9YNH: Cytoplasmic dynein 1 heavy chain 1

Full-length human cytoplasmic dynein-1 in phi-like state bound to dynactin-p150glued and LIS1. Determined by electron microscopy at 5.5 Å resolution. Released 28 Jan 2026.

Method: Electron microscopy
Resolution: 5.5 Å
Organism: Homo sapiens
Chains: 18
Atoms: 62,508
Mol. weight: 1909.38 kDa
Ligands: ADP, ATP, MG
Released: 28 Jan 2026

Explore 9YNH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9YNH contains 529 α-helices and 372 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 208 helices, 87 β-strands

Element	Residues	Length	Sheet
α-helix	27-43	17
α-helix	50-52	3
α-helix	53-57	5
α-helix	59-68	10
β-strand	82-87	6	1
β-strand	95-100	6	1
β-strand	113	1	1
β-strand	117	1	2
α-helix	132-134	3
β-strand	138	1	2
α-helix	147-152	6
α-helix	153-157	5
α-helix	158-165	8
α-helix	166-170	5
α-helix	178-192	15
α-helix	211-220	10
α-helix	233-237	5
α-helix	239-257	19
α-helix	258-260	3
α-helix	271-289	19
α-helix	295-304	10
α-helix	311-318	8
α-helix	324-330	7
α-helix	332-335	4
α-helix	340-343	4
α-helix	351-367	17
α-helix	374-397	24
α-helix	401-403	3
α-helix	406-443	38
α-helix	455-464	10
α-helix	467-482	16
α-helix	514-517	4
α-helix	520-529	10
α-helix	540-549	10
α-helix	551-563	13
α-helix	565-574	10
β-strand	575	1	3
α-helix	585-588	4
α-helix	591-593	3
α-helix	595-600	6
α-helix	605-623	19
α-helix	631-637	7
α-helix	643-668	26
α-helix	677-691	15
α-helix	696-709	14
β-strand	723	1	4
β-strand	732	1	4
α-helix	741-755	15
α-helix	764-777	14
α-helix	779-797	19
α-helix	806-818	13
α-helix	829-865	37
α-helix	871-890	20
α-helix	896-926	31
β-strand	962-963	2	5
α-helix	965-967	3
β-strand	970-971	2	5
α-helix	975-991	17
α-helix	1001-1004	4
α-helix	1021-1024	4
α-helix	1029-1055	27
α-helix	1058-1061	4
α-helix	1065-1071	7
α-helix	1083-1088	6
β-strand	1102	1	6
β-strand	1105	1	6
α-helix	1113-1153	41
α-helix	1163-1190	28
α-helix	1194-1199	6
α-helix	1212-1235	24
α-helix	1239-1263	25
α-helix	1275-1303	29
α-helix	1313-1346	34
α-helix	1356-1371	16
α-helix	1381-1403	23
α-helix	1410-1420	11
α-helix	1444-1471	28
β-strand	1474	1	7
β-strand	1478-1480	3	8
β-strand	1484-1486	3	8
α-helix	1490-1508	19
α-helix	1513-1516	4
α-helix	1517-1553	37
α-helix	1555-1560	6
α-helix	1562-1584	23
β-strand	1587	1	7
