9RDK: Human SAGA co-activator complex

Cryo-EM structure of the human SAGA co-activator complex. Determined by electron microscopy at 2.41 Å resolution. Released 1 Apr 2026.

Method: Electron microscopy
Resolution: 2.41 Å
Organism: Homo sapiens
Chains: 13
Atoms: 54,084
Mol. weight: 1086.47 kDa
Released: 1 Apr 2026

Explore 9RDK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9RDK contains 358 α-helices and 204 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 106 β-strands

Element	Residues	Length	Sheet
β-strand	3-9	7	15
α-helix	10-11	2
β-strand	16-20	5	16
β-strand	29-33	5	16
β-strand	37-43	7	16
β-strand	50-57	8	16
β-strand	62-68	7	17
β-strand	77-82	6	17
β-strand	86-93	8	17
β-strand	98-106	9	17
β-strand	120-123	4	18
β-strand	129-133	5	18
β-strand	136	1	19
β-strand	139-143	5	18
β-strand	144-146	3	20
β-strand	152-154	3	20
α-helix	155-157	3
β-strand	158-159	2	18
β-strand	165-173	9	19
α-helix	180	1
β-strand	181-188	8	19
α-helix	190-194	5
β-strand	207-214	8	19
β-strand	219-227	9	19
β-strand	234-237	4	21
α-helix	238-239	2
α-helix	241-243	3
β-strand	248-252	5	21
β-strand	255-259	5	21
α-helix	264-266	3
β-strand	267-270	4	21
α-helix	271-272	2
β-strand	273-274	2	22
β-strand	289-294	6	23
β-strand	299-304	6	23
β-strand	309-317	9	23
β-strand	322-332	11	23
β-strand	336-342	7	24
β-strand	346-351	6	24
β-strand	356-361	6	24
β-strand	373-374	2	23
β-strand	386-387	2	22
β-strand	395-401	7	24
β-strand	407-412	6	25
β-strand	423-427	5	25
α-helix	430-432	3
β-strand	434-438	5	25
β-strand	439	1	26
β-strand	448-449	2	27
β-strand	456-459	4	28
β-strand	462-463	2	29
β-strand	471-473	3	29
β-strand	476-478	3	28
β-strand	482-483	2	28
β-strand	484-486	3	30
β-strand	490-494	5	30
β-strand	507-510	4	31
β-strand	515-519	5	31
β-strand	524-528	5	31
β-strand	533-536	4	31
β-strand	544-549	6	32
β-strand	553-558	6	32
α-helix	559-561	3
β-strand	563-567	5	32
β-strand	575-581	7	32
β-strand	587-590	4	33
α-helix	593-596	4
β-strand	604-609	6	33
β-strand	613-618	6	33
β-strand	627-632	6	33
β-strand	637-644	8	34
β-strand	663-669	7	34
β-strand	674-678	5	34
β-strand	686-689	4	34
β-strand	700-701	2	35
β-strand	704-705	2	36
β-strand	710-711	2	36
β-strand	712-715	4	35
β-strand	719-725	7	35
β-strand	728-733	6	35
β-strand	741-744	4	27
β-strand	753-758	6	27
β-strand	761-766	6	27
β-strand	775	1	26
β-strand	778-780	3	25
β-strand	785-790	6	37
α-helix	796	1
β-strand	797-804	8	37
α-helix	809-824	16
α-helix	836-843	8
α-helix	849-852	4
β-strand	862-869	8	37
β-strand	876-882	7	37
β-strand	886-895	10	38
β-strand	903-911	9	38
β-strand	914	1	39
β-strand	919	1	39
β-strand	923	1	40
β-strand	925-928	4	38
β-strand	931	1	41
β-strand	936	1	41
β-strand	939-942	4	38
β-strand	945	1	40
β-strand	949-955	7	42
β-strand	958-963	6	42
β-strand	966-972	7	42
β-strand	977-983	7	42
β-strand	990-996	7	43
β-strand	999-1004	6	43
β-strand	1010-1015	6	43
β-strand	1020-1026	7	43
β-strand	1033-1040	8	44
β-strand	1043-1048	6	44
β-strand	1052-1057	6	44
β-strand	1088	1	43
β-strand	1090-1096	7	44
β-strand	1101-1107	7	15
α-helix	1113-1115	3
β-strand	1116-1121	6	15
β-strand	1126-1129	4	15
α-helix	1135-1151	17
α-helix	1160-1164	5
β-strand	1171	1	44
β-strand	1173-1175	3	15
α-helix	1176-1179	4
α-helix	1181-1184	4
α-helix	1187-1197	11
α-helix	1201-1215	15

