9O5E: The dimeric KICSTOR-GATOR1 supercomplex

The dimeric KICSTOR-GATOR1 supercomplex. Determined by electron microscopy at 5.0 Å resolution. Released 21 Jan 2026.

Method
Electron microscopy
Resolution
5.0 Å
Organism
Homo sapiens
Chains
8
Atoms
42,158
Mol. weight
1350.33 kDa
Released
21 Jan 2026

Explore 9O5E in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9O5E contains 260 α-helices and 274 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains C and F: 26 helices, 20 β-strands

ElementResiduesLengthSheet
β-strand9-1681
β-strand19-2681
β-strand4712
α-helix61-633
α-helix66-727
α-helix77-793
β-strand84-8851
β-strand91-9551
β-strand98-9921
β-strand123-13191
α-helix136-16025
α-helix162-17817
α-helix191-1944
α-helix199-21315
β-strand216-22163
β-strand225-23063
α-helix232-2354
β-strand23714
β-strand24214
α-helix243-2442
α-helix245-2528
β-strand260-26345
α-helix267-2737
α-helix280-2889
β-strand29415
α-helix295-3028
α-helix306-31813
β-strand322-32545
α-helix326-3283
β-strand333-33646
α-helix347-3559
α-helix361-3677
β-strand372-37326
α-helix374-3774
α-helix388-39912
β-strand403-40536
β-strand408-41257
α-helix481-4888
α-helix492-5009
α-helix502-5054
α-helix507-51711
β-strand521-52557
α-helix526-5338
α-helix537-54610
β-strand551-55557
α-helix559-5646
Chains D and G: 19 helices, 19 β-strands
ElementResiduesLengthSheet
β-strand9-1681
β-strand20-2781
α-helix34-4411
α-helix48-503
β-strand55-5951
β-strand62-6651
β-strand69-7131
β-strand81-90101
α-helix95-11622
α-helix122-14120
β-strand144-15078
β-strand153-15868
α-helix159-1613
α-helix163-1697
β-strand174-17749
α-helix191-1966
α-helix206-2116
α-helix217-22913
β-strand233-23649
β-strand244110
β-strand245-247311
α-helix251-2566
α-helix258-26811
β-strand269112
α-helix2701
α-helix274-2763
α-helix278-2869
β-strand293110
α-helix294-3007
α-helix304-3063
β-strand308112
α-helix310-31910
β-strand323-325311
β-strand328-332513
β-strand346113
α-helix351-3588
α-helix362-37110
β-strand375-379513
Chains E and I: 42 helices, 40 β-strands
ElementResiduesLengthSheet
β-strand11-12214
β-strand15-20615
α-helix211
α-helix28-3710
β-strand42-44314
α-helix45-473
α-helix48-514
β-strand58-64715
β-strand78-80314
β-strand86-90515
β-strand93-101916
α-helix104-1074
β-strand109-110217
β-strand115-116217
α-helix117-13317
β-strand136-137218
β-strand144-145218
β-strand148-156916
β-strand167-174816
α-helix176-1783
α-helix179-20527
α-helix234-24815
β-strand256-263816
α-helix272-28413
β-strand288-293616
α-helix310-31910
β-strand324-325216
α-helix329-3335
α-helix340-3456
β-strand348115
β-strand351119
α-helix374-3785
β-strand386-3951019
α-helix399-40810
α-helix4111
β-strand412-417619
