Protein CASC3 (CASC3) is a 703-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15234.
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The mean pLDDT of this model is 53.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 56% |
What pLDDT means and how to read it
Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes…
Identified in the spliceosome C complex (PubMed:28502770, PubMed:29301961). Component of the mRNA splicing-dependent exon junction complex (EJC), which contains at least CASC3, EIF4A3, MAGOH, NXF1 and RBM8A/Y14 (PubMed:15166247, PubMed:16170325, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). Identified in a complex composed of the EJC core, UPF3B and UPF2.…
Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Nucleus speckle, Cytoplasm, Stress granule, Cytoplasm, Cytoplasmic ribonucleoprotein granule, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2J0S | X-ray | 2.21 Å | T=137-286 |
| 2HYI | X-ray | 2.3 Å | D/J=170-246 |
| 3EX7 | X-ray | 2.3 Å | D/I=138-283 |
| 2J0U | X-ray | 3.0 Å | T=137-250 |
| 6ICZ | EM | 3.0 Å | x=1-703 |
| 2J0Q | X-ray | 3.2 Å | I/T=137-286 |
| 2XB2 | X-ray | 3.4 Å | S/T=137-286 |
| 8I0W | EM | 3.4 Å | x=1-703 |
| 5XJC | EM | 3.6 Å | x=1-703 |
| 7W59 | EM | 3.6 Å | x=1-703 |
| 7W5A | EM | 3.6 Å | x=1-703 |
| 5YZG | EM | 4.1 Å | x=1-703 |
| 7W5B | EM | 4.3 Å | x=1-703 |
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