9JR7: PCoV-GX receptor-binding domain

Crystal structure of PCoV-GX receptor-binding domain complexed with squirrel ACE2. Determined by X-ray diffraction at 3.43 Å resolution. Released 6 Aug 2025.

Method
X-ray diffraction
Resolution
3.43 Å
Organisms
Petaurus norfolcensis, Pangolin coronavirus
Chains
2
Atoms
6,443
Mol. weight
93.52 kDa
Ligands
NAG
Released
6 Aug 2025

Explore 9JR7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9JR7 contains 45 α-helices and 29 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 36 helices, 11 β-strands

ElementResiduesLengthSheet
α-helix21-5232
α-helix56-8025
α-helix85-873
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand131-13221
α-helix138-1403
β-strand142-14321
α-helix144-1485
α-helix149-1546
α-helix158-16811
α-helix169-1735
α-helix174-19320
α-helix199-2035
β-strand20912
β-strand21712
α-helix221-24929
β-strand26013
α-helix2611
β-strand26214
α-helix2631
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31815
α-helix320-3245
β-strand33215
β-strand347-35045
β-strand356-35945
α-helix366-38520
α-helix390-3923
α-helix400-41314
α-helix415-4206
α-helix432-46433
α-helix473-48311
β-strand48714
α-helix500-5023
α-helix504-5074
α-helix513-53220
α-helix539-5413
α-helix548-55811
α-helix561-5633
α-helix566-5749
α-helix582-59817
β-strand60713
Chain E: 9 helices, 18 β-strands
ElementResiduesLengthSheet
β-strand334-33526
α-helix338-3425
β-strand34917
α-helix350-3523
β-strand354-35857
β-strand361-36226
α-helix365-3717
β-strand376-37727
β-strand38017
α-helix386-3894
β-strand39216
β-strand395-40397
α-helix404-4096
α-helix417-4215
β-strand431-43777
α-helix439-4424
β-strand44818
β-strand452-45439
α-helix460-4623
α-helix471-4722
β-strand473-474210
β-strand485110
β-strand488-489210
β-strand492-49439
β-strand49718
β-strand507-51597
β-strand524-52526

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Angiotensin-converting enzymeAprotein609Petaurus norfolcensisA0A8D2KIZ1 (AlphaFold model)
Spike glycoproteinEprotein194Pangolin coronavirusQ6T1E4
Sequence of entity 1 (A), FASTA
>9JR7_1 Angiotensin-converting enzyme (chains A)
MLGSSWILLSFVAVTAAQSTIEELAKTFLDKFNQEAEDLDHQRSLAAWNYNTNITKENTE
KMNEAEAKWSAFYEEQSKLAKDYPLQEIQNFTLKRQLQALQQSGSSALSANKREQLNTIL
NTMSTIYSTGKVCNPKKPQECLLLEPGLDEIMANSTDYSERLWVWEGWRSEVGKQLRPLY
EEYVVLKNEMARANNYEDYGDYWRGDYEAEGADGYGYNRNQLIEDVERTFAEIKPLYEHL
HAYVRAKLMNTYPSYISPTGCLPAHLLGDMWGRFWTNLYSLTVPFPEKPNIDVTDAMINQ
NWNAVRIFKEAEKFFVSVGLPNMTQGFWENSMLTEPTDGRKVVCHPTAWDLQKGDFRIKM
CTKVTMDNFLTAHHEMGHIQYDMAYAMQPYLLRNGANEGFHEAVGEIMSLSASTPKHLKS
IGLLPSDFREDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM
KREIVGVMEPVPHDETYCDPAALYHVSNDFSFIRYYTRTIYQFQFQEALCQAAKHEGPLH
KCDISNSTEAGQKLLNMLRLGKSKPWTLALENVVGARNMDVRPLLNYFEPLFGWLKDQNR
NSFVGWNTD
Sequence of entity 2 (E), FASTA
>9JR7_2 Spike glycoprotein (chains E)
TNLCPFGEVFNASKFASVYAWNRKRISNCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCF
TNVYADSFVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSVKQDALTGGNYGYL
YRLFRKSKLKPFERDISTEIYQAGSTPCNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVV
LSFELLNGPATVCG

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O65

Primary citation

Cross-species recognition of squirrel ACE2 by the receptor binding domains of SARS-CoV-2, RaTG13, PCoV-GD and PCoV-GX. Wang, C., Nan, X., Deng, Y. et al. Structure (2025) 33:1750-1759.e2. DOI 10.1016/j.str.2025.07.003 · PubMed

Other PDB entries of the same protein (UniProt A0A8D2KIZ1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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