β-strand424-4341119
β-strand437-4461019
α-helix4501
β-strand457-465919
α-helix467-4748
α-helix484-51128
α-helix517-5193
α-helix522-5232
α-helix524-5274
β-strand533-534220
β-strand543-544220
α-helix553-56715
α-helix573-5753
β-strand580-585620
α-helix586-5883
α-helix592-5932
β-strand599121
α-helix6041
β-strand605121
α-helix6061
α-helix611-62414
β-strand627-630420
β-strand634-639620
β-strand649-6581020
β-strand661-667720
α-helix674-68815
β-strand740-741220
α-helix746-7494
α-helix764-7674
α-helix782-79211
β-strand794-801822
α-helix812-82817
β-strand832-837622
β-strand840-848922
β-strand864-871822
α-helix872-8743
β-strand875-876222
β-strand902-910922
α-helix922-9276
α-helix932-9343
α-helix935-96026
β-strand986-990522
α-helix995-9984
α-helix1053-106311
α-helix1247-12548
α-helix12581
Chains H and J: 43 helices, 58 β-strands
ElementResiduesLengthSheet
β-strand6-12723
β-strand23-25323
α-helix27-293
β-strand38-42523
α-helix50-512
β-strand52-54323
β-strand57-58223
α-helix631
β-strand66-70523
α-helix71-766
β-strand84-89623
α-helix92-954
β-strand96124
β-strand99-104625
α-helix111-12111
β-strand124-127424
β-strand131-134425
β-strand137-145925
β-strand146126
β-strand149126
β-strand15112
β-strand153-156424
β-strand161-166625
β-strand170-176727
α-helix179-1824
β-strand184128
β-strand190128
α-helix191-1933
α-helix194-2007
α-helix201-2099
β-strand215-2261227
α-helix231-2333
α-helix236-2416
β-strand242-244327
β-strand250-2631427
α-helix268-28417
α-helix294-2952
β-strand296-298327
α-helix299-3002
α-helix306-31813
α-helix319-3213
β-strand331-337727
β-strand342-345429
α-helix347-36014
β-strand364-368527
β-strand379-382429
β-strand397-398229
β-strand403-407527
α-helix744-7485
α-helix7501
β-strand751125
α-helix752-7543
β-strand756-757230
α-helix763-7697
β-strand770-777830
α-helix795-80915
β-strand812-814330
β-strand851-856630
β-strand859-866830
β-strand869-877930
β-strand880-8931427
β-strand902-908727
α-helix913-9153
α-helix918-92710
α-helix937-9393
β-strand942-950931
α-helix953-9608
α-helix966-9716
α-helix976-99318
β-strand1172132
α-helix1177-11815
α-helix1197-11993
β-strand1204-1206333
α-helix1207-121711
β-strand1219132
α-helix1224-123613
β-strand1240-1242333
β-strand1254-1255234
β-strand1257-1260433
α-helix1287-12904
β-strand1296-1298334
α-helix1310-13123
β-strand1351-1355531
β-strand1369-1375731
β-strand1377-1378234
β-strand1382135
β-strand1384-1392931
α-helix1395-141117
β-strand1414-1419631
β-strand1439-1442435
α-helix1445-14484
α-helix14501
α-helix1462-14643
α-helix1465-147915
β-strand1482-1484335
β-strand1501-1504435
β-strand1509-1512435
β-strand1545-1550635
α-helix1566-158015
α-helix1583-15853
α-helix1586-159712

