9VD9: Human DSS1-INTAC-PEC complex

Cryo-EM structure of the human DSS1-INTAC-PEC complex. Determined by electron microscopy at 4.6 Å resolution. Released 25 Jun 2025.

Method: Electron microscopy
Resolution: 4.6 Å
Organisms: Homo sapiens, Sus scrofa
Chains: 38
Atoms: 113,214
Mol. weight: 2065.24 kDa
Ligands: ZN, MN, MG
Released: 25 Jun 2025

Explore 9VD9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9VD9 contains 802 α-helices and 416 β-strands across 32 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	51-63	13

Chain 1: 74 helices, 61 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	58
β-strand	21-25	5	59
α-helix	28-34	7
β-strand	86-94	9	60
α-helix	99-109	11
α-helix	124-132	9
α-helix	137-148	12
β-strand	190-194	5	61
β-strand	197-201	5	61
β-strand	213-215	3	61
α-helix	218-227	10
α-helix	230-236	7
α-helix	245-248	4
β-strand	250-255	6	60
β-strand	264	1	62
β-strand	272	1	62
α-helix	275-295	21
α-helix	301-318	18
α-helix	326-328	3
α-helix	339-344	6
α-helix	351-355	5
β-strand	357-359	3	63
β-strand	362-369	8	64
β-strand	377-380	4	64
α-helix	382-387	6
β-strand	390-393	4	65
α-helix	399-408	10
β-strand	416-420	5	65
β-strand	426-428	3	65
α-helix	435-438	4
β-strand	445-448	4	65
β-strand	455-459	5	64
α-helix	466-468	3
β-strand	470-476	7	64
β-strand	482-484	3	64
α-helix	486-492	7
β-strand	500-504	5	64
α-helix	509-518	10
β-strand	520	1	64
β-strand	526	1	66
β-strand	533	1	66
α-helix	539-549	11
β-strand	555	1	67
α-helix	557-563	7
α-helix	574	1
β-strand	575	1	68
α-helix	576-577	2
β-strand	579-581	3	69
β-strand	585	1	69
β-strand	586	1	67
α-helix	588-595	8
β-strand	602-605	4	70
α-helix	611-615	5
β-strand	627-631	5	70
β-strand	634-637	4	70
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
α-helix	689-692	4
α-helix	696-721	26
α-helix	725-728	4
α-helix	733-758	26
α-helix	765-772	8
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	71
β-strand	793	1	72
β-strand	796	1	72
α-helix	797-799	3
α-helix	817-820	4
β-strand	822-823	2	71
α-helix	833-867	35
β-strand	872-873	2	73
β-strand	879-880	2	73
β-strand	886-888	3	73
α-helix	891-893	3
β-strand	896	1	74
β-strand	902-905	4	75
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	76
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	75
α-helix	983-994	12
α-helix	1001	1
β-strand	1002	1	76
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1052	2
α-helix	1053-1058	6
α-helix	1062-1079	18
β-strand	1080	1	74
α-helix	1081-1082	2
α-helix	1087-1101	15
α-helix	1104-1106	3
α-helix	1114-1116	3
α-helix	1121-1128	8
β-strand	1139-1141	3	77
β-strand	1143	1	78
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164	1	79
α-helix	1166-1169	4
β-strand	1172-1177	6	80
α-helix	1189-1194	6
β-strand	1210-1215	6	80
α-helix	1218-1224	7
α-helix	1228-1239	12
β-strand	1243-1247	5	80
β-strand	1256-1261	6	80
α-helix	1282-1295	14
β-strand	1299	1	79
β-strand	1307-1310	4	77
β-strand	1319-1323	5	81
β-strand	1327-1331	5	81
β-strand	1335-1338	4	77
α-helix	1345-1348	4
β-strand	1352	1	78
β-strand	1358-1359	2	77
α-helix	1363-1368	6
α-helix	1371-1386	16
α-helix	1387-1389	3
α-helix	1395-1406	12
β-strand	1408-1409	2	82
α-helix	1416-1419	4
α-helix	1426-1431	6
α-helix	1436-1445	10
β-strand	1448-1449	2	59
α-helix	1455-1459	5
β-strand	1472-1475	4	31
α-helix	1477-1482	6
α-helix	1483-1485	3

