubule nucleation. Xu, Y., Munoz-Hernandez, H., Krutyholowa, R. et al. Dev Cell (2024) 59:3161. DOI 10.1016/j.devcel.2024.09.002 · PubMed
Other PDB entries of the same protein (UniProt A0A480VJI0 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9G3Z 4.3 Å, Structure of the Open gamma-Tubulin Ring Complex from Pig Brain
- 9G40 4.3 Å, Structure of the Position 7 CMG-decorated gamma-Tubulin Ring Complex from Pig Brain
- 9G3X 4.5 Å, Structure of the Partially-assembled gamma-Tubulin Ring Complex from Pig Brain
Browse structure collections
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