9WVH: TONSL UBL domain

Crystal structure of TONSL UBL domain. Determined by X-ray diffraction at 1.96 Å resolution. Released 8 Oct 2025.

Method: X-ray diffraction
Resolution: 1.96 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,378
Mol. weight: 19.56 kDa
Released: 8 Oct 2025

Explore 9WVH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WVH contains 8 α-helices and 14 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	932-938	7	1
β-strand	942-947	6	2
β-strand	956	1	3
α-helix	957-972	16
β-strand	976-982	7	2
β-strand	985-986	2	2
α-helix	987-988	2
β-strand	992	1	3
α-helix	993-996	4
β-strand	1002-1010	9	2

Chain B: 5 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	932-938	7	2
α-helix	939-941	3
β-strand	942-947	6	1
α-helix	954-955	2
β-strand	956	1	4
α-helix	957-972	16
β-strand	976-982	7	1
β-strand	985-986	2	1
α-helix	987-988	2
β-strand	992	1	4
α-helix	993-996	4
β-strand	1002-1010	9	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tonsoku-like protein	A, B	protein	85	Homo sapiens	Q96HA7 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9WVH_1 Tonsoku-like protein (chains A, B)
HHHHHHIRVRVQVQDHLFLIPVPHSSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGAL
LAPQDLIPDVLQSNDEVLAEVTSWD

Primary citation

Pathogenic variants in the human TONSL protein associated with SPONASTRIME dysplasia impair protein dimerization and DNA repair. Karmakar, A., Roy, S. Sci Adv (2026) 12:eaee1129-eaee1129. DOI 10.1126/sciadv.aee1129 · PubMed

Other PDB entries of the same protein (UniProt Q96HA7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9WVI 2.19 Å, Crystal structure of TONSL UBL mutant - R934W
5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer

Browse structure collections

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