Peptidyl-prolyl cis-trans isomerase H (PPIH) is a 177-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43447.
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The mean pLDDT of this model is 96.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 94% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone
Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Heterodimer with PRPF18
Nucleus speckle, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1MZW | X-ray | 2.0 Å | A=1-177 |
| 1QOI | X-ray | 2.0 Å | A=1-177 |
| 8H6L | EM | 2.6 Å | 4H=1-177 |
| 8H6K | EM | 2.7 Å | 4H=1-177 |
| 6AHD | EM | 3.8 Å | W=1-177 |
| 8QZS | EM | 4.1 Å | W=1-177 |
| 8R09 | EM | 4.3 Å | W=1-177 |
| 8R0B | EM | 4.4 Å | W=1-177 |
| 5O9Z | EM | 4.5 Å | M=1-177 |
| 8QO9 | EM | 5.29 Å | W=1-177 |
| 8RM5 | EM | 6.9 Å | W=1-177 |
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