9H5K: SEAC-EGOC supercomplex

Cryo-EM structure of the SEAC-EGOC supercomplex. Determined by electron microscopy at 3.2 Å resolution. Released 5 Nov 2025.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Saccharomyces cerevisiae
Chains: 32
Atoms: 114,318
Mol. weight: 2344.49 kDa
Ligands: ZN, MG, AF3, GDP
Released: 5 Nov 2025

Explore 9H5K in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9H5K contains 518 α-helices and 871 β-strands across 32 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	6-13	8	216
α-helix	19-26	8
α-helix	33-35	3
α-helix	40-42	3
β-strand	45-51	7	216
β-strand	55-61	7	216
α-helix	66-72	7
α-helix	77-80	4
β-strand	86-92	7	216
α-helix	98-115	18
β-strand	120-126	7	216
α-helix	133-135	3
α-helix	136-153	18
β-strand	160-163	4	216
α-helix	170-179	10
α-helix	186-200	15
β-strand	202-208	7	217
β-strand	215-218	4	217
α-helix	242-257	16
α-helix	258-260	3
β-strand	264-269	6	217
β-strand	273-277	5	217
β-strand	283-288	6	217
α-helix	295-304	10

Chain A: 14 helices, 49 β-strands

Element	Residues	Length	Sheet
β-strand	131-133	3	41
β-strand	136	1	42
β-strand	144-146	3	43
β-strand	154-157	4	43
β-strand	164-169	6	43
β-strand	174-180	7	43
β-strand	217	1	44
α-helix	220-224	5
β-strand	225-228	4	44
β-strand	235-239	5	44
β-strand	252-254	3	44
β-strand	261-263	3	45
β-strand	266	1	45
β-strand	274-278	5	45
β-strand	282-286	5	45
β-strand	302-304	3	45
β-strand	312-315	4	46
β-strand	340-344	5	46
β-strand	349-354	6	46
β-strand	363-366	4	46
β-strand	375-377	3	47
β-strand	383-386	4	47
β-strand	392-397	6	47
β-strand	436-439	4	47
β-strand	446	1	48
β-strand	449	1	49
β-strand	462	1	49
β-strand	463-464	2	50
β-strand	465	1	48
β-strand	473-475	3	50
β-strand	486-488	3	50
β-strand	494-499	6	41
β-strand	504-509	6	41
β-strand	513	1	42
β-strand	515-518	4	41
β-strand	534-536	3	51
β-strand	544-548	5	51
α-helix	656-658	3
β-strand	659-661	3	51
α-helix	665-676	12
α-helix	696-706	11
α-helix	837-863	27
α-helix	867-889	23
α-helix	1163-1175	13
α-helix	1178-1187	10
α-helix	1197-1213	17
α-helix	1217-1225	9
β-strand	1241	1	52
β-strand	1244	1	53
β-strand	1245	1	54
β-strand	1252	1	54
α-helix	1256-1269	14
α-helix	1272-1277	6
β-strand	1283	1	55
β-strand	1288	1	55
β-strand	1292	1	56
β-strand	1299	1	56
β-strand	1307	1	57
β-strand	1312	1	57
α-helix	1316-1320	5
α-helix	1321-1325	5
β-strand	1331	1	58
β-strand	1335	1	58

Chain b: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	6-13	8	256
α-helix	19-26	8
α-helix	33-35	3
α-helix	40-42	3
β-strand	45-51	7	256
β-strand	55-61	7	256
α-helix	66-72	7
α-helix	77-80	4
β-strand	86-92	7	256
α-helix	98-115	18
β-strand	120-126	7	256
α-helix	133-135	3
α-helix	136-153	18
β-strand	160-163	4	256
α-helix	170-179	10
α-helix	186-200	15
β-strand	202-208	7	257
β-strand	215-218	4	257
α-helix	242-257	16
α-helix	258-260	3
β-strand	264-269	6	257
β-strand	273-276	4	257
β-strand	284-288	5	257
α-helix	295-304	10

