9H5K: SEAC-EGOC supercomplex
Cryo-EM structure of the SEAC-EGOC supercomplex. Determined by electron microscopy at 3.2 Å resolution. Released 5 Nov 2025.
- Method
- Electron microscopy
- Resolution
- 3.2 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 32
- Atoms
- 114,318
- Mol. weight
- 2344.49 kDa
- Ligands
- ZN, MG, AF3, GDP
- Released
- 5 Nov 2025
Explore 9H5K in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9H5K contains 518 α-helices and 871 β-strands across 32 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 13 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-13 | 8 | 216 |
| α-helix | 19-26 | 8 | |
| α-helix | 33-35 | 3 | |
| α-helix | 40-42 | 3 | |
| β-strand | 45-51 | 7 | 216 |
| β-strand | 55-61 | 7 | 216 |
| α-helix | 66-72 | 7 | |
| α-helix | 77-80 | 4 | |
| β-strand | 86-92 | 7 | 216 |
| α-helix | 98-115 | 18 | |
| β-strand | 120-126 | 7 | 216 |
| α-helix | 133-135 | 3 | |
| α-helix | 136-153 | 18 | |
| β-strand | 160-163 | 4 | 216 |
| α-helix | 170-179 | 10 | |
| α-helix | 186-200 | 15 | |
| β-strand | 202-208 | 7 | 217 |
| β-strand | 215-218 | 4 | 217 |
| α-helix | 242-257 | 16 | |
| α-helix | 258-260 | 3 | |
| β-strand | 264-269 | 6 | 217 |
| β-strand | 273-277 | 5 | 217 |
| β-strand | 283-288 | 6 | 217 |
| α-helix | 295-304 | 10 | |
Chain A: 14 helices, 49 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 131-133 | 3 | 41 |
| β-strand | 136 | 1 | 42 |
| β-strand | 144-146 | 3 | 43 |
| β-strand | 154-157 | 4 | 43 |
| β-strand | 164-169 | 6 | 43 |
| β-strand | 174-180 | 7 | 43 |
| β-strand | 217 | 1 | 44 |
| α-helix | 220-224 | 5 | |
| β-strand | 225-228 | 4 | 44 |
| β-strand | 235-239 | 5 | 44 |
| β-strand | 252-254 | 3 | 44 |
| β-strand | 261-263 | 3 | 45 |
| β-strand | 266 | 1 | 45 |
| β-strand | 274-278 | 5 | 45 |
| β-strand | 282-286 | 5 | 45 |
| β-strand | 302-304 | 3 | 45 |
| β-strand | 312-315 | 4 | 46 |
| β-strand | 340-344 | 5 | 46 |
| β-strand | 349-354 | 6 | 46 |
| β-strand | 363-366 | 4 | 46 |
| β-strand | 375-377 | 3 | 47 |
| β-strand | 383-386 | 4 | 47 |
| β-strand | 392-397 | 6 | 47 |
| β-strand | 436-439 | 4 | 47 |
| β-strand | 446 | 1 | 48 |
| β-strand | 449 | 1 | 49 |
| β-strand | 462 | 1 | 49 |
| β-strand | 463-464 | 2 | 50 |
| β-strand | 465 | 1 | 48 |
| β-strand | 473-475 | 3 | 50 |
| β-strand | 486-488 | 3 | 50 |
| β-strand | 494-499 | 6 | 41 |
| β-strand | 504-509 | 6 | 41 |
| β-strand | 513 | 1 | 42 |
| β-strand | 515-518 | 4 | 41 |
| β-strand | 534-536 | 3 | 51 |
| β-strand | 544-548 | 5 | 51 |
| α-helix | 656-658 | 3 | |
