9TAY: Human inner kinetochore CCAN

Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome. Determined by electron microscopy at 15.5 Å resolution. Released 20 May 2026.

Method: Electron microscopy
Resolution: 15.5 Å
Organisms: Homo sapiens, Mus musculus
Chains: 37
Atoms: 57,462
Mol. weight: 1051.77 kDa
Released: 20 May 2026

Explore 9TAY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9TAY contains 229 α-helices and 222 β-strands across 35 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	25-28	4	1
β-strand	32-34	3	2
β-strand	40-43	4	3
β-strand	44-47	4	1
α-helix	51-53	3
β-strand	54-62	9	2
β-strand	66-74	9	2
β-strand	79-82	4	2
α-helix	84-86	3
β-strand	87	1	3
β-strand	90-95	6	3
β-strand	100-105	6	3
α-helix	110-112	3
β-strand	114-122	9	2
β-strand	129-132	4	2
β-strand	136-140	5	2
β-strand	162-163	2	4
β-strand	168-171	4	5
β-strand	177-180	4	6
β-strand	182-183	2	4
β-strand	187	1	7
β-strand	191-196	6	5
β-strand	203-207	5	5
β-strand	211-212	2	5
α-helix	213	1
β-strand	220-225	6	6
β-strand	226	1	7
β-strand	228-233	6	6
β-strand	242-248	7	5
β-strand	255	1	5
β-strand	257	1	4
β-strand	260-264	5	5

Chain A: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	47-56	10
α-helix	64-76	13
α-helix	84	1
β-strand	85-86	2	50
α-helix	87	1
α-helix	88-115	28
β-strand	120-121	2	51
α-helix	122	1
α-helix	123-133	11

Chain B: 3 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	31-39	9
β-strand	45-46	2	51
α-helix	50-75	26
β-strand	80-81	2	50
α-helix	83-91	9
β-strand	97-98	2	52

Chain c: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	47-54	8
α-helix	64-78	15
β-strand	85-86	2	11
α-helix	88-115	28
β-strand	120-121	2	12
α-helix	123-133	11

Chain C: 6 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	17-20	4
α-helix	27-35	9
β-strand	42-43	2	53
α-helix	46-72	27
β-strand	77-78	2	54
α-helix	80-88	9
α-helix	91-96	6
β-strand	100-102	3	55
α-helix	113-115	3

Chain d: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	25-28	4
α-helix	31-40	10
β-strand	45-46	2	12
α-helix	50-75	26
β-strand	80-81	2	11
α-helix	83-91	9
β-strand	96-98	3	14

Chains D and f: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	38-48	11
β-strand	53-54	2	54
α-helix	56-83	28
β-strand	88-89	2	53
α-helix	91-101	11
α-helix	105-123	19

Chain e: 5 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	17-20	4
α-helix	27-36	10
β-strand	42-43	2	19
α-helix	47-72	26
β-strand	77-78	2	20
α-helix	80-88	9
α-helix	91-96	6
β-strand	100-102	3	21

25 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Centromere protein H	H	protein	247	Homo sapiens	Q9H3R5 (AlphaFold model)
Centromere protein I	I	protein	762	Homo sapiens	Q92674 (AlphaFold model)
Centromere protein K	K	protein	269	Homo sapiens	Q9BS16 (AlphaFold model)
Centromere protein L	L	protein	348	Homo sapiens	Q8N0S6 (AlphaFold model)
Centromere protein M	M	protein	180	Homo sapiens	Q9NSP4
Centromere protein N	N	protein	347	Homo sapiens	Q96H22
Centromere protein O	O	protein	300	Homo sapiens	Q9BU64
Centromere protein Q	Q	protein	215	Homo sapiens	Q7L2Z9
Centromere protein U	U	protein	211	Homo sapiens	Q71F23
Centromere protein P	P	protein	288	Homo sapiens	Q6IPU0
Centromere protein R	R	protein	177	Homo sapiens	Q13352
Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T	T	protein	777	Homo sapiens	P16455, Q96BT3

10 more molecules are not listed.

