9GMN: UFC1 T106V

Crystal Structure of UFC1 T106V. Determined by X-ray diffraction at 2.0 Å resolution. Released 7 May 2025.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,461
Mol. weight: 19.64 kDa
Released: 7 May 2025

Explore 9GMN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9GMN contains 10 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 10 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	1-10	10
α-helix	14-16	3
α-helix	26-48	23
β-strand	54-58	5	1
β-strand	64-73	10	1
β-strand	76-85	10	1
α-helix	86-87	2
α-helix	94-95	2
β-strand	98	1	1
α-helix	100-102	3
β-strand	109	1	2
β-strand	114	1	1
β-strand	115	1	2
α-helix	121-128	8
α-helix	134-137	4
α-helix	138-142	5
α-helix	143-155	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin-fold modifier-conjugating enzyme 1	AAA	protein	169	Homo sapiens	Q9Y3C8 (AlphaFold model)

Sequence of entity 1 (AAA), FASTA

>9GMN_1 Ubiquitin-fold modifier-conjugating enzyme 1 (chains AAA)
GSMADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLES
NKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKVAKMYRGGKICLT
DHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIHHKEKCNQ

Primary citation

UFC1 reveals the multifactorial and plastic nature of oxyanion holes in E2 conjugating enzymes. Kumar, M., Banerjee, S., Cohen-Kfir, E. et al. Nat Commun (2025) 16:3912-3912. DOI 10.1038/s41467-025-58826-y · PubMed

Other PDB entries of the same protein (UniProt Q9Y3C8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9GLH 1.11 Å, Crystal Structure of UFC1 T106S
9GLJ 1.21 Å, Crystal Structure of UFC1 T106A
9GMM 1.35 Å, Crystal Structure of UFC1 T106I
9GLI 1.43 Å, Crystal Structure of UFC1 T106C
9GLO 1.53 Å, Crystal Structure of UFC1 C116E&T106S
9I9M 1.54 Å, Crystal structure of chimeric UFC1, TAK MotiF replaced with HPN motif of other E2 proteins
2Z6O 1.6 Å, Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1
9GLL 1.65 Å, Crystal Structure of UFC1 T106L
9GLP 1.77 Å, Crystal Structure of UFC1 C116E&T106I
8BZR 1.78 Å, UFC1-UFM1 conjugate
9GLM 1.79 Å, Crystal Structure of UFC1 W145F
2Z6P 1.8 Å, Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1

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