Cortistatin (CORT) is a 105-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00230.
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The mean pLDDT of this model is 62.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 59% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Precursor of neuropeptides that bind to all somatostatin receptor (SSTR) subtypes (PubMed:9125122). Inhibits cAMP production induced by forskolin through SSTRs (PubMed:9125122)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7S8L | EM | 2.45 Å | A=92-105 |
| 7S8M | EM | 2.54 Å | A=92-105 |
| 8X8L | EM | 2.7 Å | C=89-105 |
| 7VV4 | EM | 2.97 Å | L=92-105 |
| 7VDL | EM | 3.22 Å | L=92-105 |
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