B-cell CLL/lymphoma 9 protein (BCL9) is a 1426-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00512.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 42.6 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 86% |
What pLDDT means and how to read it
Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity)
Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4'
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2VPB | X-ray | 1.59 Å | B=174-205 |
| 2VPG | X-ray | 1.6 Å | B/D=176-205 |
| 2VP7 | X-ray | 1.65 Å | B=174-205 |
| 2VPE | X-ray | 1.7 Å | B/D=176-205 |
| 3SL9 | X-ray | 2.2 Å | C/D/F/H=344-396 |
| 2GL7 | X-ray | 2.6 Å | C/F=347-392 |
| 8Y0P | X-ray | 2.62 Å | L=351-374 |
| 2VPD | X-ray | 2.77 Å | B/D=174-205 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.