Chain 2: 49 helices, 70 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-67	3	83
β-strand	84-93	10	83
β-strand	97-98	2	84
β-strand	106-107	2	84
α-helix	110-115	6
β-strand	121-131	11	83
β-strand	141-153	13	83
α-helix	168-173	6
β-strand	185-187	3	85
β-strand	190-194	5	85
β-strand	196-200	5	86
β-strand	205-209	5	87
β-strand	215-223	9	87
β-strand	233-240	8	87
α-helix	241	1
β-strand	256-259	4	87
β-strand	263	1	88
β-strand	267-268	2	87
α-helix	269-276	8
α-helix	281-288	8
α-helix	295-308	14
α-helix	314-322	9
β-strand	325	1	88
α-helix	335-341	7
α-helix	342-346	5
α-helix	349-351	3
α-helix	356-377	22
β-strand	391-394	4	86
α-helix	396-425	30
α-helix	431-434	4
α-helix	437	1
α-helix	438-442	5
α-helix	443-450	8
β-strand	467-469	3	85
β-strand	472	1	89
β-strand	474	1	89
α-helix	475-482	8
β-strand	484-486	3	86
α-helix	497-499	3
α-helix	501-502	2
β-strand	509	1	90
β-strand	523-525	3	86
β-strand	526	1	90
β-strand	531-532	2	91
α-helix	539-547	9
β-strand	551-552	2	92
α-helix	559-561	3
β-strand	565-569	5	92
β-strand	572-577	6	92
α-helix	583-593	11
β-strand	602-606	5	92
β-strand	611-615	5	92
β-strand	621-627	7	91
β-strand	628	1	93
β-strand	633	1	93
α-helix	637-644	8
α-helix	653-659	7
β-strand	662-666	5	91
α-helix	667-672	6
β-strand	675-676	2	91
β-strand	695-696	2	91
α-helix	700-703	4
α-helix	706-710	5
α-helix	719-728	10
β-strand	748-751	4	94
β-strand	755	1	95
β-strand	759-760	2	96
β-strand	776-782	7	97
β-strand	793-797	5	98
α-helix	798-803	6
β-strand	808-817	10	94
β-strand	826-829	4	99
β-strand	838	1	99
β-strand	848	1	100
β-strand	853	1	99
β-strand	854	1	100
α-helix	855	1
β-strand	859-860	2	94
β-strand	864-872	9	99
α-helix	889	1
β-strand	890-896	7	99
α-helix	897	1
β-strand	902-911	10	94
β-strand	917-927	11	94
β-strand	934-936	3	98
β-strand	943-949	7	98
β-strand	956	1	101
β-strand	965	1	97
α-helix	971-975	5
α-helix	978-993	16
β-strand	997-998	2	96
α-helix	1008-1017	10
β-strand	1025-1026	2	97
β-strand	1029	1	101
α-helix	1035	1
β-strand	1036	1	101
α-helix	1037	1
β-strand	1041-1048	8	97
β-strand	1049-1050	2	98
α-helix	1055-1058	4
β-strand	1060	1	64
α-helix	1078-1080	3
α-helix	1082-1083	2
β-strand	1084-1086	3	63
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1113-1119	7	58
β-strand	1125	1	58
β-strand	1127-1129	3	102
β-strand	1134-1136	3	102
β-strand	1146-1152	7	58
α-helix	1153-1164	12
β-strand	1167-1170	4	59

Chain 3: 8 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	103
β-strand	18-24	7	103
α-helix	28-39	12
β-strand	44-55	12	104
α-helix	61-69	9
β-strand	73	1	105
α-helix	78-81	4
β-strand	99-106	8	104
β-strand	113-116	4	106
α-helix	117-119	3
β-strand	121-122	2	104
β-strand	129	1	105
α-helix	146-148	3
β-strand	149-153	5	106
β-strand	158-168	11	104
β-strand	179-185	7	103
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	103
α-helix	241-270	30

Chain 4: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	3-24	22
β-strand	26	1	107
α-helix	30-33	4
α-helix	37-44	8
β-strand	61-63	3	108
β-strand	64	1	107
β-strand	71-75	5	108
α-helix	84-96	13
β-strand	101-106	6	108
α-helix	109-111	3
α-helix	112-121	10
β-strand	126-131	6	108
β-strand	147-150	4	82
α-helix	153-163	11
α-helix	171	1
β-strand	172-173	2	82
α-helix	178-183	6
β-strand	189-197	9	82
β-strand	201-209	9	82

Chain 5: 2 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56-57	2	109
α-helix	59-74	16
α-helix	89-99	11
β-strand	104-109	6	31
β-strand	115-119	5	31
β-strand	124-125	2	109

Chain 6: 1 helix, 14 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	110
β-strand	26-31	6	110
β-strand	38-43	6	110
β-strand	54-61	8	110
β-strand	65	1	111
β-strand	74	1	68
β-strand	83	1	111
α-helix	84-86	3
β-strand	90	1	110
β-strand	91-92	2	69
β-strand	93-101	9	110
β-strand	111-118	8	110
β-strand	121-128	8	110
β-strand	140-142	3	110
β-strand	145-147	3	110

Chain 7: 2 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	16-17	2	112
β-strand	22-23	2	112
β-strand	25-29	5	113
β-strand	34-38	5	113
β-strand	45-47	3	113
β-strand	52-57	6	80
α-helix	64-67	4
α-helix	70-74	5
β-strand	80-81	2	114
β-strand	94-97	4	114
β-strand	111-114	4	114
β-strand	122-124	3	114

