9IAX: DNA-PK, LX4, XLF - Catalytic domain of L4

DNA-PK, LX4, XLF - Catalytic domain of L4. Determined by electron microscopy at 3.97 Å resolution. Released 4 Mar 2026.

Method: Electron microscopy
Resolution: 3.97 Å
Organisms: Homo sapiens, DNA molecule
Chains: 10
Atoms: 51,268
Mol. weight: 899.78 kDa
Released: 4 Mar 2026

Explore 9IAX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9IAX contains 309 α-helices and 136 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 208 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	12-21	10
α-helix	29-46	18
α-helix	53-58	6
α-helix	61-71	11
α-helix	76-78	3
α-helix	81-94	14
α-helix	97-100	4
α-helix	104-116	13
α-helix	118-122	5
α-helix	125-140	16
α-helix	150-161	12
α-helix	169-173	5
α-helix	174-178	5
α-helix	187-207	21
α-helix	220-232	13
α-helix	241-250	10
α-helix	263-265	3
α-helix	266-277	12
α-helix	279-282	4
α-helix	290-302	13
α-helix	306-328	23
α-helix	331-333	3
α-helix	334-348	15
α-helix	357-369	13
α-helix	372-375	4
α-helix	379-395	17
α-helix	409-423	15
α-helix	429-431	3
α-helix	432-444	13
α-helix	451-469	19
α-helix	473-474	2
α-helix	475-479	5
α-helix	480-492	13
α-helix	525-527	3
α-helix	528-535	8
α-helix	538-544	7
α-helix	560-578	19
β-strand	583	1	1
β-strand	614	1	1
α-helix	617-633	17
α-helix	648-659	12
α-helix	664-679	16
α-helix	698-720	23
α-helix	726-733	8
α-helix	738-742	5
α-helix	749-759	11
α-helix	763-779	17
α-helix	782-785	4
α-helix	786-788	3
α-helix	789-796	8
α-helix	835-838	4
α-helix	849-861	13
α-helix	864-867	4
β-strand	893-895	3	2
β-strand	904-906	3	2
α-helix	907-909	3
α-helix	910-919	10
α-helix	924-947	24
α-helix	959-973	15
α-helix	978-994	17
α-helix	1005-1017	13
α-helix	1023-1042	20
α-helix	1046-1051	6
α-helix	1057-1067	11
α-helix	1072-1089	18
α-helix	1093-1098	6
α-helix	1101-1117	17
α-helix	1123-1140	18
α-helix	1143-1146	4
α-helix	1152-1154	3
α-helix	1165-1175	11
α-helix	1181-1192	12
α-helix	1206-1213	8
α-helix	1217-1223	7
α-helix	1232-1235	4
α-helix	1250-1272	23
α-helix	1278-1281	4
α-helix	1289-1297	9
α-helix	1328-1351	24
α-helix	1354-1356	3
α-helix	1357-1360	4
α-helix	1369-1377	9
α-helix	1379-1382	4
α-helix	1395-1408	14
α-helix	1412-1422	11
α-helix	1428-1431	4
α-helix	1443-1460	18
α-helix	1477-1482	6
α-helix	1483-1487	5
α-helix	1488-1489	2
β-strand	1498	1	3
α-helix	1505-1519	15
α-helix	1525-1532	8
β-strand	1537-1538	2	4
β-strand	1553-1554	2	4
α-helix	1555-1573	19
α-helix	1577-1584	8
α-helix	1591-1606	16
α-helix	1613-1624	12
α-helix	1639-1655	17
α-helix	1668-1680	13
α-helix	1686-1692	7
α-helix	1693-1698	6
α-helix	1709-1718	10
α-helix	1734-1753	20