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
GATOR complex protein NPRL3C, Fprotein590Homo sapiensQ12980 (AlphaFold model)
GATOR complex protein NPRL2D, Gprotein401Homo sapiensQ8WTW4 (AlphaFold model)
KICSTOR complex protein SZT2E, Iprotein3451Homo sapiensQ5T011 (AlphaFold model)
GATOR1 complex protein DEPDC5H, Jprotein1621Homo sapiensO75140 (AlphaFold model)
Sequence of entity 1 (C, F), FASTA
>9O5E_1 GATOR complex protein NPRL3 (chains C, F)
MGYPYDVPDYADLNGGGGGSTMRDNTSPISVILVSSGSRGNKLLFRYPFQRSQEHPASQT
SKPRSRYAASNTGDHADEQDGDSRFSDVILATILATKSEMCGQKFELKIDNVRFVGHPTL
LQHALGQISKTDPSPKREAPTMILFNVVFALRANADPSVINCLHNLSRRIATVLQHEERR
CQYLTREAKLILALQDEVSAMADGNEGPQSPFHHILPKCKLARDLKEAYDSLCTSGVVRL
HINSWLEVSFCLPHKIHYAASSLIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCS
PALVRVIKTTSAVKNLQQLAQDADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPN
ASVCLYSPLAEQFSHQFPSHDLPSVLAKFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQ
RRLLIQLHTYVCLMASPSEEEPRPREDDVPFTARVGGRSLSTPNALSFGSPTSSDDMTLT
SPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAILSVPAAQNPEDLRMFARLLHY
FRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIAVFQALLP
Sequence of entity 2 (D, G), FASTA
>9O5E_2 GATOR complex protein NPRL2 (chains D, G)
MGYPYDVPDYADLNGGGGGSTMGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDT
VQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALE
PIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKV
IEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNL
VRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLR
DVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQS
HPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK
Sequence of entity 3 (E, I), FASTA
>9O5E_3 KICSTOR complex protein SZT2 (chains E, I)
MEMDYKDDDDKGGGGGASTMASERPEPEVEEAGQVFLLMKKDYRISRNVRLAWFLSHLHQ
TVQATPQEMLLQSEQELEVLSVLPPGWQPDEPVVPRPFLLVPSTRVTFLAWQYRFVIELD
LSPSTGIVDDSTGEILFDEVFHALSRCLGGLLRPFRVPGSCIDFQPEIYVTIQAYSSIIG
LQSHQVLVQGCLLDPSQREVFLQQIYEQLCLFEDKVATMLQQQYDPQSQAEDQSPDSGDL
LGRKVGVSMVTADLGLVSMIRQGILALQLLPSNSSAGIIVITDGVTSVPDVAVCETLLNQ
LRSGTVACSFVQVGGVYSYDCSFGHVPNVELMKFIAMATFGSYLSTCPEPEPGNLGLTVY
HRAFLLYSFLRSGEALNPEYYCGSQHRLFNEHLVSASSNPALALRRKKHTEKEVPADLVS
TVSVRLREGYSVREVTLAKGGSQLEVKLVLLWKHNMRIEYVAMAPWPLEPEGPRVTRVEV
TMEGGYDILHDVSCALRQPIRSLYRTHVIRRFWNTLQSINQTDQMLAHLQSFSSVPEHFT
LPDSTKSGVPLFYIPPGSTTPVLSLQPSGSDSSHAQFAAYWKPVLSMDANSWQRWLHMHR
LVLILEHDTPIPKHLHTPGSNGRYSTIQCRISHSSLTSLLRDWSSFVLVEGYSYVKLLSS
APDQPPNSFYMVRIISKAPCMVLRLGFPIGTPAPARHKIVSGLREEILRLRFPHRVQSKE
PTPKVKRKGLGGAGGGSSPSKSPPVLGPQQALSDRPCLVVLHKPLDKLLIRYEKLPLDYR
APFLLTLEPPGPLPLVSGRSASSSLASLSRYLYHQRWLWSVPSGLAPALPLSAIAQLLSI
LTEVRLSEGFHFACSGEGIINMVLELPIQNEPPGQAAAEEKHTCVVQYILFPPHSTSTKD
SFSTDDDNDVEVEALEGDSELNLVTEVWVEPQYGRVGPGPGIWKHLQDLTYSEIPQALHP
RDAACIGSMLSFEYLIQLCQSKEWGPLPPEPRVSDGLDQGGDTCVHEIPFHFDLMGLLPQ
CQQLQMFFLLLAREPEGVPFAEGSCPANDMVLCLLHSCLGQELSDREIPLTPVDQAAFLS
EVLRRTCHVPGAEGPLLGVHGIPKEQAVGSTQATGDSAFTSLSVGLPETLKPLISAQPPQ
WRCYARLVNPQHVFLTFLPATFSDVQRLAACGLEGPPQEETKPKFGDWSGAPSLKDLGGT
GIKATKSHVPVLSVTLASDNAQNQGELSPPFRRDLQAYAGRQASQTESADGPRTRCPVYI
YSCSLEALREQMVGMQPPQAPRDLIFRTQFLDHPSPSSAWMEPRYKEAANHCALLQEHAQ
RCYVRGLFRSLQQAQSVTSQDLLTAVDACEELLQEIDITPFLLALCGHTWGLPHAPPSPG
PLSPGPFSSSMEEGAEPRERAILASESSIETEDLSEPEFQSTRVPGIPDPGPEISLTDVC
QLRGEAHGALHSVIQEKFLEISRLHFRTVPSNPHYFFYCPPSSRREDEGPRDTVDRKISD
LEFSEAELMGEEGDTSACCVVTESDPELEVEYRESRESDLGPAGLDSASLSDVDTVNPDE
DSFSILGGDSPTGPESFLHDLPPLFLHLTCSVRLRGQHSSVPVCSLPTCLGQVLSSLEGP
PVGGRVPLRDLSVTLDVFMLTLPLEVELPTASDPQHHRSTSESSASFPRSPGQPSSLRSD
DGLGPPLPPPEEERHPGLSNLATPHRLAIETTMNEIRWLLEDEMVGALRRGGIPQSPALH
RAAAHIHSSPGRSTCLRQTLPLSFVFGPERSLTQFKEEFRRLHLPGHVLLEDPDSGFFFV
AAGQQPGGSHGEPSSAAWAWHSHEDRAEGIEGETLTASPQAPGSPEDSEGVPLISLPRVP
