9T07: HUMAN PI3KDELTA

HUMAN PI3KDELTA IN COMPLEX WITH Roginolisib. Determined by X-ray diffraction at 2.75 Å resolution. Released 8 Jul 2026.

Method: X-ray diffraction
Resolution: 2.75 Å
Organisms: Homo sapiens, Bos taurus
Chains: 2
Atoms: 8,814
Mol. weight: 141.04 kDa
Ligands: QGU
Released: 8 Jul 2026

Explore 9T07 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9T07 contains 56 α-helices and 43 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 53 helices, 43 β-strands

Element	Residues	Length	Sheet
β-strand	19-25	7	1
β-strand	31-37	7	1
β-strand	41	1	2
α-helix	42-53	12
α-helix	59-61	3
α-helix	65-67	3
β-strand	68-73	6	1
β-strand	74	1	3
β-strand	79-81	3	1
β-strand	88	1	2
α-helix	89-92	4
β-strand	94	1	3
β-strand	98-103	6	1
α-helix	109-120	12
α-helix	126-129	4
α-helix	134-155	22
α-helix	159-166	8
β-strand	171	1	4
β-strand	191-196	6	5
β-strand	202-206	5	5
α-helix	213-219	7
β-strand	239-243	5	5
β-strand	246	1	6
β-strand	248-250	3	5
α-helix	256-258	3
β-strand	259	1	4
α-helix	260-268	9
α-helix	270-272	3
β-strand	275-278	4	5
α-helix	279-287	9
β-strand	322-329	8	7
β-strand	340-349	10	8
β-strand	352-358	7	8
β-strand	363-364	2	8
α-helix	365	1
β-strand	370-380	11	7
α-helix	381-383	3
β-strand	388-397	10	8
β-strand	416-424	9	8
β-strand	426	1	9
β-strand	431	1	10
β-strand	432	1	9
α-helix	433	1
β-strand	435-440	6	7
α-helix	441	1
β-strand	442-443	2	8
α-helix	444-446	3
α-helix	461-462	2
β-strand	470-475	6	7
α-helix	476-477	2
β-strand	484	1	10
α-helix	485-487	3
α-helix	488-496	9
α-helix	507-516	10
α-helix	522-524	3
α-helix	525-533	9
α-helix	535-541	7
α-helix	543-545	3
α-helix	546-552	7
α-helix	558-569	12
α-helix	571-575	5
α-helix	576-582	7
α-helix	590-600	11
α-helix	605-619	15
α-helix	628-639	12
α-helix	641-652	12
α-helix	661-673	13
α-helix	678-703	26
α-helix	708-720	13
α-helix	722-728	7
β-strand	731-732	2	11
β-strand	739	1	6
β-strand	740-741	2	11
β-strand	744	1	12
α-helix	746-748	3
β-strand	750-751	2	12
β-strand	759-764	6	12
α-helix	769-771	3
β-strand	773-780	8	12
α-helix	785-803	19
β-strand	815-819	5	12
β-strand	822-827	6	12
β-strand	831-833	3	13
α-helix	834-838	5
α-helix	855-862	8
α-helix	866-889	24
α-helix	896-898	3
β-strand	899-902	4	13
β-strand	907-909	3	13
α-helix	929-932	4
α-helix	936-942	7
α-helix	950-969	20
α-helix	971-980	10
α-helix	981-984	4
α-helix	992-1002	11
α-helix	1008-1026	19

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	442-512	71
α-helix	521-587	67
α-helix	591-598	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	A	protein	1044	Homo sapiens	O00329 (AlphaFold model)
Phosphatidylinositol 3-kinase regulatory subunit alpha	B	protein	169	Bos taurus	P23727 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9T07_1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (chains A)
MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH
MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP
GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP
HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR
QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ

Sequence of entity 2 (B), FASTA

>9T07_2 Phosphatidylinositol 3-kinase regulatory subunit alpha (chains B)
YQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMKRTAIEAFNET
IKIFEEQCQTQERYSKEYIEKFKREGNETEIQRIMHNYEKLKSRISEIVDSRRRLEEDLK
KQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG

Ligands and cofactors

ID	Name	Formula	Copies
QGU	[6-fluoranyl-1-[4-(morpholin-4-ylmethyl)phenyl]-5,5-bis(oxidanylidene)-4H-thioc…	C26 H27 F N4 O5 S	1

Primary citation

HUMAN PI3KDELTA IN COMPLEX WITH Roginolisib. Graedler, U., Augustin, M. To be published.

Other PDB entries of the same protein (UniProt O00329 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6PYR 2.21 Å, Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrim…
8S3R 2.28 Å, Human PI3KDELTA in complex with pyridazinone inhibitor 7
7JIS 2.42 Å, Human PI3KDELTA in complex with compound 2F
8BCY 2.43 Å, Human PI3KDELTA in complex with compound 13
9L3R 2.5 Å, Human PI3KDELTA in complex with Zandelisib
6PYU 2.54 Å, Human PI3Kdelta in complex with Compound 4-2 ((3S)-1'-(cyclopropanecarbonyl)-5-(quinoxali…
6OCO 2.58 Å, Human PI3KDELTA in complex with compound 6
5DXU 2.64 Å, p110delta/p85alpha with GDC-0326
6G6W 2.72 Å, Human PI3KDELTA in complex with ligand LASW1976
6OCU 2.77 Å, Human PI3KDELTA in complex with compound 29
7LM2 2.79 Å, Human PI3KDELTA in complex with compound 3C
5VLR 2.8 Å, Crystal structure of PI3K delta in complex with a trifluoro-ethyl-pyrazol-pyrolotriazine…

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