9OUG: Nucleoprotein

Influenza A Virus Nucleoprotein(8-498)NP complex with rac-5-(4-(((2R,6R)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl)methoxy)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (Compound 20). Determined by X-ray diffraction at 2.33 Å resolution. Released 6 Aug 2025.

Method
X-ray diffraction
Resolution
2.33 Å
Organism
Influenza A virus (A/(Puerto Rico/8/1934-Korea/426/1968)(H2N2))
Chains
2
Atoms
6,989
Mol. weight
113.99 kDa
Ligands
A1CEO
Released
6 Aug 2025

Explore 9OUG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9OUG contains 47 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 26 helices, 13 β-strands

ElementResiduesLengthSheet
α-helix21-4626
α-helix51-544
β-strand5611
α-helix57-7216
β-strand91-100102
β-strand103-112102
α-helix113-12311
α-helix130-14718
β-strand14913
α-helix151-1566
α-helix161-1666
α-helix178-1814
α-helix186-20217
α-helix204-2074
α-helix209-22921
α-helix233-24412
α-helix250-26213
α-helix278-2869
α-helix291-2944
α-helix301-3088
β-strand313-31641
α-helix322-33312
α-helix341-3488
α-helix355-3573
α-helix365-3662
β-strand375-37841
β-strand385-38624
β-strand417-41825
α-helix419-4213
α-helix422-4287
α-helix439-45113
β-strand456-45725
α-helix458-4592
β-strand46316
β-strand464-46524
β-strand47516
α-helix493-4942
β-strand49513
α-helix4961
Chain B: 21 helices, 11 β-strands
ElementResiduesLengthSheet
α-helix21-4626
α-helix51-544
β-strand5617
α-helix57-7216
β-strand91-100108
β-strand103-112108
α-helix113-12311
α-helix130-14718
β-strand14919
α-helix151-1566
α-helix161-1666
α-helix186-20217
α-helix204-2074
α-helix209-22921
α-helix233-24412
α-helix250-26213
α-helix278-2869
α-helix291-2944
α-helix301-3088
β-strand313-31647
α-helix322-33312
α-helix341-3488
α-helix355-3573
α-helix365-3662
β-strand375-37847
β-strand385-386210
α-helix439-45012
β-strand463111
β-strand464-465210
β-strand475111
α-helix493-4942
β-strand49519

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
NucleoproteinA, Bprotein498Influenza A virus (A/(Puerto Rico/8/1934-Korea/426/1968)(H2N2))S5G2J2
Sequence of entity 1 (A, B), FASTA
>9OUG_1 Nucleoprotein (chains A, B)
MRSYEQMETDGERQNATEIRASVGKMIGGIGRFYIQMCTELKLSDYEGRLIQNSLTIERM
VLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRVNGKWMRELILYDKEEIRRIWRQANNG
DDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGV
GTMVMELVRMIKRGINDRNFWRGENGRKTRIAYERMCNILKGKFQTAAQKAMMDQVRESR
NPGNAEFEDLTFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEREGYSLVGIDPFRL
LQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVLSFIKGTKVLPRGKLSTRGVQIA
SNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISIQPTFSVQRNLPFDRTTIM
AAFNGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKAASPIVPSFDMSNEGS
YFFGDNAEEYDNHHHHHH

Ligands and cofactors

IDNameFormulaCopies
A1CEO5-(4-{[(2R,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy}phenyl)-2-oxo…C21 H23 F3 N2 O62

Primary citation

Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction. Taft, B.R., Hesse, M.J., Mamo, M. et al. J Med Chem (2025) 68:16349-16370. DOI 10.1021/acs.jmedchem.5c01233 · PubMed

Other PDB entries of the same protein (UniProt S5G2J2), best resolution first:

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