| β-strand | 659-661 | 3 | 51 |
| α-helix | 665-676 | 12 | |
| α-helix | 696-706 | 11 | |
| α-helix | 837-863 | 27 | |
| α-helix | 867-889 | 23 | |
| α-helix | 1163-1175 | 13 | |
| α-helix | 1178-1187 | 10 | |
| α-helix | 1197-1213 | 17 | |
| α-helix | 1217-1225 | 9 | |
| β-strand | 1241 | 1 | 52 |
| β-strand | 1244 | 1 | 53 |
| β-strand | 1245 | 1 | 54 |
| β-strand | 1252 | 1 | 54 |
| α-helix | 1256-1269 | 14 | |
| α-helix | 1272-1277 | 6 | |
| β-strand | 1283 | 1 | 55 |
| β-strand | 1288 | 1 | 55 |
| β-strand | 1292 | 1 | 56 |
| β-strand | 1299 | 1 | 56 |
| β-strand | 1307 | 1 | 57 |
| β-strand | 1312 | 1 | 57 |
| α-helix | 1316-1320 | 5 | |
| α-helix | 1321-1325 | 5 | |
| β-strand | 1331 | 1 | 58 |
| β-strand | 1335 | 1 | 58 |
Chain b: 13 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-13 | 8 | 256 |
| α-helix | 19-26 | 8 | |
| α-helix | 33-35 | 3 | |
| α-helix | 40-42 | 3 | |
| β-strand | 45-51 | 7 | 256 |
| β-strand | 55-61 | 7 | 256 |
| α-helix | 66-72 | 7 | |
| α-helix | 77-80 | 4 | |
| β-strand | 86-92 | 7 | 256 |
| α-helix | 98-115 | 18 | |
| β-strand | 120-126 | 7 | 256 |
| α-helix | 133-135 | 3 | |
| α-helix | 136-153 | 18 | |
| β-strand | 160-163 | 4 | 256 |
| α-helix | 170-179 | 10 | |
| α-helix | 186-200 | 15 | |
| β-strand | 202-208 | 7 | 257 |
| β-strand | 215-218 | 4 | 257 |
| α-helix | 242-257 | 16 | |
| α-helix | 258-260 | 3 | |
| β-strand | 264-269 | 6 | 257 |
| β-strand | 273-276 | 4 | 257 |
| β-strand | 284-288 | 5 | 257 |
| α-helix | 295-304 | 10 | |
Chain B: 33 helices, 45 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-7 | 5 | 106 |
| β-strand | 16-21 | 6 | 106 |
| β-strand | 28-33 | 6 | 106 |
| α-helix | 40-42 | 3 | |
| β-strand | 43-49 | 7 | 106 |
| β-strand | 55-60 | 6 | 107 |
| β-strand | 68-72 | 5 | 107 |
| β-strand | 77-80 | 4 | 107 |
| β-strand | 141-144 | 4 | 107 |
| β-strand | 145 | 1 | 108 |
| β-strand | 152-157 | 6 | 109 |
| β-strand | 162-167 | 6 | 109 |
| β-strand | 174-180 | 7 | 109 |
| β-strand | 190 | 1 | 108 |
| β-strand | 195-199 | 5 | 109 |
| β-strand | 205-208 | 4 | 110 |
| β-strand | 213-217 | 5 | 110 |
| β-strand | 222-226 | 5 | 110 |
| β-strand | 234-236 | 3 | 110 |
| β-strand | 245-247 | 3 | 111 |
| β-strand | 250-256 | 7 | 111 |
| β-strand | 263-267 | 5 | 111 |
| α-helix | 268-272 | 5 | |
| β-strand | 287-289 | 3 | 111 |
| β-strand | 303 | 1 | 112 |
| β-strand | 307-309 | 3 | 113 |
| β-strand | 316-321 | 6 | 113 |
| β-strand | 325-335 | 11 | 113 |
| β-strand | 352-363 | 12 | 113 |
| β-strand | 369-376 | 8 | 114 |
| β-strand | 382-388 | 7 | 114 |
