7KTR: Human SAGA coactivator complex
Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core). Determined by electron microscopy at 2.93 Å resolution. Released 10 Nov 2021.
- Method
- Electron microscopy
- Resolution
- 2.93 Å
- Organisms
- Homo sapiens, unclassified Rhodococcus
- Chains
- 11
- Atoms
- 40,337
- Mol. weight
- 887.73 kDa
- Ligands
- IHP
- Released
- 10 Nov 2021
Explore 7KTR in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7KTR contains 299 α-helices and 105 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 204 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 347-349 | 3 | |
| α-helix | 355-357 | 3 | |
| α-helix | 371-385 | 15 | |
| α-helix | 392-406 | 15 | |
| α-helix | 413-434 | 22 | |
| α-helix | 436-438 | 3 | |
| α-helix | 442-458 | 17 | |
| α-helix | 459-463 | 5 | |
| α-helix | 464-469 | 6 | |
| α-helix | 471-472 | 2 | |
| α-helix | 535-564 | 30 | |
| α-helix | 578-581 | 4 | |
| α-helix | 582-598 | 17 | |
| α-helix | 599-603 | 5 | |
| β-strand | 604-606 | 3 | 1 |
| β-strand | 612-614 | 3 | 1 |
| α-helix | 615-616 | 2 | |
| α-helix | 623-625 | 3 | |
| α-helix | 626-638 | 13 | |
| α-helix | 643-653 | 11 | |
| α-helix | 656-663 | 8 | |
| α-helix | 665-667 | 3 | |
| α-helix | 668-676 | 9 | |
| α-helix | 681-694 | 14 | |
| α-helix | 703-722 | 20 | |
| α-helix | 724-731 | 8 | |
| α-helix | 732-734 | 3 | |
| α-helix | 735-746 | 12 | |
| α-helix | 753-767 | 15 | |
| α-helix | 773-778 | 6 | |
| α-helix | 779-781 | 3 | |
| α-helix | 782-794 | 13 | |
| α-helix | 799-810 | 12 | |
| α-helix | 820-826 | 7 | |
| α-helix | 827-834 | 8 | |
| α-helix | 838-854 | 17 | |
| α-helix | 857-864 | 8 | |
| α-helix | 865-867 | 3 | |
| α-helix | 868-878 | 11 | |
| α-helix | 884-897 | 14 | |
| α-helix | 898-902 | 5 | |
| α-helix | 903-905 | 3 | |
| β-strand | 922-927 | 6 | 2 |
| β-strand | 932-937 | 6 | 2 |
| α-helix | 939-950 | 12 | |
| α-helix | 956-972 | 17 | |
| β-strand | 974 | 1 | 3 |
| α-helix | 980-987 | 8 | |
| α-helix | 991-994 | 4 | |
| α-helix | 996-998 | 3 | |
| α-helix | 1004-1006 | 3 | |
| α-helix | 1009-1011 | 3 | |
| α-helix | 1012-1028 | 17 | |
| α-helix | 1034-1056 | 23 | |
| α-helix | 1063-1065 | 3 | |
| α-helix | 1073-1075 | 3 | |
| α-helix | 1090-1100 | 11 | |
| α-helix | 1106-1125 | 20 | |
| α-helix | 1128-1131 | 4 | |
| α-helix | 1135-1145 | 11 | |
| α-helix | 1146-1149 | 4 | |
| α-helix | 1153-1169 | 17 | |
| α-helix | 1172-1192 | 21 | |
| α-helix | 1201-1217 | 17 | |
| α-helix | 1219-1220 | 2 | |
| α-helix | 1227-1247 | 21 | |
| α-helix | 1253-1270 | 18 | |
| α-helix | 1274-1278 | 5 | |
| α-helix | 1279-1284 | 6 | |
| α-helix | 1296-1298 | 3 | |
| α-helix | 1301-1314 | 14 | |
| α-helix | 1329-1343 | 15 | |
| α-helix | 1346-1350 | 5 | |
| α-helix | 1362-1374 | 13 | |
| α-helix | 1379-1381 | 3 | |
| α-helix | 1382-1393 | 12 | |
| α-helix | 1398-1412 | 15 | |
| α-helix | 1419-1430 | 12 | |
| α-helix | 1441-1453 | 13 | |
| α-helix | 1460-1483 | 24 | |
| α-helix | 1490-1504 | 15 | |
| α-helix | 1513-1527 | 15 | |
| α-helix | 1536-1543 | 8 | |
| α-helix | 1547-1554 | 8 | |
| α-helix | 1557-1560 | 4 | |
| α-helix | 1563-1573 | 11 | |
| α-helix | 1579-1586 | 8 | |
| α-helix | 1590-1593 | 4 | |
| α-helix | 1619-1634 | 16 | |
| α-helix | 1638-1640 | 3 | |
| α-helix | 1642-1653 | 12 | |
| α-helix | 1655-1662 | 8 | |
| α-helix | 1673-1687 | 15 | |