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	28-45	18
α-helix	47-56	10
α-helix	61-71	11

Chain C: 222 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	21-32	12
α-helix	43-52	10
α-helix	62-73	12
α-helix	86-94	9
α-helix	95-99	5
α-helix	106-112	7
α-helix	113-115	3
α-helix	132-141	10
α-helix	153-156	4
α-helix	158-172	15
α-helix	227-236	10
α-helix	243-246	4
α-helix	252-254	3
α-helix	278-293	16
α-helix	310-318	9
α-helix	325-339	15
α-helix	347-352	6
α-helix	355-357	3
α-helix	365-369	5
α-helix	372-386	15
α-helix	387-389	3
α-helix	392-404	13
α-helix	413-436	24
α-helix	441-463	23
α-helix	544-565	22
α-helix	579-582	4
α-helix	583-599	17
α-helix	600-602	3
α-helix	626-640	15
α-helix	644-664	21
α-helix	666-668	3
α-helix	669-675	7
α-helix	681-695	15
α-helix	697-699	3
α-helix	704-723	20
α-helix	729-732	4
α-helix	736-748	13
α-helix	754-767	14
α-helix	773-779	7
α-helix	780-782	3
α-helix	783-795	13
α-helix	800-810	11
α-helix	824-827	4
α-helix	828-835	8
α-helix	839-855	17
α-helix	858-865	8
α-helix	866-868	3
α-helix	869-878	10
α-helix	879-881	3
α-helix	885-898	14
α-helix	899-903	5
β-strand	923-928	6	45
β-strand	933-938	6	45
α-helix	940-951	12
α-helix	957-973	17
β-strand	975	1	46
α-helix	981-988	8
α-helix	992-995	4
α-helix	997-999	3
α-helix	1005-1007	3
α-helix	1010-1012	3
α-helix	1013-1030	18
α-helix	1035-1056	22
α-helix	1064-1066	3
α-helix	1074-1076	3
α-helix	1091-1100	10
α-helix	1105-1107	3
α-helix	1108-1126	19
α-helix	1129-1133	5
α-helix	1136-1147	12
α-helix	1148-1150	3
α-helix	1154-1170	17
α-helix	1173-1178	6
α-helix	1180-1193	14
α-helix	1205-1218	14
α-helix	1228-1247	20
α-helix	1248-1250	3
α-helix	1254-1270	17
α-helix	1275-1279	5
α-helix	1280-1282	3
α-helix	1302-1317	16
α-helix	1332-1344	13
α-helix	1363-1374	12
α-helix	1375-1378	4
α-helix	1383-1394	12
α-helix	1399-1413	15
α-helix	1420-1426	7
α-helix	1428-1431	4
α-helix	1437-1439	3
α-helix	1442-1454	13
α-helix	1461-1481	21
α-helix	1510-1520	11
α-helix	1532-1546	15
α-helix	1555-1564	10
α-helix	1566-1573	8
α-helix	1576-1580	5
α-helix	1582-1592	11
α-helix	1598-1605	8
α-helix	1610-1615	6
α-helix	1638-1652	15
α-helix	1662-1671	10
α-helix	1692-1704	13
α-helix	1711-1715	5
α-helix	1732-1739	8
α-helix	1754-1759	6
α-helix	1767-1783	17
α-helix	1810-1816	7
α-helix	1827-1833	7
α-helix	1840-1842	3
α-helix	1859-1861	3
α-helix	1862-1865	4
α-helix	1877-1890	14
α-helix	1898-1909	12
α-helix	1914-1916	3
α-helix	1917-1930	14
α-helix	1932-1934	3
α-helix	1942-1948	7
α-helix	1963-1965	3
α-helix	1967-1970	4
α-helix	1980-1983	4
α-helix	1986-1991	6
