9PBG: TCR 19.2 complex with YEIH-HLA B*27:05

TCR 19.2 complex with YEIH-HLA B*27:05. Determined by X-ray diffraction at 2.0 Å resolution. Released 18 Mar 2026.

Method: X-ray diffraction
Resolution: 2.0 Å
Organisms: Homo sapiens, Escherichia coli
Chains: 5
Atoms: 6,848
Mol. weight: 96.69 kDa
Ligands: NAG
Released: 18 Mar 2026

Explore 9PBG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9PBG contains 25 α-helices and 71 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-54	5
α-helix	57-85	29
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-150	13
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
α-helix	182	1
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
α-helix	225-227	3
β-strand	229-230	2	3
β-strand	234-235	2	3
β-strand	241-250	10	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chain B: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 5 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	5-8	4	8
β-strand	11-15	5	9
β-strand	20-26	7	8
β-strand	31-39	9	9
β-strand	45-52	8	9
β-strand	57-60	4	8
β-strand	63-68	6	8
β-strand	73-78	6	8
α-helix	83-85	3
β-strand	87-96	10	9
β-strand	103-107	5	9
β-strand	111-116	6	9
α-helix	117-118	2
β-strand	125-130	6	10
β-strand	138-143	6	10
α-helix	151-154	4
β-strand	159-161	3	10
α-helix	162-164	3
β-strand	165-169	5	10
β-strand	174-183	10	10
α-helix	190-194	5

Chain E: 6 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	5-7	3	11
β-strand	10-14	5	12
β-strand	19-24	6	11
β-strand	31-38	8	12
β-strand	42-50	9	12
β-strand	53-57	5	12
β-strand	64-68	5	11
β-strand	74-78	5	11
α-helix	83-85	3
β-strand	87-94	8	12
β-strand	104-105	2	12
β-strand	109-114	6	12
α-helix	117-119	3
β-strand	121	1	13
β-strand	124-128	5	14
β-strand	129	1	10
α-helix	130-131	2
α-helix	132-137	6
β-strand	140-150	11	14
β-strand	151	1	13
β-strand	155-161	7	15
β-strand	164-166	3	15
β-strand	170-172	3	14
β-strand	177-178	2	14
β-strand	188-197	10	14
α-helix	198-201	4
β-strand	207-214	8	15
β-strand	217	1	16
α-helix	228-229	2
β-strand	231	1	16
β-strand	233-240	8	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	279	Homo sapiens	A3F718 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	Homo sapiens	P61769 (AlphaFold model)
UPF0324 inner membrane protein YeiH	C	protein	9	Escherichia coli	P62723 (AlphaFold model)
TCR 19.2 alpha chain	D	protein	210	Homo sapiens
TCR19.2 beta chain	E	protein	244	Homo sapiens

Sequence of entity 1 (A), FASTA

>9PBG_1 MHC class I antigen (chains A)
MGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEY
WDRETQISKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQDAYD
GKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETL
QRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDR
TFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSS

Sequence of entity 2 (B), FASTA

>9PBG_2 Beta-2-microglobulin (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>9PBG_3 UPF0324 inner membrane protein YeiH (chains C)
LRVMMLAPF

Sequence of entity 4 (D), FASTA

>9PBG_4 TCR 19.2 alpha chain (chains D)
KQEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSG
RLNASLDKSSGRSTLYIAASQPGDSATYLCGIALIGSGAGSYQLTFGKGTKLSVIPNIQN
PDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVA
WSNKSDFACANAFNNSIIPEDTFFPSPESS

Sequence of entity 5 (E), FASTA

>9PBG_5 TCR19.2 beta chain (chains E)
DSGVTQTPKHLITATGQRVTLRCSPRSGDLSVYWYQQSLDQGLQFLIQYYNGEERAKGNI
LERFSAQQFPDLHSELNLSSLELGDSALYFCASSPATYSTDTQYFGPGTRLTVLEDLKNV
FPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQ
PALNDSRYALSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAW
GRAD

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	2

Water and common crystallization additives (GOL) are not listed.

Primary citation

Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery. Wang, N., Yeh, H., Lai, B. et al. Nat Biotechnol (2026). DOI 10.1038/s41587-026-03128-x · PubMed

Other PDB entries of the same protein (UniProt A3F718 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9PBH 2.13 Å, AS19.2 TCR complex with PSG5-HLA B*27:05
8CX4 2.2 Å, TCR-antigen complex AS8.4-YEIH-HLA*B27
7N2R 2.28 Å, AS4.3-PRPF3-HLA*B27
7N2O 2.3 Å, AS4.2-yeih-HLA*B27
7N2S 2.37 Å, AS3.1-PRPF3-HLA*B27
7N2P 2.5 Å, AS4.3-RNASEH2b-HLA*B27
7N2N 2.6 Å, TCR-antigen complex AS4.2-PRPF3-HLA*B27
7N2Q 2.7 Å, AS4.3-yeih-HLA*B27
7T0L 3.0 Å, HLA-B*27:05 in complex with the pan-HLA-Ia monoclonal antibody W6/32

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