8R7J: Human TREX-2 complex

Cryo-EM structure of the human TREX-2 complex. Determined by electron microscopy at 3.5 Å resolution. Released 11 Jun 2025.

Method
Electron microscopy
Resolution
3.5 Å
Organism
Homo sapiens
Chains
3
Atoms
6,042
Mol. weight
102.54 kDa
Released
11 Jun 2025

Explore 8R7J in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8R7J contains 41 α-helices and 5 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix645-6528
α-helix673-6764
α-helix694-70310
α-helix704-7085
α-helix717-73519
α-helix742-76120
α-helix772-79625
α-helix803-81311
α-helix820-8245
α-helix829-8324
α-helix837-84812
α-helix853-8597
α-helix864-8696
α-helix874-8829
β-strand899-90021
α-helix904-9074
α-helix913-92311
β-strand931-93221
α-helix963-9675
Chain B: 22 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix6-1813
α-helix241
α-helix25-295
α-helix47-537
α-helix56-7318
α-helix78-9619
α-helix105-1128
α-helix114-1207
α-helix137-15216
α-helix168-18215
α-helix189-1968
α-helix206-22116
α-helix226-23813
α-helix247-26216
α-helix268-2736
α-helix280-2878
α-helix293-3008
α-helix311-3144
α-helix315-3173
α-helix318-33316
β-strand337-33932
α-helix340-3489
α-helix357-37014
β-strand376-37722
β-strand383-38532
Chain C: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix20-223
α-helix51-599

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Germinal-center associated nuclear proteinAprotein423Homo sapiensO60318 (AlphaFold model)
PCI domain-containing protein 2Bprotein399Homo sapiensQ5JVF3 (AlphaFold model)
26S proteasome complex subunit SEM1Cprotein70Homo sapiensP60896 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>8R7J_1 Germinal-center associated nuclear protein (chains A)
SEGLGPCVLSLSTLIGTVAETSKEKYRLLDQRDRIMRQARVKRTDLDKARTFVGTCLDMC
PEKERYMRETRSQLSVFEVVPGTDQVDHAAAVKEYSRSSADQEEPLPHELRPLPVLSRTM
DYLVTQIMDQKEGSLRDWYDFVWNRTRGIRKDITQQHLCDPLTVSLIEKCTRFHIHCAHF
MCEEPMSSFDAKINNENMTKCLQSLKEMYQDLRNKGVFCASEAEFQGYNVLLSLNKGDIL
REVQQFHPAVRNSSEVKFAVQAFAALNSNNFVRFFKLVQSASYLNACLLHCYFSQIRKDA
LRALNFAYTVSTQRSTIFPLDGVVRMLLFRDCEEATDFLTCHGLTVSDGCVELNRSAFLE
PEGLSKTRKSVFITRKLTVSVGEIVNGGPLPPVPRHTPVCSFNSQNKYIGESLAAELPVS
TQR
Sequence of entity 2 (B), FASTA
>8R7J_2 PCI domain-containing protein 2 (chains B)
MAHITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDE
MFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFAN
NADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYF
KINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHC
HRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAK
HEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEV
QCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPLSTVC
Sequence of entity 3 (C), FASTA
>8R7J_3 26S proteasome complex subunit SEM1 (chains C)
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS

Primary citation

An ATP-gated molecular switch orchestrates human messenger RNA export. Hohmann, U., Graf, M., Tirian, L. et al. Nature (2025). DOI 10.1038/s41586-025-09832-z · PubMed

Other PDB entries of the same protein (UniProt O60318 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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