9T2A: Human Single Domain TCR-like Antibody 6K23

Human Single Domain TCR-like Antibody 6K23 in complex with NY-ESO-1(C165V):HLA-A0201. Determined by X-ray diffraction at 2.04 Å resolution. Released 30 Sept 2026.

Method: X-ray diffraction
Resolution: 2.04 Å
Organism: Homo sapiens
Chains: 4
Atoms: 4,119
Mol. weight: 61.51 kDa
Released: 30 Sept 2026

Explore 9T2A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9T2A contains 14 α-helices and 42 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-150	13
α-helix	152-159	8
α-helix	160-164	5
α-helix	165-174	10
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	221-223	3	4
β-strand	229-230	2	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	258-262	5	4
β-strand	270-272	3	4

Chain B: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 3 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	8
β-strand	11-12	2	9
β-strand	18-25	8	8
α-helix	29-31	3
β-strand	34-40	7	10
β-strand	47-52	6	10
β-strand	58-60	3	10
α-helix	65-67	3
β-strand	68-73	6	8
β-strand	78-83	6	8
α-helix	88-90	3
β-strand	92-99	8	10
β-strand	109-112	4	10
β-strand	116-118	3	10
β-strand	119-120	2	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	276	Homo sapiens	A5I8L1 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	Homo sapiens	P61769 (AlphaFold model)
Cancer/testis antigen 1	C	protein	9	Homo sapiens	P78358 (AlphaFold model)
6K23 single-domain antibody	D	protein	149	Homo sapiens

Sequence of entity 1 (A), FASTA

>9T2A_1 MHC class I antigen (chains A)
MGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEY
WDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYD
GKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETL
QRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDG
TFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE

Sequence of entity 2 (B), FASTA

>9T2A_2 Beta-2-microglobulin (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>9T2A_3 Cancer/testis antigen 1 (chains C)
SLLMWITQV

Sequence of entity 4 (D), FASTA

>9T2A_4 6K23 single-domain antibody (chains D)
QVQLQESGPGLVKPSETLSLTCAVSGYSISSGYYWGWYRQPPGKERELIGSIYHSGSTYY
NPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGYGPGWESDYFDYWGQGTQVTV
SSGSASASTSEQKLISEFELNGHHHHHHH

Primary citation

Single-domain TCR-like antibody 6K23 makes an intimate contact with the NY-ESO-1 peptide. Cmunt, D., Didelot, G., Rachid, L. et al. To be published.

Other PDB entries of the same protein (UniProt A5I8L1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SKO 1.49 Å, Crystal structure of HLA-A0201 in complex with peptide LLWNGPMAVS
9SL0 1.6 Å, Crystal structure of HLA-A0201 in complex with peptide LLWNGPMAV
9SKP 1.89 Å, Crystal structure of HLA-A0201 in complex with peptide SLLWNGPMAV
9NMV 1.97 Å, TCR156 S32Halpha bound to HLA A*02:01-PAP
9NMY 2.01 Å, TCR156 S32Qalpha bound to HLA A*02:01-PAP
9NMU 2.1 Å, TCR156 bound to HLA A*02:01-PAP
9NMW 2.11 Å, TCR156 S30Ealpha S32Qalpha bound to HLA A*02:01-PAP
9NMX 2.19 Å, TCR156 S32Malpha variant bound to HLA A*02:01-PAP
9O5S 2.27 Å, minibinder-antigen complex BXMart1-3-MART1-HLA*A02
9T2B 2.34 Å, Human Single Domain TCR-like Antibody 5F17 in complex with NY-ESO-1(C165V):HLA-A0201
9YTD 2.5 Å, Designed antibody vAB66 targeting PAP-HLA A*02:01
9T2C 2.89 Å, Human Single Domain TCR-like Antibody A10 in complex with NY-ESO-1(C165V):HLA-A0201

Browse structure collections

About this viewer

MolViewer shows 9T2A directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.