9YNC: Motor domains of phi-like human dynein-1

Motor domains of phi-like human dynein-1 bound to dynactin-p150glued and LIS1. Determined by electron microscopy at 3.93 Å resolution. Released 28 Jan 2026.

Method: Electron microscopy
Resolution: 3.93 Å
Organisms: Homo sapiens, Sus scrofa
Chains: 10
Atoms: 56,882
Mol. weight: 1683.81 kDa
Ligands: ADP, ATP, MG
Released: 28 Jan 2026

Explore 9YNC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9YNC contains 339 α-helices and 194 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 160 helices, 68 β-strands

Element	Residues	Length	Sheet
α-helix	1356-1370	15
α-helix	1375-1379	5
α-helix	1381-1394	14
α-helix	1397-1404	8
α-helix	1410-1420	11
α-helix	1431-1436	6
α-helix	1444-1471	28
β-strand	1474	1	1
β-strand	1478-1480	3	2
β-strand	1484-1486	3	2
α-helix	1491-1509	19
α-helix	1511-1516	6
α-helix	1517-1553	37
α-helix	1556-1560	5
α-helix	1562-1584	23
β-strand	1587	1	1
α-helix	1588-1592	5
α-helix	1597-1614	18
α-helix	1616-1625	10
α-helix	1627-1631	5
α-helix	1634-1642	9
α-helix	1647-1652	6
α-helix	1654-1656	3
β-strand	1663-1666	4	3
β-strand	1672-1677	6	3
β-strand	1683-1691	9	3
α-helix	1698-1727	30
α-helix	1735-1744	10
α-helix	1747-1769	23
α-helix	1778-1796	19
α-helix	1802-1828	27
α-helix	1836-1840	5
β-strand	1843-1846	4	4
α-helix	1854-1856	3
β-strand	1857-1861	5	4
β-strand	1864-1867	4	4
α-helix	1879-1881	3
α-helix	1883-1897	15
β-strand	1901-1905	5	5
α-helix	1912-1922	11
β-strand	1927-1931	5	5
α-helix	1938-1951	14
β-strand	1954-1958	5	5
α-helix	1960-1962	3
α-helix	1965-1985	21
α-helix	1995-1997	3
β-strand	1998-2001	4	6
β-strand	2004-2007	4	6
β-strand	2013-2018	6	5
α-helix	2025-2029	5
α-helix	2030-2034	5
β-strand	2036-2040	5	5
α-helix	2046-2057	12
α-helix	2062-2079	18
α-helix	2081-2082	2
α-helix	2090-2118	29
α-helix	2124-2129	6
α-helix	2133-2145	13
α-helix	2146-2148	3
α-helix	2153-2164	12
α-helix	2172-2174	3
α-helix	2176-2188	13
α-helix	2201-2216	16
β-strand	2219-2223	5	7
α-helix	2231-2245	15
β-strand	2249-2254	6	7
α-helix	2261-2265	5
β-strand	2266-2268	3	8
β-strand	2275-2277	3	8
α-helix	2279-2289	11
β-strand	2298-2304	7	7
α-helix	2309-2312	4
α-helix	2313-2315	3
β-strand	2324-2326	3	9
β-strand	2332-2334	3	9
α-helix	2335-2336	2
β-strand	2339-2345	7	7
α-helix	2353-2357	5
β-strand	2360-2363	4	7
α-helix	2366-2368	3
α-helix	2371-2384	14
α-helix	2411-2423	13
α-helix	2432-2440	9
α-helix	2448-2449	2
α-helix	2451-2475	25
α-helix	2483-2503	21
α-helix	2508-2521	14
β-strand	2538-2540	3	10
β-strand	2544-2546	3	10
α-helix	2548-2551	4
α-helix	2559-2561	3
α-helix	2572-2585	14
β-strand	2591-2594	4	11
α-helix	2601-2609	9
β-strand	2615-2620	6	11
α-helix	2629-2638	10
β-strand	2639-2644	6	12
β-strand	2647-2652	6	12
β-strand	2658-2663	6	11
α-helix	2678-2689	12
