Germinal-center associated nuclear protein (MCM3AP) is a 1980-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60318.
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The mean pLDDT of this model is 64.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018)
Isoform GANP: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY (PubMed:22307388, PubMed:23591820). Interacts with RNA polymerase II subunit POLR2A and with the transcription…
Nucleus envelope, Nucleus, nuclear pore complex, Nucleus, nucleoplasm, Chromosome, Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DHX | X-ray | 2.1 Å | A/D=1163-1235 |
| 9DLP | EM | 2.79 Å | A=358-1000 |
| 9UPC | EM | 3.14 Å | A=580-1000 |
| 9UPB | EM | 3.41 Å | A=580-1000 |
| 8R7J | EM | 3.5 Å | A=582-1004 |
| 8R7K | EM | 3.5 Å | A=582-1004 |
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