9RUX: DISC1 core

Cryo-EM structure of DISC1 core. Determined by electron microscopy at 3.9 Å resolution. Released 6 May 2026.

Method
Electron microscopy
Resolution
3.9 Å
Organism
Mus musculus
Chains
4
Atoms
9,592
Mol. weight
215.36 kDa
Released
6 May 2026

Explore 9RUX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9RUX contains 38 α-helices and 2 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix328-36841
α-helix371-38818
α-helix400-41819
α-helix501-5055
α-helix510-52920
α-helix534-5374
α-helix538-59457
α-helix599-67779
α-helix684-70320
Chain B: 9 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix328-36841
α-helix371-38818
α-helix400-41819
α-helix501-5066
α-helix510-52920
α-helix534-5374
α-helix538-59457
α-helix599-67678
α-helix684-70320
Chain C: 10 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix325-36844
α-helix371-39020
α-helix400-41819
α-helix501-5077
α-helix510-52415
α-helix536-5372
α-helix538-59457
α-helix598-67881
α-helix682-70322
α-helix704-7063
Chain D: 10 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix325-36844
α-helix371-39020
α-helix400-41819
α-helix501-5077
α-helix510-52314
β-strand53011
β-strand53211
α-helix536-5372
α-helix538-59457
α-helix598-67881
α-helix682-70322
α-helix704-7063

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Disrupted in schizophrenia 1 homologA, B, C, Dprotein478Mus musculusQ811T9 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>9RUX_1 Disrupted in schizophrenia 1 homolog (chains A, B, C, D)
MQYKLALNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTEHMHH
HHHHSSGLEVLFQGPGSADAHGWHTLLREWEPMLQDYLLSNRRQLEVTSLILKLQKCQEK
VVEDGDYDTAETLRQRLEELEQEKGRLSWALPSQQPALRSFLGYLAAQIQVALHGATQRA
GSDDPEAPLEGQLRTTAQDSLPASITRRDWLIREKQRLQKEIEALQARMSALEAKEKRLS
QELEEQEVLLRWPGCDLMALVAQMSPGQLQEVSKALGETLTSANQAPFQVEPPETLRSLR
ERTKSLNLAVRELTAQVCSGEKLCSSLRRRLSDLDTRLPALLEAKMLALSGSCFSTAKEL
TEEIWALSSEREGLEMFLGRLLALSSRNSRRLGIVKEDHLRCRQDLALQDAAHKTRMKAN
TVKCMEVLEGQLSSCRCPLLGRVWKADLETCQLLMQSLQLQEAGSSPHAEDEEQVHST

Primary citation

The schizophrenia associated protein DISC1 forms a multivalent tetrameric hub via conserved UVR dimers. Zhou, J.C., Kratochvil, J., Ye, F. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-71838-6 · PubMed

Other PDB entries of the same protein (UniProt Q811T9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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