local refinement of FEM1B bound with TOM20. Determined by electron microscopy at 3.59 Å resolution. Released 9 Apr 2025.
Explore 9JCE in 3D Show helices and sheets RCSB PDB PDBe
9JCE contains 43 α-helices and 2 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 2-13 | 12 | |
| α-helix | 17-23 | 7 | |
| α-helix | 30-36 | 7 | |
| β-strand | 40-42 | 3 | 1 |
| β-strand | 45-47 | 3 | 1 |
| α-helix | 49-55 | 7 | |
| α-helix | 59-67 | 9 | |
| α-helix | 91-96 | 6 | |
| α-helix | 101-109 | 9 | |
| α-helix | 124-131 | 8 | |
| α-helix | 134-142 | 9 | |
| α-helix | 157-164 | 8 | |
| α-helix | 167-175 | 9 | |
| α-helix | 192-197 | 6 | |
| α-helix | 200-208 | 9 | |
| α-helix | 222-228 | 7 | |
| α-helix | 232-238 | 7 | |
| α-helix | 247-260 | 14 | |
| α-helix | 269-283 | 15 | |
| α-helix | 292-295 | 4 | |
| α-helix | 300-302 | 3 | |
| α-helix | 305-308 | 4 | |
| α-helix | 311-314 | 4 | |
| α-helix | 315-317 | 3 | |
| α-helix | 321-336 | 16 | |
| α-helix | 341-343 | 3 | |
| α-helix | 344-356 | 13 | |
| α-helix | 360-375 | 16 | |
| α-helix | 382-397 | 16 | |
| α-helix | 404-427 | 24 | |
| α-helix | 433-455 | 23 | |
| α-helix | 461-475 | 15 | |
| α-helix | 487-491 | 5 | |
| α-helix | 512-521 | 10 | |
| α-helix | 535-540 | 6 | |
| α-helix | 549-562 | 14 | |
| α-helix | 576-579 | 4 | |
| α-helix | 583-592 | 10 | |
| α-helix | 597-608 | 12 | |
| α-helix | 618-626 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 64-83 | 20 | |
| α-helix | 86-97 | 12 | |
| α-helix | 104-109 | 6 | |
| α-helix | 116-125 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 3-6 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein fem-1 homolog B | A | protein | 627 | Homo sapiens | Q9UK73 (AlphaFold model) |
| Poly-UNK | C | protein | 9 | Homo sapiens | |
| Mitochondrial import receptor subunit TOM20 homolog | B | protein | 121 | Homo sapiens | Q15388 (AlphaFold model) |
>9JCE_1 Protein fem-1 homolog B (chains A) MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP NAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLS HADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH AYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEF EQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQ SMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPR TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCL AARAVRANDINYQDQIPRTLEEFVGFH
>9JCE_2 Poly-UNK (chains C) XXXXXXXXX
>9JCE_3 Mitochondrial import receptor subunit TOM20 homolog (chains B) DRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQG EYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDV E
TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6. Raiff, A., Zhao, S., Bekturova, A. et al. Nat Chem Biol (2026) 22:37-47. DOI 10.1038/s41589-025-01894-4 · PubMed
Other PDB entries of the same protein (UniProt Q9UK73 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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