Eukaryotic translation initiation factor 4E type 2 (EIF4E2) is a 245-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60573.
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The mean pLDDT of this model is 80.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (PubMed:17368478, PubMed:22751931, PubMed:25624349, PubMed:33581076, PubMed:9582349). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism…
Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (PubMed:15153109, PubMed:17368478). Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3) (By similarity). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:22751931, PubMed:32726578). Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct (PubMed:22751931, PubMed:32726578,…
Cytoplasm, Cytoplasm, P-body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2JGB | X-ray | 1.7 Å | A=45-234 |
| 5NVN | X-ray | 1.9 Å | A/C=52-234 |
| 5XLN | X-ray | 1.9 Å | A=45-234 |
| 5NVM | X-ray | 2.0 Å | A/C=52-234 |
| 5NVL | X-ray | 2.3 Å | A/C=52-234 |
| 2JGC | X-ray | 2.4 Å | A=45-234 |
| 5NVK | X-ray | 2.9 Å | A/C/E/G=52-234 |
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