9OUC: Nucleoprotein

Influenza A Virus Nucleoprotein(8-498)NP complex with 5-(4-(morpholinomethyl)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (Compound 3). Determined by X-ray diffraction at 2.73 Å resolution. Released 6 Aug 2025.

Method
X-ray diffraction
Resolution
2.73 Å
Organism
Influenza A virus (A/(Puerto Rico/8/1934-Korea/426/1968)(H2N2))
Chains
2
Atoms
6,845
Mol. weight
113.87 kDa
Ligands
MG, A1CEM
Released
6 Aug 2025

Explore 9OUC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9OUC contains 50 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 11 β-strands

ElementResiduesLengthSheet
α-helix22-4726
α-helix51-544
β-strand5611
α-helix57-7216
α-helix85-873
β-strand91-100102
β-strand103-112102
α-helix113-12311
α-helix130-14718
β-strand14913
α-helix151-1577
α-helix161-1666
α-helix177-1837
α-helix186-20217
α-helix209-22921
α-helix233-24412
α-helix250-26314
α-helix278-2869
α-helix291-2944
α-helix301-3088
β-strand313-31641
α-helix322-33312
α-helix341-3488
α-helix355-3573
α-helix365-3662
β-strand375-37841
β-strand385-38624
α-helix441-4499
β-strand46315
β-strand464-46524
α-helix4741
β-strand47515
α-helix476-4772
α-helix493-4942
β-strand49513
α-helix4961
Chain B: 25 helices, 13 β-strands
ElementResiduesLengthSheet
α-helix22-4726
α-helix51-544
β-strand5616
α-helix57-7216
β-strand91-100107
β-strand103-112107
α-helix113-12311
α-helix130-14718
β-strand14918
α-helix151-1566
α-helix161-1666
α-helix177-1815
α-helix186-20217
α-helix209-22921
β-strand23019
α-helix233-24412
α-helix250-26213
β-strand26819
α-helix278-2869
α-helix291-2944
α-helix301-3088
β-strand313-31646
α-helix322-33312
α-helix341-3488
α-helix355-3573
α-helix365-3662
β-strand375-37846
β-strand386110
α-helix440-44810
α-helix452-4543
β-strand463111
β-strand464110
α-helix4741
β-strand475111
α-helix476-4772
α-helix493-4942
β-strand49518
α-helix4961

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
NucleoproteinA, Bprotein498Influenza A virus (A/(Puerto Rico/8/1934-Korea/426/1968)(H2N2))S5G2J2
Sequence of entity 1 (A, B), FASTA
>9OUC_1 Nucleoprotein (chains A, B)
MRSYEQMETDGERQNATEIRASVGKMIGGIGRFYIQMCTELKLSDYEGRLIQNSLTIERM
VLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRVNGKWMRELILYDKEEIRRIWRQANNG
DDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGV
GTMVMELVRMIKRGINDRNFWRGENGRKTRIAYERMCNILKGKFQTAAQKAMMDQVRESR
NPGNAEFEDLTFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEREGYSLVGIDPFRL
LQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVLSFIKGTKVLPRGKLSTRGVQIA
SNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISIQPTFSVQRNLPFDRTTIM
AAFNGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKAASPIVPSFDMSNEGS
YFFGDNAEEYDNHHHHHH

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg1
A1CEM5-{4-[(morpholin-4-yl)methyl]phenyl}-2-oxo-6-(trifluoromethyl)-1,2-dihydropyrid…C18 H18 F3 N3 O32

Primary citation

Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction. Taft, B.R., Hesse, M.J., Mamo, M. et al. J Med Chem (2025) 68:16349-16370. DOI 10.1021/acs.jmedchem.5c01233 · PubMed

Other PDB entries of the same protein (UniProt S5G2J2), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 9OUC directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.