9UWM: PDB entry 9UWM

A combined cryo_EM structure of Cagrilintide-CTR-Gs complex. Determined by electron microscopy at 3.1 Å resolution. Released 27 May 2026.

Method: Electron microscopy
Resolution: 3.1 Å
Organism: Homo sapiens
Chains: 5
Atoms: 8,128
Mol. weight: 145.95 kDa
Released: 27 May 2026

Explore 9UWM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9UWM contains 39 α-helices and 47 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	7-32	26
β-strand	34-39	6	1
α-helix	46-56	11
β-strand	185-191	7	1
β-strand	194-200	7	1
α-helix	211-215	5
β-strand	220-226	7	1
α-helix	230-244	15
α-helix	247-249	3
β-strand	254-259	6	1
α-helix	261-270	10
α-helix	275-277	3
α-helix	280-282	3
α-helix	299-318	20
β-strand	327-330	4	1
α-helix	337-357	21

Chain B: 4 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
α-helix	30-33	4
α-helix	38-39	2
β-strand	46-51	6	2
β-strand	58-63	6	3
β-strand	69-74	6	3
β-strand	78-83	6	3
β-strand	88-94	7	3
α-helix	95	1
β-strand	100-105	6	4
β-strand	111-116	6	4
β-strand	120-125	6	4
β-strand	134-140	7	4
β-strand	149-151	3	5
β-strand	156-159	4	5
β-strand	166-170	5	5
β-strand	176-180	5	5
β-strand	187	1	6
β-strand	191-192	2	7
β-strand	198-202	5	7
β-strand	203	1	6
β-strand	207-212	6	7
β-strand	218-223	6	7
β-strand	229-234	6	8
β-strand	240-245	6	8
β-strand	249-254	6	8
β-strand	259-265	7	8
β-strand	276-277	2	9
β-strand	286-287	2	9
β-strand	294-298	5	9
β-strand	303-308	6	9
β-strand	315-320	6	2
β-strand	327-331	5	2
β-strand	336-340	5	2

Chain D: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	8-19	12
α-helix	28-30	3
α-helix	32-35	4

Chain G: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	8-23	16
α-helix	30-43	14
α-helix	53-55	3

Chain R: 19 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	42-61	20
α-helix	63-65	3
β-strand	71-72	2	10
α-helix	73-74	2
β-strand	75-76	2	11
β-strand	81-82	2	11
β-strand	85-86	2	10
β-strand	90-94	5	12
β-strand	107-111	5	12
β-strand	112	1	13
β-strand	118	1	13
β-strand	120-121	2	14
β-strand	126-127	2	14
β-strand	130	1	12
α-helix	132-136	5
α-helix	138-172	35
α-helix	174-176	3
α-helix	179-204	26
α-helix	211-214	4
α-helix	217-248	32
α-helix	259-263	5
α-helix	264-268	5
α-helix	269-283	15
α-helix	299-329	31
α-helix	334-352	19
α-helix	354-358	5
α-helix	366-380	15
α-helix	383-388	6
α-helix	389-393	5
α-helix	396-408	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Guanine nucleotide-binding protein g(s) subunit alpha	A	protein	361	Homo sapiens	A0A5A9NRD5 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	366	Homo sapiens	P62873 (AlphaFold model)
Cagrilintide	D	protein	36	Homo sapiens	P10997 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G	protein	71	Homo sapiens	P59768 (AlphaFold model)
Calcitonin receptor	R	protein	450	Homo sapiens	P30988

Sequence of entity 1 (A), FASTA

>9UWM_1 Guanine nucleotide-binding protein g(s) subunit alpha (chains A)
MGCTLSAEDKAAVERSKMIEKQLQKDKQVYRATHRLLLLGADNSGKSTIVKQMRIYHVNG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNDF
KSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPR
VTRAKYFIRDEFLRISTASGDGRHYCYPHFTCSVDTENARRIFNDCRDIIQRMHLRQYEL
L

Sequence of entity 2 (B), FASTA

>9UWM_2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWNGSSGGGGSGGGGSSGVSGWR
LFKKIS

Sequence of entity 3 (D), FASTA

>9UWM_3 Cagrilintide (chains D)
KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNT

Sequence of entity 4 (G), FASTA

>9UWM_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains G)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 5 (R), FASTA

>9UWM_5 Calcitonin receptor (chains R)
AFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDD
TPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKN
AYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVE
VVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYL
LGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLV
TKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQG
FFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICH
QELRNEPANNQGEESAEIIPLNIIEQESSA

Primary citation

Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors. Gu, Y.M., Yuan, Q.N., Li, X. et al. Acta Pharmacol Sin (2026) 47:162-172. DOI 10.1038/s41401-025-01635-2 · PubMed

Other PDB entries of the same protein (UniProt A0A5A9NRD5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9JCO 2.36 Å, Cryo-EM structure of the proton-sensing GPCR (GPR4)-Gs protein complex at pH 6.5
9X3Z 2.54 Å, NPFF bound Mas1 Receptor Complex
27XK 2.64 Å, A cryo-EM structure of GLP1-Y11-GLP1R-Gs complex
9UWQ 3.1 Å, A combined Cryo_EM structure of Cagrilintide-AMY1R-Gs complex

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