Chain B: 33 helices, 45 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	106
β-strand	16-21	6	106
β-strand	28-33	6	106
α-helix	40-42	3
β-strand	43-49	7	106
β-strand	55-60	6	107
β-strand	68-72	5	107
β-strand	77-80	4	107
β-strand	141-144	4	107
β-strand	145	1	108
β-strand	152-157	6	109
β-strand	162-167	6	109
β-strand	174-180	7	109
β-strand	190	1	108
β-strand	195-199	5	109
β-strand	205-208	4	110
β-strand	213-217	5	110
β-strand	222-226	5	110
β-strand	234-236	3	110
β-strand	245-247	3	111
β-strand	250-256	7	111
β-strand	263-267	5	111
α-helix	268-272	5
β-strand	287-289	3	111
β-strand	303	1	112
β-strand	307-309	3	113
β-strand	316-321	6	113
β-strand	325-335	11	113
β-strand	352-363	12	113
β-strand	369-376	8	114
β-strand	382-388	7	114
β-strand	393-397	5	114
β-strand	402-407	6	115
β-strand	413-417	5	115
β-strand	423-426	4	115
α-helix	499-505	7
α-helix	507-517	11
α-helix	523-532	10
α-helix	540-557	18
β-strand	571	1	116
α-helix	573-577	5
α-helix	597-608	12
α-helix	631-640	10
α-helix	646-659	14
α-helix	662-672	11
α-helix	675-683	9
α-helix	688-698	11
α-helix	699-701	3
α-helix	712-722	11
α-helix	726-735	10
α-helix	740-742	3
α-helix	751-760	10
α-helix	764-781	18
α-helix	784-786	3
α-helix	787-790	4
β-strand	791	1	116
α-helix	794-807	14
α-helix	810-817	8
α-helix	821-824	4
α-helix	828-843	16
α-helix	847-859	13
β-strand	862	1	117
β-strand	868	1	117
α-helix	872-875	4
β-strand	879	1	53
β-strand	880	1	118
α-helix	881	1
β-strand	887	1	118
α-helix	950-951	2
β-strand	952	1	119
α-helix	953	1
α-helix	958	1
β-strand	959	1	119
α-helix	989-998	10
β-strand	1002-1004	3	120
β-strand	1010	1	52
β-strand	1011-1013	3	120
α-helix	1014-1020	7

Chains c and d: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	11-16	6	218
α-helix	22-31	10
β-strand	61-64	4	218
α-helix	69-71	3
α-helix	77-81	5
β-strand	83-91	9	218
α-helix	97-113	17
β-strand	118-124	7	218
α-helix	131-152	22
β-strand	159-163	5	218
α-helix	170-180	11
α-helix	186-198	13
β-strand	202-209	8	217
β-strand	217	1	217
α-helix	225-244	20
β-strand	270-275	6	217
β-strand	280-285	6	217
β-strand	290-296	7	217
α-helix	303-323	21

Chains C and K: 29 helices, 46 β-strands

Element	Residues	Length	Sheet
α-helix	9-11	3
β-strand	19-20	2	1
β-strand	29-32	4	2
β-strand	38-42	5	2
β-strand	46-51	6	2
α-helix	58-59	2
β-strand	60-63	4	2
α-helix	69-70	2
β-strand	73-75	3	3
β-strand	84-89	6	3
β-strand	92-97	6	3
β-strand	106-110	5	3
β-strand	117-122	6	4
β-strand	129-134	6	4
β-strand	138-143	6	4
β-strand	152-155	4	4
β-strand	161-166	6	5
β-strand	173-178	6	5
β-strand	181-186	6	5
β-strand	195-197	3	5
β-strand	207-209	3	6
β-strand	216-219	4	6
β-strand	225-230	6	6
β-strand	240-243	4	6
β-strand	248-253	6	7
β-strand	259-264	6	7
β-strand	273-276	4	7
β-strand	288-290	3	6
β-strand	293-296	4	7
β-strand	304-312	9	1
β-strand	323-330	8	1
β-strand	335-339	5	1
α-helix	342-347	6
α-helix	359-361	3
α-helix	371-373	3
α-helix	385-387	3
β-strand	391	1	8
α-helix	393-396	4
α-helix	398-399	2
α-helix	402-407	6
β-strand	411-412	2	1
α-helix	430-440	11
β-strand	445-450	6	9
β-strand	455-459	5	9
β-strand	460-462	3	10
β-strand	473-475	3	10
β-strand	478-480	3	9
α-helix	490-492	3
β-strand	493-495	3	9
α-helix	504-521	18
α-helix	530-537	8
α-helix	618-621	4
β-strand	624-627	4	11
β-strand	633-637	5	11
β-strand	774-778	5	11
α-helix	781-783	3
α-helix	788-791	4
α-helix	801-814	14
α-helix	819-829	11
α-helix	839-845	7
α-helix	852-864	13
α-helix	868-880	13
β-strand	997-1001	5	12
α-helix	1005-1010	6
α-helix	1026-1039	14
α-helix	1043-1060	18
β-strand	1080-1082	3	13
α-helix	1083-1084	2
α-helix	1090-1094	5
β-strand	1097	1	14
β-strand	1104	1	14
β-strand	1109-1111	3	15
β-strand	1118-1120	3	15
α-helix	1121-1127	7
α-helix	1142-1145	4

