9WP1: Protein-tyrosine sulfotransferase 1

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase-1. Determined by X-ray diffraction at 3.2 Å resolution. Released 3 Jun 2026.

Method
X-ray diffraction
Resolution
3.2 Å
Organism
Homo sapiens
Chains
16
Atoms
18,142
Mol. weight
260.74 kDa
Ligands
ZN, MG, A3P
Released
3 Jun 2026

Explore 9WP1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WP1 contains 128 α-helices and 72 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C and E: 16 helices, 8 β-strands

ElementResiduesLengthSheet
β-strand71-7551
α-helix82-909
β-strand95-9621
α-helix103-11513
α-helix118-1269
α-helix131-14818
β-strand155-15951
α-helix161-1666
α-helix167-1737
β-strand177-18371
α-helix186-19611
β-strand20012
α-helix208-22922
β-strand234-23851
α-helix239-2446
α-helix246-25712
α-helix263-2719
β-strand27213
β-strand27813
α-helix287-2904
α-helix293-2942
α-helix308-3125
α-helix314-3174
α-helix319-3235
Chains B, D, F and H: 16 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand71-7664
α-helix82-909
β-strand95-9624
α-helix103-11513
α-helix118-1269
α-helix131-14818
β-strand155-15954
α-helix161-1666
α-helix167-1737
β-strand177-18374
α-helix186-19611
β-strand20015
α-helix208-22922
β-strand234-23854
α-helix239-2446
α-helix246-25712
α-helix263-2719
β-strand27216
β-strand27816
α-helix287-2904
α-helix293-2942
α-helix308-3125
α-helix314-3174
α-helix319-3235
Chain G: 16 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand71-75519
α-helix82-909
β-strand95-96219
α-helix103-11513
α-helix118-1269
α-helix131-14818
β-strand155-159519
α-helix161-1666
α-helix167-1737
β-strand177-183719
α-helix186-19611
β-strand200120
α-helix208-22922
β-strand234-238519
α-helix239-2446
α-helix246-25712
α-helix263-2719
β-strand272121
β-strand278121
α-helix287-2904
α-helix2931
α-helix308-3125
α-helix314-3174
α-helix319-3235
Chains L, M, N, O, P, Q, R and S: 0 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand312

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Protein-tyrosine sulfotransferase 1A, B, C, D, E, F, G, Hprotein276Homo sapiensO60507 (AlphaFold model)
C-C chemokine receptor type 5L, M, N, O, P, Q, R, Sprotein6Homo sapiensP51681 (AlphaFold model)
Sequence of entity 1 (A, B, C, D, E, F, G, H), FASTA
>9WP1_1 Protein-tyrosine sulfotransferase 1 (chains A, B, C, D, E, F, G, H)
AYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKEKIR
LDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFLLMV
RDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLV
LHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWV
GKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPD
Sequence of entity 2 (L, M, N, O, P, Q, R, S), FASTA
>9WP1_2 C-C chemokine receptor type 5 (chains L, M, N, O, P, Q, R, S)
MDYQVS

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn4
MGMagnesium ionMg8
A3PAdenosine-3'-5'-diphosphateC10 H15 N5 O10 P28

Primary citation

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase-1. Tanaka, S., Asano, H., Toyoda, K. et al. FEBS J (2026). DOI 10.1111/febs.70597 · PubMed

Other PDB entries of the same protein (UniProt O60507 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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