Receptor activity-modifying protein 3 (RAMP3) is a 148-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60896.
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The mean pLDDT of this model is 87.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for…
Heterodimer of CALCRL and RAMP3; interaction induces allosteric modulation of CALCRL function and ligand specificity for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Heterodimer of CALCR and RAMP3; interaction form the receptor complex AMYR3 for amylin/IAPP (PubMed:35324283). Interacts with GPER1 (PubMed:23674134)
Cell membrane, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8F0K | EM | 1.9 Å | E=24-148 |
| 8F2B | EM | 2.0 Å | E=24-148 |
| 8F2A | EM | 2.2 Å | E=24-148 |
| 6UVA | EM | 2.3 Å | E=24-148 |
| 6UUS | EM | 2.4 Å | E=24-148 |
| 7TZF | EM | 2.4 Å | E=24-148 |
| 9BTW | EM | 3.0 Å | E=24-148 |
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