| α-helix | 1694-1698 | 5 | |
| α-helix | 1712-1716 | 5 | |
| α-helix | 1730-1744 | 15 | |
| α-helix | 1756-1765 | 10 | |
| α-helix | 1788-1798 | 11 | |
| α-helix | 1807-1820 | 14 | |
| α-helix | 1840-1845 | 6 | |
| α-helix | 1961-1972 | 12 | |
| α-helix | 1985-2000 | 16 | |
| α-helix | 2078-2087 | 10 | |
| α-helix | 2104-2115 | 12 | |
| α-helix | 2123-2126 | 4 | |
| α-helix | 2132-2138 | 7 | |
| α-helix | 2154-2161 | 8 | |
| α-helix | 2168-2174 | 7 | |
| α-helix | 2175-2177 | 3 | |
| α-helix | 2194-2205 | 12 | |
| α-helix | 2220-2236 | 17 | |
| α-helix | 2251-2259 | 9 | |
| α-helix | 2265-2267 | 3 | |
| α-helix | 2274-2285 | 12 | |
| α-helix | 2302-2313 | 12 | |
| α-helix | 2322-2327 | 6 | |
| α-helix | 2328-2333 | 6 | |
| α-helix | 2334-2339 | 6 | |
| α-helix | 2343-2357 | 15 | |
| α-helix | 2364-2366 | 3 | |
| α-helix | 2371-2388 | 18 | |
| α-helix | 2393-2408 | 16 | |
| α-helix | 2417-2421 | 5 | |
| α-helix | 2422-2430 | 9 | |
| α-helix | 2434-2446 | 13 | |
| α-helix | 2452-2457 | 6 | |
| α-helix | 2458-2462 | 5 | |
| α-helix | 2465-2468 | 4 | |
| α-helix | 2474-2482 | 9 | |
| β-strand | 2490 | 1 | 4 |
| β-strand | 2500 | 1 | 3 |
| α-helix | 2501-2502 | 2 | |
| α-helix | 2505-2509 | 5 | |
| α-helix | 2512-2520 | 9 | |
| α-helix | 2568-2584 | 17 | |
| β-strand | 2588 | 1 | 4 |
| α-helix | 2589-2600 | 12 | |
| α-helix | 2604-2621 | 18 | |
| α-helix | 2624-2638 | 15 | |
| α-helix | 2641-2648 | 8 | |
| α-helix | 2653-2661 | 9 | |
| α-helix | 2672-2681 | 10 | |
| α-helix | 2685-2696 | 12 | |
| α-helix | 2710-2712 | 3 | |
| α-helix | 2724-2737 | 14 | |
| α-helix | 2740-2750 | 11 | |
| α-helix | 2754-2763 | 10 | |
| α-helix | 2768-2788 | 21 | |
| α-helix | 2790-2792 | 3 | |
| α-helix | 2793-2795 | 3 | |
| α-helix | 2796-2812 | 17 | |
| α-helix | 2816-2823 | 8 | |
| β-strand | 2824 | 1 | 5 |
| β-strand | 2829 | 1 | 5 |
| α-helix | 2831-2838 | 8 | |
| α-helix | 2839-2841 | 3 | |
| α-helix | 2844-2854 | 11 | |
| α-helix | 2860-2862 | 3 | |
| α-helix | 2863-2876 | 14 | |
| α-helix | 2886-2901 | 16 | |
| α-helix | 2910-2912 | 3 | |
| α-helix | 2913-2934 | 22 | |
| α-helix | 2937-2939 | 3 | |
| α-helix | 2943-2958 | 16 | |
| α-helix | 2967-2991 | 25 | |
| α-helix | 2999-3022 | 24 | |
| α-helix | 3025-3033 | 9 | |
| α-helix | 3034-3037 | 4 | |
| α-helix | 3043-3060 | 18 | |
| α-helix | 3066-3077 | 12 | |
| α-helix | 3086-3102 | 17 | |
| α-helix | 3106-3119 | 14 | |
| α-helix | 3124-3141 | 18 | |
| α-helix | 3144-3157 | 14 | |
| α-helix | 3167-3176 | 10 | |
| α-helix | 3177-3179 | 3 | |
| α-helix | 3185-3193 | 9 | |
| α-helix | 3199-3205 | 7 | |
| α-helix | 3206-3213 | 8 | |
| α-helix | 3218-3231 | 14 | |
| α-helix | 3233-3254 | 22 | |
| α-helix | 3281-3283 | 3 | |
| α-helix | 3284-3299 | 16 | |
| α-helix | 3301-3313 | 13 | |
| α-helix | 3314-3317 | 4 | |
| α-helix | 3321-3343 | 23 | |
| α-helix | 3350 | 1 | |
| β-strand | 3351 | 1 | 6 |
| α-helix | 3352-3353 | 2 | |
| α-helix | 3354-3365 | 12 | |
| α-helix | 3385-3396 | 12 | |
| α-helix | 3400-3412 | 13 | |
| β-strand | 3422 | 1 | 6 |
| α-helix | 3423-3441 | 19 | |
| β-strand | 3447-3449 | 3 | 7 |
| α-helix | 3450-3452 | 3 | |
| α-helix | 3455-3459 | 5 | |
| β-strand | 3468 | 1 | 8 |
| α-helix | 3469 | 1 | |
| β-strand | 3484 | 1 | 8 |
| β-strand | 3485-3488 | 4 | 7 |
| β-strand | 3491-3496 | 6 | 7 |
| β-strand | 3501-3509 | 9 | 7 |
