9VUS: Akg bound OXGR1

The structure of akg bound OXGR1. Determined by electron microscopy at 2.37 Å resolution. Released 15 Jul 2026.

Method: Electron microscopy
Resolution: 2.37 Å
Organisms: Homo sapiens, Mus musculus, Escherichia coli
Chains: 5
Atoms: 9,005
Mol. weight: 330.4 kDa
Ligands: AKG
Released: 15 Jul 2026

Explore 9VUS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9VUS contains 41 α-helices and 62 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	29-34	6
α-helix	36-61	26
α-helix	63	1
α-helix	65	1
α-helix	67-84	18
α-helix	86-94	9
α-helix	103-136	34
α-helix	143-145	3
α-helix	147-165	19
α-helix	166-168	3
β-strand	174	1	15
β-strand	183	1	15
α-helix	186-188	3
α-helix	192-202	11
α-helix	203-208	6
α-helix	209-226	18
α-helix	234-269	36
α-helix	276-299	24
α-helix	300-304	5
α-helix	307-321	15

Chain B: 11 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	7-32	26
β-strand	34-40	7	1
α-helix	42-44	3
α-helix	46-55	10
β-strand	186	1	1
β-strand	189-191	3	1
β-strand	194-199	6	1
α-helix	211-215	5
β-strand	220-226	7	1
α-helix	233-244	12
β-strand	253-259	7	1
α-helix	261-268	8
α-helix	275-278	4
α-helix	280-282	3
α-helix	293-294	2
α-helix	299-318	20
β-strand	326-330	5	1
α-helix	338-357	20

Chain C: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	11-23	13
α-helix	30-43	14
α-helix	53-55	3

Chain D: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	8-25	18
α-helix	30-33	4
α-helix	38-40	3
β-strand	47-51	5	2
β-strand	58-63	6	3
β-strand	69-74	6	3
β-strand	78-83	6	3
β-strand	88-94	7	3
β-strand	100-105	6	4
β-strand	111-116	6	4
β-strand	121-125	5	4
β-strand	134-139	6	4
β-strand	146-151	6	5
β-strand	156-161	6	5
β-strand	166-170	5	5
β-strand	175-180	6	5
β-strand	187-192	6	6
β-strand	198-203	6	6
β-strand	207-212	6	6
β-strand	218-223	6	6
β-strand	229-234	6	7
β-strand	240-245	6	7
β-strand	250-254	5	7
β-strand	259-264	6	7
α-helix	272	1
β-strand	273-278	6	8
β-strand	284-289	6	8
β-strand	294-298	5	8
β-strand	304-308	5	8
β-strand	315-320	6	2
β-strand	327-331	5	2
β-strand	336-339	4	2

Chain E: 5 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	9
β-strand	11-12	2	10
β-strand	18-25	8	9
β-strand	33-39	7	11
β-strand	45-51	7	11
β-strand	58-60	3	11
α-helix	62-64	3
β-strand	68-73	6	9
α-helix	74-76	3
β-strand	78-83	6	9
α-helix	88-90	3
β-strand	92-99	8	11
β-strand	111	1	11
β-strand	115-117	3	11
β-strand	118-119	2	10
β-strand	141-142	2	12
β-strand	147-149	3	13
β-strand	156-162	7	12
β-strand	167	1	14
β-strand	173	1	14
β-strand	175-180	6	13
β-strand	187-191	5	13
β-strand	195-196	2	13
α-helix	197	1
β-strand	204-208	5	12
β-strand	212-217	6	12
β-strand	226-232	7	13
α-helix	238	1
β-strand	240	1	13
β-strand	244-247	4	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Gaq	B	protein	361	Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	C	protein	71	Homo sapiens	P59768 (AlphaFold model)
Fusion protein,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Guanine…	D	protein	609	Homo sapiens	P62873 (AlphaFold model)
scFv16	E	protein	547	Mus musculus
Soluble cytochrome b562,2-oxoglutarate receptor 1,Soluble cytochrome b562,2-oxoglutarate receptor…	A	protein	1398	Escherichia coli, Homo sapiens, Escherichia coli K-12	P0ABE7 (AlphaFold model), P0AEX9 (AlphaFold model), Q96P68

Sequence of entity 1 (B), FASTA

>9VUS_1 Gaq (chains B)
MGCTLSAEDKAAVERSKMIEKQLQKDKQVYRRTLRLLLLGADNSGKSTIVKQMRIYHVNG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNDF
KSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPR
VTRAKYFIRKEFVDISTASGDGRHICYPHFTCSVDTENARRIFNDCKDIILQMNLREYNL
V

Sequence of entity 2 (C), FASTA

>9VUS_2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains C)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 3 (D), FASTA