β-strand	2691-2694	4	12
β-strand	2699-2703	5	12
β-strand	2706-2712	7	11
α-helix	2722-2724	3
α-helix	2725-2730	6
β-strand	2733-2735	3	11
α-helix	2737-2740	4
α-helix	2741-2755	15
α-helix	2760-2765	6
α-helix	2766-2783	18
α-helix	2796-2810	15
α-helix	2818-2833	16
α-helix	2840-2857	18
α-helix	2863-2866	4
β-strand	2873-2874	2	13
β-strand	2882-2883	2	13
α-helix	2886-2903	18
α-helix	2913-2927	15
β-strand	2932-2937	6	14
α-helix	2943-2954	12
β-strand	2957-2960	4	14
α-helix	2969-2980	12
α-helix	2981-2985	5
β-strand	2990-2995	6	14
α-helix	2996-2998	3
α-helix	3002-3014	13
α-helix	3024-3040	17
α-helix	3047-3061	15
β-strand	3063-3068	6	14
α-helix	3072-3081	10
α-helix	3083-3086	4
β-strand	3089-3095	7	14
α-helix	3097-3098	2
α-helix	3099-3109	11
α-helix	3110-3112	3
α-helix	3120-3123	4
α-helix	3139-3164	26
α-helix	3169-3171	3
α-helix	3173-3251	79
α-helix	3441-3516	76
α-helix	3522-3538	17
α-helix	3549-3552	4
α-helix	3556-3564	9
α-helix	3571-3581	11
α-helix	3586	1
β-strand	3587-3590	4	15
α-helix	3595-3603	9
β-strand	3610-3613	4	15
α-helix	3619-3629	11
β-strand	3632-3636	5	15
α-helix	3638-3640	3
α-helix	3643-3645	3
α-helix	3646-3650	5
β-strand	3654-3656	3	16
β-strand	3659-3664	6	16
β-strand	3667-3670	4	16
β-strand	3676-3681	6	15
α-helix	3690-3695	6
β-strand	3697-3700	4	15
α-helix	3705-3720	16
α-helix	3722-3755	34
α-helix	3760-3762	3
α-helix	3764-3798	35
α-helix	3799-3801	3
α-helix	3802-3817	16
α-helix	3818-3820	3
α-helix	3829-3841	13
α-helix	3844-3846	3
α-helix	3852-3873	22
α-helix	3877-3893	17
α-helix	3902-3910	9
α-helix	3929-3938	10
α-helix	3942-3944	3
α-helix	3947-3953	7
α-helix	3957-3961	5
α-helix	3966-3968	3
α-helix	3982-3996	15
α-helix	3998-4000	3
α-helix	4001-4013	13
α-helix	4015-4017	3
α-helix	4019-4022	4
α-helix	4024-4025	2
α-helix	4027-4029	3
α-helix	4030-4034	5
β-strand	4041-4045	5	17
α-helix	4052-4062	11
β-strand	4066-4070	5	17
α-helix	4074-4090	17
β-strand	4093-4097	5	17
α-helix	4099-4101	3
α-helix	4103-4114	12
β-strand	4123-4129	7	17
α-helix	4136-4141	6
β-strand	4143-4147	5	17
α-helix	4153-4163	11
α-helix	4166-4169	4
α-helix	4176-4193	18
α-helix	4209-4226	18
α-helix	4235-4237	3
α-helix	4240-4246	7
α-helix	4247-4251	5
α-helix	4259-4272	14
α-helix	4275-4278	4
β-strand	4283-4285	3	18
β-strand	4294-4295	2	18
α-helix	4296-4297	2
α-helix	4302-4310	9
α-helix	4318-4321	4
α-helix	4325-4328	4
α-helix	4329-4343	15
α-helix	4375-4390	16
α-helix	4396-4398	3
α-helix	4402-4405	4
α-helix	4408-4439	32
α-helix	4446-4456	11
α-helix	4475-4497	23
α-helix	4500-4506	7
β-strand	4508-4510	3	19
α-helix	4517-4532	16
β-strand	4539-4546	8	19
β-strand	4557-4561	5	19
β-strand	4564-4571	8	20
β-strand	4574-4584	11	20
β-strand	4587-4594	8	19
β-strand	4604-4610	7	20
β-strand	4618-4626	9	20
α-helix	4632-4637	6
β-strand	4641-4643	3	20