| β-strand | 3514-3520 | 7 | 7 |
| α-helix | 3525-3541 | 17 | |
| α-helix | 3542-3546 | 5 | |
| α-helix | 3551-3554 | 4 | |
| β-strand | 3563-3567 | 5 | 7 |
| β-strand | 3570-3574 | 5 | 7 |
| β-strand | 3579-3581 | 3 | 9 |
| α-helix | 3582-3593 | 12 | |
| α-helix | 3599-3614 | 16 | |
| α-helix | 3620-3633 | 14 | |
| α-helix | 3639-3647 | 9 | |
| α-helix | 3651-3674 | 24 | |
| β-strand | 3677 | 1 | 10 |
| α-helix | 3682-3684 | 3 | |
| β-strand | 3685-3688 | 4 | 9 |
| β-strand | 3694-3696 | 3 | 9 |
| β-strand | 3701 | 1 | 10 |
| β-strand | 3703 | 1 | 11 |
| β-strand | 3710 | 1 | 11 |
| α-helix | 3722-3728 | 7 | |
| α-helix | 3730-3734 | 5 | |
| α-helix | 3736-3748 | 13 | |
| α-helix | 3755-3778 | 24 | |
| α-helix | 3787-3789 | 3 | |
| α-helix | 3793-3815 | 23 | |
| α-helix | 3818-3820 | 3 | |
| α-helix | 3823-3831 | 9 | |
| α-helix | 3834-3837 | 4 | |
| α-helix | 3842-3844 | 3 | |
Chain B: 13 helices, 35 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3 | 1 | 12 |
| α-helix | 4-5 | 2 | |
| α-helix | 6-19 | 14 | |
| α-helix | 39-50 | 12 | |
| α-helix | 69-83 | 15 | |
| α-helix | 87-91 | 5 | |
| α-helix | 96-109 | 14 | |
| α-helix | 113-123 | 11 | |
| α-helix | 134-141 | 8 | |
| α-helix | 146-151 | 6 | |
| α-helix | 154-160 | 7 | |
| α-helix | 162 | 1 | |
| β-strand | 163-168 | 6 | 13 |
| α-helix | 169-181 | 13 | |
| α-helix | 185-193 | 9 | |
| β-strand | 195-200 | 6 | 13 |
| β-strand | 258-264 | 7 | 14 |
| β-strand | 271-276 | 6 | 15 |
| β-strand | 282-287 | 6 | 15 |
| β-strand | 292-296 | 5 | 15 |
| β-strand | 302 | 1 | 16 |
| β-strand | 320-321 | 2 | 17 |
| β-strand | 333 | 1 | 16 |
| β-strand | 335-338 | 4 | 15 |
| β-strand | 345-350 | 6 | 18 |
| β-strand | 356-361 | 6 | 18 |
| β-strand | 366-370 | 5 | 18 |
| β-strand | 375-380 | 6 | 18 |
| β-strand | 387 | 1 | 19 |
| β-strand | 391-392 | 2 | 20 |
| β-strand | 398-402 | 5 | 20 |
| β-strand | 403 | 1 | 19 |
| β-strand | 408-412 | 5 | 20 |
| β-strand | 415-422 | 8 | 20 |
| β-strand | 429-434 | 6 | 21 |
| β-strand | 440-445 | 6 | 21 |
| β-strand | 450-454 | 5 | 21 |
| β-strand | 460-464 | 5 | 21 |
| β-strand | 471-476 | 6 | 22 |
| β-strand | 482-487 | 6 | 22 |
| β-strand | 492-496 | 5 | 22 |
| β-strand | 501-506 | 6 | 22 |
| β-strand | 513-518 | 6 | 23 |
| β-strand | 524-529 | 6 | 23 |
| β-strand | 533-538 | 6 | 23 |
| β-strand | 555-559 | 5 | 23 |
| β-strand | 566-569 | 4 | 14 |
| β-strand | 576-582 | 7 | 14 |
Chain C: 20 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-21 | 20 | |
| α-helix | 23-25 | 3 | |
| α-helix | 36-49 | 14 | |
| β-strand | 57 | 1 | 13 |
| α-helix | 63-69 | 7 | |
| β-strand | 76-81 | 6 | 24 |
| β-strand | 86-90 | 5 | 24 |
| β-strand | 100 | 1 | 24 |
| β-strand | 104 | 1 | 24 |
| α-helix | 110-117 | 8 | |
| β-strand | 119 | 1 | 25 |
| α-helix | 122-130 | 9 | |
| β-strand | 136-137 | 2 | 24 |
| β-strand | 140-147 | 8 | 24 |
| β-strand | 162-166 | 5 | 24 |
| β-strand | 167 | 1 | 25 |
| α-helix | 170-180 | 11 | |
| β-strand | 186 | 1 | 12 |
| α-helix | 189-202 | 14 | |
| α-helix | 204-207 | 4 | |
| α-helix | 214-226 | 13 | |
| α-helix | 232-241 | 10 | |
| α-helix | 243-251 | 9 | |
| α-helix | 252-254 | 3 | |
| α-helix | 262-271 | 10 | |
| α-helix | 300-303 | 4 | |
| α-helix | 308-310 | 3 | |
| α-helix | 314-316 | 3 | |
| β-strand | 318 | 1 | 26 |
| β-strand | 327 | 1 | 26 |
