9UPC: Human TREX-2

Structure of human TREX-2. Determined by electron microscopy at 3.14 Å resolution. Released 11 Feb 2026.

Method
Electron microscopy
Resolution
3.14 Å
Organism
Homo sapiens
Chains
3
Atoms
6,159
Mol. weight
109.35 kDa
Released
11 Feb 2026

Explore 9UPC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9UPC contains 44 α-helices and 10 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix643-65210
α-helix694-70310
α-helix704-7085
α-helix716-73520
α-helix742-76120
α-helix772-79423
α-helix803-81210
α-helix819-8257
α-helix835-84814
α-helix852-8609
α-helix864-8685
α-helix874-88714
β-strand896-89721
α-helix901-9033
α-helix913-9208
α-helix921-9233
β-strand92912
β-strand93112
β-strand934-93521
α-helix952-9565
α-helix962-9676
α-helix971-9744
Chain B: 24 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix6-1914
α-helix22-298
α-helix47-537
α-helix60-7415
α-helix77-9721
α-helix105-12622
α-helix137-15115
α-helix156-1583
α-helix164-1674
α-helix169-18214
α-helix185-19410
α-helix201-2033
α-helix207-22216
α-helix226-23914
β-strand24113
α-helix242-2443
α-helix245-26117
β-strand265-26624
α-helix2671
α-helix268-2736
α-helix278-2869
α-helix291-30010
α-helix302-3087
α-helix317-32913
α-helix340-3489
α-helix357-37014
β-strand37215
β-strand37415
Chain C: 2 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix20-223
β-strand3213
β-strand39-4024
α-helix51-6111

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Germinal-center associated nuclear proteinAprotein463Homo sapiensO60318 (AlphaFold model)
PCI domain-containing protein 2Bprotein426Homo sapiensQ5JVF3 (AlphaFold model)
26S proteasome complex subunit SEM1Cprotein70Homo sapiensP60896 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9UPC_1 Germinal-center associated nuclear protein (chains A)
SAWSHPQFEKGGGSGGGSGGSAWSHPQFEKGGGGSDEVDAAAEGSEGLGPCVLSLSTLIG
TVAETSKEKYRLLDQRDRIMRQARVKRTDLDKARTFVGTCLDMCPEKERYMRETRSQLSV
FEVVPGTDQVDHAAAVKEYSRSSADQEEPLPHELRPLPVLSRTMDYLVTQIMDQKEGSLR
DWYDFVWNRTRGIRKDITQQHLCDPLTVSLIEKCTRFHIHCAHFMCEEPMSSFDAKINNE
NMTKCLQSLKEMYQDLRNKGVFCASEAEFQGYNVLLSLNKGDILREVQQFHPAVRNSSEV
KFAVQAFAALNSNNFVRFFKLVQSASYLNACLLHCYFSQIRKDALRALNFAYTVSTQRST
IFPLDGVVRMLLFRDCEEATDFLTCHGLTVSDGCVELNRSAFLEPEGLSKTRKSVFITRK
LTVSVGEIVNGGPLPPVPRHTPVCSFNSQNKYIGESLAAELPV
Sequence of entity 2 (B), FASTA
>9UPC_2 PCI domain-containing protein 2 (chains B)
DYKDHDGDYKDHDIDYKDDDDKGSAAAMAHITINQYLQQVYEAIDSRDGASCAELVSFKH
PHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLR
AFQAHKEENWALPVMYAVALDLRVFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCA
SDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYK
YYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKK
YHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLL
KTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFP
PLSTVC
Sequence of entity 3 (C), FASTA
>9UPC_3 26S proteasome complex subunit SEM1 (chains C)
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS

Primary citation

Molecular insights into mRNA export regulation by the human TREX-2 complex. Gong, X., Tao, R., Ge, X. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-70088-w · PubMed

Other PDB entries of the same protein (UniProt O60318 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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