α-helix	2004-2006	3
α-helix	2007-2015	9
α-helix	2016-2018	3
α-helix	2091-2100	10
α-helix	2103-2106	4
α-helix	2127-2132	6
α-helix	2149-2151	3
α-helix	2166-2176	11
α-helix	2184-2187	4
α-helix	2190-2194	5
α-helix	2196-2200	5
α-helix	2201-2205	5
α-helix	2211-2214	4
α-helix	2219-2222	4
α-helix	2244-2248	5
α-helix	2266-2268	3
α-helix	2269-2281	13
α-helix	2287-2289	3
α-helix	2290-2304	15
α-helix	2319-2331	13
α-helix	2343	1
α-helix	2344-2348	5
α-helix	2349-2353	5
α-helix	2361-2376	16
α-helix	2389-2406	18
α-helix	2411-2426	16
α-helix	2440-2447	8
α-helix	2452-2464	13
α-helix	2470-2475	6
α-helix	2476-2480	5
α-helix	2483-2486	4
α-helix	2492-2501	10
β-strand	2503	1	45
β-strand	2508	1	47
α-helix	2509	1
α-helix	2514-2516	3
β-strand	2518	1	46
α-helix	2519-2520	2
α-helix	2523-2527	5
α-helix	2587-2602	16
β-strand	2606	1	47
α-helix	2607-2620	14
α-helix	2622-2639	18
α-helix	2642-2656	15
α-helix	2659-2665	7
α-helix	2671-2680	10
α-helix	2690-2699	10
α-helix	2703-2717	15
α-helix	2728-2730	3
α-helix	2742-2754	13
α-helix	2758-2766	9
α-helix	2772-2782	11
α-helix	2786-2806	21
α-helix	2814-2830	17
α-helix	2834-2841	8
α-helix	2849-2855	7
α-helix	2857-2859	3
α-helix	2862-2872	11
α-helix	2877-2879	3
α-helix	2881-2893	13
α-helix	2904-2921	18
α-helix	2928-2930	3
α-helix	2931-2952	22
α-helix	2961-2976	16
α-helix	2985-3006	22
α-helix	3029-3050	22
α-helix	3054-3061	8
α-helix	3062-3064	3
α-helix	3072-3088	17
α-helix	3099-3107	9
α-helix	3115-3131	17
α-helix	3136-3148	13
α-helix	3153-3169	17
α-helix	3173-3188	16
α-helix	3195-3205	11
α-helix	3206-3208	3
α-helix	3214-3222	9
α-helix	3228-3234	7
α-helix	3235-3244	10
α-helix	3248-3260	13
α-helix	3262-3282	21
α-helix	3295-3309	15
α-helix	3312-3324	13
α-helix	3325-3327	3
α-helix	3332-3353	22
α-helix	3365-3378	14
α-helix	3421-3424	4
α-helix	3434-3452	19
β-strand	3458-3460	3	48
α-helix	3466-3470	5
α-helix	3478	1
β-strand	3479	1	49
α-helix	3480	1
β-strand	3495	1	49
β-strand	3496-3507	12	48
β-strand	3512-3520	9	48
β-strand	3525-3532	8	48
α-helix	3536-3552	17
α-helix	3553-3557	5
α-helix	3560-3564	5
β-strand	3574-3576	3	48
β-strand	3581-3585	5	48
β-strand	3590-3592	3	50
α-helix	3593-3603	11
α-helix	3610-3624	15
α-helix	3631-3644	14
α-helix	3650-3658	9
α-helix	3662-3685	24
β-strand	3688	1	51
α-helix	3689-3690	2
β-strand	3696-3699	4	50
β-strand	3705-3707	3	50
β-strand	3712	1	51
β-strand	3714	1	52
β-strand	3721	1	52
α-helix	3733-3743	11
α-helix	3744-3748	5
α-helix	3749-3759	11
α-helix	3766-3784	19
α-helix	3806-3826	21
α-helix	3835-3843	9
α-helix	3845-3848	4
α-helix	3853-3855	3