| β-strand | 333-340 | 8 | 27 |
| β-strand | 350-356 | 7 | 27 |
| β-strand | 363-365 | 3 | 27 |
| α-helix | 368 | 1 | |
| β-strand | 369 | 1 | 27 |
| α-helix | 370-371 | 2 | |
| β-strand | 394-396 | 3 | 27 |
| α-helix | 399-417 | 19 | |
| β-strand | 422-427 | 6 | 27 |
Chain D: 12 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 39-41 | 3 | |
| α-helix | 55-57 | 3 | |
| α-helix | 58-86 | 29 | |
| α-helix | 113-116 | 4 | |
| α-helix | 137-140 | 4 | |
| α-helix | 145-148 | 4 | |
| α-helix | 151-169 | 19 | |
| β-strand | 173-175 | 3 | 28 |
| α-helix | 176-207 | 32 | |
| α-helix | 215-222 | 8 | |
| α-helix | 230-235 | 6 | |
| α-helix | 236-240 | 5 | |
| α-helix | 241-261 | 21 | |
Chain E: 7 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-26 | 13 | |
| β-strand | 31 | 1 | 29 |
| α-helix | 35-60 | 26 | |
| α-helix | 68-79 | 12 | |
| α-helix | 89-100 | 12 | |
| α-helix | 103-107 | 5 | |
| α-helix | 113-117 | 5 | |
| α-helix | 118-120 | 3 | |
| β-strand | 130-131 | 2 | 17 |
Chain F: 7 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-10 | 2 | 30 |
| α-helix | 14-24 | 11 | |
| α-helix | 30-56 | 27 | |
| β-strand | 63 | 1 | 29 |
| α-helix | 65-74 | 10 | |
| α-helix | 78-80 | 3 | |
| β-strand | 91-93 | 3 | 31 |
| β-strand | 100-102 | 3 | 31 |
| β-strand | 106-108 | 3 | 28 |
| α-helix | 109-113 | 5 | |
| α-helix | 118-120 | 3 | |
| α-helix | 122-125 | 4 | |
| β-strand | 127-133 | 7 | 14 |
Chain G: 7 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 63-70 | 8 | |
| β-strand | 76 | 1 | 32 |
| α-helix | 78-105 | 28 | |
| β-strand | 111 | 1 | 33 |
| α-helix | 113-119 | 7 | |
| α-helix | 120-124 | 5 | |
| α-helix | 137-139 | 3 | |
| α-helix | 143-145 | 3 | |
| α-helix | 146-160 | 15 | |
Chain H: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 119-123 | 5 | |
| α-helix | 132-141 | 10 | |
| α-helix | 149-177 | 29 | |
| β-strand | 194-195 | 2 | 28 |
| α-helix | 197-205 | 9 | |
| β-strand | 217 | 1 | 31 |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transformation/transcription domain-associated protein,Transformation/transcription… | A | protein | 3195 | Homo sapiens | Q9Y4A5 |
| TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L | B | protein | 589 | Homo sapiens | O75529 (AlphaFold model) |
| Isoform 3 of Transcription factor SPT20 homolog | C | protein | 811 | Homo sapiens | Q8NEM7 (AlphaFold model) |
| STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit… | D | protein | 704 | Homo sapiens, unclassified Rhodococcus | O94864 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 9B | E | protein | 251 | Homo sapiens | Q9HBM6 |
| TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L | F | protein | 622 | Homo sapiens | Q9Y6J9 |
| Transcription initiation factor TFIID subunit 12 | G | protein | 161 | Homo sapiens | Q16514 |
| Transcription initiation factor TFIID subunit 10 | H | protein | 218 | Homo sapiens | Q12962 |
| Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3… | I | protein | 299 | Homo sapiens | O75486 |
| Transcriptional adapter 1 | J | protein | 335 | Homo sapiens | Q96BN2 |
| Ataxin-7 | N | protein | 892 | Homo sapiens | O15265 |
Sequence of entity 1 (A), FASTA
>7KTR_1 Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein (chains A)
XXXXXXXXXXXXXXXXXETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESL
PSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKC
KPQSELGAVEAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPFEKQG
EKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITSCKAPGAQFIPNKQLQPKETQIYIKL
VKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQ
TTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLK
LFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSH
DLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLV
SALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAY
RVLGKFGGSNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKS
ANTEPYYRRQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDT
PARKTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQP
STAMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERA
CQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMM
DLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHDLVREVTSP
NSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGN
TFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNA
LAACNYLPQSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLM
MLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNE
MKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTV
ELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFITLLLPGGAQTAVRPGSPS
TSTMRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQERHRKENMAATNW
KEPKLLAYCLLNYCKRNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXAGTSELVMLSLELVKTRLAVMSMEMRKNFIQAIL
TSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDL
ELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVY
ERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSH
DRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHML
TNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGE
ISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLE
HQAFEKGLSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKY
SETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKEL
NQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYL
AICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINA
GLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVTAYENSSQ
HDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQ
VKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAF
SAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKV
LWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYP
QAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSVGNQSHSASDPGPIRATAPMWRCSRIM
HMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKIT
PHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDF
DFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEF
LMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREER
VLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKK
GIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATD
YWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDAN
RPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKK
TQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANS
LDNLCRMDPAWHPWL
Sequence of entity 2 (B), FASTA
>7KTR_2 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (chains B)
MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA
APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY
SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ
SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE
VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK
KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC
SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR
IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG
KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR
NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH
Sequence of entity 3 (C), FASTA
>7KTR_3 Isoform 3 of Transcription factor SPT20 homolog (chains C)
MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEVKKLRRN
VNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEEL
PPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSI
TSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKR
YSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNL
AIPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYVFECEAGTQYQKTKLTILQSLGD
PLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQELVQNEAKCP
VKMSHSSSGSASLSQVSPGKETDQTETVSVQSSVLGKGVKHRPPPIKLPSSSGNSSSGNY
FTPQQTSSFLKSPTPPPSSKPSSIPRKSSVDLNQVSMLSPAALSPASSSQRSGTPKPSTP
TPTPSSTPHPPDAQSSTPSTPSATPTPQDSGFTPQPTLLTQFAQQQRSLSQAMPVTTIPL
STMVTSITPGTTATQVMANSAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGINL
SGLLPSGGLLPNALPSAMQAASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQ
LSQFTPQQPQQPTTCSPQQPGEQGSEQGSTSQEQALSAQQAAVINLTGVGSFMQSQAAAV
AILAASNGYGSSSSTNSSATSSSAYRQPVKK
Sequence of entity 4 (D), FASTA
>7KTR_4 STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA (chains D)
XXXXXXXXXXXXXXXMLDIPSEPCSLTIHTIQLIQHNRRLRNLIATAQAQNXXXXXXXXX
XXXXXXXXXXXXXDCKNPNAPFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQAVATI
LAHAGFDCANESVLETLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQVFHEVGI
GSVLSLQKFWQHRIKDYHSYMLQISKQLSEEYERIVNPEKATEDAKPVKIKEEPVSDITF
PVSEELEADLASGDQSLPMGVLGAQSERFPSNLEVEASPQASSAEVNASPLWNLAHVKME
PQESEEGNVSGHGVLGSDVFEEPMSGMSEAGIPQSPDDSDSSYGSHSTDSLMGSSPVFNQ
RCKKRMRKIGTSGEDLYFQSGGSMAEIGTGFPFDPHYVEVLGERMHYVDVGPRDGTPVLF
LHGNPTSSYVWRNIIPHVAPTHRCIAPDLIGMGKSDKPDLGYFFDDHVRFMDAFIEALGL
EEVVLVIHDWGSALGFHWAKRNPERVKGIAFMEFIRPIPTWDEWPEFARETFQAFRTTDV
GRKLIIDQNVFIEGTLPMGVVRPLTEVEMDHYREPFLNPVDREPLWRFPNELPIAGEPAN
IVALVEEYMDWLHQSPVPKLLFWGTPGVLIPPAEAARLAKSLPNCKAVDIGPGLNLLQED
NPDLIGSEIARWLSTLEISGDYKDHDGDYKDHDIDYKDDDDKGS
Sequence of entity 5 (E), FASTA
>7KTR_5 Transcription initiation factor TFIID subunit 9B (chains E)
MESGKMAPPKNAPRDALVMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSH
AKKPNVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRY
CLTAPNYRLKSLIKKGPNQGRLVPRLSVGAVSSKPTTPTIATPQTVSVPNKVATPMSVTS
QRFTVQIPPSQSTPVKPVPATTAVQNVLINPSMIGPKNILITTNMVSSQNTANEANPLKR
KHEDDDDNDIM
Sequence of entity 6 (F), FASTA
>7KTR_6 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (chains F)
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKR
RKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPK
GCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVAL
QDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVG
SVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADP
VRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYG
AILVAVERLLKMKAQAAEPNRGGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFGSGLP
LPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPD
SVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPG
TGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPM
IGRTSRPARRWALSDYSLYLPL
Sequence of entity 7 (G), FASTA
>7KTR_7 Transcription initiation factor TFIID subunit 12 (chains G)