24 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
26S proteasome complex subunit SEM1	0	protein	70	Homo sapiens	P60896 (AlphaFold model)
Integrator complex subunit 9	I	protein	658	Homo sapiens	Q9NV88 (AlphaFold model)
Integrator complex subunit 11	K	protein	600	Homo sapiens	Q5TA45 (AlphaFold model)
RNA (5'-r(pupapapcpcpgpgpapgpapgpgpgpapapcpcpcpapcp*u)-3')	c	RNA	21	Homo sapiens
Integrator complex subunit 2	B	protein	1204	Homo sapiens	Q9H0H0 (AlphaFold model)
Integrator complex subunit 4	D	protein	963	Homo sapiens	Q96HW7
Integrator complex subunit 7	G	protein	962	Homo sapiens	Q9NVH2
DNA-directed RNA polymerase II subunit RPB1	m	protein	14	Homo sapiens	P24928
Thr-ser-pro-ser-tyr-ser-pro-thr	n	protein	8	Homo sapiens
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	P	protein	589	Homo sapiens	P30153
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	Q	protein	309	Homo sapiens	P67775
DNA-directed RNA polymerase II subunit RPB1	1	protein	1970	Homo sapiens	P24928

26 more molecules are not listed.

Sequence of entity 1 (0), FASTA

>9VD9_1 26S proteasome complex subunit SEM1 (chains 0)
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS

Sequence of entity 2 (I), FASTA

>9VD9_2 Integrator complex subunit 9 (chains I)
MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDG
NAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFT
GTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRR
CYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGS
SLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCY
PSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEP
PFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTV
IFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPP
AQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATV
SAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEK
HGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF

Sequence of entity 3 (K), FASTA

>9VD9_3 Integrator complex subunit 11 (chains K)
MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANF
FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS

Sequence of entity 4 (c), FASTA

>9VD9_4 RNA (5'-R(P*UP*AP*AP*CP*CP*GP*GP*AP*GP*AP*GP*GP*GP*AP*AP*CP*CP*CP*AP*CP*U)-3') (chains c)
UAACCGGAGAGGGAACCCACU

Sequence of entity 5 (B), FASTA

>9VD9_5 Integrator complex subunit 2 (chains B)
MKDQQTVIMTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQ
SQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVS
QLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADV
LCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEES
LGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLDHTKNEACEDGVSDLVC
FVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQLLLELMGILPTVRSTRIV
EEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAEQLLQLMTSRPP
ATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGVSASFGEML
LLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPV
TSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYI
NSILTPASKSNPEATNQPVTEQEILNIFQGVIGGDNIRLNQRFSITAQLLVLYYILSYEE
ALLANTKTLAAMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPH
LCIVDDWICEEEITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTL
LSASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSI
KFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETE
QDRPSQNNTIGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPD
SLLRNVQSVITTSAPNKGMEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGY
PCELLPLTVAGIPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLA
VNVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQT
RDIDPIITRLQQIKEKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMS
VSGI

Sequence of entity 6 (D), FASTA

>9VD9_6 Integrator complex subunit 4 (chains D)
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
ARR

Sequence of entity 7 (G), FASTA

>9VD9_7 Integrator complex subunit 7 (chains G)
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPIL
INSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKI
SEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTL
LAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECAL
QTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIA
AHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLA
KGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGR
SATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHD
MAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKG
IASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGND
LQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEAL
ILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNA
IIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSK
PGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILG
THNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYT
RF

Sequence of entity 8 (m), FASTA

>9VD9_8 DNA-directed RNA polymerase II subunit RPB1 (chains m)
TSPSYSPTSPSYSP

Sequence of entity 9 (n), FASTA

>9VD9_9 THR-SER-PRO-SER-TYR-SER-PRO-THR (chains n)
TSPSYSPT

Sequence of entity 10 (P), FASTA

>9VD9_10 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (chains P)
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY
DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS
PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM
VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL
EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA
AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN
TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR
LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA
TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV
AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA

Sequence of entity 11 (Q), FASTA

>9VD9_11 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (chains Q)
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL

Sequence of entity 12 (1), FASTA

>9VD9_12 DNA-directed RNA polymerase II subunit RPB1 (chains 1)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	10
MN	Manganese (II) ion	Mn	2
MG	Magnesium ion	Mg	1

Primary citation

DSS1 is required for proper Integrator-PP2A function. Xu, C., Zhou, Q.X., Zheng, H. et al. Nat Commun (2025) 16:6206-6206. DOI 10.1038/s41467-025-61257-4 · PubMed

Other PDB entries of the same protein (UniProt P60896 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3T5X 2.12 Å, PCID2:DSS1 Structure
9K53 2.5 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state ED2.1
9RV1 2.62 Å, Cryo-EM structure of the human UAP56-RNA - SAC3D1-PCID2-SEM1 complex
8USB 2.73 Å, Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1
9MBP 2.75 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT1 at top of spiral…
9DLP 2.79 Å, Cryo-EM structure of human TREX-2 complex bound to DDX39B(UAP56)
9NKG 2.8 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)
9E8I 2.87 Å, Human proteasome in resting state conformation bound to TXNL1 in Forward conformation
9BV3 2.9 Å, M1B Midnolin-Proteasome
9E8H 2.9 Å, Human proteasome in resting state conformation bound to TXNL1 in backward conformation
9K4J 2.9 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state EA1.0
9NKF 2.9 Å, Structure of human substrate-free 26S proteasome in the presence of ATPgS and…

Browse structure collections

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