Chains D and L: 4 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	115
β-strand	12-17	6	121
β-strand	23-28	6	121
β-strand	32-38	7	121
β-strand	45-52	8	121
β-strand	58-63	6	122
β-strand	67	1	123
β-strand	69	1	123
β-strand	71-76	6	122
β-strand	81-86	6	122
β-strand	98-103	6	122
β-strand	111-116	6	124
α-helix	117-118	2
α-helix	119-121	3
β-strand	125-129	5	124
β-strand	133-139	7	124
β-strand	148-155	8	124
α-helix	160-162	3
β-strand	170-173	4	125
β-strand	182-186	5	125
β-strand	191-196	6	125
β-strand	202-207	6	125
β-strand	215-220	6	126
α-helix	221-222	2
β-strand	228-235	8	126
β-strand	240-247	8	126
β-strand	292-300	9	126
β-strand	309-311	3	127
β-strand	318-322	5	127
β-strand	327-333	7	127
β-strand	339-346	8	127

Chains E and M: 6 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	2-5	4	83
β-strand	12-17	6	84
β-strand	23-28	6	84
β-strand	32-38	7	84
β-strand	45-52	8	84
β-strand	58-63	6	85
α-helix	64-65	2
α-helix	66-68	3
β-strand	71-76	6	85
β-strand	81-86	6	85
β-strand	98-103	6	85
β-strand	111-116	6	86
α-helix	117-118	2
α-helix	119-121	3
β-strand	124-129	6	86
β-strand	133-138	6	86
β-strand	149-155	7	86
α-helix	160-162	3
β-strand	169-173	5	87
β-strand	182-187	6	87
β-strand	191-196	6	87
β-strand	202-208	7	87
β-strand	215-220	6	88
α-helix	221-223	3
β-strand	229-235	7	88
β-strand	240-247	8	88
β-strand	292-300	9	88
β-strand	309-311	3	89
β-strand	319-322	4	89
β-strand	328-333	6	89
β-strand	339-345	7	89

16 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Maintenance of telomere capping protein 5	C, K	protein	1148	Saccharomyces cerevisiae	Q03897 (AlphaFold model)
Protein transport protein SEC13	H, P	protein	297	Saccharomyces cerevisiae	Q04491 (AlphaFold model)
Restriction of telomere capping protein 1	A, I	protein	1341	Saccharomyces cerevisiae	Q08281 (AlphaFold model)
Nucleoporin SEH1	D, E, F, L, M, N	protein	349	Saccharomyces cerevisiae	P53011 (AlphaFold model)
SEH-associated protein 4	B, G, J, O	protein	1038	Saccharomyces cerevisiae	P38164
GTP-binding protein GTR1	a, b	protein	310	Saccharomyces cerevisiae	Q00582
GTP-binding protein GTR2	c, d	protein	341	Saccharomyces cerevisiae	P53290
Nitrogen permease regulator 2	T, g	protein	615	Saccharomyces cerevisiae	P39923
Nitrogen permease regulator 3	h, i	protein	1146	Saccharomyces cerevisiae	P38742
Vacuolar membrane-associated protein IML1	X, j	protein	1584	Saccharomyces cerevisiae	P47170
Protein MEH1	R, S	protein	184	Saccharomyces cerevisiae	Q02205
Protein EGO2	U, W	protein	75	Saccharomyces cerevisiae	Q3E830

1 more molecules are not listed.