QGGSQPGPSRGLSLMSSQGSVDSDHLGYDGGSSGSDSEGPNDTLGEKAPFTLRTPPGPAP
PQPSLSGLPGPCLPDFWLIVRVLQDRVEVYAHARSLIREDGGPGTECRHLQQLLVRRVGE
ICREVNQRLLLQDLHDSHVCNSLLVAESEEDLWRSETPFHSRQRAPLPSDDYAADESCAP
RGYLAATMQFVPGHFSCDVVWGTVIRVHSRLKMGPSMGVSRAIQALRSVLNAFSVVNRKN
MFVYQERATKAVYYLRLLETSCSDRPWKGDALPPSLALSRSQEPIYSEEASGPRSPLDMV
SSRSSDAARPVGQVDRHIQLLVHGVGQAGPEITDELVRVLCRRLDEATLDVITVMLVRNC
KLTPADVEFIQPPGSLPSEVLHLALPTSCRPWLPALAWYLRQNLLIFLHSPKYTDSNSRN
HFQHPLPPQGGLPDLDIYLYNKPGGQGTGGKGVACITLAFVDEGGAPLSLALWPPSSPGP
PDPLREEEFEQLTQVIRCPVVVDSSSAQNGAPRLRLDVWEKGNISIVQLEEKLRGAARQA
LADAIIELQLLPASLCTEDTPTGSLRNGSLETKSSAGRASTFPPAPVPGEPVTPPSKAGR
RSFWDMLSKTECGDLGSPKTTDDIVLDRPEDTRGRRRHKTESVRTPGGAERAPGSDSGAQ
RQKRRTTQLEEGEVGTLHPVFARVAQRWMEFMVQIGCASVSRSSAHMVSRFLLPSILSEF
TALVTSMAGDTSVRIFEQHLGSEPEIFGPCSPGQLGPSPRPAAERHLLLLGRNFLQWRRP
TQQAAKAMQRFEPGGDGSSGRNAPRQRLLLLEVVDKKLQLLTYNWAPDLGAALGRALVRL
VQWQNARAHLIFCLLSQKLGLFHHYGQLDFPVRDEKEPNPFLLPTMEVETLIRSASPPLS
REQGRLSGSSRGGGPLPLDTFPFDEALRDITAARPSSVLGPVPRPPDPVTYHGQQFLEIK
MAERRELERQMKMENLFVTWQQRSTPATMPISAGELETLKQSSRLVHYCATAMLFDPAAW
LHGPPETSGPPDGQRRHRPESGSGSREAPTSCESLDVSPPGAREEPWLKELSLAFLQQYV
QYLQSIGFVLVPLRPPSPARSTSRPRAMAILGTEGRGSFSCPKTKTDGSPKSTSSPVTTY
HLQRALPGGIILMELAFQGCYFCVKQFALECSRIPMGQAVNSQLSMLFTEECDKVRDLMH
VHSFSYDFHLRLVHQHVLGAHLVLRHGYHLTTFLRHFLAHHPDGPHFGRNHIYQGTLELP
TPLIAAHQLYNYVADHASSYHMKPLRMARPGGPEHNEYALVSAWHSSGSYLDSEGLRHQD
DFDVSLLVCHCAAPFEEQGEAERHVLRLQFFVVLTSQRELFPRLTADMRRFRKPPRLPPE
PEAPGSSAGSPGEASGLILAPGPAPLFPPLAAEVGMARARLAQLVRLAGGHCRRDTLWKR
LFLLEPPGPDRLRLGGRLALAELEELLEAVHAKSIGDIDPQLDCFLSMTVSWYQSLIKVL
LSRFPQSCRHFQSPDLGTQYLVVLNQKFTDCFVLVFLDSHLGKTSLTVVFREPFPVQPQD
SESPPAQLVSTYHHLESVINTACFTLWTRLL
Sequence of entity 4 (H, J), FASTA
>9O5E_4 GATOR1 complex protein DEPDC5 (chains H, J)
MGDYKDDDDKGGGGGASTMRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIA
HPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVEL
TFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRV
VFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFS
RTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYP
VLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGV
FEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHW
INHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAY
DAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASD
DSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAES
MLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAE
LQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAG
MNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPD
RQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKP
NPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYE
SAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFW
RTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRS
DRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVH
GGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLD
GTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILE
AMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITH
ASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEE
LVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNN
RTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEG
PFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGF
VQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEE
RVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASA
P

Primary citation

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex. Lupton, C.J., Bayly-Jones, C., Dong, S. et al. Cell (2026) 189:1185-1200.e28. DOI 10.1016/j.cell.2025.12.005 · PubMed

Other PDB entries of the same protein (UniProt Q12980 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 9O5E directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.