α-helix	1756-1767	12
α-helix	1775-1785	11
α-helix	1791-1805	15
α-helix	1818-1819	2
α-helix	1820-1824	5
α-helix	1825-1828	4
α-helix	1833-1848	16
α-helix	1849-1851	3
α-helix	1863-1880	18
α-helix	1912-1923	12
α-helix	1937-1954	18
α-helix	2035-2047	13
α-helix	2096-2107	12
α-helix	2126-2134	9
α-helix	2140-2152	13
α-helix	2158-2160	3
α-helix	2161-2172	12
α-helix	2182-2195	14
α-helix	2206-2222	17
α-helix	2229-2245	17
α-helix	2255-2260	6
α-helix	2271-2280	10
α-helix	2298-2308	11
α-helix	2313-2328	16
α-helix	2339-2350	12
α-helix	2359-2370	12
α-helix	2372-2378	7
α-helix	2379-2385	7
α-helix	2386-2388	3
α-helix	2392-2403	12
α-helix	2411-2417	7
α-helix	2420-2423	4
α-helix	2429-2442	14
α-helix	2443-2445	3
α-helix	2448-2459	12
α-helix	2467-2483	17
α-helix	2493-2508	16
α-helix	2515-2526	12
α-helix	2535-2539	5
α-helix	2551-2564	14
β-strand	2587-2588	2	5
α-helix	2724-2728	5
α-helix	2738-2764	27
α-helix	2766-2769	4
β-strand	2776-2777	2	5
α-helix	2788-2798	11
α-helix	2802-2820	19
α-helix	2826-2844	19
α-helix	2852-2863	12
α-helix	2868-2870	3
α-helix	2873-2883	11
α-helix	2886-2900	15
α-helix	2920-2932	13
α-helix	2937-2943	7
α-helix	2951-2960	10
α-helix	2966-2977	12
α-helix	2985-2987	3
α-helix	2988-3004	17
α-helix	3010-3013	4
α-helix	3036-3039	4
α-helix	3041-3054	14
α-helix	3060-3067	8
α-helix	3072-3092	21
α-helix	3096-3116	21
α-helix	3122-3143	22
α-helix	3156-3161	6
α-helix	3164-3166	3
α-helix	3176-3195	20
α-helix	3227-3248	22
α-helix	3258-3266	9
α-helix	3270-3286	17
α-helix	3292-3298	7
α-helix	3321-3343	23
α-helix	3348-3351	4
α-helix	3355-3363	9
α-helix	3370-3392	23
α-helix	3409-3427	19
α-helix	3443-3454	12
α-helix	3459-3474	16
α-helix	3476-3482	7
α-helix	3483-3486	4
α-helix	3499-3506	8
α-helix	3513-3522	10
α-helix	3530-3536	7
α-helix	3548-3561	14
α-helix	3565-3578	14
α-helix	3581-3596	16
α-helix	3606-3613	8
α-helix	3614-3618	5
α-helix	3628-3642	15
α-helix	3659-3668	10
α-helix	3697-3699	3
β-strand	3700	1	6
β-strand	3718	1	6
β-strand	3719	1	7
β-strand	3727-3728	2	8
β-strand	3736-3740	5	8
β-strand	3742	1	7
β-strand	3748-3753	6	8
α-helix	3759-3775	17
α-helix	3779-3784	6
β-strand	3793-3795	3	8
β-strand	3801-3804	4	8
β-strand	3811	1	9
α-helix	3812-3817	6
α-helix	3822	1
α-helix	3823-3828	6
α-helix	3835-3840	6
α-helix	3855-3861	7
α-helix	3864-3877	14
α-helix	3882-3890	9
α-helix	3894-3917	24
β-strand	3928-3931	4	9
β-strand	3936-3939	4	9
α-helix	3965-3968	4
α-helix	3979-3991	13
α-helix	3995-3999	5
α-helix	4000-4002	3
α-helix	4040-4053	14
α-helix	4056-4065	10
α-helix	4074-4082	9
α-helix	4089-4092	4
α-helix	4100-4110	11
α-helix	4113-4118	6