Sequence of entity 1 (C, K), FASTA

>9H5K_1 Maintenance of telomere capping protein 5 (chains C, K)
MCSSINEGPYNSPTFGKSLSLKVDGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPR
WLHHITPWQVADVQWSPHPAKPYWIVSTSNQKAIIWNLAKSSSNAIEFVLHGHSRAITDI
NFNPQHPDVLATCSVDTYVHAWDMRSPHRPFYSTSSWRSAASQVKWNYKDPNVLASSHGN
DIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYSEIMSSSNDGTVKFWDYSKSTTESKR
TVTTNFPIWRGRYLPFGEGYCIMPMVGGNNAVYLINLCDDDDSEQNKKTKLQPIYAFKGH
SDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISDSIYGKVNFDRGKRLEEKL
PDYDYCSYNKEPENRENVQKNEFRRLRENFVTTSGLKKNKTNHITWLSGIRMNSATSQED
LFNETKIQNLGEEVSAIGHKFPKVVFEKISVSTRELCLTLNGPWSEENPDDYIFLRISIN
FPLNYPNKGDPPKFTIEENSNLTMSKRQEILSNLATIGQKYTDSNLYCLEPCIRFVLGEK
VSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYSDSQNPENLSSQSDIESYKEALVFPD
TSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANEKKPEKKQNAIIKLSQKEAGV
EKHPFKIEPQVLYDKEVDSSVITAADELKARPKRYVDTLGLGGGTNGDSRTYFDDETSSD
DSFDSVADDWDDILRNDIIVRTKIPILRGNFKAFSSVHSESGKTVESTKKNKNLVISKNF
SSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDLDEISHCWQILSDMLIDQSDYDPY
TTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSARRKKIPARYYGQELENMEG
TIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGGDNSSIRSDDHHAR
LRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMPDIKVELLHDDIIEAYEQEDLLHLEV
SDIPKFQTYIYQYSKLLFRWGLPLERVKILKVSTDFRSSYSSQGIPPNNNKKSPYNGVLT
HWIENNEFGEEKFLARNCNYCDLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGC
NCPEMFDA

Sequence of entity 2 (H, P), FASTA

>9H5K_2 Protein transport protein SEC13 (chains H, P)
MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD
WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS
SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN
LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ
GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ

Sequence of entity 3 (A, I), FASTA

>9H5K_3 Restriction of telomere capping protein 1 (chains A, I)
MSLSPHVENASIPKGSTPIPKNRNVSSIGKGEFLGSSSSNNSSFRMNHYSNSGQPSVLDS
IRRPNLTPTFSYSNGVYMPESHRTSSFNDSYLPYDKNPYAKTTGSMSNKSNMKIKTKKNA
INTNTRKSSGLIYTTKVDKELSSIDKVNDPNINGLVCAGKTHLGLYKFSPSDRSIKCVHD
FITPNSNTSTRGTTSLLPKLSKRTRQNKFSTIADVKTGFNNYKNCIAVCNNSTAISIYDL
NKSSSIDNPLITSLCEHTRSINSFDFNMVESNLIISGGQDSCVKIWDLRSNKSKSSNRSD
ISINTASDSIRDVKWMPGYNFASKNDQGSSTYGNLKSGYKFASIHDSGYLLKFDLRQPAQ
YEKKLNAHTGPGLCLNWHPNQEYIATGGRDGKCCLWFVGDNANAAENTVLNYGNSPSLHA
PNTSLNNSGSLAFPKLTINTGYPVTKLKFKPAYSSNIYNSLLGISSMGDEAEVRIYSLAR
KYIPKHVLLSETPSLGLVWWDENLIFNIDKGTRINGWDINKEPTVLENLSKNTTTWRDLD
GNGLLSVDQEIGSYEVVEPELQPTSSTTCKKHPGTIKNPKNGNPENQGIIGGIKKGFSHT
GLTSFTPERPPTLKAGPTFSTKSLTLASGASSFNSSSASLTSLTPQTENREEIAIEPPCI
ITLDIPQIFNNIRLTKIAHSRKKNVISESSSMKNSPVEKFKYLARQLKFSYIREHNVSDS
ADTAYKNDIENIDVVKNATETHGDNTTTTNNNDDGDDDDDDDDDDKIIESHLLKKYNFPE
NNTWATLMNEKVNNKKSKRNSSSSREFDEKDVRSSISSISASRQSHDRARKIDKNVEAEL
QEKIQTLVDLISIATHNASVYLSIDDLTNFKIWILIRDSLLWDLKWMTSSQISSDNASNM
DANESSDFEAGENLKTGKEFPEEDGAGTSGAESLVEERPQAFRANSDEPSDAEKKPVSKL
KEQLKNTEIIPYAQPNEDSDEVLTKLKELQNQRLESRTKMGETVSDDVIIEEDEHEHQEE
EQPHDSPTKSAQFHASPIAKSIPILQKREHRKSFIDTFMLHSPNGYNGDTDIGNEDDNIS
PRFTYNSVSPRSKVSSLQSYATTTSQLETFKKLSSHTAPIIGSPRHAPSRPDSIGREQLS
SSLTKKLAKCKKIIADPPWDTKKLIKQLYNQATETGNVVLTVNILFLFQTIYQITEIDIA
KDAIAHFLLLLHRYELFGIAADVLKYCPFEDIMGSEGDQSSIRLFCERCGELITNESSKE
KLRAEAQQTGNKKIMDKFGYWYCDSCKKKNTSCVLCERPLKKLTMVILPCGHEGHFQCIQ
EWFLDENEQECPGGCPGVAFI