α-helix	1588-1593	6
α-helix	1597-1614	18
α-helix	1616-1623	8
α-helix	1629-1631	3
α-helix	1634-1642	9
α-helix	1649-1651	3
α-helix	1654-1657	4
β-strand	1661-1666	6	9
β-strand	1672-1678	7	9
β-strand	1683-1691	9	9
α-helix	1698-1727	30
α-helix	1735-1742	8
α-helix	1747-1769	23
α-helix	1777-1796	20
α-helix	1802-1828	27
α-helix	1836-1840	5
β-strand	1843-1846	4	10
β-strand	1857-1860	4	10
β-strand	1866-1867	2	10
α-helix	1877-1880	4
α-helix	1883-1897	15
β-strand	1901-1905	5	11
α-helix	1912-1923	12
β-strand	1927-1931	5	11
α-helix	1938-1951	14
β-strand	1954-1958	5	11
α-helix	1960-1962	3
α-helix	1965-1986	22
α-helix	1995-1997	3
β-strand	1998-2000	3	12
β-strand	2005-2007	3	12
β-strand	2013-2018	6	11
α-helix	2026-2029	4
α-helix	2030-2035	6
β-strand	2036-2040	5	11
α-helix	2046-2057	12
α-helix	2062-2079	18
α-helix	2090-2118	29
α-helix	2124-2129	6
α-helix	2133-2145	13
α-helix	2146-2148	3
α-helix	2154-2164	11
α-helix	2176-2188	13
α-helix	2201-2214	14
β-strand	2219-2223	5	13
α-helix	2230-2245	16
β-strand	2252-2254	3	13
α-helix	2261-2265	5
α-helix	2279-2289	11
β-strand	2301-2304	4	13
α-helix	2309-2314	6
β-strand	2324-2325	2	14
β-strand	2333-2334	2	14
β-strand	2341-2345	5	13
α-helix	2353-2357	5
β-strand	2360-2363	4	13
α-helix	2371-2384	14
α-helix	2411-2426	16
α-helix	2432-2442	11
α-helix	2451-2475	25
α-helix	2480-2482	3
α-helix	2483-2503	21
α-helix	2508-2520	13
β-strand	2538-2540	3	15
β-strand	2544-2546	3	15
α-helix	2548-2551	4
α-helix	2559-2561	3
α-helix	2572-2586	15
β-strand	2591-2594	4	16
α-helix	2601-2609	9
β-strand	2615-2620	6	16
α-helix	2628-2638	11
β-strand	2639-2644	6	17
β-strand	2647-2652	6	17
β-strand	2658-2663	6	16
α-helix	2678-2684	7
α-helix	2685-2689	5
β-strand	2694	1	18
β-strand	2699	1	18
β-strand	2702-2703	2	17
β-strand	2706-2712	7	16
α-helix	2721-2724	4
α-helix	2725-2728	4
β-strand	2733-2735	3	16
α-helix	2738-2740	3
α-helix	2741-2756	16
α-helix	2760-2762	3
α-helix	2766-2783	18
α-helix	2796-2810	15
α-helix	2818-2833	16
α-helix	2840-2857	18
α-helix	2863-2866	4
β-strand	2873	1	19
β-strand	2883	1	19
α-helix	2886-2903	18
α-helix	2913-2927	15
β-strand	2932-2937	6	20
α-helix	2943-2954	12
α-helix	2956	1
β-strand	2957-2959	3	20
α-helix	2969-2984	16
β-strand	2990-2994	5	20
α-helix	3002-3013	12