Chain B: 18 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	35-43	9	10
α-helix	46-49	4
α-helix	59-78	20
β-strand	82-88	7	10
β-strand	102-109	8	10
α-helix	113-120	8
α-helix	124-134	11
α-helix	143-156	14
β-strand	161-170	10	10
α-helix	174-176	3
α-helix	180-196	17
β-strand	199-204	6	10
α-helix	239-242	4
α-helix	251-253	3
β-strand	257-262	6	11
β-strand	268-274	7	11
β-strand	277	1	12
α-helix	282-285	4
β-strand	288-289	2	13
β-strand	295	1	13
β-strand	296-304	9	14
β-strand	316-322	7	15
β-strand	325-329	5	15
β-strand	344-347	4	11
β-strand	350	1	16
β-strand	351-352	2	17
β-strand	367-370	4	11
β-strand	375	1	18
α-helix	378-392	15
β-strand	394-395	2	17
β-strand	397-401	5	11
β-strand	409-416	8	11
β-strand	419	1	19
β-strand	428	1	19
β-strand	431-436	6	11
α-helix	440-442	3
α-helix	447-450	4
α-helix	456-468	13
α-helix	481-494	14
α-helix	503-505	3
α-helix	511-518	8
α-helix	521-528	8

Chain C: 29 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	8-15	8	20
β-strand	17	1	21
α-helix	18-20	3
α-helix	30-48	19
β-strand	54-59	6	20
β-strand	77-84	8	20
α-helix	88-97	10
β-strand	101	1	21
α-helix	107-119	13
β-strand	129-133	5	20
α-helix	148-154	7
β-strand	160-162	3	20
α-helix	201-213	13
α-helix	219-223	5
α-helix	227-232	6
β-strand	247-253	7	22
β-strand	257-263	7	22
β-strand	265	1	22
β-strand	277-280	4	15
β-strand	289-297	9	14
β-strand	304	1	14
α-helix	307-309	3
β-strand	310-311	2	13
β-strand	313-316	4	23
β-strand	319-322	4	23
α-helix	325-331	7
β-strand	340-342	3	22
β-strand	346-347	2	24
α-helix	348-350	3
β-strand	357-366	10	22
α-helix	367	1
α-helix	371-387	17
β-strand	389-390	2	24
β-strand	391-395	5	22
β-strand	404-412	9	22
β-strand	417-423	7	22
α-helix	427-429	3
β-strand	430	1	12
α-helix	442-444	3
α-helix	445-447	3
α-helix	448-460	13
β-strand	462	1	16
β-strand	464-467	4	25
β-strand	472-475	4	25
α-helix	479-481	3
α-helix	483-484	2
α-helix	485-498	14
α-helix	510-516	7
α-helix	520-535	16
β-strand	541	1	18
α-helix	597-605	9
α-helix	610-619	10
α-helix	629-648	20
α-helix	652-668	17
α-helix	676-681	6
α-helix	694-703	10
α-helix	720-725	6

Chain D: 5 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	24	1	26
β-strand	37	1	26
α-helix	51-60	10
α-helix	69-76	8
β-strand	99	1	27
β-strand	104	1	27
β-strand	106	1	28
β-strand	121	1	28
α-helix	143-170	28
α-helix	173-175	3
α-helix	186-192	7

Chain G: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	17-20	4	29
β-strand	34-37	4	29
β-strand	43-45	3	29
α-helix	47-48	2
α-helix	55-58	4
α-helix	65-74	10
β-strand	84	1	30
β-strand	87-89	3	31
β-strand	94-96	3	31
β-strand	99-101	3	30
β-strand	104-106	3	30
α-helix	119-197	79

Chain H: 2 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	32
β-strand	5-9	5	33
β-strand	10	1	34
β-strand	17-21	5	33
β-strand	24	1	32
β-strand	35-37	3	35
β-strand	42-44	3	35
α-helix	63-71	9
β-strand	88	1	34
β-strand	97	1	34
α-helix	119-199	81

Chain K: 35 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	10-13	4
β-strand	15	1	36
α-helix	17-27	11
α-helix	32-53	22
α-helix	65-71	7
α-helix	86-97	12
α-helix	104-111	8
α-helix	125-133	9
β-strand	139	1	3
β-strand	144	1	36
α-helix	145-161	17
α-helix	164-177	14
α-helix	180-191	12
α-helix	200-207	8
α-helix	211-215	5
α-helix	221-227	7
α-helix	251	1
β-strand	252-253	2	37
α-helix	256-262	7
β-strand	268-272	5	37
β-strand	277-284	8	38
β-strand	287-289	3	38
α-helix	299-301	3
α-helix	312-316	5
β-strand	319	1	39
β-strand	325-336	12	38
β-strand	341-342	2	38
α-helix	352-354	3
α-helix	355-359	5
β-strand	361-372	12	38
β-strand	376	1	38
α-helix	382-390	9
β-strand	393	1	39
β-strand	396	1	38
β-strand	400-402	3	38
α-helix	403-404	2
β-strand	406-408	3	37
α-helix	411-423	13
β-strand	429-432	4	37
β-strand	447-450	4	37
β-strand	462-464	3	40
β-strand	465-470	6	41
β-strand	482-488	7	41
α-helix	491-492	2
β-strand	500-507	8	41
α-helix	513-523	11
β-strand	527	1	41
β-strand	538-539	2	41
β-strand	547-548	2	41
β-strand	557-560	4	40
β-strand	563-566	4	42
β-strand	574-577	4	42
β-strand	580-583	4	40
α-helix	590-592	3
α-helix	596-602	7
α-helix	657-659	3
β-strand	663-668	6	43
β-strand	670	1	44
β-strand	673	1	44
α-helix	675-684	10
β-strand	688-689	2	43
β-strand	699-702	4	43
α-helix	707-714	8
β-strand	720-721	2	43
α-helix	724-730	7
β-strand	743-745	3	43
α-helix	748-757	10
α-helix	771-780	10
α-helix	789-803	15
α-helix	838-842	5
α-helix	870-881	12

