Transcription factor BTF3 (BTF3) is a 206-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20290.
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The mean pLDDT of this model is 72.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 37% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription
Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit. Both subunits can contact nascent polypeptide chains
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MCB | X-ray | 1.9 Å | B=97-154 |
| 9I2D | EM | 2.19 Å | NB=45-206 |
| 9PBE | EM | 2.19 Å | CI=49-79 |
| 9S3D | EM | 2.32 Å | NB=45-206 |
| 9S3B | EM | 2.38 Å | NB=45-206 |
| 9S3C | EM | 2.42 Å | NB=45-206 |
| 9QLO | EM | 2.47 Å | NB=45-206 |
| 9P8B | EM | 2.48 Å | CI=49-79 |
| 3LKX | X-ray | 2.5 Å | A=97-162 |
| 9P7D | EM | 2.57 Å | CI=49-79 |
| 9QLQ | EM | 2.57 Å | NB=45-206 |
| 9P7E | EM | 2.59 Å | CI=1-206 |
| 9MR4 | EM | 2.65 Å | EF=45-206 |
| 9P7O | EM | 2.65 Å | CI=49-79 |
| 9P73 | EM | 2.66 Å | CI=49-79 |
| 9PA7 | EM | 2.67 Å | CI=49-79 |
| 9P7Y | EM | 2.75 Å | CI=49-79 |
| 9QLP | EM | 2.75 Å | NB=45-206 |
| 9P9I | EM | 2.77 Å | CI=49-79 |
| 9P7C | EM | 2.78 Å | CI=49-79 |
Showing 20 of 52 experimental structures (best resolution first).
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