Chain B: 158 helices, 68 β-strands

Element	Residues	Length	Sheet
α-helix	1356-1372	17
α-helix	1375-1378	4
α-helix	1381-1389	9
α-helix	1390-1394	5
α-helix	1397-1402	6
α-helix	1410-1419	10
α-helix	1431-1436	6
α-helix	1439-1472	34
β-strand	1474	1	21
β-strand	1476-1480	5	22
β-strand	1484-1488	5	22
α-helix	1490-1509	20
α-helix	1517-1553	37
α-helix	1556-1560	5
α-helix	1562-1584	23
β-strand	1587	1	21
α-helix	1588-1592	5
α-helix	1597-1613	17
α-helix	1616-1625	10
α-helix	1627-1631	5
α-helix	1634-1642	9
α-helix	1647-1652	6
α-helix	1654-1656	3
β-strand	1661-1666	6	23
β-strand	1672-1678	7	23
β-strand	1683-1691	9	23
α-helix	1698-1727	30
α-helix	1735-1744	10
α-helix	1747-1768	22
α-helix	1769-1771	3
α-helix	1778-1797	20
α-helix	1802-1827	26
α-helix	1836-1839	4
β-strand	1843-1846	4	24
α-helix	1853-1855	3
β-strand	1857-1861	5	24
β-strand	1864-1867	4	24
α-helix	1877-1880	4
α-helix	1883-1897	15
β-strand	1901-1905	5	25
α-helix	1912-1923	12
β-strand	1927-1931	5	25
α-helix	1938-1951	14
β-strand	1954-1958	5	25
α-helix	1960-1962	3
α-helix	1965-1984	20
β-strand	1998-2001	4	26
β-strand	2004-2007	4	26
β-strand	2013-2018	6	25
α-helix	2026-2029	4
α-helix	2030-2033	4
β-strand	2036-2040	5	25
α-helix	2046-2057	12
α-helix	2062-2079	18
α-helix	2090-2117	28
α-helix	2124-2129	6
α-helix	2133-2145	13
α-helix	2146-2148	3
α-helix	2153-2164	12
α-helix	2176-2188	13
α-helix	2201-2216	16
β-strand	2219-2223	5	27
α-helix	2230-2245	16
β-strand	2249-2254	6	27
α-helix	2261-2265	5
β-strand	2266-2268	3	28
β-strand	2275-2277	3	28
α-helix	2279-2289	11
α-helix	2294-2296	3
β-strand	2298-2303	6	27
α-helix	2313-2315	3
α-helix	2316-2319	4
β-strand	2324-2326	3	29
β-strand	2332-2334	3	29
α-helix	2335-2336	2
β-strand	2339-2345	7	27
α-helix	2353-2357	5
β-strand	2360-2363	4	27
α-helix	2366-2368	3
α-helix	2371-2384	14
α-helix	2411-2423	13
α-helix	2432-2442	11
α-helix	2451-2475	25
α-helix	2480-2482	3
α-helix	2483-2502	20
α-helix	2508-2521	14
α-helix	2534-2536	3
β-strand	2537-2539	3	30
β-strand	2545-2547	3	30
α-helix	2548-2551	4
α-helix	2559-2561	3
α-helix	2572-2586	15
β-strand	2591-2594	4	31
α-helix	2601-2611	11
β-strand	2615-2620	6	31
α-helix	2629-2638	10
β-strand	2639-2644	6	32
β-strand	2647-2652	6	32
β-strand	2658-2663	6	31
α-helix	2678-2689	12
β-strand	2691-2694	4	32
β-strand	2699-2703	5	32
β-strand	2706-2712	7	31
α-helix	2722-2724	3
α-helix	2725-2728	4
β-strand	2733-2735	3	31
α-helix	2737-2740	4
α-helix	2741-2755	15
α-helix	2756-2758	3
α-helix	2760-2765	6
α-helix	2766-2783	18
