9WS6: PAK-2p34

Crystal structure of AMP-PNP-bound PAK2 kinase domain containing D368N mutant. Determined by X-ray diffraction at 2.0 Å resolution. Released 16 Sept 2026.

Method

X-ray diffraction

Resolution

2.0 Å

Organism

Homo sapiens

Chains

4

Atoms

9,673

Mol. weight

146.15 kDa

Ligands

MG, ANP

Released

16 Sept 2026

Explore 9WS6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WS6 contains 88 α-helices and 44 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 12 β-strands

Molecules and chains

>9WS6_1 PAK-2p34 (chains A, B, C, D)
MGSSHHHHHHSQDLEVLFQGPHMASMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASG
TVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFV
VMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRNIKSDNVLLGMEGS
VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP
PYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLK
LAKPLSSLTPLIMAAKEAMKSNR

Ligands and cofactors

Water and common crystallization additives (CL) are not listed.

Primary citation

Kinetic and structural insights into the autoactivation of PAK2 kinase domain: A research paradigm for studying self-activating enzyme. Chen, F.Y., Hu, H.-F., Wang, J. et al. To be published.

Related structures

Other PDB entries of the same protein (UniProt Q13177 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 9WS3 1.85 Å, Crystal structure of phosphorylated PAK2 kinase domain containing K278R mutant
• 9WS2 1.9 Å, Crystal structure of nucleotide-bound PAK2 kinase domain containing K278R mutant
• 9D51 2.1 Å, Structure of PAK2 in complex with compound 12
• 9WS5 2.4 Å, Crystal structure of PAK2 kinase domain containing D368N mutant
• 9LBF 2.62 Å, The crystal structure of the truncated PAK2 containing D368N mutant
• 3PCS 2.86 Å, Structure of EspG-PAK2 autoinhibitory Ialpha3 helix complex
• 9LBG 2.89 Å, The crystal structure of the truncated PAK2 containing K278R mutant
• 9M41 3.02 Å, The crystal structure of full-length PAK2 containing K278R and D368N mutants

Browse structure collections

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