Mannan-binding lectin serine protease 2 (MASP2) is a 686-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00187.
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The mean pLDDT of this model is 89.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11527969, PubMed:22691502). The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface (PubMed:22691502, PubMed:22966085). MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates (PubMed:10946292, PubMed:22949645, PubMed:22966085, PubMed:9087411). Can activate prothrombin to thrombin (PubMed:39924859)
Homodimer; disulfide-linked (PubMed:15117939, PubMed:15364579). Interacts with MBL2 and FCN2; requires calcium ions (PubMed:15117939). Interacts with SERPING1 (PubMed:10946292). Interacts with guianensin, an anticoagulant and anti-complement protein from Simulium guianense saliva; the interaction results in the inhibition of MASP2 enzymatic activity (PubMed:39924859)
Secreted, Cell surface
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3TVJ | X-ray | 1.28 Å | A=363-444, B=445-686 |
| 9D40 | X-ray | 1.76 Å | A=363-686 |
| 9D17 | X-ray | 1.97 Å | A=363-686 |
| 9D3Y | X-ray | 2.08 Å | A=363-686 |
| 1ZJK | X-ray | 2.18 Å | A=287-686 |
| 1Q3X | X-ray | 2.23 Å | A/B=363-686 |
| 9D4D | X-ray | 2.36 Å | A=363-686 |
| 7PQN | X-ray | 2.4 Å | A/aa=363-444, B/bb=445-686 |
| 1SZB | X-ray | 2.5 Å | A/B=16-181 |
| 5JPM | X-ray | 3.75 Å | G/I=291-444, H/J=445-686 |
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