| β-strand | 393-397 | 5 | 114 |
| β-strand | 402-407 | 6 | 115 |
| β-strand | 413-417 | 5 | 115 |
| β-strand | 423-426 | 4 | 115 |
| α-helix | 499-505 | 7 | |
| α-helix | 507-517 | 11 | |
| α-helix | 523-532 | 10 | |
| α-helix | 540-557 | 18 | |
| β-strand | 571 | 1 | 116 |
| α-helix | 573-577 | 5 | |
| α-helix | 597-608 | 12 | |
| α-helix | 631-640 | 10 | |
| α-helix | 646-659 | 14 | |
| α-helix | 662-672 | 11 | |
| α-helix | 675-683 | 9 | |
| α-helix | 688-698 | 11 | |
| α-helix | 699-701 | 3 | |
| α-helix | 712-722 | 11 | |
| α-helix | 726-735 | 10 | |
| α-helix | 740-742 | 3 | |
| α-helix | 751-760 | 10 | |
| α-helix | 764-781 | 18 | |
| α-helix | 784-786 | 3 | |
| α-helix | 787-790 | 4 | |
| β-strand | 791 | 1 | 116 |
| α-helix | 794-807 | 14 | |
| α-helix | 810-817 | 8 | |
| α-helix | 821-824 | 4 | |
| α-helix | 828-843 | 16 | |
| α-helix | 847-859 | 13 | |
| β-strand | 862 | 1 | 117 |
| β-strand | 868 | 1 | 117 |
| α-helix | 872-875 | 4 | |
| β-strand | 879 | 1 | 53 |
| β-strand | 880 | 1 | 118 |
| α-helix | 881 | 1 | |
| β-strand | 887 | 1 | 118 |
| α-helix | 950-951 | 2 | |
| β-strand | 952 | 1 | 119 |
| α-helix | 953 | 1 | |
| α-helix | 958 | 1 | |
| β-strand | 959 | 1 | 119 |
| α-helix | 989-998 | 10 | |
| β-strand | 1002-1004 | 3 | 120 |
| β-strand | 1010 | 1 | 52 |
| β-strand | 1011-1013 | 3 | 120 |
| α-helix | 1014-1020 | 7 | |
Chains c and d: 9 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-16 | 6 | 218 |
| α-helix | 22-31 | 10 | |
| β-strand | 61-64 | 4 | 218 |
| α-helix | 69-71 | 3 | |
| α-helix | 77-81 | 5 | |
| β-strand | 83-91 | 9 | 218 |
| α-helix | 97-113 | 17 | |
| β-strand | 118-124 | 7 | 218 |
| α-helix | 131-152 | 22 | |
| β-strand | 159-163 | 5 | 218 |
| α-helix | 170-180 | 11 | |
| α-helix | 186-198 | 13 | |
| β-strand | 202-209 | 8 | 217 |
| β-strand | 217 | 1 | 217 |
| α-helix | 225-244 | 20 | |
| β-strand | 270-275 | 6 | 217 |
| β-strand | 280-285 | 6 | 217 |
| β-strand | 290-296 | 7 | 217 |
| α-helix | 303-323 | 21 | |
Chains C and K: 29 helices, 46 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| β-strand | 19-20 | 2 | 1 |
| β-strand | 29-32 | 4 | 2 |
| β-strand | 38-42 | 5 | 2 |
| β-strand | 46-51 | 6 | 2 |
| α-helix | 58-59 | 2 | |
| β-strand | 60-63 | 4 | 2 |
| α-helix | 69-70 | 2 | |
| β-strand | 73-75 | 3 | 3 |
| β-strand | 84-89 | 6 | 3 |
| β-strand | 92-97 | 6 | 3 |
| β-strand | 106-110 | 5 | 3 |
| β-strand | 117-122 | 6 | 4 |
| β-strand | 129-134 | 6 | 4 |
| β-strand | 138-143 | 6 | 4 |
| β-strand | 152-155 | 4 | 4 |