α-helix	3024-3040	17
α-helix	3047-3061	15
β-strand	3063-3068	6	20
α-helix	3072-3081	10
α-helix	3083-3087	5
β-strand	3090	1	20
β-strand	3093-3095	3	20
α-helix	3097-3098	2
α-helix	3099-3109	11
α-helix	3121-3123	3
α-helix	3139-3164	26
α-helix	3173-3251	79
α-helix	3442-3513	72
α-helix	3522-3538	17
α-helix	3556-3564	9
α-helix	3571-3581	11
β-strand	3587-3590	4	21
α-helix	3595-3603	9
β-strand	3610-3613	4	21
α-helix	3619-3629	11
β-strand	3633-3636	4	21
α-helix	3638-3640	3
α-helix	3645-3649	5
β-strand	3654-3656	3	22
β-strand	3659-3664	6	22
β-strand	3667-3670	4	22
β-strand	3677-3681	5	21
α-helix	3690-3694	5
β-strand	3697-3700	4	21
α-helix	3705-3720	16
α-helix	3722-3754	33
α-helix	3764-3817	54
α-helix	3818-3820	3
α-helix	3829-3841	13
α-helix	3844-3846	3
α-helix	3852-3871	20
α-helix	3872-3874	3
α-helix	3877-3894	18
α-helix	3902-3909	8
α-helix	3929-3938	10
α-helix	3942-3944	3
α-helix	3947-3953	7
α-helix	3957-3962	6
α-helix	3966-3968	3
α-helix	3979-3981	3
α-helix	3982-3996	15
α-helix	3998-4000	3
α-helix	4001-4013	13
α-helix	4015-4018	4
α-helix	4024-4025	2
α-helix	4027-4029	3
α-helix	4030-4034	5
β-strand	4041-4042	2	23
β-strand	4045	1	24
α-helix	4052-4061	10
β-strand	4066-4067	2	23
α-helix	4069	1
β-strand	4070	1	23
α-helix	4074-4090	17
α-helix	4092	1
β-strand	4093-4097	5	23
α-helix	4099-4101	3
α-helix	4103-4114	12
β-strand	4124-4127	4	23
β-strand	4129	1	24
α-helix	4136-4141	6
β-strand	4143-4144	2	23
β-strand	4147	1	24
α-helix	4153-4163	11
α-helix	4166-4169	4
α-helix	4174-4195	22
α-helix	4197-4200	4
α-helix	4209-4226	18
α-helix	4240-4246	7
α-helix	4247-4251	5
α-helix	4253-4255	3
α-helix	4259-4272	14
α-helix	4276-4278	3
β-strand	4283	1	25
β-strand	4295	1	25
α-helix	4296-4297	2
α-helix	4302-4310	9
α-helix	4318-4321	4
α-helix	4327-4346	20
α-helix	4375-4390	16
α-helix	4402-4406	5
α-helix	4408-4438	31
α-helix	4446-4457	12
α-helix	4475-4496	22
α-helix	4501-4506	6
β-strand	4509	1	26
α-helix	4517-4532	16
β-strand	4539-4545	7	26
β-strand	4557-4560	4	26
β-strand	4564-4565	2	27
β-strand	4568-4571	4	28
β-strand	4574-4577	4	28
β-strand	4583-4584	2	27
β-strand	4588-4594	7	26
α-helix	4595	1
β-strand	4604-4610	7	27
β-strand	4620-4625	6	27
β-strand	4626	1	28
α-helix	4627	1
α-helix	4632-4637	6
β-strand	4642-4643	2	27

