9WVI: TONSL UBL mutant - R934W

Crystal structure of TONSL UBL mutant - R934W. Determined by X-ray diffraction at 2.19 Å resolution. Released 8 Oct 2025.

Method: X-ray diffraction
Resolution: 2.19 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,656
Mol. weight: 39.2 kDa
Released: 8 Oct 2025

Explore 9WVI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WVI contains 14 α-helices and 28 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and D: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	933-939	7	1
β-strand	942-948	7	1
α-helix	954-955	2
β-strand	956	1	2
α-helix	957-972	16
β-strand	976-982	7	1
β-strand	985-986	2	1
α-helix	987-988	2
β-strand	992	1	2
α-helix	993-996	4
β-strand	1002-1010	9	1

Chain B: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	932-939	8	1
β-strand	942-949	8	1
β-strand	956	1	3
α-helix	957-972	16
β-strand	976-982	7	1
β-strand	985-987	3	1
α-helix	988	1
β-strand	992	1	3
α-helix	993-996	4
β-strand	1001-1010	10	1

Chain C: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	933-939	7	4
β-strand	942-948	7	4
β-strand	956	1	5
α-helix	957-972	16
β-strand	977-982	6	4
β-strand	985-987	3	4
α-helix	988	1
β-strand	992	1	5
α-helix	993-996	4
β-strand	1001-1009	9	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tonsoku-like protein	A, B, C, D	protein	85	Homo sapiens	Q96HA7 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>9WVI_1 Tonsoku-like protein (chains A, B, C, D)
HHHHHHIWVRVQVQDHLFLIPVPHSSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGAL
LAPQDLIPDVLQSNDEVLAEVTSWD

Primary citation

Pathogenic variants in the human TONSL protein associated with SPONASTRIME dysplasia impair protein dimerization and DNA repair. Karmakar, A., Roy, S. Sci Adv (2026) 12:eaee1129-eaee1129. DOI 10.1126/sciadv.aee1129 · PubMed

Other PDB entries of the same protein (UniProt Q96HA7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9WVH 1.96 Å, Crystal structure of TONSL UBL domain
5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer

Browse structure collections

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