| β-strand | 161-166 | 6 | 5 |
| β-strand | 173-178 | 6 | 5 |
| β-strand | 181-186 | 6 | 5 |
| β-strand | 195-197 | 3 | 5 |
| β-strand | 207-209 | 3 | 6 |
| β-strand | 216-219 | 4 | 6 |
| β-strand | 225-230 | 6 | 6 |
| β-strand | 240-243 | 4 | 6 |
| β-strand | 248-253 | 6 | 7 |
| β-strand | 259-264 | 6 | 7 |
| β-strand | 273-276 | 4 | 7 |
| β-strand | 288-290 | 3 | 6 |
| β-strand | 293-296 | 4 | 7 |
| β-strand | 304-312 | 9 | 1 |
| β-strand | 323-330 | 8 | 1 |
| β-strand | 335-339 | 5 | 1 |
| α-helix | 342-347 | 6 | |
| α-helix | 359-361 | 3 | |
| α-helix | 371-373 | 3 | |
| α-helix | 385-387 | 3 | |
| β-strand | 391 | 1 | 8 |
| α-helix | 393-396 | 4 | |
| α-helix | 398-399 | 2 | |
| α-helix | 402-407 | 6 | |
| β-strand | 411-412 | 2 | 1 |
| α-helix | 430-440 | 11 | |
| β-strand | 445-450 | 6 | 9 |
| β-strand | 455-459 | 5 | 9 |
| β-strand | 460-462 | 3 | 10 |
| β-strand | 473-475 | 3 | 10 |
| β-strand | 478-480 | 3 | 9 |
| α-helix | 490-492 | 3 | |
| β-strand | 493-495 | 3 | 9 |
| α-helix | 504-521 | 18 | |
| α-helix | 530-537 | 8 | |
| α-helix | 618-621 | 4 | |
| β-strand | 624-627 | 4 | 11 |
| β-strand | 633-637 | 5 | 11 |
| β-strand | 774-778 | 5 | 11 |
| α-helix | 781-783 | 3 | |
| α-helix | 788-791 | 4 | |
| α-helix | 801-814 | 14 | |
| α-helix | 819-829 | 11 | |
| α-helix | 839-845 | 7 | |
| α-helix | 852-864 | 13 | |
| α-helix | 868-880 | 13 | |
| β-strand | 997-1001 | 5 | 12 |
| α-helix | 1005-1010 | 6 | |
| α-helix | 1026-1039 | 14 | |
| α-helix | 1043-1060 | 18 | |
| β-strand | 1080-1082 | 3 | 13 |
| α-helix | 1083-1084 | 2 | |
| α-helix | 1090-1094 | 5 | |
| β-strand | 1097 | 1 | 14 |
| β-strand | 1104 | 1 | 14 |
| β-strand | 1109-1111 | 3 | 15 |
| β-strand | 1118-1120 | 3 | 15 |
| α-helix | 1121-1127 | 7 | |
| α-helix | 1142-1145 | 4 | |
Chains D and L: 4 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-4 | 3 | 115 |
| β-strand | 12-17 | 6 | 121 |
| β-strand | 23-28 | 6 | 121 |
| β-strand | 32-38 | 7 | 121 |
| β-strand | 45-52 | 8 | 121 |
| β-strand | 58-63 | 6 | 122 |
| β-strand | 67 | 1 | 123 |
| β-strand | 69 | 1 | 123 |
| β-strand | 71-76 | 6 | 122 |
| β-strand | 81-86 | 6 | 122 |
| β-strand | 98-103 | 6 | 122 |
| β-strand | 111-116 | 6 | 124 |
| α-helix | 117-118 | 2 | |
| α-helix | 119-121 | 3 | |
| β-strand | 125-129 | 5 | 124 |
| β-strand | 133-139 | 7 | 124 |
| β-strand | 148-155 | 8 | 124 |
| α-helix | 160-162 | 3 | |
| β-strand | 170-173 | 4 | 125 |
| β-strand | 182-186 | 5 | 125 |
| β-strand | 191-196 | 6 | 125 |
| β-strand | 202-207 | 6 | 125 |
| β-strand | 215-220 | 6 | 126 |
