ORF1ab polyprotein (orf1ab) is a 123-residue protein from Human betacoronavirus 2c EMC/2012. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: K0BWD0.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers
Interacts with host PHB and PHB2
Host cytoplasm, host perinuclear region, Host endoplasmic reticulum-Golgi intermediate compartment, Host membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5YNM | X-ray | 1.68 Å | A=6776-7078 |
| 5YNF | X-ray | 1.79 Å | A=6776-7078 |
| 5YNN | X-ray | 1.86 Å | A=6776-7078 |
| 5YN6 | X-ray | 1.95 Å | A=6776-7078 |
| 5YN5 | X-ray | 1.96 Å | A=6776-7078 |
| 5YNO | X-ray | 1.96 Å | A=6776-7078 |
| 5YNQ | X-ray | 1.96 Å | A=6776-7078 |
| 5YN8 | X-ray | 1.97 Å | A=6776-7078 |
| 5YNB | X-ray | 1.98 Å | A=6776-7078 |
| 5YNJ | X-ray | 2.04 Å | A=6776-7078 |
| 5YNI | X-ray | 2.07 Å | A=6776-7078 |
| 5YNP | X-ray | 2.27 Å | A=6776-7078 |
| 6BI8 | X-ray | 2.29 Å | A/B=1544-1801 |
| 4P16 | X-ray | 2.5 Å | A=1482-1801 |
| 5V69 | X-ray | 2.55 Å | A=1480-1803 |
| 5V6A | X-ray | 2.7 Å | A=1480-1803 |
| 5WWP | X-ray | 3.0 Å | A/B=5311-5908 |
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