Chain M: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	51-59	9
α-helix	69-77	9
β-strand	98-99	2	45
β-strand	104-105	2	45
β-strand	107-111	5	46
β-strand	116-120	5	46
α-helix	128-131	4
α-helix	132-136	5
α-helix	144-170	27
α-helix	181-183	3
α-helix	187-188	2
α-helix	189-193	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-dependent protein kinase catalytic subunit	A	protein	4128	Homo sapiens	P78527
X-ray repair cross-complementing protein 6	B	protein	609	Homo sapiens	P12956 (AlphaFold model)
X-ray repair cross-complementing protein 5	C	protein	732	Homo sapiens	P13010 (AlphaFold model)
Non-homologous end-joining factor 1	D, M	protein	299	Homo sapiens	Q9H9Q4 (AlphaFold model)
DNA repair protein XRCC4	G, H	protein	336	Homo sapiens	Q13426
DNA ligase 4	K	protein	911	Homo sapiens	P49917
DNA	d	DNA	55	DNA molecule
DNA	e	DNA	42	DNA molecule

Sequence of entity 1 (A), FASTA

>9IAX_1 DNA-dependent protein kinase catalytic subunit (chains A)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM

Sequence of entity 2 (B), FASTA

>9IAX_2 X-ray repair cross-complementing protein 6 (chains B)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD

Sequence of entity 3 (C), FASTA

>9IAX_3 X-ray repair cross-complementing protein 5 (chains C)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI

Sequence of entity 4 (D, M), FASTA

>9IAX_4 Non-homologous end-joining factor 1 (chains D, M)
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKE
LNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWN
FHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLK
TEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHT
SNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS

Sequence of entity 5 (G, H), FASTA

>9IAX_5 DNA repair protein XRCC4 (chains G, H)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI

Sequence of entity 6 (K), FASTA

>9IAX_6 DNA ligase 4 (chains K)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI

Sequence of entity 7 (d), FASTA

>9IAX_7 DNA (chains d)
CGCGCCCAGCTTTCCCAGCTAATAAACTAAAAACTATTATTATGGCCGCACGCGT

Sequence of entity 8 (e), FASTA

>9IAX_8 DNA (chains e)
ACGCGTGCGGCCATAATAATAGTTTTTAGTTTATTGGGCGCG

Primary citation

New insight into how the DNA binding domain of DNA ligase IV facilitates end-joining, independent of its catalytic activity. Chaplin, A.K., Hall, C. To be published.

Other PDB entries of the same protein (UniProt P78527), best resolution first:

7Z87 2.91 Å, DNA-PK in the active state
7OTY 2.96 Å, DNA-PKcs in complex with M3814
7OTW 2.99 Å, DNA-PKcs in complex with AZD7648
7SGL 3.0 Å, DNA-PK complex of DNA end processing
7K11 3.21 Å, CryoEM structure of inactivated-form FATKIN domain of DNA-PK
6ZFP 3.24 Å, Cryo-EM structure of DNA-PKcs (State 2)
7OTV 3.24 Å, DNA-PKcs in complex with wortmannin
7K10 3.3 Å, CryoEM structure of activated-form FATKIN domain of DNA-PK
7SU3 3.3 Å, CryoEM structure of DNA-PK complex VII
7OTM 3.33 Å, Cryo-EM structure of DNA-PKcs in complex with NU7441
7TYR 3.33 Å, Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14)
7Z88 3.33 Å, DNA-PK in the intermediate state

Browse structure collections

About this viewer

MolViewer shows 9IAX directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.