Amyloid-beta A4 precursor protein-binding family A member 1 (Apba1) is a 839-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O35430.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 59.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta
Part of a multimeric complex containing STXBP1 and STX1A. Interacts with STXBP1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Within the complex, interacts (via PDZ domain) with the motor protein…
Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9M6G | X-ray | 1.7 Å | C=338-397 |
| 4DBB | X-ray | 1.9 Å | A=453-643 |
| 6KMH | X-ray | 2.4 Å | C/D=338-397 |
| 7XSJ | X-ray | 3.2 Å | C=227-303 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.