α-helix	2796-2810	15
α-helix	2818-2834	17
α-helix	2840-2857	18
α-helix	2863-2866	4
β-strand	2873-2874	2	33
β-strand	2882-2883	2	33
α-helix	2886-2903	18
α-helix	2913-2926	14
β-strand	2932-2937	6	34
α-helix	2943-2953	11
α-helix	2956	1
β-strand	2957-2959	3	34
α-helix	2969-2980	12
α-helix	2981-2985	5
β-strand	2990-2995	6	34
α-helix	2996-2998	3
α-helix	3002-3014	13
α-helix	3024-3040	17
α-helix	3047-3061	15
β-strand	3063-3068	6	34
α-helix	3072-3081	10
α-helix	3084-3087	4
β-strand	3090-3095	6	34
α-helix	3097-3098	2
α-helix	3099-3109	11
α-helix	3139-3164	26
α-helix	3173-3251	79
α-helix	3440-3481	42
α-helix	3483-3516	34
α-helix	3522-3538	17
α-helix	3549-3553	5
α-helix	3556-3564	9
α-helix	3571-3581	11
α-helix	3586	1
β-strand	3587-3590	4	35
α-helix	3595-3604	10
β-strand	3610-3613	4	35
α-helix	3619-3629	11
β-strand	3633-3636	4	35
α-helix	3638-3640	3
α-helix	3646-3649	4
β-strand	3654	1	36
β-strand	3661-3664	4	36
β-strand	3667-3670	4	36
β-strand	3677-3681	5	35
α-helix	3690-3695	6
β-strand	3697-3700	4	35
α-helix	3705-3720	16
α-helix	3722-3754	33
α-helix	3760-3762	3
α-helix	3764-3798	35
α-helix	3799-3801	3
α-helix	3802-3817	16
α-helix	3818-3820	3
α-helix	3829-3840	12
α-helix	3844-3846	3
α-helix	3852-3873	22
α-helix	3877-3893	17
α-helix	3902-3910	9
α-helix	3929-3938	10
α-helix	3942-3944	3
α-helix	3947-3953	7
α-helix	3957-3962	6
α-helix	3966-3969	4
α-helix	3982-3996	15
α-helix	3998-4000	3
α-helix	4001-4012	12
α-helix	4015-4017	3
α-helix	4019-4022	4
α-helix	4024-4025	2
α-helix	4027-4029	3
α-helix	4030-4034	5
β-strand	4041-4045	5	37
α-helix	4052-4062	11
β-strand	4066-4070	5	37
α-helix	4074-4090	17
β-strand	4093-4097	5	37
α-helix	4099-4101	3
α-helix	4103-4114	12
β-strand	4123-4129	7	37
α-helix	4136-4141	6
β-strand	4143-4147	5	37
α-helix	4153-4163	11
α-helix	4166-4169	4
α-helix	4176-4193	18
α-helix	4197-4200	4
α-helix	4209-4226	18
α-helix	4235-4237	3
α-helix	4240-4246	7
α-helix	4247-4251	5
α-helix	4259-4272	14
α-helix	4275-4278	4
β-strand	4283-4285	3	38
β-strand	4294-4295	2	38
α-helix	4296-4297	2
α-helix	4302-4310	9
α-helix	4327-4346	20
α-helix	4375-4390	16
α-helix	4402-4405	4
α-helix	4408-4438	31
α-helix	4446-4456	11
α-helix	4459-4461	3
α-helix	4475-4497	23
α-helix	4501-4506	6
β-strand	4509-4510	2	39
α-helix	4517-4532	16
β-strand	4539-4546	8	39
β-strand	4557-4561	5	39
β-strand	4564-4571	8	40
β-strand	4574-4584	11	40
β-strand	4587-4594	8	39
β-strand	4604-4610	7	40
β-strand	4618-4626	9	40
α-helix	4632-4637	6
β-strand	4641-4643	3	40