Sequence of entity 1 (H), FASTA

>9TAY_1 Centromere protein H (chains H)
MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM

Sequence of entity 2 (I), FASTA

>9TAY_2 Centromere protein I (chains I)
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQ
AEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGK
FGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQ
INLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLS
LYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPL
KRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELP
SQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDT
IIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQ
LFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYV
GWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSIL
NQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKG
IYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYL
DYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQYENLYFQ

Sequence of entity 3 (K), FASTA

>9TAY_3 Centromere protein K (chains K)
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLL
IMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKE
DLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTL
GEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWP
PYVELLLRNGIALRHPEDPTRIRLEAFHQ

Sequence of entity 4 (L), FASTA

>9TAY_4 Centromere protein L (chains L)
GPLGMDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQ
EDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFN
IKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSE
DFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVAT
TEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFK
IHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE

Sequence of entity 5 (M), FASTA

>9TAY_5 Centromere protein M (chains M)
MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNR
PRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKL
AHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL

Sequence of entity 6 (N), FASTA

>9TAY_6 Centromere protein N (chains N)
MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKR
ASISDAALLDIIYMQFHQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVT
VSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQALT
IASKHHQIVKMDLRSRYLDSLKAIVFKQYNQTFETHNSTTPLQERSLGLDINMDSRIIHE
NIVEKERVQRITQETFGDYPQPQLEFAQYKLETKFKSGLNGSILAERKEPLRCLIKFSSP
HLLEALKSLAPAGIADAPLSPLLTCIPNKRMNYFKIRDKSDLEVLFQ

Sequence of entity 7 (O), FASTA

>9TAY_7 Centromere protein O (chains O)
MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRD
ELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSR
GVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSL
CEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYK
DLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS

Sequence of entity 8 (Q), FASTA

>9TAY_8 Centromere protein Q (chains Q)
MTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFL
KKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMT
GNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIP
NQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS

Sequence of entity 9 (U), FASTA

>9TAY_9 Centromere protein U (chains U)
MKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNL
KRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLK
QLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQGENLY
FQSWSHPQFEKGGGSGGGSGGGSWSHPQFEK

Sequence of entity 10 (P), FASTA

>9TAY_10 Centromere protein P (chains P)
MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQL
GHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEF
QILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYR
KRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLT
KVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN

Sequence of entity 11 (R), FASTA

>9TAY_11 Centromere protein R (chains R)
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLS
NEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE
NLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN

Sequence of entity 12 (T), FASTA

>9TAY_12 Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T (chains T)
MSYYHHHHHHDYDIPTTENLYFQGMDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGK
GTSAADAVEVPAPAAVLGGPEPLMQATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTR
QVLWKLLKVVKFGEVISYSHLAALAGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVG
GYEGGLAVKEWLLAHEGHRLGKPGLGSDLEVLFQGPMADHNPDSDSTPRTLLRRVLDTAD
PRTPRRPRSARAGARRALLETASPRKLSGQTRTIARGRSHGARSVGRSAHIQASGHLEEQ
TPRTLLKNILLTAPESSILMPESVVKPVPAPQAVQPSRQESSCGSLELQLPELEPPTTLA
PGLLAPGRRKQRLRLSVFQQGVDQGLSLSQEPQGNADASSLTRSLNLTFATPLQPQSVQR
PGLARRPPARRAVDVGAFLRDLRDTSLAPPNIVLEDTQPFSQPMVGSPNVYHSLPCTPHT
GAEDAEQAAGRKTQSSGPGLQKNSPGKPAQFLAGEAEEVNAFALGFLSTSSGVSGEDEVE
PLHDGVEEAEKKMEEEGVSVSEMEATGAQGPSRVEEAEGHTEVTEAEGSQGTAEADGPGA
SSGDEDASGRAASPESASSTPESLQARRHHQFLEPAPAPGAAVLSSEPAEPLLVRHPPRP
RTTGPRPRQDPHKAGLSHYVKLFSFYAKMPMERKALEMVEKCLDKYFQHLCDDLEVFAAH
AGRKTVKPEDLELLMRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAYSGNSVFPAQ

Primary citation

Models for the architecture of the human inner kinetochore on centromeric alpha-satellite CENP-A nucleosome arrays. Yu, C., Muir, K.W., Yang, J. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-72856-0 · PubMed

Other PDB entries of the same protein (UniProt Q9H3R5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7PB4 2.49 Å, Cenp-HIK 3-protein complex
28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
7R5S 2.83 Å, Structure of the human CCAN bound to alpha satellite DNA
7PKN 3.2 Å, Structure of the human CCAN deltaCT complex
7XHO 3.29 Å, Structure of human inner kinetochore CCAN complex
9TAW 3.54 Å, Structure of the human inner kinetochore CCAN bound to DNA
7XHN 3.71 Å, Structure of human inner kinetochore CCAN-DNA complex
9TAX 4.5 Å, Structure of the human inner kinetochore CCAN bound to a mono-CENP-A nucleosome
7R5V 4.55 Å, Structure of the human CCAN CENP-A alpha-satellite complex
7QOO 4.6 Å, Structure of the human inner kinetochore CCAN complex
7YYH 8.9 Å, Structure of the human CCANdeltaT CENP-A alpha-satellite complex
7YWX 12.0 Å, Structure of the human CCAN CENP-A alpha-satellite complex

Browse structure collections

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