Sequence of entity 4 (D, E, F, L, M, N), FASTA

>9H5K_4 Nucleoporin SEH1 (chains D, E, F, L, M, N)
MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA
IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH
LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP
EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI
RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH
DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ

Sequence of entity 5 (B, G, J, O), FASTA

>9H5K_5 SEH-associated protein 4 (chains B, G, J, O)
MGLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKDFGSITCLDY
SESEIGMIGVGEKNGYLRIFNISGQNSSSPASHAPVGLNANNETSMTNASGGKAAQAENI
VGSVSNLKDTQGYPVSETNYDIRVRAKKQRCINSLGINTNGLIAMGLDRNKHDSSLQIWD
MNYHDDSHETINPMFSYCTNESIVSLKFLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRL
TYDIKLNPFNDWQFSTYGDDGTLAIWDRRKLSDQASLGDLNVASPLLTFEKLVGSGAASR
KYMNSCFRWSCVRNNEFATLHRGDTIKRWRLGYYCDSNRDIAADDDNEMNIENLFVSSVH
DTNTMYDRVATFDYIPRSNNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFEN
TEIDEIRVNNEHEKSNLENVKTILKNLSFEDLDVSEDYFPSGHDEPNNEIEYSELSEEEN
EGSNDVLDSKRGFELFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKNLQNNA
YIRNTWRWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGINGISNQDRYRQETILSDKQL
NKEMEKIIKLRRKNRDRNSPIANAAGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNG
HYEKAAAWAVFFGDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMS
SELDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLDRTSSTVIE
NGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSPRYFRDQRVDEWIQTYRDM
LKSWELFSMRARFDVLRSKLSRTKTGVLTADIKPRQIYIQCQNCKQNINTPRTSSPSSAV
STSAGNYKNGEAYRRNNADYKKFNTGSSEAQAADEKPRHKYCCPHCGSSFPRCAICLMPL
GTSNLPFVINGTQSRDPMQTEDSQDGANRELVSRKLKLNEWFSFCLSCNHGMHAGHAEEW
FDRHNVCPTPGCTCQCNK

Sequence of entity 6 (a, b), FASTA

>9H5K_6 GTP-binding protein GTR1 (chains a, b)
MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLW
DCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDIEIFAKALKQLRKYSPDAK
IFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLIGFPTSIWDESLYKAWSQIVC
SLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICSSNGENSNENHDSSDNNNVLLDP
KRFEKISNIMKNFKQSCTKLKSGFKTLILNNNIYVSELSSNMVCFIVLKDMNIPQELVLE
NIKKAKEFFQ

Sequence of entity 7 (c, d), FASTA

>9H5K_7 GTP-binding protein GTR2 (chains c, d)
MSLEATDSKAMVLLMGVRRCGKSSICKVVFHNMQPLDTLYLESTSNPSLEHFSTLIDLAV
MELPGQLNYFEPSYDSERLFKSVGALVYVIDSQDEYINAITNLAMIIEYAYKVNPSINIE
VLIHKVDGLSEDFKVDAQRDIMQRTGEELLELGLDGVQVSFYLTSIFDHSIYEAFSRIVQ
KLIPELSFLENMLDNLIQHSKIEKAFLFDVNSKIYVSTDSNPVDIQMYEVCSEFIDVTID
LFDLYKAPVLRNSQKSSDKDNVINPRNELQNVSQLANGVIIYLRQMIRGLALVAIIRPNG
TDMESCLTVADYNIDIFKKGLEDIWANARASQAKNSIEDDV

