9P78: SERPINE1 mRNA-binding protein 1

Name: PDB 9P78: In situ human Hibernating rotate 3 with E-site tRNA state 80S ribosome
Published: 2025-12-24
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ribosome

In situ human Hibernating rotate 3 with E-site tRNA state 80S ribosome. Determined by electron microscopy at 2.9 Å resolution. Released 24 Dec 2025.

Method: Electron microscopy
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 86
Atoms: 228,149
Mol. weight: 3868.94 kDa
Ligands: ZN, SPD, SPM, MG
Released: 24 Dec 2025

Explore 9P78 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9P78 contains 614 α-helices and 632 β-strands across 81 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain CA: 12 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	15-38	24
β-strand	44	1	79
α-helix	45-62	18
β-strand	73-82	10	80
β-strand	85	1	81
β-strand	99	1	79
β-strand	105-114	10	80
β-strand	117-126	10	80
α-helix	141-156	16
β-strand	162	1	82
α-helix	164-176	13
β-strand	180-181	2	83
α-helix	182	1
β-strand	185-191	7	80
β-strand	194-203	10	80
α-helix	207-210	4
β-strand	217	1	82
β-strand	223-226	4	80
β-strand	229-231	3	83
β-strand	238	1	81
α-helix	242-244	3
β-strand	246-249	4	84
α-helix	260-272	13
β-strand	278	1	84
α-helix	280-282	3
α-helix	289-298	10
β-strand	302-305	4	84
β-strand	309	1	81
β-strand	316-318	3	83
β-strand	321-324	4	80
β-strand	332	1	80
α-helix	340-342	3
α-helix	352-359	8

Chain CB: 47 helices, 42 β-strands

Element	Residues	Length	Sheet
α-helix	6-13	8
β-strand	19-26	8	62
α-helix	32-42	11
α-helix	61-66	6
β-strand	73-80	8	62
α-helix	83-86	4
β-strand	97-104	8	62
α-helix	112-121	10
β-strand	124-130	7	62
α-helix	137-148	12
β-strand	152-158	7	62
α-helix	160-165	6
α-helix	171-192	22
α-helix	207-209	3
β-strand	212-216	5	62
β-strand	221-224	4	62
α-helix	225-235	11
α-helix	248-260	13
β-strand	265-266	2	63
β-strand	273-274	2	63
β-strand	278	1	64
α-helix	283	1
β-strand	284	1	64
α-helix	285-286	2
β-strand	287	1	63
α-helix	288-289	2
α-helix	290-294	5
α-helix	295-305	11
α-helix	309-318	10
α-helix	333-343	11
β-strand	345	1	62
α-helix	346-357	12
α-helix	359-360	2
α-helix	361-368	8
α-helix	369-371	3
β-strand	373	1	65
α-helix	380-387	8
β-strand	395-403	9	66
β-strand	410-418	9	66
β-strand	421-422	2	67
β-strand	427-430	4	66
β-strand	442-445	4	66
β-strand	449-453	5	66
β-strand	458-461	4	66
β-strand	463-464	2	67
β-strand	469-473	5	66
β-strand	483-486	4	66
α-helix	493	1
β-strand	494	1	65
α-helix	495-497	3
β-strand	505-511	7	68
α-helix	514-516	3
α-helix	517-530	14
β-strand	535-538	4	68
β-strand	544-548	5	68
α-helix	551-560	10
α-helix	561-565	5
β-strand	570-573	4	68
α-helix	574-578	5
β-strand	580-583	4	69
β-strand	591-594	4	70
β-strand	601-608	8	70
α-helix	609-610	2
α-helix	613-619	7
α-helix	628-639	12
α-helix	643-647	5
β-strand	649-652	4	70
α-helix	654-656	3
β-strand	661-664	4	70
α-helix	671-673	3
α-helix	676-688	13
β-strand	697	1	69
β-strand	700-708	9	70
α-helix	713-716	4
α-helix	718-735	18
α-helix	737	1
β-strand	738-742	5	69
β-strand	744-752	9	71
α-helix	757-765	9
β-strand	769-776	8	71
β-strand	779-789	11	71
α-helix	790-792	3
α-helix	796-804	9
β-strand	809-813	5	71
β-strand	818-819	2	69
α-helix	830-842	13
α-helix	848-850	3
α-helix	851-853	3
α-helix	855-857	3

Chain CD: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	185	1	1
β-strand	191	1	1
α-helix	209-211	3
α-helix	221-224	4
α-helix	283-290	8

Chain CI: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	52-62	11
α-helix	70-72	3

Chain La: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	7-9	3
α-helix	42-48	7
β-strand	72-73	2	35
α-helix	75-81	7
α-helix	84-92	9
β-strand	97-98	2	138
β-strand	100-102	3	36
α-helix	103-106	4
β-strand	110-111	2	35
β-strand	123-126	4	36
β-strand	128-129	2	35
α-helix	131-139	9
β-strand	143-146	4	36

Chain LA: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	4-5	2
α-helix	9-11	3
α-helix	29-32	4
α-helix	34-38	5
β-strand	40-50	11	46
β-strand	57-64	8	46
β-strand	71-74	4	46
β-strand	77	1	46
β-strand	79	1	47
β-strand	83	1	48
β-strand	87-91	5	46
β-strand	101-103	3	46
α-helix	104-106	3
β-strand	112-113	2	49
β-strand	116	1	50
β-strand	126	1	50
β-strand	134-140	7	49
β-strand	145-149	5	49
β-strand	155-159	5	49
β-strand	163-165	3	46
β-strand	166	1	49
α-helix	168	1
β-strand	169	1	47
α-helix	174-176	3
α-helix	182-190	9
α-helix	201-203	3
β-strand	224-225	2	51
α-helix	229-230	2
β-strand	237-238	2	51

