9NL0: Fab MAM01

Crystal structure of Fab MAM01 in complex with NPNA3 peptide from circumsporozoite protein. Determined by X-ray diffraction at 1.54 Å resolution. Released 4 Mar 2026.

Method: X-ray diffraction
Resolution: 1.54 Å
Organisms: Homo sapiens, Plasmodium falciparum 3D7
Chains: 3
Atoms: 3,664
Mol. weight: 48.6 kDa
Released: 4 Mar 2026

Explore 9NL0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9NL0 contains 23 α-helices and 48 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3

Chain H: 13 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	1
β-strand	10-12	3	2
β-strand	18-25	8	1
α-helix	29-31	3
β-strand	34-39	6	2
β-strand	45-51	7	2
α-helix	52B-53	3
β-strand	57-59	3	2
α-helix	61-63	3
β-strand	67-72	6	1
α-helix	73-75	3
β-strand	77-82	6	1
α-helix	84-86	3
β-strand	88-95	8	2
α-helix	96	1
β-strand	99	1	3
β-strand	100D	1	3
β-strand	100H-103	4	2
β-strand	107-111	5	2
β-strand	117	1	4
α-helix	118-119	2
β-strand	120-124	5	5
α-helix	128-130	3
β-strand	131-132	2	5
β-strand	135-145	11	5
β-strand	146	1	4
β-strand	151-154	4	6
α-helix	155-157	3
β-strand	159	1	6
β-strand	163-165	3	5
α-helix	166-168	3
β-strand	169-170	2	5
β-strand	176-185	10	5
α-helix	186-188	3
β-strand	195-200	6	6
α-helix	201-203	3
β-strand	205-210	6	6
α-helix	212-214	3

Chain L: 9 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	5	1	7
β-strand	9-13	4	8
β-strand	18-24	7	7
α-helix	27C-29	3
α-helix	31-33	3
β-strand	34-38	5	8
β-strand	45-48	4	8
β-strand	49	1	9
β-strand	53	1	9
α-helix	54-55	2
β-strand	62-67	6	7
β-strand	70-76	7	7
α-helix	80-82	3
β-strand	84-92	9	8
β-strand	95B-98	4	8
β-strand	102-106	5	8
β-strand	111	1	10
α-helix	112-113	2
β-strand	114-118	5	11
α-helix	119-121	3
α-helix	122-126	5
β-strand	130-139	10	11
β-strand	140	1	10
β-strand	145-150	6	12
β-strand	153-155	3	12
β-strand	159-161	3	11
α-helix	162-164	3
β-strand	165-166	2	11
β-strand	172-180	9	11
α-helix	182-186	5
β-strand	191-197	7	12
β-strand	200-206	7	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Heavy Chain of Fab MAM01	H	protein	230	Homo sapiens
Circumsporozoite protein	A	protein	12	Plasmodium falciparum 3D7	Q7K740 (AlphaFold model)
Light Chain of Fab MAM01	L	protein	217	Homo sapiens

Sequence of entity 1 (H), FASTA

>9NL0_1 Heavy Chain of Fab MAM01 (chains H)
EVQLVESGGGLVQPGRSLRLSCTASGFSFGDHAMSWVRQAPGKGLEWVGFIRKTTYGATT
HYAAAVRGRFTISRDDSKSTVYLQMNSLKAEDTAVYFCARVQLDYGPGYQYYGMDVWGQG
TTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTF
PAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

Sequence of entity 2 (A), FASTA

>9NL0_2 Circumsporozoite protein (chains A)
NPNANPNANPNA

Sequence of entity 3 (L), FASTA

>9NL0_3 Light Chain of Fab MAM01 (chains L)
QSVLTQPPSVSGAPGQRVTISCTGMNSNIGAGYDVYWYQQLPGTAPKLLIYGNSNRPSGV
PDRFSGSRSGTSASLAITGLQAEDEADYYCQSYDTSLNGWAFGGGTKLTVLGQPKAAPSV
TLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAAS
SYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS

Primary citation

Engineered antibodies preserve structural and functional recognition of Plasmodium falciparum circumsporozoite protein. Jain, M., Agrawal, S., Cannac, F. et al. Protein Sci (2026) 35:e70738-e70738. DOI 10.1002/pro.70738 · PubMed

Other PDB entries of the same protein (UniProt Q7K740 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SG5 1.4 Å, Structure of PfCSP peptide 21 with antibody CIS43_Var2
9C79 1.46 Å, Human monoclonal antibody MAD21-101 bound to the N-terminus of cleaved circumsporozoite…
9NKZ 1.48 Å, Crystal structure of Fab MAM01 in complex with NANP6 peptide from circumsporozoite protein
7SG6 1.55 Å, Structure of PfCSP peptide 21 with antibody CIS43_Var10
6PBV 1.57 Å, Crystal structure of Fab668 complex
9NCY 1.63 Å, Fab1392 in complex with the C-terminal alpha-TSR domain of the P. falciparum…
3VDJ 1.7 Å, Crystal structure of circumsporozoite protein aTSR domain, R32 native form
9DST 1.74 Å, Crystal structure of Fab MS-1805 in complex with N-terminal junction peptide from…
9NI1 1.75 Å, Fab389 in complex with the C-terminal alpha-TSR domain of the P. falciparum…
7RXP 1.76 Å, Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum
6BQB 1.77 Å, MGG4 Fab in complex with peptide
7LKB 1.8 Å, Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody…

Browse structure collections

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