| α-helix | 221-222 | 2 | |
| β-strand | 228-235 | 8 | 126 |
| β-strand | 240-247 | 8 | 126 |
| β-strand | 292-300 | 9 | 126 |
| β-strand | 309-311 | 3 | 127 |
| β-strand | 318-322 | 5 | 127 |
| β-strand | 327-333 | 7 | 127 |
| β-strand | 339-346 | 8 | 127 |
Chains E and M: 6 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-5 | 4 | 83 |
| β-strand | 12-17 | 6 | 84 |
| β-strand | 23-28 | 6 | 84 |
| β-strand | 32-38 | 7 | 84 |
| β-strand | 45-52 | 8 | 84 |
| β-strand | 58-63 | 6 | 85 |
| α-helix | 64-65 | 2 | |
| α-helix | 66-68 | 3 | |
| β-strand | 71-76 | 6 | 85 |
| β-strand | 81-86 | 6 | 85 |
| β-strand | 98-103 | 6 | 85 |
| β-strand | 111-116 | 6 | 86 |
| α-helix | 117-118 | 2 | |
| α-helix | 119-121 | 3 | |
| β-strand | 124-129 | 6 | 86 |
| β-strand | 133-138 | 6 | 86 |
| β-strand | 149-155 | 7 | 86 |
| α-helix | 160-162 | 3 | |
| β-strand | 169-173 | 5 | 87 |
| β-strand | 182-187 | 6 | 87 |
| β-strand | 191-196 | 6 | 87 |
| β-strand | 202-208 | 7 | 87 |
| β-strand | 215-220 | 6 | 88 |
| α-helix | 221-223 | 3 | |
| β-strand | 229-235 | 7 | 88 |
| β-strand | 240-247 | 8 | 88 |
| β-strand | 292-300 | 9 | 88 |
| β-strand | 309-311 | 3 | 89 |
| β-strand | 319-322 | 4 | 89 |
| β-strand | 328-333 | 6 | 89 |
| β-strand | 339-345 | 7 | 89 |
16 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Maintenance of telomere capping protein 5 | C, K | protein | 1148 | Saccharomyces cerevisiae | Q03897 (AlphaFold model) |
| Protein transport protein SEC13 | H, P | protein | 297 | Saccharomyces cerevisiae | Q04491 (AlphaFold model) |
| Restriction of telomere capping protein 1 | A, I | protein | 1341 | Saccharomyces cerevisiae | Q08281 (AlphaFold model) |
| Nucleoporin SEH1 | D, E, F, L, M, N | protein | 349 | Saccharomyces cerevisiae | P53011 (AlphaFold model) |
| SEH-associated protein 4 | B, G, J, O | protein | 1038 | Saccharomyces cerevisiae | P38164 |
| GTP-binding protein GTR1 | a, b | protein | 310 | Saccharomyces cerevisiae | Q00582 |
| GTP-binding protein GTR2 | c, d | protein | 341 | Saccharomyces cerevisiae | P53290 |
| Nitrogen permease regulator 2 | T, g | protein | 615 | Saccharomyces cerevisiae | P39923 |
| Nitrogen permease regulator 3 | h, i | protein | 1146 | Saccharomyces cerevisiae | P38742 |
| Vacuolar membrane-associated protein IML1 | X, j | protein | 1584 | Saccharomyces cerevisiae | P47170 |
| Protein MEH1 | R, S | protein | 184 | Saccharomyces cerevisiae | Q02205 |
| Protein EGO2 | U, W | protein | 75 | Saccharomyces cerevisiae | Q3E830 |
1 more molecules are not listed.
