9HGN: Glycoprotein

Cryo-EM structure of VSV-Indiana (MUDD-SUMMERS strain) glycoprotein under its acidic conformation. Determined by electron microscopy at 2.94 Å resolution. Released 22 Oct 2025.

Method: Electron microscopy
Resolution: 2.94 Å
Organism: Vesicular stomatitis virus
Chains: 3
Atoms: 10,119
Mol. weight: 167.17 kDa
Released: 22 Oct 2025

Explore 9HGN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9HGN contains 48 α-helices and 108 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 33 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	1
β-strand	15-16	2	1
α-helix	17-18	2
α-helix	25-28	4
β-strand	37-46	10	2
α-helix	49-52	4
β-strand	53-69	17	3
β-strand	77-84	8	3
α-helix	86-88	3
α-helix	89-101	13
α-helix	110-112	3
β-strand	120-122	3	3
β-strand	125-137	13	3
β-strand	142-144	3	3
β-strand	148	1	4
α-helix	149-151	3
β-strand	152-153	2	3
β-strand	157-159	3	3
β-strand	160	1	4
β-strand	165-169	5	3
α-helix	173-178	6
β-strand	181-190	10	2
α-helix	195-197	3
β-strand	204-206	3	2
β-strand	213-214	2	2
β-strand	219-223	5	5
β-strand	226-230	5	5
β-strand	235	1	6
β-strand	236-237	2	5
β-strand	238-239	2	2
α-helix	242-248	7
α-helix	253-254	2
β-strand	260	1	6
α-helix	266-292	27
α-helix	299-305	7
β-strand	311-319	9	1
β-strand	322-335	14	1
β-strand	339-340	2	7
β-strand	344-347	4	1
β-strand	353-355	3	1
β-strand	361-363	3	7
β-strand	366-368	3	7
α-helix	370-372	3
β-strand	374-376	3	7
β-strand	379-381	3	7
α-helix	384-399	16
β-strand	404	1	6
α-helix	405-407	3
β-strand	423	1	3

Chain B: 16 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	8
β-strand	15-16	2	8
α-helix	17-18	2
α-helix	25-28	4
β-strand	37-46	10	9
α-helix	50-52	3
β-strand	53-54	2	10
β-strand	56-70	15	11
β-strand	76-85	10	11
α-helix	86-88	3
α-helix	89-100	12
α-helix	110-112	3
β-strand	115-116	2	11
β-strand	121-131	11	11
β-strand	134-137	4	10
β-strand	142-144	3	10
β-strand	148	1	12
α-helix	149-151	3
β-strand	152-153	2	10
β-strand	157-159	3	11
β-strand	160	1	12
β-strand	166-169	4	11
α-helix	173-178	6
β-strand	181-190	10	9
α-helix	195-197	3
β-strand	204-207	4	9
β-strand	210-214	5	9
β-strand	219-222	4	13
β-strand	227-231	5	13
β-strand	235-237	3	13
β-strand	238-239	2	9
α-helix	242-247	6
α-helix	250-251	2
β-strand	252	1	13
α-helix	253-254	2
β-strand	260-261	2	13
α-helix	266-293	28
α-helix	299-305	7
β-strand	311-319	9	8
β-strand	322-335	14	8
β-strand	339-340	2	14
β-strand	344-347	4	8
β-strand	353-355	3	8
β-strand	361-363	3	14
β-strand	366-368	3	14
α-helix	370-372	3
β-strand	374-376	3	14
β-strand	379-381	3	14
α-helix	384-399	16
β-strand	403-404	2	13
β-strand	423	1	11

Chain C: 16 helices, 40 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	15
β-strand	15-16	2	15
α-helix	17-18	2
α-helix	25-28	4
β-strand	37-42	6	16
β-strand	43-44	2	17
β-strand	45	1	18
α-helix	50-52	3
β-strand	53-54	2	19
β-strand	56-65	10	20
β-strand	69	1	21
β-strand	81-83	3	20
α-helix	89-100	12
β-strand	119	1	21
β-strand	124-131	8	20
β-strand	134-137	4	19
β-strand	142-144	3	19
β-strand	148	1	22
α-helix	149-151	3
β-strand	152-153	2	19
β-strand	157-159	3	20
β-strand	160	1	22
β-strand	165-169	5	20
α-helix	173-178	6
β-strand	182	1	18
β-strand	185-190	6	16
α-helix	195-197	3
β-strand	204-206	3	16
β-strand	213-214	2	16
β-strand	219-222	4	23
β-strand	227-230	4	23
β-strand	235	1	24
β-strand	236-237	2	23
β-strand	238-239	2	17
α-helix	242-248	7
α-helix	250-251	2
β-strand	252	1	23
α-helix	253-254	2
β-strand	260-261	2	24
α-helix	262-263	2
α-helix	267-292	26
α-helix	299-305	7
β-strand	311-319	9	15
β-strand	322-335	14	15
β-strand	339-340	2	25
β-strand	344-347	4	15
β-strand	353-355	3	15
β-strand	361-363	3	25
β-strand	366-368	3	25
α-helix	370-372	3
β-strand	374-376	3	25
β-strand	379-381	3	25
α-helix	384-399	16
β-strand	403-404	2	24
α-helix	405-406	2
β-strand	423	1	20

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Glycoprotein	A, B, C	protein	495	Vesicular stomatitis virus	B7UCZ5 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>9HGN_1 Glycoprotein (chains A, B, C)
KFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTALQVKMPKSHKAIQADGWMCH
ASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESIEQTKQGTWLNPGFPPQSCGYATVT
DAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNSTTWHSDYKVKGLCDSN
LISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYCKHWGVRLPSGVWFEMA
DKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSLCQETWSKIRAGLPISPV
DLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRMVGMISGTTTERELWDDW
APYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDD
ESLFFGDTGLSKNPIELVEGWFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTK
KRQIYTDIEMNRLGK

Primary citation

Cryo-EM structure of VSV-Indiana (MUDD-SUMMERS strain) glycoprotein under its acidic conformation. Albertini, A., Minoves, M.J., OuldAli, M. et al. To be published.

Other PDB entries of the same protein (UniProt B7UCZ5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6TIT 2.07 Å, Vsv G_440
5OYL 2.25 Å, Vsv G CR2
9HHR 2.81 Å, Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its post-fusion…
9HH9 2.93 Å, Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its pre-fusion…
9I8Q 2.93 Å, Cryo-EM structure of VSV-Indiana (MUDD-SUMMERS strain) glycoprotein under its pre-fusion…

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