Chain C: 3 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	96-104	9	41
β-strand	111-116	6	42
β-strand	123-127	5	42
β-strand	132-136	5	42
β-strand	141-146	6	42
β-strand	153-158	6	43
β-strand	164-169	6	43
β-strand	174-178	5	43
β-strand	183-188	6	43
β-strand	195-200	6	44
β-strand	206-211	6	44
β-strand	215-220	6	44
β-strand	226-231	6	44
β-strand	237-242	6	45
β-strand	248-253	6	45
β-strand	258-262	5	45
β-strand	267-272	6	45
β-strand	279-284	6	46
α-helix	287-289	3
α-helix	290-297	8
α-helix	299-302	4
β-strand	310-315	6	46
β-strand	319-324	6	46
β-strand	329-335	7	46
β-strand	341-346	6	47
β-strand	353-357	5	47
β-strand	361-366	6	47
β-strand	371-376	6	47
β-strand	385-388	4	41
β-strand	394-398	5	41
β-strand	404-409	6	41

Chain D: 3 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	91-93	3
β-strand	96	1	48
β-strand	102-105	4	49
β-strand	111-116	6	50
β-strand	123-127	5	50
β-strand	132-136	5	50
β-strand	141-146	6	50
β-strand	153-158	6	51
β-strand	164-169	6	51
β-strand	173-178	6	51
β-strand	183-189	7	51
β-strand	197-199	3	52
β-strand	206-210	5	52
β-strand	215-220	6	52
β-strand	226-231	6	52
β-strand	237-242	6	53
β-strand	248-253	6	53
β-strand	257-262	6	53
β-strand	267-272	6	53
β-strand	279-284	6	54
α-helix	285-286	2
α-helix	289-296	8
β-strand	310-315	6	54
β-strand	319-324	6	54
β-strand	329-335	7	54
β-strand	341-346	6	55
β-strand	352-357	6	55
β-strand	361-366	6	55
β-strand	371-377	7	55
β-strand	385-388	4	49
β-strand	394-398	5	49
β-strand	403-408	6	49
β-strand	409	1	48

Chain E: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	5-21	17
α-helix	25-35	11
α-helix	41-44	4
α-helix	45-47	3
α-helix	50-56	7
α-helix	58-74	17

Chain F: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	5-20	16
α-helix	25-35	11
α-helix	42-46	5
α-helix	50-74	25

Chains G and H: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	4-34	31

Chain I: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	418-537	120

1 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cytoplasmic dynein 1 heavy chain 1	A, B	protein	4646	Homo sapiens	Q14204
Platelet-activating factor acetylhydrolase IB subunit beta	C, D, E, F	protein	410	Homo sapiens	P43034 (AlphaFold model)
Cytoplasmic dynein 1 intermediate chain 2	G, H	protein	638	Homo sapiens	Q13409 (AlphaFold model)
Dynactin subunit 1	I, J	protein	1281	Sus scrofa	A0A287B8J2 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9YNC_1 Cytoplasmic dynein 1 heavy chain 1 (chains A, B)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE

Sequence of entity 2 (C, D, E, F), FASTA

>9YNC_2 Platelet-activating factor acetylhydrolase IB subunit beta (chains C, D, E, F)
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR

Sequence of entity 3 (G, H), FASTA

>9YNC_3 Cytoplasmic dynein 1 intermediate chain 2 (chains G, H)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA

Sequence of entity 4 (I, J), FASTA

>9YNC_4 Dynactin subunit 1 (chains I, J)
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRRE
GTDSNAKTSKLRGPKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGAQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGIRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGI
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSVLKGAQMKASLAALPPLHVAKLSLPPHE
GPGSELAAGALYRKTNQLLETLNQLSTHTHVVDITRSSPAAKSPSAQLLEQVTQLKSLSD
TIEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLG
QRHRLVLTQEQLHQLHDRLIS

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	2
MG	Magnesium ion	Mg	4

Primary citation

Roles of microtubules and LIS1 in dynein transport machinery assembly. Rao, Q., Yang, J., Chai, P. et al. Nature (2026) 652:1384-1392. DOI 10.1038/s41586-026-10153-y · PubMed

Other PDB entries of the same protein (UniProt Q14204), best resolution first:

5OWO 1.79 Å, Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution
9BLZ 2.2 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATP
9BMR 2.6 Å, State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP
9DH5 2.6 Å, State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+
9E0X 2.7 Å, Cryo-EM structure of Phi dynein
9E10 2.71 Å, Dimeric motor domains from phi dynein-1 under Lis1 condition
9BM0 2.8 Å, State-2 of motor domain from full-length human dynein-1 in 5mM ATP
9BMF 2.8 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi
9BMH 2.8 Å, State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi
9BN3 2.8 Å, The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1
9BM2 2.82 Å, State-4 of motor domain from full-length human dynein-1 in 5 mM ATP
9BMG 2.86 Å, State-2 of full-length human dynein-1 in 5mM ATPVi

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