9S9U: Adhesion G-protein coupled receptor G1

Structure of the human ADGRG1 GAIN domain with engineered disulfides. Determined by X-ray diffraction at 1.92 Å resolution. Released 19 Aug 2026.

Method: X-ray diffraction
Resolution: 1.92 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,815
Mol. weight: 117.93 kDa
Released: 19 Aug 2026

Explore 9S9U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9S9U contains 15 α-helices and 26 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	6-21	16
α-helix	26-27	2
α-helix	35-48	14
β-strand	55-60	6	1
β-strand	63-69	7	1
α-helix	72-76	5
β-strand	79-82	4	2
β-strand	92-99	8	2
α-helix	101-104	4
β-strand	117-123	7	1
β-strand	137	1	1
α-helix	138-140	3
β-strand	142-147	6	1
β-strand	159-165	7	2
α-helix	166-169	4
β-strand	174-180	7	1
β-strand	190-192	3	1
β-strand	196-200	5	2
β-strand	204-209	6	2

Chains B and D: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	214-219	6	1

Chain C: 8 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	6-21	16
α-helix	26-27	2
α-helix	35-48	14
β-strand	55-60	6	3
β-strand	63-69	7	3
α-helix	72-76	5
β-strand	79-82	4	4
α-helix	83-85	3
β-strand	92-99	8	4
α-helix	101-104	4
β-strand	117-123	7	3
β-strand	137	1	3
α-helix	138-140	3
β-strand	142-147	6	3
β-strand	159-165	7	4
α-helix	166-169	4
β-strand	174-180	7	3
β-strand	190-192	3	3
β-strand	196-200	5	4
β-strand	204-209	6	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Adhesion G-protein coupled receptor G1	A, B, C, D	protein	255	Homo sapiens	Q9Y653 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>9S9U_1 Adhesion G-protein coupled receptor G1 (chains A, B, C, D)
MKLCILLAVVAFVGLSLGATNASCDMSELKRDLQLLSQFLKHPQKASRRPSAAPACQQLQ
SLESKLTCVRFMGDMVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLP
RTLFQRTKGRSGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVV
LTFQHQLQPKNVTLQCVFWVCDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMV
SGSGSHHHHHHHHHH

Primary citation

Uncovering and engineering the adhesion GPCR GAIN domain under force. Barth, P., Dumas, L. To be published.

Other PDB entries of the same protein (UniProt Q9Y653 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SF8 2.7 Å, GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer

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