9WYD: HAstV8 spike and FcRn

Crystal structure of HAstV8 spike and FcRn. Determined by X-ray diffraction at 2.65 Å resolution. Released 11 Feb 2026.

Method: X-ray diffraction
Resolution: 2.65 Å
Organisms: Homo sapiens, Human astrovirus-8
Chains: 3
Atoms: 4,581
Mol. weight: 68.3 kDa
Released: 11 Feb 2026

Explore 9WYD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WYD contains 15 α-helices and 44 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	29-37	9	1
α-helix	40-41	2
β-strand	47-53	7	1
β-strand	56-62	7	1
β-strand	69-70	2	1
α-helix	83-103	21
β-strand	112-122	11	1
β-strand	126-135	10	1
β-strand	138-144	7	1
β-strand	149-151	3	1
α-helix	155-167	13
α-helix	169-171	3
α-helix	172-175	4
α-helix	176-181	6
α-helix	182-192	11
α-helix	194-198	5
β-strand	201	1	2
β-strand	205-209	5	3
β-strand	219-226	8	3
β-strand	227	1	2
β-strand	232-237	6	4
β-strand	240	1	4
β-strand	246-251	6	3
β-strand	257-263	7	3
β-strand	273-278	6	4
β-strand	286-288	3	4

Chain B: 3 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	24-25	2
β-strand	26-31	6	5
β-strand	41-50	10	5
β-strand	56-61	6	6
β-strand	64-65	2	6
α-helix	66	1
β-strand	70-71	2	5
α-helix	72-74	3
β-strand	75-76	2	5
β-strand	82-90	9	5
β-strand	98-103	6	6
β-strand	111-114	4	6

Chain C: 4 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	492-498	7	7
α-helix	501-502	2
β-strand	513-514	2	8
β-strand	527-531	5	7
β-strand	534-537	4	7
β-strand	540-550	11	7
β-strand	556	1	7
α-helix	561-563	3
β-strand	567-570	4	7
β-strand	573-588	16	7
β-strand	592-603	12	7
β-strand	607-614	8	8
β-strand	616-617	2	9
β-strand	629	1	10
β-strand	630-631	2	9
β-strand	636-642	7	8
β-strand	647-657	11	7
α-helix	670-672	3
β-strand	677	1	10
α-helix	689-691	3
β-strand	695-701	7	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
IgG receptor FcRn large subunit p51	A	protein	274	Homo sapiens	P55899 (AlphaFold model)
Beta-2-microglobulin	B	protein	99	Homo sapiens	P61769 (AlphaFold model)
Spike protein VP27	C	protein	232	Human astrovirus-8	Q9IFX1

Sequence of entity 1 (A), FASTA

>9WYD_1 IgG receptor FcRn large subunit p51 (chains A)
AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWY
WEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNF
DLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPP
SMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSL
TVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSS

Sequence of entity 2 (B), FASTA

>9WYD_2 Beta-2-microglobulin (chains B)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>9WYD_3 Spike protein VP27 (chains C)
GATPMTFGRSIPEPGEQFRVLLTVGPPMAPNTANSQNWVNKTIVPPENQYTVKIGIDLEH
YTTMQGFTPVESVSWYTADFQPSDEPSPIPGLYARVNNTKKADVYGVQQFKSSHTNNRHQ
ITSVFLVRVTTSFQVINYTSYFIRGAESGSNVSNLKIRDQTYHTPLQFTQGKWYLLTSTV
MHDGPTSSGWVWMNQELTNNIAYRVDPGMMYLITPPPAASQLYFELHTVLPQ

Primary citation

The conserved human astrovirus-receptor interface reveals a targetable vulnerability for antiviral development. Wang, W., Xu, Y., Li, Z. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-70465-5 · PubMed

Other PDB entries of the same protein (UniProt P55899 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6C98 1.85 Å, Crystal structure of FcRn bound to UCB-84
6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
6C97 2.0 Å, Crystal structure of FcRn at pH3
6C99 2.0 Å, Crystal structure of FcRn bound to UCB-303
9TF0 2.26 Å, Structure of echovirus 18 in complex with neonatal Fc receptor
6NHA 2.38 Å, Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
6LA6 2.39 Å, Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4
4K71 2.4 Å, Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal…
6WNA 2.4 Å, Next generation monomeric IgG4 Fc
9MI6 2.41 Å, Crystal structure of human FcRn in complex with nipocalimab Fab fragment
6QIP 2.45 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
6WOL 2.49 Å, Next generation monomeric IgG4 Fc bound to neonatal Fc receptor

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