Chain Lb: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	12-16	5
α-helix	22-24	3
α-helix	37-48	12
α-helix	54-73	20
α-helix	92-100	9
α-helix	106-117	12

Chain LB: 18 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	9-10	2
α-helix	14-16	3
α-helix	32-35	4
α-helix	40-41	2
β-strand	42-43	2	54
β-strand	45-59	15	55
β-strand	60	1	56
β-strand	68	1	56
β-strand	71-80	10	55
α-helix	82-83	2
β-strand	84-95	12	57
β-strand	98-106	9	57
α-helix	112-115	4
α-helix	116-118	3
α-helix	134-137	4
α-helix	140-156	17
β-strand	159-165	7	57
α-helix	177-179	3
β-strand	180-184	5	57
β-strand	185-186	2	54
α-helix	190-199	10
β-strand	204-205	2	57
α-helix	207-209	3
β-strand	216-222	7	55
β-strand	227-229	3	58
α-helix	231-234	4
α-helix	237-241	5
β-strand	270-272	3	58
β-strand	276-287	12	55
β-strand	292-293	2	59
β-strand	297-298	2	59
α-helix	300-302	3
β-strand	320	1	60
β-strand	324	1	60
β-strand	330-334	5	55
β-strand	344-349	6	55
α-helix	357-360	4
β-strand	365-368	4	55
α-helix	382-389	8
α-helix	393-402	10

73 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
SERPINE1 mRNA-binding protein 1	CD	protein	408	Homo sapiens	Q8NC51 (AlphaFold model)
Transcription factor BTF3	CI	protein	31	Homo sapiens	P20290 (AlphaFold model)
28S rRNA	L5	RNA	5070	Homo sapiens
5S rRNA	L7	RNA	120	Homo sapiens
5.8S rRNA	L8	RNA	156	Homo sapiens
60S ribosomal protein L8	LA	protein	248	Homo sapiens	P62917 (AlphaFold model)
Large ribosomal subunit protein uL3	LB	protein	402	Homo sapiens	P39023 (AlphaFold model)
60S ribosomal protein L4	LC	protein	368	Homo sapiens	P36578
Large ribosomal subunit protein uL18	LD	protein	293	Homo sapiens	P46777
Large ribosomal subunit protein eL6	LE	protein	250	Homo sapiens	Q02878
60S ribosomal protein L7	LF	protein	225	Homo sapiens	P18124
60S ribosomal protein L7a	LG	protein	241	Homo sapiens	P62424

74 more molecules are not listed.

Sequence of entity 1 (CD), FASTA

>9P78_1 SERPINE1 mRNA-binding protein 1 (chains CD)
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ
TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE
GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG
RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQK
QISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKD
RAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFG
DLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA

Sequence of entity 2 (CI), FASTA

>9P78_2 Transcription factor BTF3 (chains CI)
IMNQEKLAKLQAQVRIGGKGTARRKKKVVHR

Sequence of entity 3 (L5), FASTA

>9P78_3 28S rRNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGGGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAXGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG

Sequence of entity 4 (L7), FASTA

>9P78_4 5S rRNA (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU

Sequence of entity 5 (L8), FASTA

>9P78_5 5.8S rRNA (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU

Sequence of entity 6 (LA), FASTA

>9P78_6 60S ribosomal protein L8 (chains LA)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGRLRGT

Sequence of entity 7 (LB), FASTA

>9P78_7 Large ribosomal subunit protein uL3 (chains LB)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA

Sequence of entity 8 (LC), FASTA

>9P78_8 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEK

Sequence of entity 9 (LD), FASTA

>9P78_9 Large ribosomal subunit protein uL18 (chains LD)
GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDII
CQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEG
QVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFP
GYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYK
KAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERA

Sequence of entity 10 (LE), FASTA

>9P78_10 Large ribosomal subunit protein eL6 (chains LE)
KGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGG
DKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHR
GKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFK
KKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALT
NGIYPHKLVF

Sequence of entity 11 (LF), FASTA

>9P78_11 60S ribosomal protein L7 (chains LF)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN

Sequence of entity 12 (LG), FASTA

>9P78_12 60S ribosomal protein L7a (chains LG)
KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQ
ALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTT
LVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFT
QVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKL
G

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6
SPD	Spermidine	C7 H19 N3	10
SPM	Spermine	C10 H26 N4	7
MG	Magnesium ion	Mg	218

Primary citation

Visualizing the translation landscape in human cells at high resolution. Zheng, W., Zhang, Y., Wang, J. et al. Nat Commun (2025) 16:10757-10757. DOI 10.1038/s41467-025-65795-9 · PubMed

Other PDB entries of the same protein (UniProt Q8NC51 (AlphaFold model), which also has an AlphaFold model), best resolution first:

29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
9PBE 2.19 Å, In situ human 80S ribosome (composite map)
8K2C 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline
8XSX 2.4 Å, Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2
9P7D 2.57 Å, In situ human Hibernating class4 80S ribosome
9P7E 2.59 Å, In situ human Hibernating class5 80S ribosome
9PA7 2.67 Å, In situ human 80S consensus ribosome with EBP1
9T6D 2.67 Å, NAA40-NAC bound human 80S (combined translation states)
9P7C 2.78 Å, In situ human Hibernating class3 80S ribosome
9P7A 2.81 Å, In situ human hibernating class2 80S ribosome
9B0P 2.82 Å, In situ human Hibernating class1 80S ribosome
9FQZ 2.85 Å, cryo-EM structure of HCT15 polysomes bound to EEF2, EBP1, and SERBP1

Browse structure collections

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