9VMG: Spermine-bound sea lamprey TAAR348-Gs complex

Cryo-EM structure of the spermine-bound sea lamprey TAAR348-Gs complex. Determined by electron microscopy at 2.82 Å resolution. Released 13 May 2026.

Method: Electron microscopy
Resolution: 2.82 Å
Organisms: Petromyzon marinus, Homo sapiens, Lama glama
Chains: 6
Atoms: 9,818
Mol. weight: 155.92 kDa
Ligands: SPM
Released: 13 May 2026

Explore 9VMG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9VMG contains 41 α-helices and 75 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	13-34	22
β-strand	40-46	7	1
β-strand	69-75	7	1
β-strand	80-86	7	1
α-helix	97-99	3
β-strand	105-111	7	1
α-helix	118-129	12
β-strand	138-144	7	1
α-helix	146-155	10
α-helix	160-163	4
α-helix	165-167	3
α-helix	184-201	18
β-strand	211	1	1
β-strand	214-215	2	1
α-helix	223-242	20

Chain B: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	4-25	22
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	2
β-strand	58-63	6	3
β-strand	69-74	6	3
β-strand	78-83	6	3
β-strand	88-94	7	3
β-strand	100-105	6	4
β-strand	111-116	6	4
β-strand	121-125	5	4
β-strand	134-139	6	4
β-strand	146-151	6	5
β-strand	156-161	6	5
β-strand	166-170	5	5
β-strand	175-180	6	5
β-strand	187-192	6	6
β-strand	198-203	6	6
β-strand	207-212	6	6
β-strand	218-223	6	6
β-strand	229-234	6	7
β-strand	240-245	6	7
β-strand	250-254	5	7
β-strand	260-264	5	7
α-helix	272	1
β-strand	273-278	6	8
β-strand	284-289	6	8
β-strand	295-298	4	8
β-strand	303-307	5	8
β-strand	319-320	2	2
β-strand	327-329	3	2
β-strand	336-339	4	2

Chain C: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	7-23	17
α-helix	27-29	3
α-helix	30-43	14

Chain N: 3 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	9
β-strand	11-12	2	10
β-strand	17-25	9	9
α-helix	29-31	3
β-strand	34-35	2	11
β-strand	38-39	2	12
β-strand	45-46	2	12
β-strand	49-51	3	11
β-strand	58-60	3	11
α-helix	62-64	3
β-strand	68-73	6	9
β-strand	78-84	7	9
α-helix	88-90	3
β-strand	92-94	3	12
β-strand	97-98	2	11
β-strand	122-124	3	12
β-strand	125-126	2	10

Chain R: 16 helices, 0 β-strands

Element	Residues	Length
α-helix	29-59	31
α-helix	66-83	18
α-helix	86-93	8
α-helix	102-135	34
α-helix	140-143	4
α-helix	146-155	10
α-helix	160-168	9
α-helix	177-182	6
α-helix	184	1
α-helix	194-201	8
α-helix	202-206	5
α-helix	208-231	24
α-helix	252-279	28
α-helix	286-301	16
α-helix	303-307	5
α-helix	312-321	10

Chain S: 7 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	13
β-strand	11-12	2	14
β-strand	18-25	8	13
α-helix	29-31	3
β-strand	35-39	5	15
β-strand	45-51	7	15
α-helix	53-55	3
β-strand	58-60	3	15
α-helix	62-64	3
β-strand	68-73	6	13
β-strand	78-83	6	13
α-helix	88-90	3
β-strand	92-98	7	15
β-strand	110-111	2	15
β-strand	115-117	3	15
β-strand	118-119	2	14
β-strand	140	1	16
β-strand	146-147	2	17
β-strand	155-160	6	18
β-strand	161	1	16
β-strand	166	1	19
β-strand	172	1	19
β-strand	174-179	6	17
β-strand	186-189	4	17
α-helix	194	1
β-strand	195	1	17
α-helix	196	1
β-strand	203-207	5	18
β-strand	211-216	6	18
α-helix	221-223	3
β-strand	225-231	7	17
β-strand	240	1	16
β-strand	243-245	3	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Trace amine-associated receptor 12707.TAAR348	R	protein	348	Petromyzon marinus	A0A678XLR1 (AlphaFold model)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	A	protein	247	Homo sapiens	A0A590UJY2 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	340	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	C	protein	71	Homo sapiens	P59768 (AlphaFold model)
Nb35	N	protein	139	Lama glama
scFv16	S	protein	259	synthetic construct

Sequence of entity 1 (R), FASTA

>9VMG_1 Trace amine-associated receptor 12707.TAAR348 (chains R)
MSSHANTTSPACGLTFYDFNCSRASVTSSSERAQVMSLLLSISAITIAGNLLTITSILYF
RQLQTRTNVLTLSLAVADLLVGLLIMPFSVMRSVHNCWFYGRVFCRVHTWLDYTFCTSSI
VHLSCISFDRYVAISDPLRYEQRVTRRACVRMLVCCWLCLLVYGLAFMMEWNLVGLEEEV
AHICPDDCPVLLNLPFAMANTIFACIVPMMLMTLAYGRIYQLARQQARKITSAAVGSNAD
SARSSLRREHSATITMGIIVGVFISLWIPYFVVSVTEPIFGYHASSVTWEVINWFTYINS
TANPILFAAFNRPFRNAFYLILSGRMFASSCRGVDLFDVLRALAKARG

Sequence of entity 2 (A), FASTA

>9VMG_2 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (chains A)
MGSTVSAEDKAAAERSKMIDKNLREDGEKAAAATHRLLLLGADNSGKSTIVKQMRIYHGG
SGGSGGTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQ
EALNDFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPE
PGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCSVDTENARRIFNDCRDIIQRMH
LRQYELL

Sequence of entity 3 (B), FASTA

>9VMG_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (C), FASTA

>9VMG_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains C)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 5 (N), FASTA

>9VMG_5 Nb35 (chains N)
MQVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASIS
YTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRG
QGTQVTVSSHHHHHHEPEA

Sequence of entity 6 (S), FASTA

>9VMG_6 scFv16 (chains S)
DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYY
ADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVS
SGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQR
PGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG
AGTKLELKAAAHHHHHHHH

Ligands and cofactors

ID	Name	Formula	Copies
SPM	Spermine	C10 H26 N4	1

Primary citation

Chemosensation of the pheromone spermine by the olfactory TAAR-like receptor TAAR348. Jiang, K., Zeng, L., Zhang, W. et al. Cell Discov (2025) 11:79-79. DOI 10.1038/s41421-025-00839-4 · PubMed

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