Chain B: 212 helices, 97 β-strands

Element	Residues	Length	Sheet
α-helix	27-37	11
α-helix	38-42	5
α-helix	50-56	7
α-helix	59-70	12
β-strand	77	1	29
β-strand	78-86	9	30
α-helix	95	1
β-strand	96-104	9	30
β-strand	111	1	31
β-strand	113-115	3	30
β-strand	118-119	2	29
β-strand	136-137	2	29
β-strand	140	1	30
β-strand	143	1	31
α-helix	146-156	11
α-helix	158-166	9
α-helix	178-195	18
β-strand	199	1	32
α-helix	211-219	9
α-helix	229-231	3
α-helix	239-260	22
β-strand	263	1	32
α-helix	271-291	21
α-helix	295-305	11
α-helix	310-313	4
α-helix	314-318	5
α-helix	322-332	11
α-helix	333-335	3
α-helix	342-346	5
α-helix	350-366	17
α-helix	367-369	3
α-helix	374-399	26
α-helix	406-443	38
α-helix	455-482	28
α-helix	514-531	18
α-helix	542-567	26
α-helix	568-572	5
α-helix	580-585	6
α-helix	595-598	4
α-helix	601-603	3
α-helix	604-608	5
α-helix	609-613	5
α-helix	617-624	8
α-helix	631-638	8
α-helix	643-669	27
α-helix	677-680	4
α-helix	682-692	11
α-helix	696-709	14
β-strand	716	1	33
β-strand	719	1	34
β-strand	722-723	2	35
β-strand	732-733	2	35
β-strand	736	1	34
α-helix	742-755	14
α-helix	763-797	35
α-helix	799-814	16
α-helix	818-821	4
β-strand	823	1	33
α-helix	829-865	37
α-helix	871-890	20
α-helix	896-926	31
β-strand	958-960	3	36
β-strand	962-965	4	37
β-strand	968-971	4	37
α-helix	975-994	20
α-helix	1014-1017	4
α-helix	1022-1025	4
α-helix	1031-1062	32
α-helix	1065-1072	8
α-helix	1076-1079	4
α-helix	1083-1092	10
β-strand	1102	1	36
β-strand	1105-1107	3	36
α-helix	1110-1139	30
α-helix	1142-1155	14
α-helix	1163-1174	12
α-helix	1176-1180	5
α-helix	1181-1199	19
α-helix	1206-1208	3
α-helix	1211-1214	4
α-helix	1216-1232	17
α-helix	1237-1263	27
α-helix	1276-1304	29
α-helix	1313-1330	18
α-helix	1333-1336	4
α-helix	1341-1348	8
α-helix	1356-1365	10
α-helix	1366-1369	4
α-helix	1384-1386	3
α-helix	1389-1391	3
α-helix	1397-1402	6
α-helix	1410-1420	11
α-helix	1431-1435	5
α-helix	1439-1472	34
β-strand	1474	1	38
β-strand	1477-1480	4	39
β-strand	1484-1487	4	39
α-helix	1490-1508	19
α-helix	1517-1553	37
α-helix	1556-1560	5
α-helix	1562-1584	23
β-strand	1587	1	38
α-helix	1588-1593	6
α-helix	1597-1613	17
α-helix	1616-1625	10
α-helix	1627-1630	4
α-helix	1634-1642	9
α-helix	1647-1657	11
β-strand	1663-1666	4	40
β-strand	1672-1677	6	40
β-strand	1683-1691	9	40
α-helix	1698-1727	30
α-helix	1735-1743	9
α-helix	1747-1769	23
α-helix	1777-1797	21
α-helix	1802-1828	27
α-helix	1836-1840	5
β-strand	1844-1846	3	41
β-strand	1857-1859	3	41
β-strand	1866-1867	2	41
α-helix	1883-1897	15
β-strand	1901-1905	5	42
α-helix	1912-1923	12
β-strand	1927-1931	5	42
α-helix	1938-1951	14
β-strand	1954-1958	5	42
α-helix	1960-1962	3
α-helix	1965-1985	21
α-helix	1995-1996	2
β-strand	1998-2000	3	43
β-strand	2005-2007	3	43
β-strand	2014-2018	5	42
α-helix	2026-2029	4
α-helix	2030-2033	4
β-strand	2036-2040	5	42
α-helix	2046-2057	12
α-helix	2062-2067	6
α-helix	2070-2079	10
α-helix	2090-2117	28
α-helix	2124-2129	6
α-helix	2133-2145	13
α-helix	2153-2164	12
α-helix	2176-2188	13
α-helix	2201-2216	16
β-strand	2219-2221	3	44
α-helix	2230-2245	16
β-strand	2249-2254	6	44
α-helix	2261-2264	4
α-helix	2279-2289	11
α-helix	2294-2296	3
β-strand	2298-2305	8	44
α-helix	2314-2316	3
β-strand	2324-2326	3	45
β-strand	2332-2334	3	45
β-strand	2339-2345	7	44
α-helix	2353-2357	5
β-strand	2360-2361	2	44