Sequence of entity 1 (C, K), FASTA
>9H5K_1 Maintenance of telomere capping protein 5 (chains C, K)
MCSSINEGPYNSPTFGKSLSLKVDGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPR
WLHHITPWQVADVQWSPHPAKPYWIVSTSNQKAIIWNLAKSSSNAIEFVLHGHSRAITDI
NFNPQHPDVLATCSVDTYVHAWDMRSPHRPFYSTSSWRSAASQVKWNYKDPNVLASSHGN
DIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYSEIMSSSNDGTVKFWDYSKSTTESKR
TVTTNFPIWRGRYLPFGEGYCIMPMVGGNNAVYLINLCDDDDSEQNKKTKLQPIYAFKGH
SDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISDSIYGKVNFDRGKRLEEKL
PDYDYCSYNKEPENRENVQKNEFRRLRENFVTTSGLKKNKTNHITWLSGIRMNSATSQED
LFNETKIQNLGEEVSAIGHKFPKVVFEKISVSTRELCLTLNGPWSEENPDDYIFLRISIN
FPLNYPNKGDPPKFTIEENSNLTMSKRQEILSNLATIGQKYTDSNLYCLEPCIRFVLGEK
VSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYSDSQNPENLSSQSDIESYKEALVFPD
TSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANEKKPEKKQNAIIKLSQKEAGV
EKHPFKIEPQVLYDKEVDSSVITAADELKARPKRYVDTLGLGGGTNGDSRTYFDDETSSD
DSFDSVADDWDDILRNDIIVRTKIPILRGNFKAFSSVHSESGKTVESTKKNKNLVISKNF
SSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDLDEISHCWQILSDMLIDQSDYDPY
TTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSARRKKIPARYYGQELENMEG
TIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGGDNSSIRSDDHHAR
LRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMPDIKVELLHDDIIEAYEQEDLLHLEV
SDIPKFQTYIYQYSKLLFRWGLPLERVKILKVSTDFRSSYSSQGIPPNNNKKSPYNGVLT
HWIENNEFGEEKFLARNCNYCDLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGC
NCPEMFDA
Sequence of entity 2 (H, P), FASTA
>9H5K_2 Protein transport protein SEC13 (chains H, P)
MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD
WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS
SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN
LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ
GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ
Sequence of entity 3 (A, I), FASTA
>9H5K_3 Restriction of telomere capping protein 1 (chains A, I)
MSLSPHVENASIPKGSTPIPKNRNVSSIGKGEFLGSSSSNNSSFRMNHYSNSGQPSVLDS
IRRPNLTPTFSYSNGVYMPESHRTSSFNDSYLPYDKNPYAKTTGSMSNKSNMKIKTKKNA
INTNTRKSSGLIYTTKVDKELSSIDKVNDPNINGLVCAGKTHLGLYKFSPSDRSIKCVHD
FITPNSNTSTRGTTSLLPKLSKRTRQNKFSTIADVKTGFNNYKNCIAVCNNSTAISIYDL
NKSSSIDNPLITSLCEHTRSINSFDFNMVESNLIISGGQDSCVKIWDLRSNKSKSSNRSD
ISINTASDSIRDVKWMPGYNFASKNDQGSSTYGNLKSGYKFASIHDSGYLLKFDLRQPAQ
YEKKLNAHTGPGLCLNWHPNQEYIATGGRDGKCCLWFVGDNANAAENTVLNYGNSPSLHA
PNTSLNNSGSLAFPKLTINTGYPVTKLKFKPAYSSNIYNSLLGISSMGDEAEVRIYSLAR
KYIPKHVLLSETPSLGLVWWDENLIFNIDKGTRINGWDINKEPTVLENLSKNTTTWRDLD
GNGLLSVDQEIGSYEVVEPELQPTSSTTCKKHPGTIKNPKNGNPENQGIIGGIKKGFSHT
GLTSFTPERPPTLKAGPTFSTKSLTLASGASSFNSSSASLTSLTPQTENREEIAIEPPCI
ITLDIPQIFNNIRLTKIAHSRKKNVISESSSMKNSPVEKFKYLARQLKFSYIREHNVSDS
ADTAYKNDIENIDVVKNATETHGDNTTTTNNNDDGDDDDDDDDDDKIIESHLLKKYNFPE
NNTWATLMNEKVNNKKSKRNSSSSREFDEKDVRSSISSISASRQSHDRARKIDKNVEAEL
QEKIQTLVDLISIATHNASVYLSIDDLTNFKIWILIRDSLLWDLKWMTSSQISSDNASNM
DANESSDFEAGENLKTGKEFPEEDGAGTSGAESLVEERPQAFRANSDEPSDAEKKPVSKL
KEQLKNTEIIPYAQPNEDSDEVLTKLKELQNQRLESRTKMGETVSDDVIIEEDEHEHQEE
EQPHDSPTKSAQFHASPIAKSIPILQKREHRKSFIDTFMLHSPNGYNGDTDIGNEDDNIS
PRFTYNSVSPRSKVSSLQSYATTTSQLETFKKLSSHTAPIIGSPRHAPSRPDSIGREQLS
SSLTKKLAKCKKIIADPPWDTKKLIKQLYNQATETGNVVLTVNILFLFQTIYQITEIDIA
KDAIAHFLLLLHRYELFGIAADVLKYCPFEDIMGSEGDQSSIRLFCERCGELITNESSKE
KLRAEAQQTGNKKIMDKFGYWYCDSCKKKNTSCVLCERPLKKLTMVILPCGHEGHFQCIQ
EWFLDENEQECPGGCPGVAFI
Sequence of entity 4 (D, E, F, L, M, N), FASTA
>9H5K_4 Nucleoporin SEH1 (chains D, E, F, L, M, N)
MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA
IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH
LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP
EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI
RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH
DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ
Sequence of entity 5 (B, G, J, O), FASTA
>9H5K_5 SEH-associated protein 4 (chains B, G, J, O)
MGLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKDFGSITCLDY
SESEIGMIGVGEKNGYLRIFNISGQNSSSPASHAPVGLNANNETSMTNASGGKAAQAENI
VGSVSNLKDTQGYPVSETNYDIRVRAKKQRCINSLGINTNGLIAMGLDRNKHDSSLQIWD
MNYHDDSHETINPMFSYCTNESIVSLKFLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRL
TYDIKLNPFNDWQFSTYGDDGTLAIWDRRKLSDQASLGDLNVASPLLTFEKLVGSGAASR
KYMNSCFRWSCVRNNEFATLHRGDTIKRWRLGYYCDSNRDIAADDDNEMNIENLFVSSVH
DTNTMYDRVATFDYIPRSNNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFEN
TEIDEIRVNNEHEKSNLENVKTILKNLSFEDLDVSEDYFPSGHDEPNNEIEYSELSEEEN
EGSNDVLDSKRGFELFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKNLQNNA
YIRNTWRWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGINGISNQDRYRQETILSDKQL
NKEMEKIIKLRRKNRDRNSPIANAAGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNG
HYEKAAAWAVFFGDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMS
SELDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLDRTSSTVIE
NGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSPRYFRDQRVDEWIQTYRDM
LKSWELFSMRARFDVLRSKLSRTKTGVLTADIKPRQIYIQCQNCKQNINTPRTSSPSSAV
STSAGNYKNGEAYRRNNADYKKFNTGSSEAQAADEKPRHKYCCPHCGSSFPRCAICLMPL
GTSNLPFVINGTQSRDPMQTEDSQDGANRELVSRKLKLNEWFSFCLSCNHGMHAGHAEEW
FDRHNVCPTPGCTCQCNK
Sequence of entity 6 (a, b), FASTA
>9H5K_6 GTP-binding protein GTR1 (chains a, b)
MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLW
DCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDIEIFAKALKQLRKYSPDAK
IFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLIGFPTSIWDESLYKAWSQIVC
SLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICSSNGENSNENHDSSDNNNVLLDP
KRFEKISNIMKNFKQSCTKLKSGFKTLILNNNIYVSELSSNMVCFIVLKDMNIPQELVLE
NIKKAKEFFQ
Sequence of entity 7 (c, d), FASTA
>9H5K_7 GTP-binding protein GTR2 (chains c, d)
MSLEATDSKAMVLLMGVRRCGKSSICKVVFHNMQPLDTLYLESTSNPSLEHFSTLIDLAV
MELPGQLNYFEPSYDSERLFKSVGALVYVIDSQDEYINAITNLAMIIEYAYKVNPSINIE
VLIHKVDGLSEDFKVDAQRDIMQRTGEELLELGLDGVQVSFYLTSIFDHSIYEAFSRIVQ
KLIPELSFLENMLDNLIQHSKIEKAFLFDVNSKIYVSTDSNPVDIQMYEVCSEFIDVTID
LFDLYKAPVLRNSQKSSDKDNVINPRNELQNVSQLANGVIIYLRQMIRGLALVAIIRPNG
TDMESCLTVADYNIDIFKKGLEDIWANARASQAKNSIEDDV
Sequence of entity 8 (T, g), FASTA
>9H5K_8 Nitrogen permease regulator 2 (chains T, g)
MLSYFQGFVPIHTIFYSVFHPTEGSKIKYEFPPNNLKNHGINFNTFKNYIIPKPILCHKL
ITFKYGTYRIVCYPVTINSPIYARNFFSFNFVFVFPYDCETSPYEPAITRLGKMFKVLEE
QNQLLSKSERDPVFFDLKVLENSTTTPSTAGPSSTPNPSSNTTPTHPTSEKDTKDMRSSR
YSDLIKDLGLPQSAFSIQDLLMRIFQDLNNYSECLIPIDEGNAVDIKIFPLLRPPTTCVS
LEDVPLSSVNLKKIIDVNWDPTMMSIVPYIDGLNSIAKISKLSNSDPGLVIECIRHLIYY
KCVTLSDIFQFSNIYAPSSLIRNFLTDPLMASDCQSYVTFPEVSKISNLPLNKSLGSGDQ
DSPSFSVRRKSKSSSIPSNPDSRTTSFSSTSRVSQNSSLNSSFSSIYKDWRQSQTSCSSS
NIHVINNRNRFLPTRSCLFDLYRSLSQGQTLKTWYESKYMILKENNIDIRRFITFGLEKR
IIYRCYSFPVMINAGSREPKEMTPIITKDLVNNDKLLEKRNHNHLLSATGSRNTAQSGNL
KPERPSKVSFEMQRVSSLATGKSTMPKLSDEEEGILEESIRNAETFDKICVLLSKPKLEV
ESYLNELGEFKVINS
Sequence of entity 9 (h, i), FASTA
>9H5K_9 Nitrogen permease regulator 3 (chains h, i)
MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTST
NKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSS
IPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLS
SSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTN
NKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNA
FTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQ
YDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRF
EFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENT
LKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMN
PHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIR
GAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMP
NFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGH
CGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLV
RNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPL
SSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRS
KFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRV
DKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGM
QSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERAT
AIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYL
IEIHHW
Sequence of entity 10 (X, j), FASTA
>9H5K_10 Vacuolar membrane-associated protein IML1 (chains X, j)
MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSNRNLRQKKEQFGSQQRA
SGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVML
NLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQ
TLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLA
FLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLF
QKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVD
QVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTIL
TDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIV
PLFRYRDFENKLHHCVPLWLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVD
VEYLQLNKKVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARK
IPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKIST
PTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTS
KNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNL
SIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQL
KHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITIS
DFPSKDDFDRNFIFRNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIE
LSRESGESETVVNKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFD
QVPSYIPLVKTRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKY
VVLPTDIPPNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREE
IQPEVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGED
RITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKH
NFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVV
PAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIR
LEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWE
DPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQFKYVQY
IHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCL
DYQKLRSIFLDAKEMWITGKIVED
Sequence of entity 11 (R, S), FASTA
>9H5K_11 Protein MEH1 (chains R, S)
MGAVLSCCRNHSGEENEALLREQQAGYGSQGNANDEYDAEQMRLKEHEHEQKLLAREQEL
RDIVANTNDKLIDISMINNSGIVIQGTDLQEALDKRQQEEGGDSREDERSAGDDNLSGHS
VPSSGSAQATTHQTAPRTNTFTLLTSPDSAKISKEQLKKLHSNILNEIFSQSQVNKPGPL
TVPF
Sequence of entity 12 (U, W), FASTA
>9H5K_12 Protein EGO2 (chains U, W)
MEAEKQSDIKGTIAFDTHGNVIESTGVGSQRIEDIGDLSKVTLDAEGFAQVQGDSLLVHL
YKRNDITLAVYTSAQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 28 |
| MG | Magnesium ion | Mg | 2 |
| AF3 | Aluminum fluoride | Al F3 | 2 |
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 4 |
Primary citation
Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex. Tafur, L., Bonadei, L., Zheng, Y. et al. Nat Struct Mol Biol (2026) 33:488-498. DOI 10.1038/s41594-026-01746-2 · PubMed
Other PDB entries of the same protein (UniProt Q03897 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8AE6 2.7 Å, Cryo-EM structure of the SEA complex wing (SEACIT)
- 8ADL 2.95 Å, Cryo-EM structure of the SEA complex
- 9H4Q 3.1 Å, Cryo-EM structure of the SEAC wing - EGOC
Browse structure collections
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