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTK
KKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHL
ERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK
Sequence of entity 8 (H), FASTA
>7KTR_8 Transcription initiation factor TFIID subunit 10 (chains H)
MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKASPAGTAGGPGAGAAAGG
TGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSAANGDVKPVVSSTPLVDFL
MQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTA
SGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
Sequence of entity 9 (I), FASTA
>7KTR_9 Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog (chains I)
MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPLHETAVLVEDVVHTQLI
NLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDEDDLL
EDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDXXXXXXXXXXXXESRQLSFSKKAS
KFRDWLDCSSMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISAT
FIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPLSPFTNAYRRNGMAFLAC
Sequence of entity 10 (J), FASTA
>7KTR_10 Transcriptional adapter 1 (chains J)
MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHN
DFLLAILTRCQILVSTPDGAGSLPWPGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLS
GAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVE
NHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFTAPCA
GQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALN
IERIITKLWHPNHEELQQDKVHRQRLAAKEGLLLC
Sequence of entity 11 (N), FASTA
>7KTR_11 Ataxin-7 (chains N)
MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRP
EDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFG
KNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPPLAV
PPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHP
IQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTL
PSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTR
SLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPR
TSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPP
LPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRW
NRLRCALNLMVEKHLNAQLWKKIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVS
TSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLS
SVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSS
SSSSSSSSHSMESFRKNCVAHSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPP
TGSPAESIKRMSVMVNSSDSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCS
PSSSSINNSSSKPTKVAKVPAVNNVHMKHTGTIPGAQGLMNSSLLHQPKARP
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
Primary citation
Structure of the human SAGA coactivator complex. Herbst, D.A., Esbin, M.N., Louder, R.K. et al. Nat Struct Mol Biol (2021) 28:989-996. DOI 10.1038/s41594-021-00682-7 · PubMed
Other PDB entries of the same protein (UniProt Q9Y4A5), best resolution first:
- 9CAF 2.35 Å, Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite…
- 9RDK 2.41 Å, Cryo-EM structure of the human SAGA co-activator complex
- 9CAD 3.05 Å, Cryo-EM structure of the TRRAP lobe of the native human TIP60 complex (composite…
- 8XVV 3.2 Å, The TRRAP module of human NuA4/TIP60 complex
- 9C47 3.4 Å, TRRAP module of the human TIP60 complex
- 8QRI 3.5 Å, TRRAP and EP400 in the human Tip60 complex
- 8H7G 3.7 Å, Cryo-EM structure of the human SAGA complex
- 8XVG 9.4 Å, Structure of human NuA4/TIP60 complex
Browse structure collections
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