α-helix	2371-2384	14
α-helix	2411-2426	16
α-helix	2432-2442	11
α-helix	2451-2475	25
α-helix	2483-2503	21
α-helix	2508-2521	14
β-strand	2538-2540	3	46
β-strand	2544-2546	3	46
α-helix	2549-2551	3
α-helix	2572-2586	15
β-strand	2593-2594	2	47
α-helix	2601-2609	9
β-strand	2615-2620	6	48
α-helix	2628-2638	11
β-strand	2639-2644	6	49
β-strand	2647-2652	6	49
β-strand	2658-2663	6	48
α-helix	2678-2688	11
β-strand	2694	1	50
β-strand	2699	1	50
β-strand	2702-2703	2	49
β-strand	2706-2709	4	48
β-strand	2711-2712	2	47
α-helix	2721-2724	4
α-helix	2725-2729	5
β-strand	2735	1	47
α-helix	2737-2740	4
α-helix	2741-2756	16
α-helix	2760-2765	6
α-helix	2766-2783	18
α-helix	2796-2810	15
α-helix	2818-2833	16
α-helix	2840-2857	18
α-helix	2863-2866	4
β-strand	2873-2874	2	51
β-strand	2882-2883	2	51
α-helix	2886-2903	18
α-helix	2913-2927	15
β-strand	2932-2937	6	52
α-helix	2943-2954	12
β-strand	2957-2960	4	52
α-helix	2969-2980	12
α-helix	2981-2985	5
β-strand	2990-2995	6	52
α-helix	3002-3014	13
α-helix	3024-3040	17
α-helix	3047-3061	15
β-strand	3064-3068	5	52
α-helix	3072-3081	10
α-helix	3083-3087	5
β-strand	3090-3095	6	52
α-helix	3099-3109	11
α-helix	3139-3164	26
α-helix	3173-3250	78
α-helix	3441-3494	54
α-helix	3496-3501	6
α-helix	3503-3515	13
α-helix	3522-3538	17
α-helix	3551-3553	3
α-helix	3556-3564	9
α-helix	3571-3581	11
β-strand	3587-3590	4	53
α-helix	3595-3603	9
β-strand	3612-3613	2	53
α-helix	3618-3629	12
β-strand	3634-3636	3	53
α-helix	3638-3640	3
α-helix	3643-3645	3
α-helix	3646-3649	4
β-strand	3654	1	54
β-strand	3661	1	54
β-strand	3662-3664	3	55
β-strand	3667-3669	3	55
β-strand	3678-3681	4	53
α-helix	3690-3694	5
β-strand	3697-3699	3	53
α-helix	3705-3720	16
α-helix	3722-3754	33
α-helix	3764-3798	35
α-helix	3799-3801	3
α-helix	3802-3817	16
α-helix	3818-3820	3
α-helix	3829-3840	12
α-helix	3845-3848	4
α-helix	3852-3872	21
α-helix	3877-3894	18
α-helix	3902-3910	9
α-helix	3929-3938	10
α-helix	3942-3945	4
α-helix	3947-3953	7
α-helix	3957-3962	6
α-helix	3966-3968	3
α-helix	3982-3996	15
α-helix	3998-4000	3
α-helix	4001-4012	12
α-helix	4016-4019	4
α-helix	4020-4022	3
α-helix	4027-4029	3
α-helix	4030-4034	5
β-strand	4041-4045	5	56
α-helix	4052-4062	11
β-strand	4066-4067	2	57
α-helix	4074-4090	17
β-strand	4093-4094	2	57
β-strand	4097	1	56
α-helix	4103-4114	12
β-strand	4124	1	57
β-strand	4125-4129	5	56
α-helix	4136-4141	6
β-strand	4143-4144	2	56
β-strand	4147	1	56
α-helix	4153-4163	11
α-helix	4166-4169	4
α-helix	4176-4195	20
α-helix	4197-4200	4
α-helix	4209-4226	18
α-helix	4240-4246	7
α-helix	4247-4251	5
α-helix	4253-4255	3
α-helix	4259-4272	14
α-helix	4276-4278	3
β-strand	4285	1	58
β-strand	4294	1	58
α-helix	4295-4297	3
α-helix	4302-4310	9
α-helix	4318-4321	4
α-helix	4327-4346	20
α-helix	4375-4390	16
α-helix	4396-4400	5
α-helix	4402-4406	5
α-helix	4408-4438	31
α-helix	4446-4457	12
α-helix	4459-4461	3
α-helix	4475-4497	23
α-helix	4500-4506	7
β-strand	4509-4510	2	59
α-helix	4517-4532	16
β-strand	4539-4545	7	59
α-helix	4551-4554	4
β-strand	4557-4561	5	59
β-strand	4564-4566	3	60
β-strand	4568-4571	4	61
β-strand	4574-4577	4	61
β-strand	4583-4584	2	60
β-strand	4588-4594	7	59
α-helix	4595	1
β-strand	4604-4607	4	61
β-strand	4609-4610	2	60
β-strand	4622-4626	5	61
α-helix	4627	1
α-helix	4632-4638	7
β-strand	4641-4643	3	60