>9VUS_3 Fusion protein,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains D)
MVSKGEEENMASTPFKFQLKGTINGKSFTVEGEGEGNSHEGSHKGKYVCTSGKLPMSWAA
LGTTFGYGMKYYTKYPSGLKNWFREVMPGGFTYDRHIQYKGDGSIHAKHQHFMKNGTYHN
IVEFTGQDFKENSPVLTGDMNVSLPNEVPQIPRDDGVECPVTLLYPLLSDKSKYVEAHQY
TICKPLHNQPAPDVPYHWIRKQYTQSKDDAEERDHICQSETLEAHLKGMDELYKGGGGSG
GGSMSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAK
IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL
DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQT
TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN
GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW
DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWNGSSGGGGSGGGGSSGVS
GWRLFKKIS

Sequence of entity 4 (E), FASTA

>9VUS_4 scFv16 (chains E)
MDMRVPAQLLGLLLLWLSGARCDVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVR
QAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVR
SIYYYGSSPFDFWGQGTTLTVSAGGGGSGGGGSGGGGSADIVMTQATSSVPVTPGESVSI
SCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTIS
RLEAEDVGVYYCMQHLEYPLTFGAGTKLELGGGSMDSTEAVIKEFMRFKVHMEGSMNGHE
FEIEGEGEGRPYEGTQTAKLKVTKGGPLPFSWDILSPQFMYGSRAFIKHPADIPDYWKQS
FPEGFKWERVMIFEDGGTVSVTQDTSLEDGTLIYKVKLRGGNFPPDGPVMQKRTMGWEAS
TERLYPEDVVLKGDIKMALRLKDGGRYLADFKTTYKAKKPVQMPGAFNIDRKLDITSHNE
DYTVVEQYERSVARHSTGGSGGSAAAWSHPQFEKGGGSGGGSGGSAWSHPQFEKGGGGSH
HHHHHHH

Sequence of entity 5 (A), FASTA

>9VUS_5 Soluble cytochrome b562,2-oxoglutarate receptor 1,Soluble cytochrome b562,2-oxoglutarate receptor 1,Soluble cytochrome b562,2-oxoglutarate receptor 1,Fusion protein,Maltose/maltodextrin-binding periplasmic protein,Maltose/maltodextrin-binding periplasmic protein,Maltose/maltodextrin-binding periplasmic protein (chains A)
MDMRVPAQLLGLLLLWLSGARCMDYKDDDDKGGSADLEDNWETLNDNLKVIEKADNAAQV
KDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKE
AQAAAEQLKTTRNAYIQKYLGSMNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPV
IYGIIFLVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGEN
WIFGDFMCKFIRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVW
IISLVAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCY
TTIIHTLTHGLQTDSCLKQKARRLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSIEN
QIHEAYIVSRPLAALNTFGNLLLYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYSNNPM
VFTLEDFVGDWEQTAAYNLDQVLEQGGVSSLLQNLAVSVTPIQRIVRSGENALKIDIHVI
IPYEGLSADQMAQIEEVFKVVYPVDDHHFKVILPYGTLVIDGVTPNMLNYFGRPYEGIAV
FDGKKITVTGTLWNGNKIIDERLITPDGSMLFRVTINSGGGSGGDEVDAGGSMAKIEEGK
LVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDR
FGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPP
KTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNA
GAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTV
LPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKS
YEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQT
GGGGSGGGGSMAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFP
QVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPI
AVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYA
FKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTING
PWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDE
GLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVI
NAASGRQTVDEALKDAQT

Ligands and cofactors

ID	Name	Formula	Copies
AKG	2-oxoglutaric acid	C5 H6 O5	1

Primary citation

The structure of akg bound OXGR1. Liang, E.Y., Su, Q., Ma, T.S. et al. To be published.

Other PDB entries of the same protein (UniProt P59768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8QEH 1.43 Å, Crystal structure of the G11 protein heterotrimer bound to FR900359 inhibitor
8QEG 1.7 Å, Crystal structure of the G11 protein heterotrimer bound to YM-254890 inhibitor
8F0K 1.9 Å, Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
9YDQ 1.94 Å, Human delta opioid receptor complex with mini-Gi and agonist DADLE and allosteric…
7MBX 1.95 Å, Human Cholecystokinin 1 receptor (CCK1R) Gs complex
9YDP 1.95 Å, Human delta opioid receptor complex with mini-Gi and agonist DADLE
6CRK 2.0 Å, Heterotrimeric G-protein in complex with an antibody fragment
8F0J 2.0 Å, Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
8F2B 2.0 Å, Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
9XXT 2.0 Å, Cryo-EM structure of lysophosphatidylserine (18:0)-bound GPR174-Gs complex
9EJZ 2.06 Å, Human M5 muscarinic acetylcholine receptor complex with mini-Gq, agonist acetylcholine…
6X18 2.1 Å, GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor

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