Chain D: 9 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	58-85	28
α-helix	137-140	4
α-helix	144-148	5
α-helix	151-169	19
β-strand	173-175	3	53
α-helix	176-207	32
α-helix	215-222	8
α-helix	230-235	6
α-helix	236-241	6
α-helix	242-261	20

Chain E: 8 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	14-25	12
β-strand	30-31	2	1
α-helix	35-61	27
α-helix	68-79	12
α-helix	86-88	3
α-helix	89-99	11
α-helix	103-107	5
α-helix	113-115	3
α-helix	118-120	3

Chain G: 5 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	63-70	8
α-helix	78-105	28
β-strand	110-111	2	54
α-helix	113-119	7
α-helix	120-124	5
α-helix	146-155	10

Chain H: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	119-125	7
α-helix	132-141	10
α-helix	149-175	27
β-strand	194-195	2	53
α-helix	197-205	9
β-strand	217	1	55

Chain I: 11 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	27-37	11
α-helix	45-73	29
β-strand	78	1	56
α-helix	80-86	7
α-helix	91-106	16
α-helix	134-144	11
α-helix	149-154	6
α-helix	161-173	13
α-helix	199-203	5
β-strand	213	1	56
α-helix	215-244	30
α-helix	283-294	12
α-helix	312-314	3

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transcription initiation factor TFIID subunit 9B	E	protein	251	Homo sapiens	Q9HBM6 (AlphaFold model)
Ataxin-7	N	protein	892	Homo sapiens	O15265 (AlphaFold model)
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L	L	protein	589	Homo sapiens	O75529 (AlphaFold model)
Splicing factor 3B subunit 3	A	protein	1217	Homo sapiens	Q15393 (AlphaFold model)
Transformation/transcription domain-associated protein	C	protein	3859	Homo sapiens	Q9Y4A5
STAGA complex 65 subunit gamma	D	protein	414	Homo sapiens	O94864
Transcription initiation factor TFIID subunit 12	G	protein	161	Homo sapiens	Q16514
Transcription initiation factor TFIID subunit 10	H	protein	218	Homo sapiens	Q12962
Transcription initiation protein SPT3 homolog	I	protein	317	Homo sapiens	O75486
Transcriptional adapter 1	J	protein	335	Homo sapiens	Q96BN2
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	K	protein	622	Homo sapiens	Q9Y6J9
Transcription factor SPT20 homolog	M	protein	779	Homo sapiens	Q8NEM7

1 more molecules are not listed.

Sequence of entity 1 (E), FASTA

>9RDK_1 Transcription initiation factor TFIID subunit 9B (chains E)
MESGKMAPPKNAPRDALVMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSH
AKKPNVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRY
CLTAPNYRLKSLIKKGPNQGRLVPRLSVGAVSSKPTTPTIATPQTVSVPNKVATPMSVTS
QRFTVQIPPSQSTPVKPVPATTAVQNVLINPSMIGPKNILITTNMVSSQNTANEANPLKR
KHEDDDDNDIM

Sequence of entity 2 (N), FASTA

>9RDK_2 Ataxin-7 (chains N)
MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRP
EDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFG
KNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPPLAV
PPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHP
IQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTL
PSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTR
SLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPR
TSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPP
LPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRW
NRLRCALNLMVEKHLNAQLWKKIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVS
TSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLS
SVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSS
SSSSSSSSHSMESFRKNCVAHSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPP
TGSPAESIKRMSVMVNSSDSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCS
PSSSSINNSSSKPTKVAKVPAVNNVHMKHTGTIPGAQGLMNSSLLHQPKARP

Sequence of entity 3 (L), FASTA

>9RDK_3 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (chains L)
MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA
APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY
SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ
SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE
VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK
KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC
SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR
IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG
KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR
NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH

Sequence of entity 4 (A), FASTA

>9RDK_4 Splicing factor 3B subunit 3 (chains A)
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF

Sequence of entity 5 (C), FASTA

>9RDK_5 Transformation/transcription domain-associated protein (chains C)
MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYST
FLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRF
LETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIP
ENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYK
LNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQE
LVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESIL
IGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSC
KLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAV
EAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPFEKQGEKDKEDKQT
FQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQAL
DIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVE
RISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGS
VSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFL
PLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQT
LVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGG
SNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYR
RQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQ
ALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSE
ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSY
IVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSN
GAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQA
MHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQP
RLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLP
QSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSL
TLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNESISECGRC
PLSPFCQFEEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIK
FLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFITLLLPGGA
QTAVRPGSPSTSTMRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQERH
RKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEI
PKNYSIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPE
GDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNKNRNSKLRR
LMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIV
RQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHH
LVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVN
SVSSSIKRGLSVDSAQEVKRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNF
LIRVACQVNDNTNTAGSPGEVLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTVEQPN
QVNYGNICTGLEVLSFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLM
SIFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACS
NNPSYIDRLISVFMRSLQKMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLAVMSM
EMRKNFIQAILTSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMM
TYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFE
VFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPS
ITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELS
EKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKIL
SDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTH
NLWFRSTLMLEHQAFEKGLSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDM
WAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLW
EDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEM
AWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQI
IELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQ
GKPTWSGMHSSSIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDI
LSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAE
FYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAI
TCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLT
CLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDPGPIRATAPMWRC
SRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSD
AKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQF
TTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEI
PGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESR
REERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQR
CAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFP
NATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGD
LDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIA
WHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVA
AANSLDNLCRMDPAWHPWL

Sequence of entity 6 (D), FASTA

>9RDK_6 STAGA complex 65 subunit gamma (chains D)
MNLQRYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSANKPKPPTMLDIPSEPC
SLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPLPSCPGSPPLPDDLLPLDC
KNPNAPFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQAVATILAHAGFDCANESVLE
TLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQVFHEVGIGSVLSLQKFWQHRIK
DYHSYMLQISKQLSEEYERIVNPEKATEDAKPVKIKEEPVSDITFPVSEELEADLASGDQ
SLPMGVLGAQSERFPSNLEVEASPQASSAEVNASPLWNLAHVKMEPQESEEGNVSGHGVL
GSDVFEEPMSGMSEAGIPQSPDDSDSSYGSHSTDSLMGSSPVFNQRCKKRMRKI

Sequence of entity 7 (G), FASTA

>9RDK_7 Transcription initiation factor TFIID subunit 12 (chains G)
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTK
KKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHL
ERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK

Sequence of entity 8 (H), FASTA

>9RDK_8 Transcription initiation factor TFIID subunit 10 (chains H)
MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKASPAGTAGGPGAGAAAGG
TGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSAANGDVKPVVSSTPLVDFL
MQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTA
SGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT

Sequence of entity 9 (I), FASTA

>9RDK_9 Transcription initiation protein SPT3 homolog (chains I)
MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPLHETAVLVEDVVHTQLI
NLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDEDDLL
EDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSA
QYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVVAMEILAYLAYETVAQLVDLALLVR
QDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPL
SPFTNAYRRNGMAFLAC

Sequence of entity 10 (J), FASTA

>9RDK_10 Transcriptional adapter 1 (chains J)
MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHN
DFLLAILTRCQILVSTPDGAGSLPWPGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLS
GAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVE
NHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFTAPCA
GQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALN
IERIITKLWHPNHEELQQDKVHRQRLAAKEGLLLC

Sequence of entity 11 (K), FASTA

>9RDK_11 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (chains K)
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKR
RKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPK
GCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVAL
QDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVG
SVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADP
VRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYG
AILVAVERLLKMKAQAAEPNRGGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFGSGLP
LPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPD
SVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPG
TGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPM
IGRTSRPARRWALSDYSLYLPL

Sequence of entity 12 (M), FASTA

>9RDK_12 Transcription factor SPT20 homolog (chains M)
MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEVKKLRRN
VNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEEL
PPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSI
TSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKR
YSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNL
AIPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYVFECEAGTQYQKTKLTILQSLGD
PLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQELVQNEAKCP
VKMSHSSSGSASLSQVSPGKETDQTETVSVQSSVLGKGVKHRPPPIKLPSSSGNSSSGNY
FTPQQTSSFLKSPTPPPSSKPSSIPRKSSVDLNQVSMLSPAALSPASSSQRTTATQVMAN
SAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQ
AASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQLSQFTPQQPQQPTTCSPQQ
PGEQGSEQGSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRF
QLSSAFQQQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPTTPKF

Primary citation

Insights into the structure and evolution of the human SAGA complex by affinity-ligand purification. Damilot, M., Schoeps, T., Tora, L. et al. Sci Adv (2026) 12:eaec8104-eaec8104. DOI 10.1126/sciadv.aec8104 · PubMed

Other PDB entries of the same protein (UniProt Q9HBM6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7KTR 2.93 Å, Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core)
7KTS 19.09 Å, Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing…

Browse structure collections

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