Chain C: 5 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	187-191	5
α-helix	196-209	14
β-strand	267-271	5	62
β-strand	284	1	63
β-strand	288	1	64
β-strand	291	1	64
β-strand	297-299	3	63
β-strand	312-314	3	63
β-strand	335-339	5	65
β-strand	349-352	4	65
β-strand	357-359	3	65
β-strand	371-372	2	65
β-strand	386-390	5	66
β-strand	397-401	5	66
β-strand	407-410	4	66
β-strand	421-422	2	66
β-strand	427	1	67
β-strand	430	1	67
β-strand	436-437	2	68
β-strand	449-450	2	68
β-strand	456-459	4	68
β-strand	468-472	5	68
β-strand	479-484	6	69
β-strand	497-501	5	69
β-strand	505-509	5	69
β-strand	518-521	4	69
β-strand	540-542	3	70
β-strand	550-552	3	70
β-strand	563-564	2	70
β-strand	587	1	62
β-strand	594-597	4	62
α-helix	601-604	4
α-helix	608-616	9
α-helix	617-619	3

Chain D: 5 helices, 35 β-strands

Element	Residues	Length	Sheet
α-helix	186-192	7
α-helix	196-209	14
β-strand	266-270	5	71
β-strand	280-286	7	72
β-strand	288	1	73
β-strand	294-302	9	72
β-strand	311-317	7	72
β-strand	327-331	5	72
β-strand	339-341	3	73
β-strand	344-351	8	73
β-strand	352	1	74
β-strand	357-361	5	73
β-strand	369-371	3	73
β-strand	384	1	74
β-strand	399-400	2	75
β-strand	407-409	3	75
β-strand	421-422	2	75
β-strand	427	1	76
β-strand	430	1	76
β-strand	434	1	77
β-strand	438	1	78
β-strand	448-449	2	78
β-strand	451	1	77
β-strand	457-458	2	78
α-helix	478-479	2
β-strand	481-483	3	79
β-strand	488	1	80
β-strand	492	1	80
β-strand	497-500	4	79
β-strand	505-509	5	79
β-strand	516-521	6	79
β-strand	539	1	81
β-strand	549-551	3	82
β-strand	553	1	81
β-strand	563-565	3	82
β-strand	575-578	4	71
β-strand	584-588	5	71
β-strand	594-598	5	71
α-helix	601-604	4
α-helix	608-618	11

Chain E: 14 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	43-45	3
β-strand	59	1	83
α-helix	67-75	9
β-strand	88-93	6	84
β-strand	102-107	6	84
α-helix	114-116	3
α-helix	118-122	5
α-helix	128-130	3
β-strand	133	1	85
β-strand	134	1	83
α-helix	142-163	22
α-helix	167-182	16
β-strand	185	1	86
β-strand	227-230	4	85
α-helix	238	1
α-helix	239-243	5
α-helix	248-265	18
β-strand	267-270	4	85
β-strand	273	1	87
β-strand	278	1	87
α-helix	282-290	9
β-strand	309	1	85
β-strand	312-313	2	86
α-helix	317-326	10
α-helix	336-339	4
α-helix	359-372	14

Chain F: 12 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	40-45	6
β-strand	55-57	3	88
β-strand	60-61	2	89
α-helix	68-74	7
β-strand	90	1	88
β-strand	93-95	3	90
β-strand	100-102	3	90
β-strand	104-106	3	88
α-helix	113-115	3
α-helix	117-121	5
β-strand	131-132	2	88
β-strand	133	1	91
β-strand	135-136	2	89
α-helix	144-163	20
α-helix	167-183	17
β-strand	227	1	91
α-helix	238-242	5
α-helix	248-264	17
α-helix	281-290	10
α-helix	317-326	10
α-helix	336-340	5
α-helix	359-371	13

