SH3 domain-binding protein 5 (SH3BP5) is a 455-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60239.
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The mean pLDDT of this model is 70.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death
Interacts with BTK (PubMed:10339589, PubMed:9571151). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309, PubMed:30217979)
Cytoplasmic vesicle membrane, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4H3B | X-ray | 2.08 Å | B/D=341-350 |
| 6DJL | X-ray | 3.1 Å | B/C/D/E=1-265 |
| 6IXE | X-ray | 3.35 Å | A=41-266 |
| 6IXF | X-ray | 3.6 Å | A/B=41-266 |
| 6IXG | X-ray | 3.8 Å | A/B=41-266 |
| 6IXV | X-ray | 3.8 Å | A/B/C/D=10-276 |
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