Sequence of entity 8 (T, g), FASTA

>9H5K_8 Nitrogen permease regulator 2 (chains T, g)
MLSYFQGFVPIHTIFYSVFHPTEGSKIKYEFPPNNLKNHGINFNTFKNYIIPKPILCHKL
ITFKYGTYRIVCYPVTINSPIYARNFFSFNFVFVFPYDCETSPYEPAITRLGKMFKVLEE
QNQLLSKSERDPVFFDLKVLENSTTTPSTAGPSSTPNPSSNTTPTHPTSEKDTKDMRSSR
YSDLIKDLGLPQSAFSIQDLLMRIFQDLNNYSECLIPIDEGNAVDIKIFPLLRPPTTCVS
LEDVPLSSVNLKKIIDVNWDPTMMSIVPYIDGLNSIAKISKLSNSDPGLVIECIRHLIYY
KCVTLSDIFQFSNIYAPSSLIRNFLTDPLMASDCQSYVTFPEVSKISNLPLNKSLGSGDQ
DSPSFSVRRKSKSSSIPSNPDSRTTSFSSTSRVSQNSSLNSSFSSIYKDWRQSQTSCSSS
NIHVINNRNRFLPTRSCLFDLYRSLSQGQTLKTWYESKYMILKENNIDIRRFITFGLEKR
IIYRCYSFPVMINAGSREPKEMTPIITKDLVNNDKLLEKRNHNHLLSATGSRNTAQSGNL
KPERPSKVSFEMQRVSSLATGKSTMPKLSDEEEGILEESIRNAETFDKICVLLSKPKLEV
ESYLNELGEFKVINS

Sequence of entity 9 (h, i), FASTA

>9H5K_9 Nitrogen permease regulator 3 (chains h, i)
MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTST
NKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSS
IPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLS
SSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTN
NKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNA
FTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQ
YDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRF
EFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENT
LKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMN
PHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIR
GAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMP
NFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGH
CGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLV
RNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPL
SSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRS
KFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRV
DKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGM
QSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERAT
AIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYL
IEIHHW

Sequence of entity 10 (X, j), FASTA

>9H5K_10 Vacuolar membrane-associated protein IML1 (chains X, j)
MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSNRNLRQKKEQFGSQQRA
SGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVML
NLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQ
TLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLA
FLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLF
QKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVD
QVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTIL
TDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIV
PLFRYRDFENKLHHCVPLWLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVD
VEYLQLNKKVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARK
IPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKIST
PTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTS
KNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNL
SIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQL
KHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITIS
DFPSKDDFDRNFIFRNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIE
LSRESGESETVVNKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFD
QVPSYIPLVKTRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKY
VVLPTDIPPNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREE
IQPEVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGED
RITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKH
NFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVV
PAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIR
LEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWE
DPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQFKYVQY
IHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCL
DYQKLRSIFLDAKEMWITGKIVED

Sequence of entity 11 (R, S), FASTA

>9H5K_11 Protein MEH1 (chains R, S)
MGAVLSCCRNHSGEENEALLREQQAGYGSQGNANDEYDAEQMRLKEHEHEQKLLAREQEL
RDIVANTNDKLIDISMINNSGIVIQGTDLQEALDKRQQEEGGDSREDERSAGDDNLSGHS
VPSSGSAQATTHQTAPRTNTFTLLTSPDSAKISKEQLKKLHSNILNEIFSQSQVNKPGPL
TVPF

Sequence of entity 12 (U, W), FASTA

>9H5K_12 Protein EGO2 (chains U, W)
MEAEKQSDIKGTIAFDTHGNVIESTGVGSQRIEDIGDLSKVTLDAEGFAQVQGDSLLVHL
YKRNDITLAVYTSAQ

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	28
MG	Magnesium ion	Mg	2
AF3	Aluminum fluoride	Al F3	2
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	4

Primary citation

Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex. Tafur, L., Bonadei, L., Zheng, Y. et al. Nat Struct Mol Biol (2026) 33:488-498. DOI 10.1038/s41594-026-01746-2 · PubMed

Other PDB entries of the same protein (UniProt Q03897 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8AE6 2.7 Å, Cryo-EM structure of the SEA complex wing (SEACIT)
8ADL 2.95 Å, Cryo-EM structure of the SEA complex
9H4Q 3.1 Å, Cryo-EM structure of the SEAC wing - EGOC

Browse structure collections

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