Chain G: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	4-13	10
β-strand	23	1	92
β-strand	29	1	92
α-helix	36-60	25
β-strand	68-73	6	93
β-strand	78-80	3	93
β-strand	89-91	3	93

Chain H: 3 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	5-15	11
β-strand	17-23	7	93
β-strand	31	1	93
α-helix	36-41	6
α-helix	42-60	19
β-strand	66-72	7	93
β-strand	77-79	3	93
β-strand	87-92	6	93

9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cytoplasmic dynein 1 heavy chain 1	A, B	protein	4646	Homo sapiens	Q14204
Cytoplasmic dynein 1 intermediate chain 2	C, D, U, V	protein	638	Homo sapiens	Q13409 (AlphaFold model)
Cytoplasmic dynein 1 light intermediate chain 2	E, F	protein	492	Homo sapiens	O43237 (AlphaFold model)
Dynein light chain roadblock-type 1	G, H	protein	96	Homo sapiens	Q9NP97 (AlphaFold model)
Dynein light chain 1, cytoplasmic	I, J	protein	89	Homo sapiens	P63167
Dynein light chain Tctex-type 1	K, L	protein	113	Homo sapiens	P63172
Platelet-activating factor acetylhydrolase IB subunit beta	O, P	protein	410	Homo sapiens	P43034
Dynactin subunit 1	W, X	protein	1281	Homo sapiens	Q14203

Sequence of entity 1 (A, B), FASTA

>9YNH_1 Cytoplasmic dynein 1 heavy chain 1 (chains A, B)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE

Sequence of entity 2 (C, D, U, V), FASTA

>9YNH_2 Cytoplasmic dynein 1 intermediate chain 2 (chains C, D, U, V)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA

Sequence of entity 3 (E, F), FASTA

>9YNH_3 Cytoplasmic dynein 1 light intermediate chain 2 (chains E, F)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA

Sequence of entity 4 (G, H), FASTA

>9YNH_4 Dynein light chain roadblock-type 1 (chains G, H)
MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Sequence of entity 5 (I, J), FASTA

>9YNH_5 Dynein light chain 1, cytoplasmic (chains I, J)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG

Sequence of entity 6 (K, L), FASTA

>9YNH_6 Dynein light chain Tctex-type 1 (chains K, L)
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKP
FKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI

Sequence of entity 7 (O, P), FASTA

>9YNH_7 Platelet-activating factor acetylhydrolase IB subunit beta (chains O, P)
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR

Sequence of entity 8 (W, X), FASTA

>9YNH_8 Dynactin subunit 1 (chains W, X)
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRRE
GTDSNAKTSKLRGPKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGAQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGIRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGI
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSVLKGAQMKASLAALPPLHVAKLSLPPHE
GPGSELAAGALYRKTNQLLETLNQLSTHTHVVDITRSSPAAKSPSAQLLEQVTQLKSLSD
TIEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLG
QRHRLVLTQEQLHQLHDRLIS

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	2
MG	Magnesium ion	Mg	4

Primary citation

Roles of microtubules and LIS1 in dynein transport machinery assembly. Rao, Q., Yang, J., Chai, P. et al. Nature (2026) 652:1384-1392. DOI 10.1038/s41586-026-10153-y · PubMed

Other PDB entries of the same protein (UniProt Q14204), best resolution first:

5OWO 1.79 Å, Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution
9BLZ 2.2 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATP
9BMR 2.6 Å, State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP
9DH5 2.6 Å, State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+
9E0X 2.7 Å, Cryo-EM structure of Phi dynein
9E10 2.71 Å, Dimeric motor domains from phi dynein-1 under Lis1 condition
9BM0 2.8 Å, State-2 of motor domain from full-length human dynein-1 in 5mM ATP
9BMF 2.8 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi
9BMH 2.8 Å, State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi
9BN3 2.8 Å, The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1
9BM2 2.82 Å, State-4 of motor domain from full-length human dynein-1 in 5 mM ATP
9BMG 2.86 Å, State-2 of full-length human dynein-1 in 5mM ATPVi

Browse structure collections

About this viewer

MolViewer shows 9YNH directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.